ZONEGRAN Reviews (ZONISAMIDE)

Average Rating: 2.9 (90 Ratings)

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 ANTICONVULSANTS

 Type: Rx Drug

  

ZONEGRAN  (ZONISAMIDE):  Zonisamide is used with other medications to prevent and control seizures (epilepsy). Zonisamide is a sulfonamide anticonvulsant and a carbonic anhydrase inhibitor. It is unknown how zonisamide works to prevent seizures.   FDA Approval Date: 2000-03-27 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Gender males first.

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on ZONEGRAN: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR ZONEGRANCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  Epilepsy some loss of appetite, some fatigue, takes longer to take tests in school, some difficulty with math problems F 7 4 months
7/11/2005
 4  migraines insomnia!!! (anxiety and nervousness when I got to 100 mgs, but both stabilized after a week) I have tried a lot of drugs, and zonegran has been the only one to get rid of both my killer migraines and those irritating little headaches. I don't sleep as much (or as well) as I used to, but I'll deal with that if I can be almost migraine free! F 23 3 months
5/19/2006
 4  migraine prevention very sleepy a couple hours after taking, (not a problem since I take it in the evening) present nausea may be related to the drug reduced my number of migraine days from 15 to only 5 per month. I'd have rated it a 5 if I wasn't suspicious that the mild intermittant nausea I've had for awhile now might not be related to the zonegran. But I'd rather have occasional mild nausea than migraines! F 52 8 months
4/14/2006
 4  Epilepsy Hair loss every time my dosage was increased. I eventually had to wear a wig for a while. Once I was on the dosage for a while, my hair would start to grow back, but at the start I was getting my dosage increased regularly so it never had much chance. Now, my hair is thinner than it once was, but I at least don't have to wear a wig. Other than that, nothing I can for certain pin on the Zonegran...possibly it is the cause of increased insomnia, but possibly not. It has certainly helped, and is one of the only seizure medications that doesn't seem to want to make me gain weight. F 38 1.5 years
300 mg 2X day
11/28/2010
Email
 4  migraine insomina and very hyper at first abdominal pain F 40 30 days
100 1X day
3/4/2016
 4  Migraine I get extremely tired, and very low. I lack motivation to do very much. I can be moody when Im tired and I was never like this before this drug. However it has stopped migraines....except during my monthly periods. The migraines are not as severe in this time but I still have one for a few days. I assume Zonegran doesnt help hormones! I am relieved to have this drug. I was on Topamaz before Zonegran and I find this much better. My migraines are less frequent and I have a much better quality of life. I would like to reduce the dose to test if I can reduce it. F 47 4 months
100 1X day
6/5/2016
 4  Migraines/seizures Blurry vision, depression, brain fog But no migraines and has controlled seizures and my hair stopped falling out like it was on Topomax, it was falling out in clumps!! So I’m grateful for that Why is it I can’t ever have the good side effects like weight loss! Lol F 41 45 days
100
11/8/2019
 3  epilepsy memory is just trash now this used to work great for me but after 3 years of working it just stopped and i had 3 seizures on it F 20 3 years
500 1X day
10/6/2020
 3  pain from nerve compression lost 6 lbs, loss of appetite, constant feeling of mild nausea, taste of foods have changed, insomnia, word retrieval problems and forgetfulness Has minimized the numbness and pain in my legs from nerve compression in my spine. F 59 3 months
300 1X day
7/16/2017
 3  to prevent migraines so tired i was falling asleep at my desk. this never improved in the month taking it. i couldn't drink enough caffeine to wake myself up, so much caffeine it was creating digestion problems. as time went on i became more and more anxious on top of the grogginess, and some past anxiety disorders came up like phobias. i got really jumpy and was concerned i would have a panic attack. i haven't had these issues for 18 years but it was starting to come back. i would so much rather have a constant migraine than have the mental health issues i used to have and panic attacks. my doctor agreed i should stop taking it immediately. i've been off for 3 days but i'm still feeling tired and jumpy. i hope the anxiety goes away so i'm not preoccupied with past phobias (spiders, bugs). this sucks. unfortunately it is the only drug i've found so far that helps with my extreme light sensitivity, but i prefer light sensitivity, migraines, or any physical problem over anxiety disorders. F 35 30 days
25mg 1X day
8/11/2011
 3  chronic daily headache minimal weight loss; Kidney Stone Was so disappointed! Took this drug for 2 months. At the onset it didn't seem to help, but after approximately 2-3 weeks my daily headaches were gone when nothing else had worked. HOWEVER, be sure to heed the warnings to drink alot of water so that you don't develop kidney stones - apparently I didn't drink enough because I developed a kidney stone. I discontinued the drug so that I won't have to go through that pain again! F 4 2 months
4/25/2008
 3  Migraines Only slightly lethargic if I don't keep busy. I'm also feeling a slight ache in the back of my head, but I don't now if it's related to our drastic weather/barometric pressure change here lately or not. I was on Topamax for over 3 months and couldn't take the side effects. Two major ones being daily sinus pain/problems and sexual side effects. I started taking 100 mg the 1st week at night and now I am taking 200 mg also at night. F 33 2 weeks
6/28/2005
 3  bipolar disorder At a higher dose I was uncoordinated and fell, but this went away when the dose was lowered. I have also lost some weight F 48 3 years
10/3/2006
 3  seizures Very dizzy, swollen gums, loss of appetite, sleepy, I had insomnia on my previous seizure med, this put me to sleep. All I wanted to do was sleep. I could not function. I was in a cloud. I was taking 200mg @ night. Lips and tongue were numb. Weight loss. Unclear thinking. I called my doctor and he cut the dosage to 100 mg. but then I had a seizure. The first one in 2 years. I felt better taking 100mg. wasn't as dizzy. I liked the idea of the weight loss, but since I had a seizure my med was changed. I could not function on this medicine. I was taking 200mg. I couldn't even drive. Once my dosage was cut, I did feel a lot better, but it didn't work for me because I had a seizure. I only have seizures at night when I'm sleeping. F 39 1 months
6/6/2009
Email
 3  migraine and bipolar severe anxiety and agitation. Nervousness. Insomnia. Weight loss. Possible worsening of depression. It has helped my migraines which required several Imitrex shots a week prior. I had no idea of the severity of the anxiety before taking, and I am a pharmacist. At one point I thought I was going senile. None of the common literature says anything. It's really a toss up as to which is worse at this point. I am taking Lamictal for the migraines as well, and I have added Wellbutrin to try to help the depression. Now I think I may need to add an SSRI or benzodiazepine. I guess anything is better than a migraine. F 30 6 months
9/11/2007
 3  epilepsy anxiety, increased heart rate, decreased appetite,anal leakage(eww), moodiness, extreme lethargy, depression, severe memory loss i was diagnosed with epilespy in april of 09 and my original neuro (who was a quack) perscribed lamictal..but i had two other partial seizures and it caused me to hallucinate and have horrible nightmares.I consulted another neuro who suggested i try zonegran...His goal was to get me to 400 mgs over a 4 week (take at night my seizures happen in my sleep..or right before i wake up)period. Initially i noticed a loss of appetite and irritability/moodiness. As my dosage increased, I felt like a dope, i couldnt remember anything and it was extemely difficult to stay awake. If i needed to take any other medicine, forget about it. Often times i wouldnt take this med because the side effects for mixing both werent worth it until this past dec i had a seizure at work...if u dont have any life threatening side effects try to stick with it for about 3 mos before giving up, sometimes your body has to adjust..i know i have to be consistent and i'm not so thats my problem F 30 9 months
1/12/2010
 3  SEIZURES MEMORY LOSS LOSS OF SMELL AND TASTE F 54 1 years
100mg
11/25/2013
 2  Epilepsy Extreme sleepiness ....very difficult to find words....slow thought processing.... has not yet helped with seizures going to continue for a while longer to see if side effects go away and things get better F 5 3 weeks
60 2X day
10/29/2013
Email
 2  headaches & seizures I was never hungry, It was very difficult to study concencentrate, and remember pretty much anything. Within 3 weeks after I went off it the first time I had my second seizure. I was on it for 5 months for my headaches, and it didn't help, so my neurologist switched me to another medication, when I had my 2nd seizure. I went back on it, and while I didn't have my siezures I had all of the same side effects, so it wasn't worth it. F 21 10 months
11/18/2008
 2  migraines weight loss, never hungry, hardly urinated at all, skin always smelled like urine 100mg every night. It did absolutely nothing for the migraines and I didn't like the side effects I experienced. F 55 1 years
6/12/2009

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