ZONEGRAN Reviews (ZONISAMIDE)

Average Rating: 2.9 (90 Ratings)

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 ANTICONVULSANTS

 Type: Rx Drug

  

ZONEGRAN  (ZONISAMIDE):  Zonisamide is used with other medications to prevent and control seizures (epilepsy). Zonisamide is a sulfonamide anticonvulsant and a carbonic anhydrase inhibitor. It is unknown how zonisamide works to prevent seizures.   FDA Approval Date: 2000-03-27 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on ZONEGRAN: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR ZONEGRANCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  headaches & seizures I was never hungry, It was very difficult to study concencentrate, and remember pretty much anything. Within 3 weeks after I went off it the first time I had my second seizure. I was on it for 5 months for my headaches, and it didn't help, so my neurologist switched me to another medication, when I had my 2nd seizure. I went back on it, and while I didn't have my siezures I had all of the same side effects, so it wasn't worth it. F 21 10 months
11/18/2008
 5  epilepsy dry mouth, tiredness, dizziness, weight loss, gum problems no seizures since taking this drug; 100mg in morning and 100mg in evening; dizziness disappeared after a few weeks; lost 30 lbs and have kept it off for over a year without any trouble just have a smaller appetite; play tennis everyday so obviously got over tiredness and sleep like a rock; drink 64 oz of water plus per day and have since starting this drug; very happy; glad my doc encouraged me to stick with it... F 48 16 months
11/14/2008
 5  migraines none Take 100mg every other night, can do this because this med has very long half life. Also makes it very affordable as a generic. Took a full 3 months to work for me but after trying Depakote, Lamictal, Topamax, Elavil with no help and many side effects love this medicine. Have been on it for 4 years and has given me my life back. I still have some symptoms from migraines and migrane syndrone but they are 80% better. My neurologist said making me 50% better would be a success. F 50 4 years
10/8/2008
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 2  migraine prevention After a satisfactory year on Zonegran which did greatly reduce frequency & severity of my migraines, the medicine caused severe neurological pain, curtailing my range of motion in my arms so much that my husband had to help dress & undress me. I saw an orthopedist as well as a neuro, had an MRI, muscle and nerve testing done at great expense. After tapering off the Zonegran, it took six months but I eventually returned to normal. Having said that, my experience may have been one in a million. If the neuro problems hadn't shown up, I would have stayed on Zonegran for a long time because it was great for my migraines and had the nice side effect of keeping my weight under control. But it hurt a lot and it was scary. F 54 18 months
7/25/2008
 3  chronic daily headache minimal weight loss; Kidney Stone Was so disappointed! Took this drug for 2 months. At the onset it didn't seem to help, but after approximately 2-3 weeks my daily headaches were gone when nothing else had worked. HOWEVER, be sure to heed the warnings to drink alot of water so that you don't develop kidney stones - apparently I didn't drink enough because I developed a kidney stone. I discontinued the drug so that I won't have to go through that pain again! F 4 2 months
4/25/2008
 4  Post traumatic stress disorder None that I am aware of. My psychiatrist prescribes it for PTSD from childhood, along with 2 mg. Ativan at night about 2.5 hrs. before bedtime. The combination of Zonegran/Ativan has worked well for me for insomnia thus far. F 59 2.4 years
3/28/2008
 3  migraine and bipolar severe anxiety and agitation. Nervousness. Insomnia. Weight loss. Possible worsening of depression. It has helped my migraines which required several Imitrex shots a week prior. I had no idea of the severity of the anxiety before taking, and I am a pharmacist. At one point I thought I was going senile. None of the common literature says anything. It's really a toss up as to which is worse at this point. I am taking Lamictal for the migraines as well, and I have added Wellbutrin to try to help the depression. Now I think I may need to add an SSRI or benzodiazepine. I guess anything is better than a migraine. F 30 6 months
9/11/2007
 2  epilepsy None at first. After about a month I started getting nausiated frequently and experianced frequent stomach cramps. Also felt very tired and "out of it". Going to talk to my dr about going back on Lamictal F 25 3 months
8/9/2007
 2  Epilepsy Completely drained, loss of appetite, irritable, and an all around lack of motivation to do anything. No improvement on the seizures. F 25 1 months
7/23/2007
 5  migraine weight loss, increased thirst I am on 100mg every night. I have not had any side effects except for weight loss. This is the only med that has kept my migraines under control! F 27 1 months
3/18/2007
 5  Migraine 200mg at night. I took this drug before I went to bed. I had to sleep with the light on just until I fell asleep because of extreme hallucinations that haunted me. The hallucinations were so real too. I saw monks hovering over me... It felt like a salvia trip sort of. Besides this it works SOO GOOD for migraines preventative treatment. It works similar to Topamax just without the nasty, unbearable side effects. Topamax made me stupid, cold hands feet, speech problems, waking dreams and sleep paralysis. This works soo good for migraines without the nasty side effects. It made me lose a ton of weight too. I gained it back when I stopped taking it for a bit but that could be because of a few other reasons though. F 24 1.5 years
3/6/2007
 5  Epilepsy I feel dehydrated, which isn't so bad it makes me drink more water which is good for you and I have the muchies. Other than that I feel good, I have energy, I'm very clear headed. I like this stuff and so far no seizures, I hope it keeps up! F 34 1 months
2/23/2007
 2  mood stabilization Constipation, constipation, constipation. I only took it for about two weeks when the side effect got to me, so I don't know about any benefits the drug may have had. F 25 2 weeks
1/15/2007
 3  bipolar disorder At a higher dose I was uncoordinated and fell, but this went away when the dose was lowered. I have also lost some weight F 48 3 years
10/3/2006
 2  Epilepsy Weight loss for the first 3 months, consistent expressive aphasia (can't get the words out) and recall memory problems that became worse as dosage was increased. Skin rash at 500 mg/d. Ultimately didn't control the seizures so discontinued it. M 20 9 months
7/11/2006
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 4  migraines insomnia!!! (anxiety and nervousness when I got to 100 mgs, but both stabilized after a week) I have tried a lot of drugs, and zonegran has been the only one to get rid of both my killer migraines and those irritating little headaches. I don't sleep as much (or as well) as I used to, but I'll deal with that if I can be almost migraine free! F 23 3 months
5/19/2006
 4  migraine prevention very sleepy a couple hours after taking, (not a problem since I take it in the evening) present nausea may be related to the drug reduced my number of migraine days from 15 to only 5 per month. I'd have rated it a 5 if I wasn't suspicious that the mild intermittant nausea I've had for awhile now might not be related to the zonegran. But I'd rather have occasional mild nausea than migraines! F 52 8 months
4/14/2006
 5  Mixed Bipolar II/ADD None, except maybe a slowing of my thoughts. I've been taking 50 miligrams for quite some time. I didn't experience the weight loss that I thought I would, but it has really helped my mood and my organization! F 17 6 months
12/12/2005
 2  epilepsy Extreme loss of appetite and my head felt heavy all the time. Ultimately, Zonegran really didn't control my seizures, but just left me feeling like I was in a dull fog all the time. I had to take a nap every afternoon. F 30 2 months
9/27/2005
 1  Epilepsy Horrible vomiting which caused metabolic acidosis. The metabolic acidosis was almost not reversible and my son almost died. My son almost died from this drug. I found a 24 page document at the FDA that said the #1 problem with this drug (in adults during clinical trials) in the GI tract was vomiting. It was not mentioned in the PDR or the package insert. I found it on my own and told the doctor we needed to wean from it to see if the vomiting decreased. It did. My son almost didn't make it. This is not a benign drug. M 5 11 months
8/17/2005

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