SAPHRIS Reviews (ASENAPINE MALEATE)

Average Rating: 3.4 (131 Ratings)

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 ANTIPSYCHOTICS ANTIMANICS

 Type: Rx Drug

  

SAPHRIS  (ASENAPINE MALEATE):  This medication is used to treat certain mental/mood disorders (such as schizophrenia, bipolar disorder). Asenapine helps you to think more clearly, feel less nervous, and take part in everyday life. It may also help to decrease hallucinations (hearing/seeing things that are not there) and prevent severe mood swings. Asenapine is a psychiatric medication that belongs to the class of drugs called atypical antipsychotics. It works by helping to restore the balance of certain natural substances in the brain (neurotransmitters).   FDA Approval Date: 2009-08-13 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR SAPHRISCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  Bipolar 2 Dizzy, sore mouth, ulcers, loss of taste, depression The wafers taste awful and started out making tongue and gums numb. Now it feels like my teeth will fall out. Mouth broke out in ulcers. Bombed me out night time and left feeling groggy in the morning. No weight gain but other side effects make it an unviable option. F 41 30 days
10 1X day
2/22/2012
 1  Bipolar Rage, Fatigue, HIGHLY Irritable, Naseau, Hunger Hated it. I was SO PSYCHO on that drug. I took it once or twice and then I threw it away. My husband was scared of me, I was just... crazy. lol The WORST drug I have ever taken. The thing is though, it works differently for everyone. It DID NOT work for me, but everyone's chemistry is different! I now take: Lamictal, Lithium, Seroquel. F 22 2 days
100 mg 1X day
1/7/2012
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 5  Bipolar II I have experienced: (1) A numbing effect on parts of the mouth exposed to the dissolving pill. It's similar to the effect of an over the counter oral analgesic; lasts maybe an hour. (2) Sleepiness. Given a choice, take it just before bed. After taking it about a week, the sleepiness is less pronounced. (3) First night only: sleepiness was extreme; had a restless feeling while falling to asleep particular in my legs. (4) Waking up with a leftover taste in my mouth very much like I would get when I was a smoker. I've found that keeping my tongue out of my mouth (I'm serious!) until well after the pill dissolves prevents this *and* reduces the numbing effect. The downside is that I miss the taste of that black cherry goodness. Wow. Some of my feelings and experiences: (1) I felt the effects the very next morning; a HUGE difference from the weeks-long wait for antidepressants and mood stabilizers. My mood went from a marginally "not-bad" to a full blown "good" and reached "very good" in another two days. I was able to get things done including a couple of tasks that were pending for almost 18 months. (2) Mild calming effect. Anxiety (unrelated to external sources) has never been a notable problem for me but it seems most likely it has been with me at a low "background noise" level. (3) Very mild euphoria. I'm closely monitoring myself: am I in a low-level hypomanic state? Perhaps, but I'm finding it very easy to exert self control. It may well just be feeling good about feeling good. (4) I *do* have racing thoughts from time to time but they aren't scattered; more "rushing" with deliberation than "racing" aimlessly. Note that I have subclinical ADD (a common comorbidity as I understand it). (5) Within a period of 24 hours I learned a lot: I missed a dose yesterday. While clearing out dust covered computer equipment to accomplish (success!) those 18 month old tasks, I misplaced my pills. I called my doctor in the AM to call in a prescription. In early PM I discovered that I'd have to wait until tomorrow. M 51 11 days
5 1X day
11/1/2011
 4  Bipolar I Restlessness; Insomnia; Difficulty swallowing (usually last about 1.5 hours after administration) Lamictal seems to have conquered the depressive episodes of my bipolar, but I've been struggling with persistent mania for over a year. I've tried at least 5 of the main anti-manics to no available. My main symptoms were extreme irritability, debilitating anxiety, hyperactivity and insomnia. To my amazement, I'd have to say the saphris has pretty much conquered the irritability and anxiety. However, my sleep cycle is still erratic. Also, I'm still exercising excessively (about 4-5 hours a day of swimming and biking.) I can't sit still, and have boundless energy even on two hours of sleep. Still, life is as good as its been in about three years. If I could get my sleep normalized and energy levels toned down I could go back to work. M 37 3 weeks
5 MG 2X day
11/1/2011
 3  schizophrenia Pretty good medicine. Feel good in the morning. First help me sleep at night, then I stopped taking it for a while and it's been giving me bad insominia. I take the black cherry flavor which is a funny option. This medicine is very expensive, might have to switch to olanzapine. Sublingual tablet is kind of fun to take, black cherry flavor taste just as nasty as the original. M 33 6 months
5mg 1X day
10/26/2011
 4  BIPOLAR This antipsychotic is like heaven compared to other atypicals . Works great for (voices). M 23 4 months
10MG 1X day
8/30/2011
 4  schizophrenia Can't have sex all day long, but that's about it. I was taking two anti-psychotics and wellbutrin before switching to saphris. I stuck with the wellbutrin, but replaced the two drugs with saphris only. This drug is great. It is a MAJOR IMPROVEMENT. It may turn out to be a blockbuster drug like the one that came out in the nineties that makes you hungry and sleepy all day long but preserved your sexual functioning better than any of the other ones at the time. I am becoming progressively more sane, so much so that if I had a disability evaluation in the near future, I would probably pass. Economy sucks, but who knows, maybe I could get a job modeling. I have even dropped about five to ten pounds since switching to saphris, so I am not entirely bsing about modeling work. Best weight in years. The pharmaceuticals people are getting really close to truly side-effect free medication. If I were eighteen or twenty five, I could probably make love four or five or maybe six times a day on this drug. If only the young guys knew how much the old school anti-psychotics sucked, they would be begging for a drug like saphris. What kind of a schizophrenic do you want to be, one that is remembered for doing something terrible, or one that is remembered for taking their medication every day, staying out of trouble and supporting themselves? I predict that 100% side-effect free medication will be on the horizon in no more than ten or fifteen years. M 37 6 months
5mg 2X day
8/24/2011
 3  bipolar Switched to BLACK CHERRY flavor. Will never go back to original it taste like plastic is burning in your mouth and gets mouth numb. BLACK CHERRY flavor taste 100 % better. F 31 3 months
10mg 1X day
8/11/2011
 1  to help stabilize my mood I was on Saphris and finally feeling great about my life. Until a few days ago when I had the worst anxiety attack I've ever experienced. It is still continuing to where I have to take 0.5 mg of xanax about 3X a day. I called my psychiatrist and she suggested stopping the saphris tonight. I'm also on luvox and had to increase that from 100 to 150 to stop the obsessing about the attacks. I've felt suicidal, lost, dreamy, and terrified. I'm praying that getting of of this drug will help me. I would rather be somewhat depressed than feel like this. F 21 3 months
2.5mg 1X day
8/9/2011
 3  Bipolar 1 Nausea At first I was very satisfied and excited about Saphris.It has taken away the voices, but as time goes on I am becoming more depressed, and the nausea is no fun. I recently stopped taking Lithium because I was doing better on Saphris, maybe that has something to do with it. I'll stick it out and see how it goes, what other choice do I have. F 45 4 months
10mg 1X day
7/17/2011
 5  Shizophrenia Sleepy when I take my dose at night. Burns under the tongue for a couple seconds. I'm going to ask my pdoc for the black cherry flavor next time i see him. So far its been great for symptoms-no voices-it also gives me less anxiety and makes me feel relaxed during the day. I sleep well at night with this stuff. M 31 2 months
10MG 1X day
6/30/2011
 5  Schizoaffective disorder Saphris is the best antipsychotic on the market to date. I'v been on all the Schizo pills and Saphris has the best side effect profile. The dissolving tablet is a wonderful option to have because it does not require getting a glass of water everytime you need to take a dose, in fact increasing your compliance of the medicine. I have experienced NO WEIGHT GAIN with Saphris. I would recommend this drug to anyone on antipsychotic medicine. second generation antipsychotic. NO WEIGHT GAIN. M 27 5 months
10MG 1X day
6/19/2011
 5  bipolar disorder None Saphris has reduced my son's depression and anger. His mood is much more even and he says he feels much better taking it. He also takes lithium, depakote, and sertraline, but these alone did not stabilize his mood. M 14 2 months
5 mg 2X day
5/14/2011
 1  Psychosis and racing thoughts Another terrible drug I started taking after I was taken off of the Geodon. I only took this drug for maybe three weeks to a month. Just like Geodon it caused the same side effects. Uncontrolable muscle clenching, panic and anxiety attacks that made me literally want to kill myself. I became almost paranoid at everyday things. Could neither sleep nor eat or drink most of the time. Horrible sweating and disturbing dreams. This drug is very new but even on such a low dose of 5mg per day it was enough to drive me to the edge. The symptoms became so severe I had to be placed in a mental hospital for a week which helped to calm me down, although not a hundred percent. The drug magnified my symtoms to the extreme and I felt the side effects on and off for months after taking both the Geodon and the Saphris. I should note that the way the drug was administered was through a lozenge which I placed under my tongue and it dissolved in my mouth. I was taking this drug in April of 2010 until May when I was hospitalized and finally taken off of the drug. M 26 25 days
5 1X day
3/20/2011
 3  Bipolar Knocked out an hour after taking it, tired, irritability, RLS at first but went away I really wanted to give this more of a chance but the extreme tiredness after taking it wasn't decreasing and the irritability was getting worse to the point I couldn't stand being around my 4 year old. It did seem to stabilize my mood though. M 41 8 days
5 MG 1X day
12/20/2010
 2  bipolar I gained 5 pounds in 4 days. Too much too fast. Bad taste was okay after day 1. I was also racing, becage more aggressive, agitated and annoying. I have tried all of the major anti-psychotics in an effort to get off of navane/thiothixene, no avail. I am worried about tardive, but I am kind of stuck at the moment. M 38 4 days
5 mg 1X day
12/20/2010
 1  bipolar 2 Very bad dizziness; extremely restless legs at night; dry mouth. Saphris was awful. After just one dose, I had to stay home from work and was unable to drive for two days. It took about two and a half days for it to clear from my system, and that was from just one dose. I will never take it again. F 54 1 days
5 mg 1X day
12/13/2010
 3  schizoaffective disorder depression, weight gain? Saphris has worked better for me than any other drug, but I am still very depressed and sleep 14 hours a day. I gained 30 pounds over the summer while taking it, but I was also on depakote, which I believe was the problem. Once I stopped taking depakote and switched to lithium, I stopped gaining weight. However, that was three months ago and I have not lost any weight either. I exercise regularly, but am mostly a vegetable otherwise. I'll probably stop this medication and try a new one. F 27 5 months
1X day
11/22/2010
 4  bipolar II none My first review was 9-28-10 Saphris did indeed take away my depression in one day. Saddly the depression did come back in about 5 weeks. I increased Saphris and this worsened the depression. I am grateful for 5 good weeks. I think it just pooped out on me. I would recommended it for bipolar II depression. M 55 50 days
5 1X day
11/14/2010
Email
 5  Schizophrenia no side effects I have tried: Zyprexa, Risperdal, Seroquel, Geodon, Abilify. They all made me Weight gain or caused me severe mood disorder. Saphris gave me clear thought and I feel right! I don't know about the weight gain, but on the review it saids it only makes you gain 2~4pounds. M 28
5 2X day
11/12/2010

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