Average Rating: 2.8 (44 Ratings)

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 Type: Rx Drug

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on ZESTORETIC: Reviews Summary  |  Drug Safety Information

 1  Hypertension Terrible dry cough. Constant colds with phlegm. Easily catch any illness going around. Frequent urination at night Will change as soon as I can contact physician F 69 14 years
 5  High blood pressure No side effect very good for me.l just drink lots of water and changed my eating habit I only take this one medication. F 68 6 years
 1  slightly elevated blood pressure Lowered my blood pressure, but made it TOO low. Gave my a dry mouth, headache, dizziness, fatigue, total brain fog. This also made my postassium level plummet and I passed out at work recently due to my b/p and potassium being too low I never want to take this again!! F 38 3 weeks
10-12.5mg 1X D
 1  Blood pressure Joint,knee and back pain also hair breakage and thinning. F 49 2 years
 2  High blood pressure Stomach upset, intestinal issues, and COUGH !!! The cough is ridiculous. Keeps me awake, bothers family. F/UP w/dr in 4 days - hope to switch. Don't want to feel this way anymore - especially on vacation - can't afford to feel crappy and be oversensitive to sun. F 50 10 days
20-25 1X D
 1  High Blood Pressure I switched to this pill because it was cheaper but I developed a horrible chronic cough and dry throat after the first day. I took this pill for 5 days and then my doctor put me back on Micardis HCT which is amazing it keeps my blood pressure down and keeps my weight down. Stay away from this drug!!! Please. F 42 5 days
20mg 1X D
 1  High blood pressure Severe leg cramps, foot cramps, knee pain, heart flutters, back pain, joint pain. After only 2 days of taking this drug I awoke to a excruciating shin pain. Felt like something was squeezing my legs and at same time hitting with a baseball bat. I was on Lisinopril w/out hctz 40 mg several months before this drug and I developed severe ear congestion and muscle clicking in my right ear. Still have ear clicks. Went off drug. Switched to Valsartan/ hctz. On it for 2 months. Same horrible effects. Bone pain, muscle spasms in legs, weakness, no energy, hair thinning. After being on all three of these drugs for a total of approx. 5 months , I feel like I am 90 years old. I so much want this out of my system ! I just hope and pray there is no permanent damage. I had to take a leave of absence from work due to these drugs. THIS IS POISON. Do NOT take this drug. I am thankful for this site for I now know my symptoms are not from some other disease. These drug companies claim these side effects are very rare. Not so. they should be taken off the market. F 49 23 days
20 / 25 mg 1X D
 2  hypertension 150-170/90-100 My doc put me on this drug for my hypertension, and told me to watch for cough, as the most distressing symptom. I never experienced that, but did have headaches a lot, even when my BP was not elevated. That could be attributed to it. It worked mediocre, I'd say, for me. It lowered my BP sometimes, but wasn't consistent. It might be 110-132 when I'd first wake up, and throughout the day, would be in the 130s to 150s, sometimes as much as 160. It just depended. I also started on Synthroid at the same time, and began having other symptoms such as: hair loss, weight gain, nipple discharge, irregular menstruations, headaches, and dizziness. The dizziness was only the first 2 days. So I attributed many of these symptoms being from the synthroid. After discussing with my doc, he thinks many of these (minus the female problems) are side effects of the Zestoretic. He's seen this in other patients and discussed it before with pharmacists. Due to my BP not being lowered as much as he wants and the ill-effects of the diuretic part of the drug, he is discontinuing this drug and starting me on another one. F 29 7 weeks
 3  Borderline high BP I only noticed now that every time I standup after sitting down I get light headed. It definately is a result of the drug due to te fact I never had it before this bad. It could also be the fact that I started insanity workouts. 35 2 weeks
 3  high blood pressure no little dizziness M 16 10 weeks
 5  Hypertension Intermittent dry cough which does not awaken me during the night. Great at lowering my blood pressure and has not affected my erections! M 52 2 months
 1  Hypertension Uncontrollable coughing, itching, vitiligo rash. Overall not a good experience at all. M 61 5 months
20 mg 1X D
 4  high blood pressure 180/110 headache at first, some stomach upset. This med lowered my bp within 3 hours. I was on benicar for 4 years and took weeks to work and never was able tolower my diastolic as well and I felt terrible on benicar. F 45 5 days
10mg 1X D
 3  140/90 blood pressure irritating dry cough, throat mucus seems a little worse This is my first bp medicine. Nagging cough is irritating. Night leg cramps have also occurred, but only once during first week. Considering trying a different medication. M 60 7 days
 4  High Blood Pressure Orthostatic hypotension, other than that nothing else. M 38 6 months
 1  high blood pressure This was some bad stuff for me. Experienced fairly severe joint pain in elbows, and various other places sometimes. Up several times during the night peeing, and put a severe damper on sexual performance. Took a while to realize what the problem was, just thought it was getting older. M 44 6 months
 2  High Blood Pressure Light headed first day, with a headache. Headache gone by day three, However it SEVERELY affected abilitity to get/maintain erection. Never had that trouble before. Side effect never improved. Worked well at reducing blood pressure, but sexual dysfunction side effect not worth it. Have discontinued after 28 days, and will try Norvasc next. M 51 28 days
 2  hypertension Shortly after I began taking this medication I developed a horrible cough. I have been taking this medication for 6months and the cough has just gotten worse.I cough so hard at times I can hardly breath. Tomorrow I am going to see my doctor and I will ask for something different. Benicar w/hctz seems to have less of the horrible side effects. I will never take Zestoretic again! Why exactly does it cause coughing? F 28 6 months
 4  blood pressure severe chronic cough.... keeps pressure down really good. F 37 5 months
 1  High Blood Pressure Already had problems with my erections but was getting by. A couple of weeks after taking Zestoretic penetration became impossible because of the diuretic in Zestoretic. Turns out that diuretics (Chlorothiazide in this case) are a known factor in causing Impotence in a high percentage of males. Luckily my Dr increased the dosage to 40mg. Zestoretic doesn't come in 40mg dosages so he prescribed Lisinopril 40mg and Chlorothiazide (diuretic in Zestoretic). I was in my late fifties at the time and coping with serious erectile difficulties which I attributed to aging. Not so, I found out. At least not the only cause. When I finally talked to another Dr he confirmed the problems were probably being caused by the Chlorothiazide. On my own I stopped taking the diuretic on weekends and after some improvement erection-wise I stopped it altogether. I still take Zestril 40mg and my blood pressure is down and my erections are up (okay, as good as a sixty-something male could hope for anyway). M 66 4 weeks

ZESTORETIC  (HYDROCHLOROTHIAZIDE; LISINOPRIL):  This medication is used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This product contains two medications: lisinopril and hydrochlorothiazide. Lisinopril is an ACE inhibitor and works by relaxing blood vessels so that blood can flow more easily. Hydrochlorothiazide is a "water pill" (diuretic) that causes you to make more urine, which helps your body get rid of extra salt and water. This product is used when one drug is not controlling your blood pressure. Your doctor may direct you to take the individual medications first, and then switch you to this combination product. Do not continue taking the individual medications (lisinopril and/or hydrochlorothiazide) after you start this medication.   (Sources: U.S. Centers for Medicare Services, FDA)