ANAFRANIL Reviews (CLOMIPRAMINE HYDROCHLORIDE)

Average Rating: 3.7 (133 Ratings)

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 ANTIDEPRESSANTS CNS, MISCELLANEOUS

 Type: Rx Drug

  

ANAFRANIL  (CLOMIPRAMINE HYDROCHLORIDE):  Clomipramine is used to treat obsessive compulsive disorder (OCD). It helps decrease persistent/unwanted thoughts (obsessions), and it helps reduce the urge to perform repeated tasks (compulsions such as hand-washing, counting, checking) that interfere with daily living. This medication belongs to a class of medications called tricyclic antidepressants. It works by restoring the balance of certain natural substances (serotonin, among others) in the brain.   FDA Approval Date: 1989-12-29 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Age from youngest to oldest (reviews with no age reported listed first).

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on ANAFRANIL: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR ANAFRANILCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  panic attacks, obsessive thoughts Weight gain, tiredness, sedation. M 20 1 years
100mg
3/9/2014
Email
 1  depressipn Weight gain,comtsipation,sweating,sex problem,excessive sleepy, Above effects occurs when i was using clomoprill for 3 years.but i have still side effects like weight gain and excessive sleep. Was doctor suggest rightly ,such long course for boy of 17 M 20 3 years
150
7/14/2015
Email
 5  OCD/disturbing reoccurring thoughts Constipation, Sleep ALOT, no orgasm, black out when stand up too fast LOVE it. I've been having awful thoughts for many years and I had no idea that anything could stop them. Anafranil has saved my life. I no longer go to sleep fearful, so far, so good. F 21 1 months
3/16/2009
 5  ocd, anxiety, depression none I'm mainly trying to take this for anxiety and ocd, so far the drug has cleared my head a lot, everything is so much clearer at 50mg. It has done a little for my anxiety so far, I know doses from 100mg to 250mg are used for ocd, best drug taken I've also taken ssri's, cymbalta,klonopin,herbal remedies,abilfy, nardil and wellbutrin none compare. M 21 7 days
10/22/2008
 4  OCD/Anxiety Dry Mouth, Difficulty Urinating,Body pain (went away after the first couple months) However exhaustion increased over time along with chest pain/pressure and blood pressure problems. The most effective drug I've ever taken. My OCD felt under control for the first time in 10 years; I felt stable and happy. The side effects were unpleasant but I was willing to undergo anything. However by month 6 I was so exhausted and my heart was so stressed I had to discontinue the meds. Very strong chemical. By day 3 off Anafranil I am back to my old mental state, no control. F 21 6 months
50MG 1X day
7/3/2012
 3  OCD, depression Frequent urination, sleepiness, headaches, thirst, strange euphoria, increased hunger. I REALLY wanted to like this drug and to stay on it. I mean, it made me so happy and carefree. But I had the worst headache on it, my mouth was bone dry, and even if I wasn't drinking water, I had to pee every 20 minutes for some reason. I also gained 10 pounds because it made me ravenous! It did help with OCD a lot, but it just wasn't worth it. F 21 21 days
50 mg 1X day
9/27/2010
 5  Depression, Anxiety, Obsessions Dry Mouth, Sweatiness, Longer time till orgasm Within a week this medicine has near completely erased my depression, panic, anxiety and mild OCD. Each day gets better and I havent even made it up to 50 mg's yet. So much better than SSRI's and with fewer side effects - plus it doesnt numb you into hapiness, just amplifies everything good about life! 22 2 weeks
1/29/2008
Email
 5  Depression/OCD/Social Anxiety Constipation and slight dry mouth. Higher sex drive which is not usual in anti depressants. Works GREAT for OCD and Depression. Also helps a bit with anxiety! I went on this drug about 18 months months ago and my life completley turned around. I felt like I needed a break from it a few months ago so came off it. I was feeling fine for about 6 weeks then all of my symptoms came back, especially severe depression. I have gone back on it now and realised I need this medication at this point in my life. I have to put up with the side effects because this is the only drug I have had that has been effective. F 22 18 months
1/5/2010
 5  Ocd M 22 3 weeks
25
2/28/2016
 4  OCD Acid reflux When I first started Anafranil, I started with one a day, and slowly increased to where I am now-- 4 a day. I initially didn't feel any difference until week 4 and it has seriously helped me. I get this "acid reflux" like feeling after I take them. I try to eat a little something before I take it, but it doesn't seem to make a difference. F 22 6 weeks
25mg 4X day
10/7/2014
 4  depression and anxiety The first few days: dry mouth, blurry vision, heat flashes, sweating, anxiety, drowsiness, sedation, etc. After a few weeks: postural hypotension, constipation, weight gain. This medicine works very fast. However, it should only be used for a short period of itme F 22 3 weeks
2/24/2005
 4  OCD/dermatillomania, Anxiety, depression Dry mouth, brain zaps, night sweats,sexual dysfunction, tremmors, muscle twitching,insomnia Side effects halted after 6-8 weeks of starting medication as well as with every dosage adjustment. Sexual dysfunction is still an issue a year later F 23 1 years
175mg
4/17/2018
 1  Depression, Anxiety ,Panic attacks Paranoia, Dizziness, Did not sleep Head ache, Lack of hunger, Heart feels like its beating wrong, Jittery, equilibrium is off Horrible feeling F 23 2 days
6/19/2009
Email
 1  OCD Nausea, heart palpations, vision, sickness, dizzy, blood issues, Took for one day insomia bad sickness to avoid this crap mellows you out but has sides M 24 1 days
25 MG
12/21/2015
 5  OCD, Panic Attacks, Anxiety 1st Week: mild twitching, loss of appetite. Week 2 & subsequent: very few side effects other than excessive drymouth when nervous, sweating more when its hot, constipation & anorgasmia This drug is wonderful. The benefits far outweight the side effects. It takes away obsessive thoughts & anxiety without taking away your personality. I started using Anafranil after SSRIs (zoloft) made anxiety & OCD worse. Feel free to contact me. M 25 4 months
9/25/2007
 4  Depression, anxiety. Weight gain and bloating It helped M 25 8 months
10
10/26/2016
 1  Somatic OCD Triggered an autoimmune disorder, dangerous lack of concern for self, suicidal ideation, memory loss, brain zaps, seizures, heart damage, began serious self-harming. This medication is the turning point where my life fell apart and everything along with it. The side effects were severe and some have been permanent over 5 years later. I have almost no memory of the time I was on it. I now have a permanent autoimmune disorder that this medication set off that I will spend the rest of my life fighting to keep it from killing me. The skin on my arms is destroyed, have damage to the side of my head and several arteries, and it made my OCD a million times worse. I wish I could sue due to how much this medication ruined my life, if only to pay for the medical bills it caused me to rack up (and continue to rack up). F 25 1 years
1X day
11/7/2020
 5  Depression, BDD Dry mouth, dizziness(1st weeks) loss of sex drive and orgasm (1st months), weight gain, drowsiness, constipation, vivid nightmares (when i forget to take it) I felt better almost immediately after taking this drug. I have tried a number of SSRIs and other drugs without relief. This drug has completely turned my life around. Suicidal thoughts, days spent hiding in bed, frequent bouts of crying, are all bad memories. I have so much more energy and have developed a lust for life that I haven't had since I was young. Within months of starting this drug my life turned around - I got the job I'd dreamed of, I moved out of my parent's home, weekends started filling up again. Now I have a career, a full social life and am living independently. On the down side I have put on 10kg in 6 months. I went through a period of not being able to achieve orgasm but that has passed. And if I forget to take it at night I get bad nightmares. I also feel drowsy in the mornings and it takes me a while to wake up. All in all the positive effects far outweigh the side effects though. F 26 6 months
4/19/2008
 5  OCD Dry mouth, weight gain, excessive sweating (head), harder to orgasm I was diagnosed with OCD at 13 - hand washing, checking, intrusive thoughts. This drug made my OCD completely disappear. Yes the side effects are not great, but they are not the end of the world. When I had OCD I could not function normally at all, all my time was taken up with my obsessions, I can function normally with these side effects. I have tried coming off the drug many times in the last 13 years but when I do, I get very emotional and depressed and my intrusive thoughts come back. I would recommend this drug to anyone with OCD, the dull headaches and tiredness do go with time, just keep taking it regularly and they will disappear. The side effects I have sited above, however do not seem to disappear. F 26 13 years
75mg 1X day
6/25/2011
 3  Gen.Depression Phobias OCD Libido loss, dizziness, unoriented, too many questions unanswered (Imagining I'm in the right place to start answering them). Felt at my best as never before in my whole life and started rediscovering myself and my abilities. Then hallucinations(like seeing halos around people's faces). After the 1 month on this, then went in the manic phase and then totally totally out of control and tried to cut my wrist. I was lucky the damage on my wrist was minimal. Well I had to be inserted in a psychiatric ward and doctors started experimenting doses of various drugs. M 26 1 months
8/6/2008

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