PARNATE Reviews (TRANYLCYPROMINE SULFATE)Average Rating: 4.1 (143 Ratings)Filter ResultsCompare PARNATE with similar:
Type: Rx Drug
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Results are sorted by Date added. Key to Ratings: 1=LOW (I would not recommend taking this medicine.) |
More on PARNATE: Reviews Summary | Drug Safety Information
| RATING | REASON | SIDE EFFECTS FOR PARNATE | COMMENTS | SEX | AGE | DURATION/ DOSAGE | DATE ADDED |
| 4 | Depression | Dry mouth, some difficulty sleeping. | This isn't the miracle drug for me that it was for others, but it was able to give me a little lift where SSRIs weren't. It's tough not being able to eat cheese, but overall it's worth it. (Can still eat mozzarella and American cheese.) I take 0.5 mg ambien for sleeping but can only take 5x/week to prevent dependence so the weekends can be a little tough for sleeping. | F | 53 | 2 years | 11/19/2008 | 5 | depression/ social anxiety | At first, vertigo (went away), weight loss (Okay by me), sleeplesness | I've tried every antidepressant imaginable, nothing seemed to work. I take 3 tablets a day (10 mgs.) a day. To help with the insomnia, I first tried ambien, which didn't work for me for some reason. My doctor put me on Klonopin 1 or 2 as needed to help with anxiety and sleeplesness (But only at bed time!). I feel that the combination of these two medications is life saver! Also, I've lost 15 lbs. since starting the pills:) I actually want to get out of bed and do things now!:) Highly recommended!! | F | 31 | 3 weeks | 9/24/2008 | 5 | depression | I have been on Parnate (starting at 5mg,10mg,15mg, and now have leveled off) It is the first anti depressant that has worked in fifteen years. I have lost 70 pounds. I do notice a rapid heartbeat, my pulse has increased a bit. Coffee seems to interact after one cup. My doctor would like to switch from Ambien to Klonepin and was addicted to that drug three years ago. He says different anti-depressants work with vs against klonepin. Any comments? I have no cravings for sugar or carbs as I did with the newer anti-depressants. The weight simply came off. I find it a strong, but lifesaving drug. concerned about the pulse and ambien. Still anxiety.. | F | 54 | 150 days | 9/14/2008 | 4 | atypical bipolar depression, PTSD | Insomnia, muddy thinking?, "flatness", memory problems?, initial weight gain, frustration w/dietary restrictions, had to correct nutritional deficiencies due to change in diet from mostly vegetarian. | After 17 years on mostly lithium and Zoloft with no hospitalizations, I suffered some personal losses and consequent severe depression in 2004. For 2 years I tried other meds and had bad doctors, wound up on Parnate for "atypical" reasons. Insomnia was helped by a dx of sleep apnea, and had lots of therapy. I hate the food restrictions but don't know whether it's worth getting off Parnate and going back to an SSRI/SNRI with all the risks involved and possibly losing some of what I've worked so hard to recover. I welcome comments. | F | 42 | 1.5 years | 8/31/2008 | 5 | depression | low blood pressure and sleepiness (these happen sometimes after my final dose wears off- it happens to a lesser degree now that I've been on parnate for a year) | Great antidepressant! IMO should be prescribed much more often. I feel much happier w/this than every ssri I took. It also lessons social anxiety for me. It doesn't (for me) have the awful sexual side effects that ssris had. It hasn't caused any weight gain. | F | 40 | 1 years | 8/30/2008 | 3 | clinical depression | horrible taste in mouth all the time | Started Tranylcypromine (UK name)30mg/daily 2 months ago, still waiting for it to kick in. I agree with the comments about being 'dull'. A friend said I looked sadder than usual. I suppose he meant the same thing. Being very cautious about food, lost loads of weight as a result! Being your own cook/baker does help, you know everything in your shopping basket. Wouldn't describe it in the ecstatic terms some reveiews have used, unless of course, when it does kick in... | M | 44 | | 8/17/2008 | 5 | Depression | Insomnia | Lifesaving drug. Nothing else (tricyclics, SSRIs) has anything like it efficacy. Although it is viewed as 'old fashioned' I think it should be used more. The side effects, though real, are exaggerated and harmless. This is one of those drugs that actually works. | M | 50 | 25 years | 7/23/2008 | 5 | Severe Atypical depression | If I take Parnate after 4pm, I get a strange and agitated sleep. This is helped by taking 1/4 a clonazepam (or of course by not forgetting to take the tablet!). Also, sometimes I get anxiety if I take the tablets (im on 40mg) too close together, or without food. But all of these pale in comparison to the depression I had!! Dry mouth sometimes. | This drug quite literally saved my life. I had been on 13 different antidepressants, in various combinations, for three years. None of them worked, hence my diagnosis of severe atypical treatment resistant depression (whew, what a title!). The "atypical" bit came about because i put on weight (lots of it) rather than lost it, my depression was MUCH worse at night rather than during the day, and I wasnt particularly melancholic. As a last resort I researched drugs myself and read about parnate. THe Dr initially refused to put me on it, but relented after significant pressure from me. Within one week most of my "depression" had gone (though the aftereffects of living with depression for 3 years without remission took a lot longer to overcome), and I was back to normal. I was initially on 20mgs (the max dose in new zealand where i live), and it stopped working after about 3 months. THe dr put me up to 40, and i was fine for 3 years. Then dr asked me to go down | F | 30 | 5 years | 6/9/2008 | 5 | Treatment resistant depression | This drug has had the longest efficacy (2+ years) of anything I've taken. The dietary restrictions are really not so bad--so long as you eat most of your meals at home. Restaurants tend to put cheese in everything! I've had some problems with insomnia and urinary retention, but the relief from depression is worth almost any side-effect. | A couple of points: (1) One very interesting strategy that my doctor has suggested, which has worked four times when Parnate started to "poop out". At his suggestion, I have tapered off very rapidly (3-4 days) gone without the drug for a week, and quickly tapered up to the old dose (60 mg/day. I have never heard of this idea before, but it has worked extremely well for me. (Noting that everyone is different, and one should do this only under MD direction.) (2) At age 63, I wonder if I should be increasing the dose. I've read that dopamine falls off rapidly with age, and I think that in my case the dopamine increase may be a major feature of the drug. I will consult my MD on this. | M | 63 | 2 years | 5/23/2008 | 4 | chronic depression & severe anxiety | dry mouth, headaches (w/o high BP), loss of appetite, heart palpitations, often cold (went way), water retention, agitation (went away) | I was *severely* depressed when I started parnate; after about 3 weeks and a dose of 30mg/day I felt better for about a week... now I feel like I'm "sliding backwards," don't want to get out of bed in the morning, don't want to leave my house, less energy. I'm going up to 40mg, hoping this will help because SSRI's are pretty useless for me. For the week that I did feel better it was a big improvement... so maybe a higher does will do the trick. | F | 30 | 25 days | 5/1/2008 | 5 | Panic Attacks, Anxiety, Depression | I have been taking it for so long I cannot remember but it was the only medicine I took that did not have nasty or long lasting side affects like other medicines. Of course the only thing you have to watch is certain foods, OTC products and if you have surgery. You will be able to determine what you can or cannot eat over time. I would recommend getting a Blood Pressure kit just to be safe. | The only medicine that worked for my symptoms quickly(within a few weeks)and I tried alot of different meds before Parnate. After 25 years of taking this medicine I just had my first panic attack My new doctor said that my body is now just metabolizing the medicine in my body faster and I have to increase my dosage from 5 tabs to 6 tabs and possibly 7 tabs on an very other day basis. I was thinking about switching to a "new" medicine but the Dr. said there is not one better than this. As for all you who have problems trying to sleep at night on Parnate, I would recommend talking to your doctor about Klonopin. I have been taking a .25mg 1/2tab for 25 years and never have had a problem with sleeping. Plus you get the added benefit that Klonopin also helps with Panic and Anxiety. Alot of Doctors will not subscribe Klonopin for use over a long period of time because some people can abuse this drug and get addicted to it. If your not an addictive type person I would recommend | F | 50 | 25 years | 4/28/2008 | 1 | depression anxiety | Insomnia, daytime tiredness | After really hoping this medication would work and getting my hopes up I am really dissatisfied. One thing I notice is a temporary relief for about one three hours after I take the pill. But I don't feel happy, just numb, but my anxiety is less. I feel sort of zombie like on this med. My personality is much duller and my moods are very uneven depending on when I take the pill. | F | 14 days | 4/12/2008 | 5 | depression | I do have a rapid heartbeat when I take it ( 50 mg) which is in the morning. But I take propanalol for that. I have no problems with food restrictions. Just be careful with cold medications with a decongestant, demerol, etc. Even surgery is no problem if you alert anesthesiologist to what you are taking. They know what do do, they've had to treat patients in the ER that were on Parnate. It is the best drug I have had and really the only one that worked for me. My only problem is that it's very very hard to fall asleep without help, like Ambien. But after years, the side effects of Ambien ( vivid nightmares) have made me try all kinds of behavioral changes. | I wish I knew what to do about the sleeplessness problem. The only time I really feel tired is around 4 in the afternoon. I've stopped talking a nap, hoping that would help later on. | F | 65 | 25 years | 2/17/2008 | 5 | Chronic depression. | NONE! | It is the first antidepressant that helped me for any period of time at all. I was tried on many before making a serious suicide attempt in 2004. In the hospital I was put on 60mg of Parnate, plus Seroquel. I now take 70mg. Miraculously, none of the prohibited foods affect me at all--red wine, cheese, all ok, but that is very unusual. (I've now had some serious personal losses and am thinking of taking more--does anyone know about that? | F | 65 | 4 years | 2/14/2008 | 3 | chronic depression | daily drowsiness and lethargy, but insomnia if taken at night, tingling goosebumps feelings, fast hearbeat | I have taken 50mg parnate (generic tranylcypromine) and 50mg lamictal for depression ever since I got out of the psych hospital around 6 months ago. My depression seems to have gotten much better after starting these drugs, but unfortunately it is difficult to tell which drug is responsible for my improvement. The side effects from both of these drugs are quite bothersome. Parnate causes me to be very drowsy and lethargic during the day and I often need to lay down and rest for a few hours, but if I take it at night or in the afternoon, I can't sleep. | M | 20 | 6 months | 1/16/2008 | 4 | treatment-resistent depression | I have already rated parnate but I am now experiencing a new side effect I thought I would share, insomnia. | I was taking seroquel at the time of my last rating and since then it I became to tolerant of it, I them moved on to a few more but nothing works for more then a night or 2. It seems they stimulants in parnate prevent me from sleeping days on end. It is not awful though because I do not feel tired, and as long as its a 'good day' I enjoy the peaceful night (how long it is healthy to go without sleep though I am not sure). My doctor doesn't seem to have any suggestions either. right now i'm taking 30 mg dalmane, it worked well (TOO WELL) for the first 2 days but then I became tolerant. When reading about it I read it was used for extreme insomnia and not to expect it to work for me then a week before tolerance builds up so I guess even the doctor is grasping as straws. | F | 19 | 8 months | 8/7/2007 | 5 | treatment-resistent depression | light headed, fainted very often in the beginning, sensitive to a lot of sun, no appetite for a few days | Started parnate at 30mg (10mg 3x a day) felt better right away for about a week and a half, then back to how i was before. Once I got to about 40mg and had been taking it 2months and added topamax, and seraquel to sleep I felt world better. I have tried almost every anti depressent and this is the first one to have any effect what so ever good or bad. It is amazing I think. Their have been articles stating if other antidepressants don't work you usallly need a rather high dose a parnate (maybe even up to 100mg a day - very high for parnate) depending on your size. I now am at 60mg and probably won't go higher because of size but it aboslutly amazing- i am finally starting to leave the house, slowly beginning to communicate with people again. i suggest parnate! | F | 19 | 120 days | 6/22/2007 | 4 | depression | dry mouth, agitation, decreased appetite, colder than usual, initial insomnia (goes away), craving for sweet foods (does not go away), extreme fatigue in afternoon, constipation. | Works for depression. Not a "happy pill," but it evens out my moods and prevents panic attacks and sporadic weeping. However, tends to dull the personality a bit. | F | 38 | 3 years | 5/21/2007 | 5 | I went into major depression | the key to reducing side effects is to start with a low dose and work up gradually to a therapudic dose. I do not have side effects if I am careful with the dosage, and careful not to eat the foods that I know are my triggers. Msg. is a bad one. | I have taken Parnate for 30 years. I will never forget my initial response to the medication. It was like waking from a bad dream and I said "where have I been" My only quandry is what to do before major surgery. | F | 61 | 30 years | 5/20/2007 | 5 | MAJOR DEPRESSION AND ADHD | SOME HEADACHE IN P.M., RAISED PULSE RATE P.M., BOTH POSSIBLY FOOD RELATED | MY LIFE BEGAN AFTER I STARTED TAKING PARNATE, AFTER 16 YEARS OF TRYING SO MANY MEDS AND COMBINATIONS,AND A PURE TORTURED EXISTENCE,I FINALLY FEEL LIKE A NORMAL PERSON. I AM SO RELIEVED. | F | 45 | 8 months | 4/24/2007 |