ZONEGRAN Reviews (ZONISAMIDE)

Average Rating: 2.9 (90 Ratings)

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 ANTICONVULSANTS

 Type: Rx Drug

  

ZONEGRAN  (ZONISAMIDE):  Zonisamide is used with other medications to prevent and control seizures (epilepsy). Zonisamide is a sulfonamide anticonvulsant and a carbonic anhydrase inhibitor. It is unknown how zonisamide works to prevent seizures.   FDA Approval Date: 2000-03-27 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on ZONEGRAN: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR ZONEGRANCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  migraine prevention After a satisfactory year on Zonegran which did greatly reduce frequency & severity of my migraines, the medicine caused severe neurological pain, curtailing my range of motion in my arms so much that my husband had to help dress & undress me. I saw an orthopedist as well as a neuro, had an MRI, muscle and nerve testing done at great expense. After tapering off the Zonegran, it took six months but I eventually returned to normal. Having said that, my experience may have been one in a million. If the neuro problems hadn't shown up, I would have stayed on Zonegran for a long time because it was great for my migraines and had the nice side effect of keeping my weight under control. But it hurt a lot and it was scary. F 54 18 months
7/25/2008
 2  mood stabilization Constipation, constipation, constipation. I only took it for about two weeks when the side effect got to me, so I don't know about any benefits the drug may have had. F 25 2 weeks
1/15/2007
 2  Epilepsy Completely drained, loss of appetite, irritable, and an all around lack of motivation to do anything. No improvement on the seizures. F 25 1 months
7/23/2007
 2  epilepsy None at first. After about a month I started getting nausiated frequently and experianced frequent stomach cramps. Also felt very tired and "out of it". Going to talk to my dr about going back on Lamictal F 25 3 months
8/9/2007
 2  To decrease neck pain weight loss, mental slowing, difficulty concentrating, irritability, anxiety, speech problems, depression, I was seeing things that didn't exist and was ready to end my life. I was hospitalized, weened off of Zonegran and slowly regained my physical and mental health. Started with a dose of 100mg day first month, 200mg a day the second and 300mg a day the third. It did control the pain, but there was no way I could continue taking this med. F 43 3 months
3/25/2005
 2  Headache prevention Depression, mood swings, lost of concentration, crazy animAl nightmares, and still have headaches F 23 2 years
100mg
4/26/2013
Email
 2  epilepsy Extreme loss of appetite and my head felt heavy all the time. Ultimately, Zonegran really didn't control my seizures, but just left me feeling like I was in a dull fog all the time. I had to take a nap every afternoon. F 30 2 months
9/27/2005
 2  Psuedo Tumor Headache EXTREME fatigue, slowed motor and cognitive function - forgetting words and the like, feelings of extreme panic after I take it, sleep paralysis/ horrible dreams. Haven't noticed any positives yet since it's only been 4 days, but at the rate the negative side effects are coming I don't think i'll make to a week. Worried the side effects will end up causing a schizo-effective episode. F 22 4 days
100mg 2X day
8/18/2013
Email
 2  Trigeminal Neuralgia see things not there. Depression. Sucidal thoughts.Cold spots on legs and feet.Memory problems.Thinning hair.Made kidney problems. I was taking Zonisamide for Trigeeminal Neuralgia. At first i wasnt having any prolems with it at all. But then as we increased the dose it really knocked me for a loop. The neuroligist wanted to raise it to 400, and when i went to 300 it felt like my kidneys were processing glass. I could barely walk it hurt so much. Thats also when i started seeing stuff. Like i'd see spiders crawling across my pillow or bugs that werent there. just small stuff. i thought i was loosing my mind. Im still on a lower dose and the systems have abated but not completely gone away. i go soon for surgery then hopefully can stop taking the meds for this. must remain hopeful. F 50 9 months
100 Mg 1X day
1/19/2012
Email
 2  epilepsy Insomnia; Kidney stones Zonegran is one of the two seizure meds. I take. The insomnia would be debilitating if I couldn't sleep during the day to make up for the sleep loss at night. I know Zonegran is the problem, because my other med causes no side effects, but within an hour of taking the Zonegran, I'm "wired", & toss and turn. Also, causes kidney stones: I never had a kidney stone in my life before I started this med. I've talked to the docs about changing meds or times that I take them, but no go. F 58 5 years
100 mg 4X day
3/8/2010
 2  Temperal lobe epilepsy Sucidal thoughts, sore heart, brain fog, depression, severe anxiety, weight loss, migranes, irritabillity, hostillity, lack of sex drive,paranoia, hearing things like co workers talking about me or my name being called. This drug is a double eged sword its controlled my seizures for 10 months now however it has completely ruined my life. I have suicidal thoughts on a daily basis zonegran is 43% suicidal approved by the fda. Im extremely depressed and anxious all the time my relationships and friendships have broken down because im a constant mess and its put a huge strain on my relations with my family too. I feel that i have completely lost the person i was while on this stuff i doubt myself all the time and think the worst of every situation before it even occours. I cant hold a conversation without stummbling and forgetting what im talking about, in the past month i even forgot my own first name twice. Im describe myself as half a person these days to my mum and i no longer know how to dance for the anxiety and fear just take over and my mind races with crippling self destructive thoughts. If you can handle this and just want to control your eplilepsy then be my guest however if you wish for something more and want to remain feeling just a little bit humane please avoid it at all costs. F 25 2 years
200mg
7/22/2017
Email
 2  One seizure Lost 35 pounds in less than two months on 100 mg due to no appetite neurologist dropped dose to 50. Gained back all the weight and more. Numbness/tingling in throat, tongue, feet, hands. Double vision (terrible). Other problems not sure related but after reading comments I think so Just in recent days started with weird "sores" or rash on leg and arm doctor can't identify. Sore muscles in chest/arm. Itching all over. I'm afraid I've become allergic to the Zonisamide but I refuse to take any other seizure medication since I only had one three years ago and neurologist has no idea what caused it. I believe it was from my doctor lowering my Synthroid (thyroid med) for no reason from .150 to .112. I'd like to stop taking seizure med altogether but I'm scared TO take it and scared NOT TO for fear I'll have another one. F 63 3 years
50
6/25/2017
Email
 1  Seizures Just don t stop seizures. Take 500 mg. Don t work F 60 3 years
100mg
6/1/2018
Email
 1  Severe migraines Severe mood swings deeply depressed Barry manic anxiety through the roof panic attacks loss of interest all I wanna do is stay in my bed very negative thoughts wanting to commit suicide .everything tastes weird Very shaky don't want to get out of my bed lethargic My migraines have stopped for the most part and I'm thankful for that but my mental status but I have to go through it's not worth it risking my life is not worth it it was probably one of my darkest parts of my life very very sad F 24 2 months
200mg 2X day
10/10/2020
Email
 1  Migraines Worst drug I have had. Sent my heart rate through the roof, almost passed out in the shower multiple times, no appetite, very agitated, anxious and not effective. And started having involuntary movements in my hands, shaking. Continue to have very severe migraines It did not effect my depression but I am already medicated for that F 26 14 days
50mg 1X day
11/23/2020
Email
 1  Migraine Prevention Increased Anxiety, Agitation, Difficulty Falling Asleep, Just Felt WEIRD. I was supposed to increase my dose by 25mg a week until I reached 100mg. At 50 mg, I began to feel agitated, edgy and snappy which is NOT like me at all. I already take Celexa for anxiety, and haven't had issues in some time. I had a mild panic attack today, and am stopping this medicine ASAP. Not much change with my migraines, and I hate the way I feel. F 31 2 weeks
50 mg 1X day
7/31/2011
Email
 1  bipolar 2 Super anxious to the point of tears, hair falling out, very tired. Took this to replace Topamax, which worked wonders for me, but made my hair fall out. This does the same, but without the mood stabilizing effects. F 33 5 days
25mg 1X day
2/9/2010
 1  rsd pain they just took me up to 500 mg aday i dont like it but what to do for pain they will not give out pain medswe will see how this go F 18 9 months
500mg
11/12/2012
Email
 1  Weight loss, insomnia Have all but lost my sense of smell and taste. At first things tasted or smelled funny. Then I couldn't smell or taste at all. I am tapering down now since I have lost the weight and do sleep at night, I hate to think the sense of smell is lost for good! Prescribed Zonegran when I came off of Elavil. Needed to loose 20-30 lbs and sleep at night. I did loose the weight and have been able to sleep. But have a lot of anxiety and terrible problems with smell and taste. F 56 1 years
300 mg 1X day
6/22/2013
Email
 1  epilepsy Zonegran made me extremely nervous, moody and confused. Plus I broke out with a horrible rash all over my body! As I was getting off the medicine, the rash was coming back again. Plus it gave me horrendous headaches. It was like I had swallowed a monster! It should be destroyed!!!!!! F 38 9 weeks
10/9/2004

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