ANAFRANIL Reviews (CLOMIPRAMINE HYDROCHLORIDE)

Average Rating: 3.7 (133 Ratings)

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 ANTIDEPRESSANTS CNS, MISCELLANEOUS

 Type: Rx Drug

  

ANAFRANIL  (CLOMIPRAMINE HYDROCHLORIDE):  Clomipramine is used to treat obsessive compulsive disorder (OCD). It helps decrease persistent/unwanted thoughts (obsessions), and it helps reduce the urge to perform repeated tasks (compulsions such as hand-washing, counting, checking) that interfere with daily living. This medication belongs to a class of medications called tricyclic antidepressants. It works by restoring the balance of certain natural substances (serotonin, among others) in the brain.   FDA Approval Date: 1989-12-29 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on ANAFRANIL: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR ANAFRANILCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  ocd anxiety dry mouth sweating not sure if the rest was me or the drug M 54 27 days
2/18/2009
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 3  OCD and depression Dry mouth, Dizziness when standing up, nausea, diarhoea, constipation, drowsiness, twitching muscles and hands, indigestion- this drug is quite acidic, edgy feelings after being on it a while, increases anxiety and skipped heartbeats, fatigue for first few weeks- wears off. Upon forgetting to take it I had nasty side effects, i sweated profusely, shortness of breath, frequent toileting, alerted feeling, a little panicky at times from the high temperature. I find this particularly nasty, the physical addiction our body goes into. I think Anafranil is good for anyone with acute anxiety condition or panick disorder like me. Panic disorders can be hard to treat, but not impossible, it can be gotten rid of for long periods thank God. But its a strong drug even at 225mg a day, forgetting to take it for 3 days i thught i had a stomach bug and flu. I was throwing up and toileteing frequently. I feel these drugs are good for as long as you need to take them and no longer. I feel that with prolonged use side effects would increase. I really dont like the edgy feelings ive been getting with cramps in my gut. I certainly hope toc hange it and recieve therapy from a HSE in crises. F 30 9 months
3/2/2009
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 5  suicidal depression, anxiety, OCD 25 years experience. Works very well but side effects keep me trying other meds. Yet always a relief to get back to clomipramine (anafranil). Anticholinergic effects include acid reflux leading to scarring of esophagus and inability to swallow many foods without simultaneously drinking lots of warm/hot water, necessitating so far 2 outpatient operations to stretch esophagus. No sexual dysfunction for first 12 years but now severe (depending on dosage, as is libido loss) as I age. Reflux plus dry mouth anticholinergic effect have caused bad tooth decay. Bloating and weight gain. Mental confusion and difficulty urinating on higher doses, i.e., over 100 mg daily sometimes, but at other times fine on 165mg. Constipation, sweating, trembling, imbalance were mainly issues in the earlier years during which I often experienced some borderline serotonin syndrome. Saved my life for sure. I was hospitalized, so they could go straight to 150 mg, and by the 4th day I felt great. Maintains a real sense of well-being. Still have intrusive obsessional thoughts at times, but now I'm almost detached from them and they pass quickly. I keep trying to lower the dose because of side effects, and success depends upon changing life circumstances, seasons and how much anti-anxiety meds I am prescribed. Tricky, but I've done this often enough I don't have to wait to feel suicidal anymore to know I need to increase my dose. I've been on as little as 40 mg daily for 2 months and as much as 200 mg daily when things aren't going well, soon tapering to 150 due to borderline serotonin syndrome. A dose increase like this after falling into depression is like being plucked out of hell into a state of grace, no exaggeration. My average daily dose is 75-90 mg. Also really helps against anxiety and insomnia. Higher doses are the best painkiller ever for my bad back. My generic is APO. Once I filled my Rx at a different pharmacy and sunk into a severe depression. I hadn't noticed the generic was GEN. My shrink said that generic had that reputation. Why don't these dummies tell you these things beforehand? I've also never had a doc tell me about tooth decay from dry-mouth-causing drugs. Drinking water, etc. isn't enough. Dental hygienist says you need a salivary enzyme replacement toothpaste and/or mouthwash, e.g., Biotene. M 62 25 years
3/13/2009
 4  Trichotillomania I don't remember any minor side effects, but I had a real problem with mental confusion, to the point that I stopped this medicine even though it was working. It was like functioning on 3 hours sleep - my short term memory was shot and I had trouble recalling passwords and facts. This drug is amazing for OCD and trichotillomania. I took a pill and within minutes had zero desire to pull. I stopped taking it because I couldn't tolerate the mental confusion but I'm not sure if it it is a brief side effect that gets better over time or not. I plan on trying it again soon because I need the help. F 31 2 weeks
3/15/2009
 5  OCD/disturbing reoccurring thoughts Constipation, Sleep ALOT, no orgasm, black out when stand up too fast LOVE it. I've been having awful thoughts for many years and I had no idea that anything could stop them. Anafranil has saved my life. I no longer go to sleep fearful, so far, so good. F 21 1 months
3/16/2009
 5  Depression/Anxiety/Depersonalizatio None as yet I have tried Aropax/Zoloft/Luvox/Clonoazepam/Xanax and more recently Cymbalta - most of these with valium, as needed to varying degrees. The side effects of these drugs as well as there inefficacy has led me to try Anafranil - Having only been on this drug for about a week i have felt much better! Less distracted and able to concentrate on uni, and the people i care about. M 6 days
5/13/2009
 5  Depression/Anxiety Sweating, weight gain (about 20 lbs) other than that none really. I have tried all SSRI's and this so far is the best. I take 100-150 mg per day. I was surprised because alot of the pharmacies don't even carry it anymore. Helped my anxiety, obsessive thoughts, which in turn eased my depression. I would highly recommend it. F 55 7 months
6/10/2009
 1  Depression, Anxiety ,Panic attacks Paranoia, Dizziness, Did not sleep Head ache, Lack of hunger, Heart feels like its beating wrong, Jittery, equilibrium is off Horrible feeling F 23 2 days
6/19/2009
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 5  BPD; depression; ocd spontaneous, tic like, random movement of my muscles (extremities); "busy mind" when I sleep - wake up feeling refreshed but not enough sleep (like I will wake after just a couple hrs of sleep); agitation in the manner of nervousness/restlessness, not anger like agitation. Of all the meds I have ever taken for depression this one seems to help me the most, but now after 1 1/2 months I am starting to get side effects F 46 7 weeks
6/21/2009
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 5  OCD Anxiety Disorder I took this drug over 10 years ago for 6 years.It saved my life.I have had horrible phobias since I was 5.It took all of that away.I stopped due to the incredible weight gain and profuse sweating.Now I find myself in really bad shape from phobias again and have gone back on it.The side effects I have now are in the morning, dry mouth,slight dizziness,shaking/tremors,hot flushes all over my body.Im on 25 mgs now and am going to bump up to 50 soon.It has already helped some and I've only been on it 2 weeks.If you can get past the side effects,it is the most effective drug for OCD. Does anyone else have excessive thirst or bad taste in their mouth from this? F 44 2 weeks
7/24/2009
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 4  Social Anxiety & Paranoia Sweating more (head),dry mouth,sudden movements of hands when sleeping,lower sex drive & Weight Gain Has helped me quite a bit through anxiety M 44 2 years
8/5/2009
 2  Anxiety, OCD, Panic Attacks Terrible nausea, zero energy, and extremely sleepy, Zombie-Like state, very dry mouth. I have tried to go on this drug twice without success due to the bad side effects. I was only on it twice for 2 days each but could not handle the horrible feelings. May work for some but not for me. I even had to special order this drug since it is not readily available at most pharmacies. M 63 4 days
8/6/2009
 1  OCD phobias and panic disorder I wanted to revise my previous comments.I took this for almost 3 months and got worse on it,manic,racing thoughts,shaking,worsening of my OCD and anxiety.This durg worked for me for 6 years,but doesnt anymore.I pray I never have to take another antidepressant of any kind,they have all be horrible.I will stick to my Ativan and my therapy,but most of all will stop this madness on my own.Hope you all have better results than I did this time around. F 44 90 days
8/22/2009
 5  OCD/depression constipation, weird dreams, difficulty losing weight I rather be overweight and happy than thin and miserable. Really helped with both depression and obsessive thoughts, F 56 2 years
9/24/2009
 5  FOR ANXIETY WITH OBSESSIVE THOUGHS DRY MOUTH,CONSTIPATION,HEART BURN I HAVE TRIED MANY OTHER ANTIDEPRESSANTS AND HAVE NOT HAD SUCCESS WITH THEM LIKE ANAFRANIL.I AM ABLE TO WORK AND HAVE A NORMAL LIFE. I HAVE STRUGGLED WITH THIS DISEASE ON AND OFF SINCE I WAS TWENTY ONE. F 43 10 years
12/19/2009
 5  depression weight gain, sleepiness It changed my life, now I´m a happy person again. It is the best medicine by far. M 31 5 years
1/4/2010
 5  Depression/OCD/Social Anxiety Constipation and slight dry mouth. Higher sex drive which is not usual in anti depressants. Works GREAT for OCD and Depression. Also helps a bit with anxiety! I went on this drug about 18 months months ago and my life completley turned around. I felt like I needed a break from it a few months ago so came off it. I was feeling fine for about 6 weeks then all of my symptoms came back, especially severe depression. I have gone back on it now and realised I need this medication at this point in my life. I have to put up with the side effects because this is the only drug I have had that has been effective. F 22 18 months
1/5/2010
 5  OCD Side-effects as to be expected from a TCA: dry mouth, little sedation (got less after weeks), obstipation and ... no orgasm anymore Life-safer. First time I visited a psychiatrist I was diagnose as bipolar disordered because I decribed my thoughts as "racing" and got a terrible acathisia on SSRI's which he thought to be hypomaniac symptoms. Took me 8 years to get rid of that diagnosis. I'll save you that story. Anafranil made the violent, sexual thoughts, the continuous doubt and need to position things "right" and the need to "confess" so much less. Adding a little risperdal (0.5 mg) made things even better! Symptoms are 60% less and I can have a professional life again! Damn that anorgasmia though ... but it is worth it. I actually don't really understand why TCA have this bad reputation; I personally find them even to be better tolerated than the SSRI's, that for sure. M 32 6 months
1/6/2010
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 4  OCD,PSTD,DEPRESSION,ANXIETY constipation, dry mouth, sleepy, extreme thirst, heart burn, acid reflux rampant thoughts have left, ocd still there when i get extremely agitated, but the racing obsessive thoughts are tamed, i can't believe how quiet my head is. Depression and suicidal thoughts, still lurk in the shadows. F 34 3 months
1/31/2010
 5  OCD None-minor constipation M 45
25 1X day
3/18/2010

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