SAVELLA Reviews (MILNACIPRAN HYDROCHLORIDE)

Average Rating: 3.0 (158 Ratings)

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 Type: Rx Drug

  

SAVELLA  (MILNACIPRAN HYDROCHLORIDE):  Milnacipran is used to treat pain caused by a condition called fibromyalgia that affects the muscles, tendons, ligaments, and supporting tissues. This medication is a serotonin-norepinephrine reuptake inhibitor (SNRI) that works by helping to restore the balance of certain natural substances in the brain (neurotransmitters).   FDA Approval Date: 2009-01-14 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR SAVELLACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  m.s Sweating bad M 43 1 years
50 2X day
9/26/2010
 5  Fibromyalgia Initially, very nauseas and loss of appetite. As dosage increased, started at 12.5 mg and am now at 100 mg, so did the hot flashes, light headedness, dry mouth, and high blood pressure. Even though the side effects continue, the freedom from pain, due to the fibromyalgia, has been worth it. I can now walk without a cane, and have no pain in my lower body. The one area that seems to be the stubborn one are my arms. I feel no relief in my arms, but the fact that I can walk without a cane, is a wonderful feeling. I have a lot more energy, and can even walk my dog, which I have not been able to do for years! F 54 60 days
50 mg 2X day
9/19/2010
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 1  fibro pain pain in abdomen, night sweats, compulsive crying, bad mood, sores on skin,palpitations, anxiety,headache,dry mouth, agitation I was on Pristiq 50 mg/day with good effect on my fibro. Even though it is not listed for fibro. I also have depression with anxiety. MD suggested Savella as it is for fibro. Took the full 50 mg twice a day for 3 days so far. Not helping...more pain in legs and chest muscles, some shortness of breath (not activity related) and other symptoms already mentioned. I am not going to take this med any longer. I cannot spend my life crying. I will go back to my Pristiq. This Savella is killing my gut. I am on Celebrex also and cannot take the combo of both of them. I feel very anxious. M 58 4 days
50 2X day
9/15/2010
 4  Fibromyalgia Sweating! Nausea. HBP at 50mg/day. Gum soreness. Initially mood swings and crying, but now feel better about life than in years! Decrease in fatigue. Hair thinning. Leg bruising. Titrated up slowly (only 1 pill a day). Then, 50 mg 1xday for last 3 weeks. Side effects too scary, put down to 25 mg 1xday. Hoping I can maintain this feeling of coping with pain, etc. at this lower dose. Oh yes, appetite control, weight loss bonus! Many of us are sensitive to meds - try a lower dose! M 51 7 weeks
25 mg 1X day
9/11/2010
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 2  Fibromyalgia Excessive sweating while feeling cold to touch. Heart racing and beating very strong. Blood pressure became dangerous also. Constipation and the feeling that bladder was leaking. It took most of the muscle pain and nerve pain away and it was good to be able to get right up out of bed in the morning, but those side affects are worse than I have ever experienced with a drug. F 58 50 days
25 mg. 2X day
9/9/2010
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 3  Fibromyalgia I went off of Cymbalta and started Savella. This was in addition to Lyrica. Initially the Savella gave me more energy but it did not decrease my pain. I had to take more break thru meds. After 5 months, I weaned off of it and went back to Cymbalta and feel much better. F 50 182 days
50 mg 2X day
8/31/2010
 5  Fibro. Heartburn, dry mouth and bit of anxiety. After slowwwllly uping my dose to the full dose, I am having luck for once with a drug that is supposed to help with fibro. Most of the slight side affects are gone. I have barely a need for my ibprofin or Tramadol. I took 50 mg. only once a day for about 10 days, then every other day I took another in the afternoon. I am now taking it as rx'd, 2x's day. I am not hurting! Also lost allot of the brain fog. F 45 1 months
50 mg. 2X day
8/12/2010
 5  fibro No sleep for the first 2 nights (at 12.5mg dose), 3rd night, i slept fine only to increase the dose the next day but have slept well ever since. Loss of appetite (lost 12 pounds in 3 weeks). no other side effects noted. Pain free, finally. Tried Cymbalta and Lyrica and had reactions to both but Savella is working fine so far. My muscles haven't felt this good in years. F 52 3 weeks
50mg 2X day
8/10/2010
 4  fibromyalgia & nerve pain nausea, sweating, fatigue, temporary loss of appetite seems to really work for the severe nerve pain in my feet...also helps with sleep at night. Still trying to work myself up to 100mg a day but not there yet. Have tried almost all other types of drugs for treatment of fibromyalgia & this is the only one I can tolerate and still work daily. F 41 6 months
50mg 1X day
8/9/2010
 1  Undiagnosed muscle pain Constipation, Insomnia, Excessive Sweating Ummm... This drug does NOTHING positive for me. No relief in pain. I was recentely told to down grade from 50mg 2x a day to 50mg once a day to see if that helps my symptoms. The constipation is better ( Thank goodness! )... But the insomnia is still there and as for the sweating, well, even my sweat sweats. I want off it but the doctor said to give it about 3 months.... And since I am desparate for relief, I am trying.... F 37 20 days
50mg 2X day
8/8/2010
 4  Fibromyalgia Hot flashes, sweating and a bit foggy headed at first. High blood pressure and Tachycardia. Decreased sex drive and sensation. The side effects I encountered with this drug are very unfortunate because it actually works for the pain ! I was ready to put up with the lesser side effects until the high blood pressure and tachycardia developed. This happened a week into the full dose after titration. I'm wondering if maybe the 12.5 mg twice a day would work. Going to rheumatologist next week. Savella works, but, not at the risk it caused me. F 44 3 weeks
50 mg 2X day
8/6/2010
 3  body pain Extreme sweating! Whole head would get wet and it would drip down my back. This stopped when I totally got off the Savella. It did help with pain. F 58 60 days
50mg 2X day
8/3/2010
 1  fibromylagia Awful side effects. Hot flashes or Hot flushes and nausea-- F 57 60 days
25 to 100 1X day
7/27/2010
 1  Fibromyalgia Brain buzzing and auditory buzzing, severe hot flashes and sweating, increased heart rate, increased blood pressure, anxiety, irritability, aggression, bladder infection, upper respiratory infection, light headed, headaches, quick changes in mood, feels like fire is running through my veins, trouble concentrating, insomnia, shakiness I too had hoped this med would help with fibro, but I had even worse side effects on this than when I took Lyrica (and that was bad enough). Will be calling my doctor tomorrow to get off of this medication. Seriously, when the side effects are worse than the illness, why take the chance! Especially of concern to me was the huge jump in heart rate (to nearly dangerous levels). Please do your homework before starting this and/or other meds...I do not think doctors and drug companies care WHAT the side effects are. They are in it for the money - bottom line! M 54 10 days
25 2X day
7/25/2010
 5  Fibromyalgia/depression A little "high" at first but nothing now THIS DRUG GAVE ME MY LIFE BACK!! After years of trying to cope with fibromyalgia pain and depression, I finally have found something that works. I feel like a new person! Increased energy, able to sleep well, improved concentration and memory, everything I was looking for. This drug, combined with Lyrica for fibro pain has truly given me my life back! F 42 3 months
50 MG 2X day
6/27/2010
 2  Fibromyalgia increased brain fog, increased GERD symptoms, fatigue, dizziness, shortness of breath, increased heart rate, sweating and chills, rash inside mouth I was so disappointed that I had to discontinue Savella, because I read that you just have to stick with it to get past the side effects. I was really willing to keep going until the rash in my mouth. That's when I figured it was time to call it a day. I've had fibro for 8 years or longer. I am usually an active person (even with fibro), but the Savella slowed me down to almost a grinding halt. Can't think straight, can hardly keep my list of chores organized in my head. I've had to double my PPI dosage, and the sweating is as bad as menopause (so I'm told, because I've not yet gone through that). I'm glad that it's working for some folks, sad I'm not one of them. F 52 3 weeks
50mg 2X day
6/11/2010
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 3  Joint Pain (Tentatively diag. FM) Worst side effects have been nausea and sweating. Followed by headaches and sexual dysfunction (urethra pain?) It has been very hard to stay on the "full" dose, and with Dr.'s permission have been adjusting dosing, however effectiveness goes down on lower doses and side effects stay about the same - so no overall benefit. Seems my best day occurred 2 days after quitting "cold turkey" from the "full" dose where joint pain was gone and I had no lingering side effects. Lasted a few hours and then I was "slammed" with the old joint pain. M 39 6 months
50mg 2X day
6/9/2010
 4  fibromyalgia Sweating, craved salty foods. I took with food and didn't have much nausea. Had some muscle cramps I feel certain were caused by my dose of Savella. I eliminated corn and all corn products from my diet and the fibromyalgia pain stopped. It took only 2 or 3 days to see the difference. Shoulder and back pain are gone now, as long as I do not eat corn. F 54 10 months
150 mg 1X day
6/3/2010
 3  Major Depression Nausea, Dizziness, Lightheaded, spaced out, increased anxiety and panic, blurred vision, mood swings, melancholia, high pulse rate, shortness of breath, Upper respiratory tract infection like symptoms, excessive sweating, hot flashes Very shaky start up effects - anxiety and panic increased, felt an ominous fear all the time, mood swings and irritability, sometimes subtle euphoria and sometimes severe malaise and dysphoria. I think this drug is very dose dependent because of its very short half life of 8 hours. I felt disadvantaged because unlike other SNRIs like Effexor and Cymbalta there are almost very few patient ratings and information on use of Milnacipran in treatment of MDD. Side effects felt: Nausea esp first few days and when taken without food. Dizziness and lightheadedness, feeling drunk and spaced out. Blurred vision Hyper-emotionality mainly towards melancholia and sadness. Sleep - improved, but dreams are sometimes very lucid. Tachycardia - pulse upto 120 bpm, dyspnea Upper respiratory tract infection like symptoms - post nasal drip - sore throat, and nasty mucous - but without fever - which actually makes GPs treat it as allergy. Jittery, nervous and spaced out - especially in the evening when the effects kick in. This drug has apparently helped those who have failed ECT which should make it quite efficient, but I would suggest this to be definitely not the first line of treatment for MDD, and should perhaps be reserved for depression with anhedonia and apathy, not for melancholic depression. Probably its too early for me to have a definitive view. M 30 20 days
25mg 1X day
6/3/2010
 4  Fibromyalgia Sweat really bad and anxiety attacks get worse in the beginning. Stopped it for a little while b/c I didn't think it was working so I stoped, but after a few weeks after stopping I realized it was working so I went back on. Stay on it if you feel it is working for you! 38 7 months
50 mg 1X day
5/27/2010

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