PARNATE Reviews (TRANYLCYPROMINE SULFATE)

Average Rating: 4.1 (143 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

PARNATE  (TRANYLCYPROMINE SULFATE):  Tranylcypromine is an antidepressant (monoamine oxidase inhibitor). This medication treats depression by restoring the balance of certain natural substances (neurotransmitters) in the brain. Tranylcypromine can improve your mood and feelings of well-being. Usually, this medication is used in persons who have not responded to treatment with other drugs.   FDA Approval Date: 1985-08-16 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Date added.

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

Page: 1 2 3 4 5 6 7 8


RATING  REASONSIDE EFFECTS FOR PARNATECOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  Severe depression weight gain and loss of libido and unsteady walk. Saved my life and now life is a joy. M 75 7 years
4/24/2007
 5  severe depression and anxiety weight gain, blurred vision in the evening Parnate saved my life 13 years ago. They tried other antidepressants on me and as a last resort gave me Parnate. It was a miracle drug. I got my life back. You just have to be responsible and take it as prescribed. DO NOT listen to anyone who thinks you should be off of it, like massage,healing work, health food experts, EVEN FRIENDS AND FAMILY etc. They have no idea what the world is like for you without parnate. I had a bad accident and was given many pain drugs which caused a chemical inbalance when I was taken off of them. I couldn't cope with anything,was severly depressed and had horrible"jump out of your skin" anxiety. Within three months or less of taking parnate my biggest fear was it would not keep working because I felt like a normal person again. As I said that was 13 years ago. I am still taking parnate 40mg a day. I also did a lot of research on parnate and the one thing that has always stayed in my mind was a statement in one book 'PARNATE ALWAYS WORKS.&qu F 54 13 years
3/30/2007
 5  Depression; over sleep & overeat Dry mouth occasionally, and I believe,heart palpitations. I have experienced increased sexual desire and it works in 24 hours. In all the years that I've been taking it, I've had only 2 episodes because of food. I can have a little white wine or champagne; fresh cheeses; and I drink decaf anyway. For colds, I use the menthol breathe right strips and Vicks Vaporub to keep my head clear.And I stay at home and stay in bed. It's probably a good idea to wear a medic alert bracelet--which I plan to get. I've been taking the drug since 1979, but usually was on it for about 1-2 years and then was off (I had a depression every 7 years). But this time around, I've been on it for about 5 years. My doctor says that I'll probably stay on it because as you get older...you may need it more. I'm on 40 mg a day; my highest dosage was 50 mgs. I didn't even want to try another drug because this one works and works fast. And my psychiatrist still feels that this is the right drug for me. F 59 5 years
3/26/2007
 1  atypical depression I was one of the UNlucky few who experienced the dreaded MAOI hypertensive crisis. I was very careful with the diet. My best guess is that peanut butter was the culprit - excessive peanuts are on the eat with caution list, but not forbidden. I might just be more susceptible than most. The H/C was the worst experience of my life and landed me in the local trauma center. Started with a MAJOR headache (the type where you consider throwing yourself in front of a train to ease the pain). Blood pressure went off the scales. Took two weeks to fully recover. Be forewarned - these MAOI hypertensive crises can and do happen. I was just getting to the maintenance dose when I had the hypertensive crisis. The drug was actually working very well up to that point and I was hopeful that I finally found one that was going to work. If only this could be designed without the tyramine issues!! M 43 3 weeks
1/29/2007
 5  severe depression Always cold, headaches sometimes, eventually stopped working after 20 years. I took this miracle drug for 20 years and was convinced to go off it to try newer antidepressants. It was a nightmare to withdraw from. If you are on it and wish to try other newer meds. DON'T. I've tried them all and am going back to Parnate. If you can manage the food restrictions, it is WORTH IT. Don't mess with a good thing. AND... If you are hesitant to take an MAO... go for it! If nothing else works... you will know what "real life" is like. F 50 20 years
12/28/2006
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 5  clinical (major) depression Insomnia, delay of orgasm. Possibly intolerant/agressive sometimes (but maybe after lifetime as a virtual 'doormat', just flexing muscles). In brief: Parnate has given me a whole new life. My only great fear is that I may one day have to stop taing it, or that it will stop working. This drug, for me, has been like being reborn :) Fears that were crucifying me, I now laugh about. I feel I have become the person I was meant to be. M 55 5 years
4/20/2006
 5  Major depression Dificulty in ejaculating, loss of libido, became a bit aggressive and insensitive, so I'm told. POWER drug. Parnate kicks ass. I've taken them all, and this one is in a different category. I took it for 12 years, and my life went from a sloppy mess to a LOT of fun. Parnate if you're a strong responder, and I was, comes on with an amphetimine like minor "rush," and you feel no fear or self doubt. It takes bedridden disasters and turns them into hitters. Love this shit, but it finally petered out on it. I'm waiting for selegiline to hit the shelves in a month or so. MAOI's rule!! M 57 12 years
3/21/2006
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 4  DEPPRESION I HAVE DEVELOPED SIDE EFFECTS OF MUSCLE TENSION AND DISYNESS IN THE LAST FEW YEARS . I WAS HOPEING TO GET SOME FEEDBACK ON HOW THE NEWER SAFER MEDS WORK . UNFORTUNATLY OLD SYMPTOMS ARE COMING BACK I WILL HAVE TO TRY ANOTHER ONE OR GO BACK TO PARNATE M 50 18 years
2/17/2006
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 5  unipolar major depression At the beginning only --hypotension, dry mouth weight gain, craving for carbohydrates. Ongoing--reduced need for sleep (not insomnia I've been taking this drug for 20 (TWENTY) YEARS and it has always been a lifesaver, in knocking out my symptoms of depression. M 56 20 years
5/9/2005
 5  Sever Non-responsive depression Trouble sleeping at night, food restrictions or else severe migraine with blood pressure shooting up, dizziness & very occasional fainting (learned to stand up slowly and eat regularly). It's not an easy drug to take, at high dose I have to take it 3xday and watch what I eat. But, after trying many other drugs over the years, nothing has helped as much. I am not 100%, but I am much better than I have been for over 20 years. F 37 4 years
5/8/2005
 5  Major depressive disorder loss of libido, sleeplessness, perception difficulties (bump into things with my hips), some difficulty This drug is a miracle and saved my life. For the first time, I feel like a human being after many years of suffering and trying almost all other drugs and ECT. I would probably be dead without Parnate. I take 100 mg. daily. F 51 13 months
5/8/2005
 5  Bi-Polar Type 2 Insomnia, afternoon fatigue, weight gain, altered depth perception, sensitivity to heat, increased libido, leg weakness For the first time in my life i am depression free. I love this med and find the diet is not at all restrictive. Very few things must be strictly avoided F 55 2 years
5/8/2005
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 4  Atypical depression Sleeplessness. Also a profound fear of the Very good med but the (welcome) alertness it give you disappears after a while. Am taking 40mg a day and want to go higher but my doc is very reluctant. M 48 6 months
12/27/2004
 3  atypical depression- Helped lift depression. Severe dizzyness spells..Fell down a few times. Dizzyness pronounced while getting up from bed.. passing out spells Taking fludrocortisone to help dizzyness.. Not sure how its all going to turn out. TRIED ALL SSRI before this one M 37 3 months
12/24/2004
 5  Major Depression Some insomnia at night. Afternoon sleepiness. The only thing that's helped my depression. The dietary restrictions are, in my opinion, trivial, compared to the relief I've gotten. I'm not looking forward to my first cold/flu without the help of OTC drugs, but, again, how does that inconveniance compare with 15 years of horrible depression finally being lifted? F 28 2 months
11/13/2004
 4  Depression loss of libido, sleep disruption, MAOI diet restriction, afternoon fatigure attacks very powerful AD, the libido loss & deep fatigue (lasting ~30 min-1 hr) in the afternoon and/or early evening, on top of the diet restrictions, ultimately led me to go off M 35 2 years
10/26/2004
 3  bipolar depression Have been on it for 15 yrs. and works well for depression. Have developed side effects of muscle tightness and dizzyness in the last few yrs. and have to switch. This drug is difficult to switch off of if need be. As a MAOI it reguires 14 days off before another SSRI or SSNRI can be used. I would use one of the newer drugs. Good luck. M 59 15 years
10/22/2004
 4  panic disorder dry mouth,sleepines,some constipation i have been on very long term but low dose of 20 mg a day. I take at bedtime so sleep through most side effects. No panic attacks on this med. F 43 20 years
8/9/2004
 4  General Anxiety Sleeplessness Alcohol makes you very groggy M 40 45 days
7/10/2004
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 5  Anxiety None. I just had to watch my diet. Was on this for 18 years. Worked like a charm. After this time began to get irritable easily and it was decided to change meds. Currently on remeron, but not having much success. The old symptoms which I haven't experienced in 18 years are coming back. I feel if parnate had been invented after (instead of before) the SSRIs etc, it may have been viewed as an improvement. on them M 43 18 years
4/23/2004

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