SAVELLA Reviews (MILNACIPRAN HYDROCHLORIDE)

Average Rating: 3.0 (158 Ratings)

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 NOREPINEPHRINE REUPTAKE INHIBITORS

 Type: Rx Drug

  

SAVELLA  (MILNACIPRAN HYDROCHLORIDE):  Milnacipran is used to treat pain caused by a condition called fibromyalgia that affects the muscles, tendons, ligaments, and supporting tissues. This medication is a serotonin-norepinephrine reuptake inhibitor (SNRI) that works by helping to restore the balance of certain natural substances in the brain (neurotransmitters).   FDA Approval Date: 2009-01-14 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Date added.

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR SAVELLACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  Chronic disabling pain Constipation, insomnia F 44 1 months
25mgs 2x
11/27/2012
 2   My doctor had me work up to a full dose of this medication, but I couldn't last that long. While the first few days were fine, as I increased the dosage it became so painful that even the pressure of my hands on my thighs would be too much. All I could do was lay in bed and cry. I felt weaker and more tired than usual when I took this medication. I haven't found side effects like this anywhere else, so it is possible that this is just a strange side effect isolated to me. F 26 7 days
30MG 1X day
11/23/2012
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 1  Fibromyalgia Panic, personality change, forgetfulness, burst of anger, literally craziness, racing heart I was put on this to help with my numbness and tingling. It was a horrible mistake. I have been on medicines throughout my life and never felt the way I did. I forgot where I was driving (with kids in the car), blew up on my son who did nothing wrong, cried and was sick. It was horrible. My heart was racing, I was clammy and just couldn't function. I almost went to the er. It is most likely my inability to handle too much serotonin, or whichever it is, but yikes! F 28 6 days
30 1X day
11/19/2012
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 1  Chronic migraines Sweat like a stuck pig, head felt like it was on fire. Dreams were awesome though. Had to quit after 7 days. M 50 7 days
5 2X day
8/23/2012
 5  fibromalgia None F 49 2 years
100 MG
7/18/2012
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 5  Fibromyalgia and + ANA Insomnia and felt like I couldn't lie still but that went away after about 3 weeks. I've been having problems since 14 so the insomnia was nothing new since I haven't slept thru a night in years because of my nawing joint pain and discomfort. I feel great after being in this for almost 3 months. I still have my days but that's a lot better than everyday being miserable. F 24 3 months
50mg 2xD
7/13/2012
 5  Fibromyalgia some dizziness and slight weight loss in the first month, but have maintained a constant weight since. I've been extremely happy with Savella. I was first on cymbalta, which was ok, so I thought, then my Dr switched me to Savella, huge pain relief! I had a brief experience after about a year of taking it where my Dr switched me back to cymbalta, and the pain was unbearable! Within weeks of switching again to savella I was again pain free (minus the occasional flare-up). I've been on it a little over 3 years and am now able to again play tennis, volleyball, etc. and live my life without the pain and exhaustion :) F 29 3 years
50mg 2X day
7/13/2012
 1  Back Pain Heart Pounding,High Blood Pressure,Extreme Nausea,Vomiting,Stomache Pain, Irritable, Hot Flashes, Sweating Worst Medicine Ive Ever Taken!!!!! F 18 1 days
50MG 2X day
7/12/2012
 5  Fibro Fortunately NONE Having my first flare up since starting Savella. I'm scared to increase the dose because it may not work. Going back to the doctor tomorrow for help, none of the opioids worked this was the only drug that gave me any relief. F 48 4 months
50 mg 2X day
6/12/2012
 5  Chronic joint and muscle pain I started with 15 mg a day for a week and they 15 2X a day for a week 25 and 15 a day for a week. 25 and 25...25 50...50 and 50 a day. My dr had me start very slow because of the side effects and it helped. I would get nausea about 90 minutes to 2 hours after I took the pill and my heart raced and I could not sleep at all. I also noticed I was short of breath and if I did anything that took effort (mowing the yard) I could not catch my breath. It would take about 4 to 5 days for my body to get use to it and then it was time to does up again. I also lost about 5 pounds and my body felt flushed. After two months of the pill the my side effects are gone except the shortness of breath and I don’t require as much sleep as I did before. I do notice if I don’t eat at regular intervals I get nausea but if I eat it goes away. It took my pain away!!!!! I have been dealing with pain since I was a teenager and the last few years it has taken away my life. This medicine has been amazing even with the crapy side effects. It was scary as hell that first month with my heart racing and being short of breath ( I even went to the hospital one night because of chest pains) but it was worth it. What is one month of hell compared to a life that is pain free. I have more energy, I am happy, I am motivated to live again. I fixed my garage door after I replaced a leaky faucet all on the same day!!! I feel amazing. I am hoping with time the short of breath goes away. But even still, I am very satisfied F 32 2 months
50 2X day
5/29/2012
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 3  Fibromyalgia Savella made me sick, as if I were pregnant. I didn't correctly wean off of cymbalta, so I was overdosing to begin with. However, once on savella alone I did notice that my limbs werent as numb and also that I didn't seem as fatigued. The pain was worse though, and my vision became messed up again F 28 3 weeks
50
5/21/2012
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 1  Bipolar/chronic pain Wow so taking this medicine was one of the weirdest experiences I've ever had. At first I was incredibly nauseous and felt like I had to burp or I'd throw up. Then I got incredibly irritated. I just wanted to bitch to everyone about how I felt cause honest I felt sick at first. Not to mention my body was so hot. Then I felt so wide awake and couldn't stop laughing uncontrollably. Literally, I couldn't stop laughing and nothing was funny. I had to actually try not to laugh. During this time I had so much energy I was debating doing a workout video. lol Finally the laughing wore off but was still wide awake. I dont know what the hell my doctor was thinking putting me on this medicine. Its stupid. I was supposed to take this medicine twice a day. Basically if I did I'd be a nutcase that couldn't function. This was terrible for me and did not react will to my mental disease. Made me incredibly manic so I couldn't sleep. Finally I surrendered and had to take my saphris. Seriously what a weird night. F 23 1 days
50 2X day
5/17/2012
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 5  CFS I'm the 62 year old male who recently posted about Savella. It did wonders for my cfs but adversely affected my heart. To update: The cfs problems returned within 2 days of ending Savella. Now I'm on Norco 5mg, twice a day, one in morning and one in the afternoon. It does a good job of knocking out the pain and fatigue. I know people go nuts when you mention using an opiate because of the addiction potential. They need to back down. I intend to stay on the Norco as long as my m.d. allows. M 62 6 weeks
50mg 2X day
5/11/2012
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 5  CFS Savella did wonders for my CFS. It knocked out 90% of my fatigue problems. But I had to get off it. It substantially increased my heart rate. The blood pressure went up, too. My cardiologist wanted me off it. I'm on a pacemaker so I have a danger of other heart problems so there's no need to aggravate my heart. I'm hoping against hope that the CFS doesn't return. Savella is a good drug for CFS. I, unfortunately, had a side effect that wasn't tolerable. M 62 6 weeks
50mg 2X day
5/9/2012
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 2  fibromyalgia When I started Savella, I had hot sweats, nausea, vomitting, a great deal of anxiety and worst of all an increase in blood pressure. I went up to 100mg because I was not seeing any benefits, but the side effects were much too severe. I had to be started on a second blood pressure medication to even be able to tolerate a 50mg dose. Due to the bad side effects, I decreased again to 25mg. That had much less side effects except for my blood pressure. It seemed OK for a while but my blood pressure became very unstable and my doctor took me off of Savella due to the high risk of stroke or death from high blood pressure. I think savella wants to blame peoples blood pressure reactions on SSRI antidepresants being taken with it, but I think the Savella itself is a high risk drug for high blood pressure without them. It did help, but is not worth the risk of death. I wonder how many people it has killed or caused a stroke in. I predict it will eventually be taken off the market. F 48 8 months
25mg 2X day
5/1/2012
 3  Tension Type Headaches Extremely lethargic, irritation on small things, major side effect was my inability to pass urine properly. Severe lower abdomen pain, with back pressure. I've had TTH for 5 years now, I switched from clonazepam (Klonopin) to Savella as a trial drug. The medication definitely was working on the receptors and I was feeling much better. I had less frequent headaches, no unilateral dispersion of pain on the right side of the head. Although the side effects of the pain in the groin and lower abdomen compelled me to stop taking this medication. If women are not having the same problem, this might be a better drug for them. After 1 week of taking the medication, I returned to my normal routine, and I experienced severe pain in my legs, pain in my chest, shortness of breath, dry nostrils, I wanted to go to the rest room, but then I could not pass any urine, which made my body go cold. M 27 1 weeks
50 2X day
4/24/2012
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 2  fibromyalgia Increased anxiety, high blood pressure, severe flushing, nausea. F 33 4 months
100 mg
4/21/2012
 5  Chronic severe pain None. It relieved the constant unrelenting pain in my hands I had been experiencing for 6 years during the 1st wk of titration. Now pain in shoulders is bearable. F 52 3 months
100mg 2x/d
3/17/2012
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 3  Fibromyalgia I experience the hot flashes and sweating. I sweat anyway but it's increased a good bit. I felt completely stoned with my first dose. I just increased this morning to the 25mg twice per day so still waiting to see what happens. My head itches/tingles after every dose. I still sleep ok. No nausea yet. So far, so good. Nothing to report yet on how it helps pain. F 32 5 days
25 mg 2X day
3/16/2012
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 3  Fibromyalgia - Severe Aches Extreme nausea, vomitting Switched to Savella from Lyrica due to over 50# weight gain in just 6 mos. & other adverse side effects. Nausea was mild w/ titration pack, but once regular dosage started, it got worse each day, ultimately resulting in vomitting about an hr. after each dose. Before the vomitting, I started to feel some relief from the deep, unrelenting aching & pain from the Fibro. Was so disappointed to have to discontinue it. 38 1.5 months
50 MG 2X day
3/12/2012
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