Average Rating: 3.1 (58 Ratings)

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 Type: Rx Drug

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on AMITRIPTYLINE HCL: Reviews Summary  |  Drug Safety Information

 5  Anxiety, chronic tmj pain, insomni Working well on my anxiety and sleep. Never slept so good since I was a child. Don't wake up groggy. No brain fog. It dosen't make very sleepy but once I am asleep I sleep more sound than ever. It has also helped my chronic TMD/TMJ pain. I might seek a bit higher dose soon to see if it would help more with the pain. I take this in addition to Lexapro and Ambien PRN. I took 10 mg Ambien for years but now 5mg seems to work fine since starting amitriptyline. Very happy with this medication so far. No real side effects thank goodness. Be well! M 49 4 months
10mg 1X D
 5  Anxiety and Panic Some physical side effects. The usual: Dry mouth, constipation etc. The first drug that I have responded well to and tolerated. I think SSRI medications are seriously overrated and overused! M 24 8 weeks
100mg 2X D
 1  Nerve pain I was like a zombie during the day, made me moody and psychotic, caused anxiety and made my pain worse. I was only taking it for approximately 3 weeks and I still had side effects after a week F 41 3 weeks
5mg 1X D
 1  IBS Prescribed for IBS-d as a neuromodulator to stop diarrhea. WORSENED the diarrhea and cramping. More MD's need to know the paradoxical effects of these drugs -- look at the studies - half the subjects drop out. F 69 3 days
10 mg 1X D
 4  Neuropathy dry mouth sleepy and dizzy just hope I don't gain weight from this F 47 6 days
25mg 1X D
 3  CFS, Insomnia, IBS, Panic disorder Very hungover upon waking up everyday, extreme dry mouth, weight gain, tachycardia, postural hypotension Amitriptyline worked great putting me to sleep for the first 2 years, but by the 3rd year it's effect was extremely delayed. Waking up was very difficult and couldn't function for first 3 hours after waking. Weak and dizzy most days, but no daytime sleepiness. It controls anxiety well and helped IBS about 50%. Didn't seem to do much for my CFS pain. 15 lb weight gain was gradual over 3 year period. F 42 3 years
 3  Insomnia Works for 3AM awakening and I go back to sleep. Without I am awake for 1-2 hours. Sometimes I split pill in half. Sometimes I feel tired in the morning but not terrible. M 72 12 years
 5  Pain Dry mouth and sedative effects F 57 5 years
150 1X D
 3  CFS, anorexia, insomnia Weight gain, allergy suppression, fatigue, depression, electrolyte imbalance This worked for me at first but I had to start low, didn't gain too much weight but it no longer helped with insomnia after I came off it. Had hurt my back and the amitriptyline didn't cover the pain anymore. Went crazy with pain treatments which made my body lose more nutrients. Lead to a total loss of electrolytes, weight loss, depression, allergies came back. Use a short while if you have to but consider healthy alternatives with diet and exercise, cognitive therapy if you need it first. Avoid too many additional drugs you can get dehydrated taking this. F 63 15 years
 3  Chronic headaches Slept a lot (10 hours a night), brain fog, weight gain Be very careful COMING OFF of this medication. I was only taking 50 mg a day (at night), and tapered by 10 mg per month over five months (i.e., took 40 mg/day during the first taper month, 30 mg/day during the second taper month, etc.). I was very sick for about two months while tapering and thought something was seriously wrong with me -- I went to my PCP and had a full (expensive) blood work-up which was normal. The withdrawal symptoms were a general sense of malaise -- muscle aches, slight fever, feeling like I had the flu every day for two months. My neurologist completely invalidated that this was amitriptyline withdrawal, claiming my dosage was too low to cause such withdrawal symptoms. He was clueless! I went to the primary literature about "cholinergic rebound" and apparently it's very common (Google "cholinergic rebound syndrome"). Another consideration is that this medication, along with other "strong anticholinergics," has been associated with significantly higher risk for dementia, even in middle-aged patents -- see Gray et al. 2015, Cumulative Use of Strong Anticholinergics and Incident Dementia: A Prospective Cohort Study, JAMA Internal Medicine (available online). This paper by Gray et al. is what made me decide to go off the medicine, but going off it was hell. Be careful! F 47 1.5 years
50 mg 1X D
 4  Chest pain associated with anxiety It helped me immediately...however the "hazey" feeling in the morning took some adjusting. No weight gain..although I have had some minor heart palpitations. F 68 1 years
 2  Sciatica, back pain and leg pain When I first started taking amitryptaline it would immediately put me into a deep sleep after about 30 minutes of taking it, I would be in the deepest sleep and be a complete zombie the day after. It gave me an incredibly dry mouth and very dry eyes. These side effects disappeared after a couple of months and I actually started to enjoy getting a good nights sleep! The most noticable physical side effect I still have is that I can no longer drive at night as it has effected my sight quite badly - the lights all blur into one and I can't see anything, this has never been a problem for me before. In honesty I'm not sure if it improved my sciatic pain or whether it just naturally improved itself. I do know that it let me completely relax during the night, maybe that was why it helped me. I initially started on 20mg and reduced myself to 10mg about a year ago as my pain has virtually gone. About 3 months ago I had a complete mental breakdown for absolutely no reason - I have a great life a F 24 2 years
10/20mg 1X D
 4  For depression None Do endep still work after taking it for around 20 years F 70 10 years
 1  Chronic intractable migraine I have suffered from severe migraine for 28 years and have been on just about every med out there. When my neurologist prescribed this I had an extremely dry mouth and was very forgetful. I asked about it and he said it should go away. It was so bad I felt like I could hardly function. I would forget what I was talking about mid sentence . Then it finally did get better. Not all the way better, but better. However my biggest issue was weight gain. I have been within 5 pounds of the same weight for 20+ years. Even after having a child, I returned to the same weight. This caused me to go from 120 to 143!!!!! My eating was really no different. My neurologist told me it can totally slow your metabolism. What?!?! I should have been told that!! I told him I was done and he weaned me off it. It's been 1.5 years now and I am still struggling to get that weight off and waiting for my metabolism to go back to "normal." I am just furious about it as I didn't "earn" my weight gain. As if 28 years with debilitating migraine want bad I gained a good amount of weight. UGH!!! My advice? DON'T take this! Too many other meds out there! F 43 6 months
 5  Migraines? None as yet? I have a Paradoxical effect with meds. I will use Adderal to help me sleep at night and get rid of my leg cramps. Today, I had a migraine and lethargic. I went thru my usual rituals of trying to feel better and nothing was working. I remembered that my new Primary doctor wanted me to start this new medicine; she said it was for my Migraines, BUT, I know why she wanted me to try it, (Just Diagnosed with Elemental Mercury Poisoning after 6 years of it destroying me mentally and physically). I thought to myself, what do I have to lose, let me try it today. AND I WAS RIGHT...all of the sudden I was organizing a drawer and thought to myself, why do I feel well enough to organize this drawer when I could be cleaning the bathrooms, etc...AND I realized, the new medicine had kicked in and instead of making me LETHARGIC like Adderall, it gave me a kick without any side effects. Just pure joy to have energy without any heart palpitations or a headache. 5 hours later, my headache did come back, but with only one Fiorcet I was good! So, now it is 11:30 at night and I am wide awake. I took this at 11:00am this morning. So, I decided to research what others are saying about this drug. I truly hope this is not a fluke. I really need a break. If I can feel as great as this everyday, I will be able to get my life back, WISH ME LUCK! I am comparing this drug to Forfivo 450XL. When the pharmacist told me to take it in the morning because it would make me hyper, I knew that I better take it at n F 51 1 days
10mg 1X D
 1  Migraines/Chronic Headaches Increased anxiety, Increased hunger, Drowsiness throughout entire day. I'm going to try to get off this medication asap, I can not work in school due to hunger, drowsiness, and extreme anxiety. I now have headaches more often, just not as bad. M 15 6 days
25mg 1X D
 4  Chronic tension headache, migraine Initially, dry mouth, dizziness, deep and long sleep, and slight weight gain (3-5 lbs). These side effects have subsided, and my weight has stabilized. Although I still get headaches regularly, they're much less frequent and less intense than before I started taking this medication. The medication seems to "re-set" my tension headaches, so they don't intensify into migraines over the period of a few consecutive "bad headache" days. For me, the side effects are worth the improved quality of life (and the side effects subsided after a week or two anyway). F 46 4 months
50 mg 1X D
 1  Pain Dizzy/Vertigo Loss of interest. Urine retention. Am I not taking enough or too much? Side effects are still symptomatic after 2 months use. F 2 months
10 mg
 1  Depression The primary concern for me was inanillity to get and or main tain an erection and a total lost interest in sex no interest at all it brought on another condition called ISD or ISDD (look it up ) not good when followed on all meds I was taking I had diagnos my self my pharmacist nor my doctor would render a clue as to what was wrong with but I know my body I totally blame my self I did not check these people I did not research these meds I thought they were under some kind oath to look out for they,re patients expecislly the doctor I mean how do you put a person on this type of dangerous drug and not even look back never check for toxic build up never tell the patient anything about this, four straight years I took this medicine if I was seemly on mild depression this drug could have made me commit suicide a no one would have been the wider o say never again and I'm consulting an attorney. Take control of your life your meds flak are all taking f-ing pay from the pharmcutical industry. M 53 4 years
 1  Migraines, insomnia, anxiety Increased hunger, more frequent headaches, more frequent anxiety attacks. Next day fatigue. I have never been so hungry in my life than on this medication. I constantly eat and once I'm done almost immediately feel hungry again. Gained weight in very short amount of time. It doesn't necessarily make me sleep better or longer but the next day o cannot seem to wake up and feel exhausted all day long. Also I have noticed my anxiety is heightened and I'm in a constant state of fear. and since taking it I've had a headache every single day. Not as bad as a migraine so I guess that's a plus but pretty annoying headaches that still disrupt my day to day. Will be working to wean off this med. No relief at all . F 24 2 weeks

AMITRIPTYLINE HCL  (AMITRIPTYLINE HYDROCHLORIDE):  This medication is used to treat mental/mood problems such as depression. It may help improve mood and feelings of well-being, relieve anxiety and tension, help you sleep better, and increase your energy level. This medication belongs to a class of medications called tricyclic antidepressants. It works by affecting the balance of certain natural chemicals (neurotransmitters such as serotonin) in the brain.   (Sources: U.S. Centers for Medicare Services, FDA)