ANAFRANIL Reviews (CLOMIPRAMINE HYDROCHLORIDE)

Average Rating: 3.7 (133 Ratings)

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 ANTIDEPRESSANTS CNS, MISCELLANEOUS

 Type: Rx Drug

  

ANAFRANIL  (CLOMIPRAMINE HYDROCHLORIDE):  Clomipramine is used to treat obsessive compulsive disorder (OCD). It helps decrease persistent/unwanted thoughts (obsessions), and it helps reduce the urge to perform repeated tasks (compulsions such as hand-washing, counting, checking) that interfere with daily living. This medication belongs to a class of medications called tricyclic antidepressants. It works by restoring the balance of certain natural substances (serotonin, among others) in the brain.   FDA Approval Date: 1989-12-29 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on ANAFRANIL: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR ANAFRANILCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  racing thoughts and anxiety So far I have had dizziness and very sleepy during the day After taking the 1st dose, my racing thoughts had disappeared. I haven't had to take my antianxiety medicine for a week now!!!! I can't wait for the beginning side effects to go away, I feel better than I have in 4 years!!!! F 34 7 days
.25mg 1X day
4/24/2010
 3  ocd,anxiety,depression sweating,sleepiness,insomnia,dry mouth, M 38 9 weeks
100mg 1X day
5/28/2010
 1  OCD Anxiety, dry mouth, constipation, zombie-like, emotionally numb, personality changes, suicidal, cutting I was introduced to anafranil in 1990 by Dr. Jenike at the OCD Clinic at Mass General Hospital. I had a history of panic disorder from the time I was 10 and it manifested into OCD when I was 25. Approximately 5 hours after taking my very first dose which was probably 50 MG, I went into one of the worst anxiety attacks of my life and had to be taken to the hospital. Anyone with pre-existing anxiety disorder should be aware that anti-depressants can trigger extreme panic attacks! Be sure to take your xanax or klonpin when taking anafranil. After 4 years (not consecutive as I became pregnant and stopped all meds during that 9 months), I couldn't bear not having the desire to play my musical instruments or do art any more. I felt like a zombie most of the time. Looking back, there is so much that I cannot remember from 1990 - 1995. I do recall cutting myself (the scars are still there on the back of my arm) and threatening suicide in front of my parents. Anafranil may have stopped me from doing a lot of the obsessive rituals, but it also ruined my kids' and my life. I was introduced to zoloft in 1995 and that actually worked amazingly well for the OCD without all the horrible side effects of anafranil. I've been med-free and I'd say about 95% OCD-free since 2004. F 45 5 years
100 MG 1X day
6/26/2010
Email
 5  depression/anxity after the first week no side effects remain worked like magic was very happy with it. M 32 4 months
50mg 1X day
7/18/2010
 5  anxiety panic bad constipation, sleepiness, hungry feeling, dry mouth, dizziness upon standing. Shut down the panic. But side effects and using Phillips all the time made me change. Took six weeks to finally tolerate the side effects to a limited degree M 52 3 years
75 1X day
8/18/2010
 5  OCD, depression, fibromyalgia At first many such as anorgasmia and weight gain and sweating profusely but these have to be lived with sometimes for weeks because it is such an old medication. The good news is that with time these subside and adding 30 min of cardio 4 times per week can really help with the weight as well as the depression. Old medicines sometimes work better than newer ones M 37 5 years
225 mg 1X day
9/6/2010
 2  Anxiety and Depression Dry mouth, severe constipation (successfully treated with 20mg lactulose daily) and extreme difficulty reaching orgasm (even through masturbation; and if I managed, I would experience a strong headache for hours afterwards). I've tried SSRIs, SNRIs, tricyclics, Aurorix, Avanza, etc. Efexor is the only one that's worked (though only temporarily). I had high hopes after reading the positive experiences of others here. Sadly, I observed no benefit after being on 75mg for four weeks and I was not prepared to go higher due to the side effects. I'm weening myself off clomipramine and have just commenced Valdoxan. M 34 4 weeks
75mg 1X day
9/19/2010
 3  OCD, depression Frequent urination, sleepiness, headaches, thirst, strange euphoria, increased hunger. I REALLY wanted to like this drug and to stay on it. I mean, it made me so happy and carefree. But I had the worst headache on it, my mouth was bone dry, and even if I wasn't drinking water, I had to pee every 20 minutes for some reason. I also gained 10 pounds because it made me ravenous! It did help with OCD a lot, but it just wasn't worth it. F 21 21 days
50 mg 1X day
9/27/2010
 3  Severe depression, anxiety Rapid weight gain, doped up feeling, insomnia at night, sleepiness during the day (even when taken at night), no sex drive, etc. It seemed to lift my depression, but am considering getting off of it due to the weight gain. :( F 30 2 weeks
150mg 1X day
10/3/2010
 1  ocd dry mouth,constipation,priapism,weight gain,sleeping too much,mania,heart attack,agitation horrible drug. do not take this chemical. M 30 2 years
150 mg 1X day
10/22/2010
 5  pure O, anxiety, intrusive thoughts at first tired! then just one day i woke up feeling great. sweating!!! id wash dishes and be pouring in sweat! but that side effect is gone away. anafranil literally saved my life!! i had sever derealization after smoking weed one time!! lasted for 2 and a half years before i finally decided to get help. i am so glad i did!! i never thought my life would be "normal" again but after 2 months on anafranil it is!! im happy again, im going places, i am not afraid of panic attacks or anxiety when i go into wal mart!! im taking my kids to the park again!! as my oldest says, mommy your better!! F 32 3 months
150mgs 1X day
1/17/2011
 4  OCD, Anxiety & Aggression Constantly having dry mouth, confusion, increased urination, feeling tired most of the time, loss of apetiate sometimes would be light headed, headaches it did help me in the OCD matter, I would say about 60% its gone. regarding agression I would say I still have it and currently taking Xanx for such problems.. This drug is good and bad at the same time, for higher doses I won't suggest it because I was on 150 MG per day and made my life a living hell for 10 days had severe constipation, sweeting, excesive urination, feeling tired all the time and of course lower sex drive!! is it worth it to go for high doses ..NO. M 27 4 months
50 MG 1X day
1/27/2011
 3  OCD it has helped but I have noticed an increase in low back pain and pain in the joints of my hands. The pain is worse in the mornings and as the day progresses improves. Other than that its good. F 53 1 years
25 1X day
2/3/2011
 2  Anxiety Awful. It reduced to a degree my anxiety, but also reduced any motivation I had. Had very painful abdominal reflux ( pain 9/10), which pain killers reduced to 7/10, hot burning stomach acid, burping and trapped wind. Belly felt solid like SEVERE colic. Due to long half life, endured this for two days! I would not try this drug again. If I had to I would only take 10mg and stock up with lots of pain relief and antacids. F 50 1 days
25mg 1X O
4/24/2011
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 5  OCD Dry mouth, weight gain, excessive sweating (head), harder to orgasm I was diagnosed with OCD at 13 - hand washing, checking, intrusive thoughts. This drug made my OCD completely disappear. Yes the side effects are not great, but they are not the end of the world. When I had OCD I could not function normally at all, all my time was taken up with my obsessions, I can function normally with these side effects. I have tried coming off the drug many times in the last 13 years but when I do, I get very emotional and depressed and my intrusive thoughts come back. I would recommend this drug to anyone with OCD, the dull headaches and tiredness do go with time, just keep taking it regularly and they will disappear. The side effects I have sited above, however do not seem to disappear. F 26 13 years
75mg 1X day
6/25/2011
 4  OCD Lethargic, Nauseous I'm already feeling a great effect, even though it hasn't even reached full strength in my body yet. The only bad thing is that I'm very drowsy, and I can't aim a ball as well as I could before. M 14 17 days
25mg 1X day
7/5/2011
 4  Depression, anxiety Acid reflux, hard to orgasm, severe sweating (head only), tiredness Clomipramine (as it's called here in the UK) has really helped me. It has made me the person I want to be and really helped me face life again. I found I was suffering more acid reflux after taking them so I started to take them at lunchtime with food. The sweating is a problem but not a 'deal breaker' and I take much, much longer to orgasm and when I do it feels somehow different (not bad, just different) so I see why these are prescribed for premature ejaculation. The side effects are OK and I would strongly recommend this medication M 39 8 months
100mg 1X day
9/26/2011
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 5  Severe Depression and Anxiety Dry mouth, constipation, nightmares, sweating, muscle pain, yawing, fatigue, hypersomnolence A miracle drug for depression and anxiety when 8 other antidepressants failed. F 42 9 months
100mg 1X day
10/12/2011
Email
 2  OCD I was started on 50MG and was supposed to titrate up to 150MG by week 3. I am still on the 50MG because these side effects wont go away. • Reduced mental focus • Confusion • Zoned out or auto pilot feeling • Lack of visual focus especially in far sighted vision • Dizziness • Increased forgetfulness • Reduced limb sensibility especially in hands • Reduced sex drive • Inability to get or maintain erection • Unable to ejaculate Although I did get the results listed below I would not recommend this drug. • Reduced Irritability • Slight ability to control “obsessive” or “fearful” thoughts during compulsive behavior. • Slight ability to control minor compulsive behaviors. M 26 17 days
50MG 1X day
2/21/2012
Email
 5  OCD, Depression Dry mouth, constipation F 60 10 years
100mg ?
3/6/2012

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