ANAFRANIL Reviews (CLOMIPRAMINE HYDROCHLORIDE)

Average Rating: 3.7 (133 Ratings)

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 ANTIDEPRESSANTS CNS, MISCELLANEOUS

 Type: Rx Drug

  

ANAFRANIL  (CLOMIPRAMINE HYDROCHLORIDE):  Clomipramine is used to treat obsessive compulsive disorder (OCD). It helps decrease persistent/unwanted thoughts (obsessions), and it helps reduce the urge to perform repeated tasks (compulsions such as hand-washing, counting, checking) that interfere with daily living. This medication belongs to a class of medications called tricyclic antidepressants. It works by restoring the balance of certain natural substances (serotonin, among others) in the brain.   FDA Approval Date: 1989-12-29 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on ANAFRANIL: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR ANAFRANILCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  OCD, Panic Attacks, Anxiety 1st Week: mild twitching, loss of appetite. Week 2 & subsequent: very few side effects other than excessive drymouth when nervous, sweating more when its hot, constipation & anorgasmia This drug is wonderful. The benefits far outweight the side effects. It takes away obsessive thoughts & anxiety without taking away your personality. I started using Anafranil after SSRIs (zoloft) made anxiety & OCD worse. Feel free to contact me. M 25 4 months
9/25/2007
 1  OCD, Depression I was shocked. This was supposed to be the perfect med for me. It had worked for a relative with OCD. Moreover, the fact that I had comorbid depression and anxiety seemed to imply that it would be a great fit. In addition, the med was rated very highly by a lot of other people. Surprisingly, the med made me more anxious, irritated my nervous system to the point of making me feel like I was jumping out of my skin. It also did nothing to improve my poor appetite and intense fear of the future. M 34 6 weeks
12/12/2007
 4  OCD depression/anxiety no effect on current anxiety problems, weakness, decreased sex drive, loss of orgasm, mania like symptoms in high dose Other then the side effects it completely stopped my OCD, if you have OCD and you don't mind the side effects then this med is great. But the sexual problems completely sucked, so I wont be taking this anymore. M 17 4 weeks
1/3/2008
 4  ocd, panic constipation, but i take movicolon for that now, previously sweating and probably weight gain, about 5 kilo's i was on this medication for 6 years and it helped great against ocd, although i became a bit reckless with money. i stopped because i could only do a number 2 once a week and only after taking a laxative. i've went through terrible withdrawings(after 6 months), completely paranoid, bordering on psychois. i've started again 8 weeks ago, together with a very mild laxative prescibed by my gp, and i feel so much better. i just have to come to terms with the conspiraries i've come up with during my anafranil free period, and that's quite hard, because a very small part of me still thinks they are true. so be warned, once you're on anafranil there's no turning back (for me that is) i take 75mg retard tablet a day F 39 8 weeks
1/10/2008
 5  anxiety I've taken 50mg in one dose in the morning for 2 months and have now got a very dry mouth, apart from that it has been very good. This is by far the best med I've tried. M 43 2 months
1/11/2008
 5  OCD Heavy sweating, very mild occasional dizziness Works great for my symptoms. i have now been taking it for about two years. M 45 2 years
1/14/2008
 5  depression, anxiety, obsessions Dry mouth, slight fatigue, some sexual problems I have only been on this medicine for a week and it has been a GODSEND!! After only four days I started feeling better and each day is an improvement on the last. I recomend taking this with huperzine A to counter the anticholinergic effects. This medicine puts zoloft/Prozac/lexapro to shame. The SSRIs have more side effects (don't believe the anti tricyclic marketing) and can barely come close to the fast depression relief anafranil has offered-much less the anxiety and obsession relief. This drug has cured my mind of all doubts, worries, obsessions and paranoia and has left me with clarity to concentrate and happiness to show compassion once again! If your afraid of the side effects, done be, just give it a try and your life as well as those of your loved ones will benefit ! M 7 days
1/28/2008
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 5  Depression, Anxiety, Obsessions Dry Mouth, Sweatiness, Longer time till orgasm Within a week this medicine has near completely erased my depression, panic, anxiety and mild OCD. Each day gets better and I havent even made it up to 50 mg's yet. So much better than SSRI's and with fewer side effects - plus it doesnt numb you into hapiness, just amplifies everything good about life! 22 2 weeks
1/29/2008
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 5  Depression, Anxiety, OCD, Paranoia Dry mouth, Lowered libido, Increased sweating during excersize Before Anafranil, my life seemed so chaotic. I was constantly fighting with my parents, struggling to meet demands at school, having friendship troubles due to reluctance to participate in large social groups and crowded events. Also, I would constantly obsess over the way I looked and had an overly cynical outlook/sense of humor, all while feeling guilty for no good reason, and believing that strangers were either critisizing my appearance or annoyed by my prescence. My old life seemed meaningless and it got to the point where all I cared about were a couple friends, any kind of illegal 'upper', and obsessing over my looks and my health. An insane asylum seemed appropriate, as I convinced myself that I was schizophrenic. I would skip class if I was late due to my phobia of being stared at when entering the classroom. I would tense up and begin a negatibe loop of thoughts concerning and obsess for days over what other students were saying about me behind my back (how arrogant of me); M 19 8 days
1/29/2008
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 2  Anxiety and Depersonalization Increased Anxiety, Panic Attacks, Sleeplesness, Ear Ringing, Pins and Needles in Body, Sore Throat, lengthened the time to reach orgasm. I took Anafranil for Depersonalization and General Anxiety Disorder. For the first 7 days I felt absolutely Nothing. It's as if I was swallowing candy. But then on day 8 I started to feel very anxious a few hours after I took it. Also couldn't sleep very well. This medication usually makes people tired. But it had the opposite effect on me. It didn't make me any more tired than usual. It actually made it harder to get to sleep. Then on Day 9 I had a full blown panic attack after I took it. I thought I was going to have to call 911. My anxiety went through the roof and I thought I was going to have a heart attack. I was scared!!! The next day my left ear started ringing and I felt as if I was getting a sore throat. This stuff started doing some weird things to me, so I decided to stop taking it before the side effects got even worse. Medication can effect everyone differently. This just isn't the right one for me. Use at your own risk! M 39 9 days
4/3/2008
 5  OCD Dry mouth, constipation for a couple weeks, lower libido Anafranil has worked the best of all the SRI's I have tried for OCD. I have tried Zoloft, Cymbalta, Lexapro and none made much of a difference, Anafranil is in its own league, it was night and day better than any other med I have tried. The dry mouth is the only real side effect that still bugs me along with occasional night sweats especially on my legs which is funky. Libido is lower and orgasm is more difficult but that isn't all bad! M 27 4 months
4/12/2008
 5  Depression, BDD Dry mouth, dizziness(1st weeks) loss of sex drive and orgasm (1st months), weight gain, drowsiness, constipation, vivid nightmares (when i forget to take it) I felt better almost immediately after taking this drug. I have tried a number of SSRIs and other drugs without relief. This drug has completely turned my life around. Suicidal thoughts, days spent hiding in bed, frequent bouts of crying, are all bad memories. I have so much more energy and have developed a lust for life that I haven't had since I was young. Within months of starting this drug my life turned around - I got the job I'd dreamed of, I moved out of my parent's home, weekends started filling up again. Now I have a career, a full social life and am living independently. On the down side I have put on 10kg in 6 months. I went through a period of not being able to achieve orgasm but that has passed. And if I forget to take it at night I get bad nightmares. I also feel drowsy in the mornings and it takes me a while to wake up. All in all the positive effects far outweigh the side effects though. F 26 6 months
4/19/2008
 3  Gen.Depression Phobias OCD Libido loss, dizziness, unoriented, too many questions unanswered (Imagining I'm in the right place to start answering them). Felt at my best as never before in my whole life and started rediscovering myself and my abilities. Then hallucinations(like seeing halos around people's faces). After the 1 month on this, then went in the manic phase and then totally totally out of control and tried to cut my wrist. I was lucky the damage on my wrist was minimal. Well I had to be inserted in a psychiatric ward and doctors started experimenting doses of various drugs. M 26 1 months
8/6/2008
 5  ocd, anxiety, depression none I'm mainly trying to take this for anxiety and ocd, so far the drug has cleared my head a lot, everything is so much clearer at 50mg. It has done a little for my anxiety so far, I know doses from 100mg to 250mg are used for ocd, best drug taken I've also taken ssri's, cymbalta,klonopin,herbal remedies,abilfy, nardil and wellbutrin none compare. M 21 7 days
10/22/2008
 4  OCD, anxiety depression low sex drive; dry mouth, occasional dizziness upon abruptly standing up, occasional facial flushing. Of these side effects, the dry mouth, dizziness, and facial flushing diminished as time went on, and in sum these 3 problems have been quite minor. The low sex drive, however, has been problematic, and must be addressed. Struggled with OCD/anxiety symptoms, along with mild depression, from about age 20 onward (though intermittent symptoms appeared earlier). These problems gradually worsened as my 20s progressed. At around age 30, due to some adverse experiences, I developed a couple of new obsessions that caused my condition to worsen rapidly and substantially. Over a period of 4 years, I tried, in various doses and combinations, Luvox (fluvoxamine, I believe), Celexa (citalopram), Wellbutrin, and Effexor (the most effective of this group), and received only minimal benefit. As a "last ditch" attempt to resolve my problem, believing it was something I just had to learn to live with, I tried Anafranil (clomipramine) and within three days began to feel some improvement: the intense tightening I would feel in my chest whenever an upsetting thought entered my mind was diminished--the first real relief I'd felt in 4 years. As the weeks passed, my symptoms improved further, and now the upsett M 37 3.5 years
11/3/2008
 5  OCD Surprisingly few. A little dry mouth, but only for short periods of time I have tried all SSRIs other than Celexa. They just didn't cut it. Prozac worked well until poop out after 17 yrs. Anafranil was different (better). With my first dose I could tell the difference. Calming. Now up to 150 mgs and loving it. Don't hesitate if you have stubborn OCD. M 58 5 weeks
11/26/2008
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 1  
12/4/2008
 2  social anxiety shakeiness all over,esp in hands and neck,blurred vision,headaches,increased anxiety,difficult to sleep.not on it long enough to experience no ejaculation,but its common. not the drug for social anxiety!we spend our lives trying to hide anxiety from others and this maks it tenfold.i think my shrink was going through his med book 1 by 1-have exhausted all the ssris,tried moclomebide,and duloxetine,neither worked. im trying to get him to put me on nardil,the "gold" standard for sa...we shall see....feel free to contact me M 43 7 days
1/4/2009
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 5  OCD, anxiety, depression difficulty urinating, constipation, dry mouth, decreased libido, difficulty ejaculating, sleepiness Highly effective drug but with many bothersome side effects and a really nasty withdrawal. I would certainly reccomend it to anyone whose symptoms are severe and wants to be relieved no matter the price. M 29 8 months
1/27/2009
 4  OCD,panic,GAD,Mjr depresion,moods dry mouth, spaced out, decreased sex drive. Feeling sleepy and zombified. Fatigued, numb, frequent UTIs, constipation, tremors, feeling of not being myself. Have tried just about every other medication and nothing helped. This actually works. Sometimes i find the side effects are a bit too much to deal with but would rather have them than my original problems. Don't know what i would have done without anafranil. It saved my life. F 30 10 years
2/3/2009

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