SAVELLA Reviews (MILNACIPRAN HYDROCHLORIDE)

Average Rating: 3.0 (158 Ratings)

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 NOREPINEPHRINE REUPTAKE INHIBITORS

 Type: Rx Drug

  

SAVELLA  (MILNACIPRAN HYDROCHLORIDE):  Milnacipran is used to treat pain caused by a condition called fibromyalgia that affects the muscles, tendons, ligaments, and supporting tissues. This medication is a serotonin-norepinephrine reuptake inhibitor (SNRI) that works by helping to restore the balance of certain natural substances in the brain (neurotransmitters).   FDA Approval Date: 2009-01-14 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by length of time drug was taken longest to shortest.

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR SAVELLACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  Fibromyalgia Headaches, nausea, heart pounding, crying spells, agitation, insomnia, sweating. Unfortunately, these side effects were severe enough that I had to stop taking this medication. It was effective for joint pain and stiffness, but the side effects were just too much. F 46 2 months
50mg x 2
7/2/2013
 1  Fibro & CFS Severe memory loss, 3 times I was driving down the road and had no clue where I was, who I was or where I was going. And I had my 6 kids in the van with me. Very Scary! I still have memory problems today. Other problem, tingly scalp, nausea, cramping, hot flashes, increased heart rate and blood pressure. I had really bad mood swings, went off on my children for no reason. I felt jittery, had my 1 and only ever panic attack on this medicine. Helped with my pain a bunch. Normal pain level a 12 on a 1-10 scale. While on meds I would say a 3-4. I felt like I had energy again, but. The side effects were WAY too BAD! F 34 2 months
50 mg 2X day
7/27/2013
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 1  fibromyalgia Extreme headaches, blurry vision, excessive sweating to the point I was soaked during night in bed and during day. Memory gets fuzzy and all I have wanted to do is cry, which is not like me. I also feel like my insides are quivering all the time and when I go to bed I cannot get my body to relax.. I hope that some people did not have these reactions and maybe it will help them, but I cannot keep taking it and feeling this way. F 60 2 months
50mg 2X day
7/14/2016
 1  Fibromyalgia Nausea, vomiting, severe stomach pain, diarrhea, gas, bloating, headaches, anger, irritable, no appetite, weight loss This medication is awful. I started on the sample pack from the doctor's office. My symptoms began the day I took the 50 mg dose. Severe vomiting and diarrhea. My doctor told me to wean off the drug. I took my last dose of 12.5 mg yesterday. I will NEVER take this medicine again. I would rather suffer daily flares then swallow a Savella pill. Dangerous drug! F 43 2 months
25 mg 1X day
4/16/2014
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 3  Fibromyalgia - Severe Aches Extreme nausea, vomitting Switched to Savella from Lyrica due to over 50# weight gain in just 6 mos. & other adverse side effects. Nausea was mild w/ titration pack, but once regular dosage started, it got worse each day, ultimately resulting in vomitting about an hr. after each dose. Before the vomitting, I started to feel some relief from the deep, unrelenting aching & pain from the Fibro. Was so disappointed to have to discontinue it. 38 1.5 months
50 MG 2X day
3/12/2012
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 5  Chronic disabling pain Constipation, insomnia F 44 1 months
25mgs 2x
11/27/2012
 5  Fibro. Heartburn, dry mouth and bit of anxiety. After slowwwllly uping my dose to the full dose, I am having luck for once with a drug that is supposed to help with fibro. Most of the slight side affects are gone. I have barely a need for my ibprofin or Tramadol. I took 50 mg. only once a day for about 10 days, then every other day I took another in the afternoon. I am now taking it as rx'd, 2x's day. I am not hurting! Also lost allot of the brain fog. F 45 1 months
50 mg. 2X day
8/12/2010
 2  Fibromyalgia, depression Started out on the tiration dosage pack of 12.5 to 50 in 3 weeks, the first week was great, the second week great, then the third week hit me and I literally could not get out of bed, I had extreme tiredness and fatique unlike anything I have ever had and I am a very active Mother of four, four grandchildren a gardener, etc. I stopped cold turkey when I read the precautions included calling a Dr. immediately if extreme fatique or tiredness happened. My Dr. was out of town. I need a drug to help me, I have tried sooooo many and need one, I take Tramadol for pain, (I believe it is the best antidepressant out there) and Xanax for anxiety. Good luck on Savella, I had such hopes for it, maybe if I went back to the initial 12.5 twice a day it would help? F 55 1 months
6/9/2009
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 2  RSD/CRPS Tried out Savella for RSD/CRPS (already on Lyrica, Ultram, & a bunch of other stuff). Suffered through the whole trial pack with the severe sweating, red face & neck, shaking, etc. I finally broke down and called the doc when I couldn't handle the anxiety attacks and shaking anymore. (when I called the pharmacy, they told me I should maybe check myself into a rehab!!!) My doc told me to stop immediately and have an appointment next week to discuss other options. Boy, I guess I'm the FDA posterchild for bad side effects!!! F 45 1 months
10/23/2009
 3  For fibromyalgia Severe hot flashes and cold sweats . Also made my stomach very sick . Im trying to wean myself off ..right now. F 56 0 months
50mg 2 dai 2X day
7/10/2020
Email
 5  Fibromyalgia Nausea, perspiration. I started with the titration pack, and the first week was tough on my stomach (felt nautious). I also felt sudden increases in heart rate and was sweating more. After about 3 weeks, the side effects went away, and so did most of the pain. This drug really works if you can stick with it. 42 8 weeks
11/9/2009
 3  chronic daily headache Hot flashes, flushing, heart palpitations, difficulty sleeping, weepy feeling, brain zaps seemed to help my head pain at first, side effects not as bad as other meds I've tried for headache (tricyclics, AEDs). worth a try IMO for those who have "tried everything". F 42 8 weeks
25 mg 2X day
1/26/2011
 3  FibroMyalgia Severe hot flashes that caused such terrible perspiration as to drench my hair and clothes. Itchy painful rashes wherever I perspired; terrible dry mouth; constipation; dizziness to the point of falling over even while sitting down. It worked to eliminate the pain and "fibro fog"; but the side effects were so ghastly as to impair my ability to do my job. Diagnosed with FM 12 yrs. ago, I am now trying to taper off of this and my dr. will try something else. I still feel terrible and am so saddened that it didn't work for me. F 55 8 weeks
100 mg 2X day
11/4/2010
 2  Fibromyalgia anxiety, depression, insomnia, excessive sweating Had no effect on my joint/muscle pain caused by Fibromyalgia, so I stopped after 8 weeks. Just another SNRI that supposedly cure all ailments (depresion! anxiety! panic attacks! pain! fibromyalgia! OCD!.....doctors have no idea what the f&*$ they're prescribing, or how these drugs work. It's reprehensible. F 27 8 weeks
100 mg 2X day
3/24/2011
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 5  Fibromyalgia FIRST WEEK: nausea, headache, nervousness. TAKE IT WITH FOOD - AND TAKE IT EARLY IN THE MORNING AND BY MID-DAY, OR IT WILL KEEP YOU AWAKE AT NIGHT. Give it at least two months for it to fully kick in & work properly. It isn't an instant fix - and it is nothing like Lyrica! Lyrica is poison. Savella gives real hope to fibro sufferers - if taken correctly! Savella works great. But the first week of side effects while titrating are a bit uncomfortable. After that, it's GREAT for energy, pain & brain fog, although it takes a couple months to see dramatic improvement. IGNORE any reviews from people who stopped taking it after the first week, because they most likely did not take it properly and just are not giving it a real chance to work. Savella is not a pain pill; it does not work instantly. Very important to remember: TAKE SAVELLA EARLY AND TAKE IT WITH FOOD; always take it with food. I take it at 5 a.m. & 2 a.m. (for 7 weeks now). If not taken correctly, it'll cause headaches/nausea. Don't give up; just give it at least two months to work. I take my doses halfway through my meals. If you take the second dose too late in the day, it will interfere with sleep. The second dose should be taken before 2 p.m. Unfortunately, doctors also aren't telling patients that because Savella is an SNRI, it SHOULD NOT be taken w/ other antidepressants or it'll make you sick (serotonin syndrome). Take it properly & give it a chance - because Savella helps A LOT for fibro sufferers! Wonderful for pain, energy & fibro fog. F 38 7 weeks
6/16/2009
 4  Fibromyalgia Sweating! Nausea. HBP at 50mg/day. Gum soreness. Initially mood swings and crying, but now feel better about life than in years! Decrease in fatigue. Hair thinning. Leg bruising. Titrated up slowly (only 1 pill a day). Then, 50 mg 1xday for last 3 weeks. Side effects too scary, put down to 25 mg 1xday. Hoping I can maintain this feeling of coping with pain, etc. at this lower dose. Oh yes, appetite control, weight loss bonus! Many of us are sensitive to meds - try a lower dose! M 51 7 weeks
25 mg 1X day
9/11/2010
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 1  Fibromyalgia management Blurry vision, dilated eyes, headaches, dizziness, nausea I was taking 50mg twice a day but reduced to just once a day in hopes side effects would reduce. They have not. I have no reduced to 25mg once a day and I am having withdrawal episodes from lowering my dose. F 21 7 weeks
50
11/25/2016
 5  CFS I'm the 62 year old male who recently posted about Savella. It did wonders for my cfs but adversely affected my heart. To update: The cfs problems returned within 2 days of ending Savella. Now I'm on Norco 5mg, twice a day, one in morning and one in the afternoon. It does a good job of knocking out the pain and fatigue. I know people go nuts when you mention using an opiate because of the addiction potential. They need to back down. I intend to stay on the Norco as long as my m.d. allows. M 62 6 weeks
50mg 2X day
5/11/2012
Email
 5  CFS Savella did wonders for my CFS. It knocked out 90% of my fatigue problems. But I had to get off it. It substantially increased my heart rate. The blood pressure went up, too. My cardiologist wanted me off it. I'm on a pacemaker so I have a danger of other heart problems so there's no need to aggravate my heart. I'm hoping against hope that the CFS doesn't return. Savella is a good drug for CFS. I, unfortunately, had a side effect that wasn't tolerable. M 62 6 weeks
50mg 2X day
5/9/2012
Email
 5  Fibromyalgia A little hyper at first, heart palpations, hot flashes, sweating The side effects seemed heavy the first few days, but disappeared completely after a week. Once in a while I will get a sweat for no reason, but its rare. It took away a lot of my pain, although nothing has ever done anything 100 percent for fibro. Out of all that I have tried, Savella is the best, with the least side effects. I felt more mobile and less pain throughout my body. I am on 50 mg now, but I will ask for an increase to 100 mg, the max per day, because I feel it working real well. Since there are almost no side effects after the first few days, I can tolerate Savella real well. I just hope that 100 mg will not give me side effects. This new drug has potential. Beautiful. F 37 6 weeks
10/20/2009

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