ANAFRANIL Reviews (CLOMIPRAMINE HYDROCHLORIDE)

Average Rating: 3.7 (133 Ratings)

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 ANTIDEPRESSANTS CNS, MISCELLANEOUS

 Type: Rx Drug

  

ANAFRANIL  (CLOMIPRAMINE HYDROCHLORIDE):  Clomipramine is used to treat obsessive compulsive disorder (OCD). It helps decrease persistent/unwanted thoughts (obsessions), and it helps reduce the urge to perform repeated tasks (compulsions such as hand-washing, counting, checking) that interfere with daily living. This medication belongs to a class of medications called tricyclic antidepressants. It works by restoring the balance of certain natural substances (serotonin, among others) in the brain.   FDA Approval Date: 1989-12-29 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on ANAFRANIL: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR ANAFRANILCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  Depression Panic Disorder Felt this weird sensation like I had a weight sitting on top of my head. Not beneficial for me but I understand it will improve OCD symptoms quite well. Watch out for blood disorder side effects M 50 9 days
25 MG 1X day
9/30/2014
 4  OCD Acid reflux When I first started Anafranil, I started with one a day, and slowly increased to where I am now-- 4 a day. I initially didn't feel any difference until week 4 and it has seriously helped me. I get this "acid reflux" like feeling after I take them. I try to eat a little something before I take it, but it doesn't seem to make a difference. F 22 6 weeks
25mg 4X day
10/7/2014
 4  Sexual disorder Very bad constipation F 63 30 years
25mg 1X day
10/13/2014
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 5  depression Hypergydrose, tremor, low blood pressure, hypo-salivation. This antidepressant only helped me. M 34 1 years
150
12/6/2014
 4  Severe pure ocd and anxiety Severe Weight Gain Acid Reflux Saved my life but came off it because of weight gain but started on it back again. F 34 5 years
150 mg
3/18/2015
Email
 1  depressipn Weight gain,comtsipation,sweating,sex problem,excessive sleepy, Above effects occurs when i was using clomoprill for 3 years.but i have still side effects like weight gain and excessive sleep. Was doctor suggest rightly ,such long course for boy of 17 M 20 3 years
150
7/14/2015
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 1  Tinnitus Nausea, myoclonus, hypothermia, insomnia, anal itching. I have been suffering from a low pitch tinnitus in my right ear for the past 4 years and have tried numerous drugs without much success. I thought I'd give this one a try after reading that tricyclic antidepressants have helped some people get rid of their tinnitus. Well, in my case we'll never know. The side effects were so bad (esp. the nausea, insomnia and hypothermia) that I gave up after only 4 days. The tinnitus bothers me, the Anafranil however made me really sick. You do feel high on this drug though so there's definitely an antidepressant effect there, hidden beneath all the nasty side effects. M 42 4 days
25 MG 1X day
11/24/2015
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 1  anxiety ocd Sleepy I found it really didn't do anything at all good or bad. Not sure if I needed to up the dose and stay on it longer. Could others please include the dosage they were on for ocd purposes. F 32 2 weeks
50 MG
12/2/2015
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 1  anxiety and depression Shaky worse anxiety sick feeling crying all the time no relief. Dear God I need some relief from this medicine if my Dr. will not take me off I going to take my self off couldn't feel any worst from withdrawal. I took this back in 1990's the Generic doesn't come close to the original. This is working in reverse of what it did at that time. Thanks drug companies always looking for ways to make money and don't really care about the patients. If you did you make it affordable and make back to the original. F 64 35 days
100 1X day
12/7/2015
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 1  OCD Nausea, heart palpations, vision, sickness, dizzy, blood issues, Took for one day insomia bad sickness to avoid this crap mellows you out but has sides M 24 1 days
25 MG
12/21/2015
 5  ocd, anxiety, bulimia nausea, acid reflux if I don't eat right after taking it The only med out of 6 or 7 antidepressants I tried for my anxiety/ocd/eating disorder. I take dramamine for if I'm not the driver in the car. I feel SO much better than I have since I was 7 years old. My bulimia is totally gone. F 29 2 years
150 1X day
1/13/2016
 5  Ocd M 22 3 weeks
25
2/28/2016
 4  Depression, anxiety. Weight gain and bloating It helped M 25 8 months
10
10/26/2016
 1  Depression and anxiety, thougts Suicide attempts. Aggressive. Teeth pain. Erratic behaviour. Memory loss Tried once before years ago and worked on a low dose, tried again and not helped at all. Still in a state of unreality and another psychiatrist took me off 200mg.He stated he would like me on 10/30max or not at all. I've since had propranolol but I've ceased all meds for time being. Currently got the and social anxiety. No purpose M 37 34 months
200
6/28/2017
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 1  OCD an Depressin Dry mouth, insomnia, pains in joints, burping, terribe constipation, increased depression I did note a slight decrease in my OCD within a day or two, but the side effects such as insomnia made me feel worse and overall I got more depressed. I would rather have my OCD than put up with the terrible side effects. Celexa 20mg controls my depression well, by the way. F 49 5 days
50mg 1X day
8/6/2017
 5  Anxiety, major depression, OCD Constipation, Short term memory loss, hand tremor, weight gain... all minor but much better than not taking the medicine. My Doctor quickly upped the dosage higher and higher. Over 150 mg at one point. I cut it down to 25 mg and kept it that was for many years. Now I have reduced it to 10 mg. Doctors like to increase the dosage but I feel fine now at 10 mg. My Doctor is aware that I cut it back. Anafranil is an old drug but was brand new when I first started. I tried the newer drugs but they don't work for me. Zoloft was terrible. I also tried Citalopram, Wellbutrin and others but for me I seem to do best with Anafranil. What works for one person won't always work for another. Anafranil is a miracle drug for me. M 49 32 years
10 1X day
12/22/2017
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 2  Depression & OCPD Dry mouth, night sweats, sweating, ringing ears, dry eyes, loss of sex drive M 35 7 weeks
150 mg
1/22/2018
 4  OCD/dermatillomania, Anxiety, depression Dry mouth, brain zaps, night sweats,sexual dysfunction, tremmors, muscle twitching,insomnia Side effects halted after 6-8 weeks of starting medication as well as with every dosage adjustment. Sexual dysfunction is still an issue a year later F 23 1 years
175mg
4/17/2018
 1  ocd Extreme insomnia,Excessive thirst, M 28 2 days
25 1X day
8/17/2019
 4  Anxiety, PTSD Unfortunately some anticholinergic effects are present. Dry mouth at the beginning, but that went away after a few weeks. A feeling of heart burn / reflux that didn't go away. Brain fog / cognitive impairment. This caused sexual dysfunction on a way different level than SSRIs, with almost complete anorgasmia. Also a slight increase in heart rate. Really potent antidepressant, but with a number of annoying side effects. In my experience it packs quite a bit more punch that SSRIs. Go slow with the dosage increases, starting with 10mg for at least two weeks and then move to 25mg. The dosage often prescribed is WAY too high and won't increase effectiveness, but will markedly increase side-effects. Don't recommend going higher than 25mg as you already have very high binding to the serotonin and noradrenalin transporters at this dosage. Drug takes about 4 weeks to show it's full effect, and during that time you may feel worse. M 40 3 months
25 mg 1X day
11/23/2019
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