ZYBAN Reviews (BUPROPION HYDROCHLORIDE)

Average Rating: 3.2 (580 Ratings)

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 ANTIDEPRESSANTS SMOKING CESSATION AIDS UNCLASSIFIED

 Type: Brand name discontinued; available as generic

  

ZYBAN  (BUPROPION HYDROCHLORIDE):  This medication is used in combination with a stop-smoking program (e.g., support group, counseling) to help you quit smoking. Bupropion can decrease your nicotine withdrawal symptoms (e.g., irritability, anxiety, restlessness) and your urge to smoke. Quitting smoking decreases your risk of heart and lung disease, as well as cancer. This medication belongs to a class of medications known as antidepressants. It is not known exactly how bupropion works to reduce smoking urges. It may work by restoring the balance of certain natural chemicals (neurotransmitters) in the brain. Discuss the risks and benefits of this medication, as well as other ways to quit smoking (such as nicotine replacement treatment), with your doctor.   FDA Approval Date: 1997-05-14 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Age oldest to youngest.

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR ZYBANCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  My husband took to stop smoking Zyban send my husband into psychosis. In and out for a week then he finally snapped . He stabbed me multiple times in a psychotic rage . Three months later he committed suicide. So please don't put your family through the hell that I went through. M 43 5 months
1X day
2/20/2023
 5  Stop Smoking Poor quality sleep yet constantly dozy. Irritable eyes, flushy. Worth these side effects to stop smoking, effects ceased on course completion M 42 1 months
12/9/2004
Email
 5  smoking cessation For the first 7 days, I felt "wired" and shaky. My speech was disconnected at times. Then on the 8th day, I started the crying. Crying for absolutely no reason! Yesterday on the 10the day, I realized during the uncontrollable crying that I was feeling very depressed. Since I am normally bubbly and perky, this was alarming. Today, I am decreasing my dosage to 1 pill a day. After one week at this dosage, I will discontinue the medicine. For its intended use- in my case- smoking cessation, it worked great!! I have absolutely no cravings for cigarettes. Unfortunately, the side effects are too alarming for me. For anyone considering or already taking this medication, I urge you to have your physician monitor your progress and side effects. Additionally, do not stop this medicine abruptly. Consult your physician and decrease your dosage. Thank you to everyone for posting your experiences- it is nice to know that I am not going crazy- at least not by myself :) F 42 11 days
150 mg 2X day
4/14/2010
Email
 5  Quit smoking Dry mouth, heightend sex drive, slightly "trippy", blured vision if looking at a computer screen too much - but I think that may have to do with withdrawl I started with one 150mg a day for 7 days while still smoking and was wondering what effect this drug was supposed to be having as I didn't feel any different whatsoever and was still smoking a pack of 25 a day. When I stepped up to two a day per instructions I immediately noticed that I wasn't particularly interested in smoking. When I did, it had no real effect and actually gave me a slight nausia. Having tried NRT products which just change the delivery mode for nicotine, Zyban has really worked for me. I have absolutely no desire to smoke, and on the odd occasion when I have been offered one socially, it did absolutely nothing for me, apart from make me feel slightly ill. M 42 30 days
150mg 2X day
2/7/2011
 4  stopping smoking It worked very well. Lost interest in smoking and stopped after a week, hardly any cravings. Noticeable weight loss, not complaining. Quite sleepy, headaches every day, and some very annoying dreams. Didn't complete the course of tablets (went halfway through) since 1. Had effectively stopped smoking, it worked brilliantly for that 2. was starting to feel depressed, possibly from sleep disruption and headaches. It's strong stuff. Much easier than cold turkey though. M 42 15 days
150 2X day
3/1/2012
Email
 4  Stop smoking Light headedness, tightening of the chest, heart palpitations, the fear of having a stroke or heart attack. Also anxiety, sadness and fear. This all happened in the short span of 5 days. Now I have to be perfectly clear I did not follow the prescribed method of the recomended dose. Since I had been on this drug before, I thought it was pretty safe and tame and without any real side effects. So I immediately started taking 2 pills / day. It was extremely stupid and reckless and I strongly believe that the symptoms I experienced this time was a direct result of that. I have been taking Zyban off and on for the last year. I quit smoking 1 year ago with the aid of Zyban. It worked as promised. I would discontinue the use of the drug but if at anytime I felt an overwhelming urge to smoke, I would get right back on it but always under the supervision of my doctor. I began smoking about 3 weeks ago. I began taking Zyban again but immediately started with 2 pills per day. My experiences of the drug in the past were mild. This time is was very awful and I now see how powerful this drug is. I think this drug can help some quit smoking as it did help me but if abused or if you are not the right fit for the drug, it can be very dangerous. M 42 5 days
4/30/2007
 3  to stop smoking Retrograde ejaculation. i had a prostate problem (just swallen a little) and since i took zyban i am having retrograde ejaculations: in other words the muscle which controls the opening of the bladder does not close properly and the sperm goes into the bladder. i looked at the causes of retrograde ejaculation and here they are: 1. Nerve damage caused by medical illness — This is especially common in men with multiple sclerosis or with long-term, poorly controlled diabetes. WHICH I DON'T HAVE 2.Side effects of medication, including some drugs used to treat hypertension (high blood pressure) and some mood-altering drugs. (which i believe ZYban does) Otherwise, the ZYban helped me to get out of the nicotin need, and no other side effects. M 42 2 weeks
8/31/2005
 2  To stop smoking I noticed after the second tablet feeling spaced out and jittery. After about the fourth tablet I noticed becoming more aggresive, at home, at work and whilst driving. I have been taking them for 10 days - one a day only (no way am I taking two a day). I have problems sleeping - wake up every hour. I feel slightly confused and today have started experiencing numbness in my left hand and foot. I smoked my last cigerette on day 6 so have been nicotine free for 4 days. Because of the numbness I shall stop taken them for fear of a stroke. I have not felt like smoking and have not put on any weight. F 42 10 days
3/17/2007
 1  smoking nettle rash everywhere can not swallow food no sore throat and tired all the time M 42 17 days
7/12/2004
 1  Smoking Cessation Psychological disassociation, inability to communicate with others, extreme irritability, disconnection with reality, frequent thoughts of death/suicide/murder, frequent thoughts of harming others by beating them with anything I could find, impulsive thoughts of suicide/murder, hearing voices, feelings of demonic possession, fearful of everything, feeling as though I lost my sanity. Though it may be tough to read and understand my side effects, they are very real. Zyban may work for some, but I firmly believe that more research is needed to make this a safer drug, or to remove it from the market completely. I've read the opinion poll, and I sympathize with those who have had severe reactions, as I believe I've had, to taking Zyban. I was very happy before I began taking Zyban - I was just a guy who wanted to quit smoking. I never dreamed I would be fighting for my sanity by taking a M 42 5 days
5/11/2004
 1  Stop smoking Feel totally "spaced-out" - like my brain is being re-wired! Not safe to drive - concentration a problem. Easily agitated. Panic attacks. Dry mouth. Headache. All this on only 150 mg a day.... Amazed that this drug is still on the market! Does help alleviate withdrawal symptoms but if the short-term experience is this bad, I'd be afraid - very afraid. Stopping tomorrow before my brain becomes completely cooked! F 42 5 days
7/7/2008
 1  to quit smoking DID NOT alter my desire to smoke. Matter of fact I felt obsessed about smoking, more than prior to meds. Severe anxiety, internal tremors, shaking, depersonalization, fear, paranoia, racing thoughts, insomnia, nausea, loss of appetite, feeling completely CRAZY and unstable , crying outbursts, anger and violent. Short term memory loss, severe. Headache, sore throat, got a sinus infection, chills. note: took 1 x 150 mg for 3 days, then upped to 2 x 150 mg per day (not at same time). First day I felt a bit weird, my body started twitching and I could feel my pulse all over my body. I figured it was tolerable. Same symptoms for 3 days while on one pill/day, with added jitters, and some feeling of anxiety but was tolerable. After 3 days still not feeling any change in smoking desire. On day 4 I upped to 2 pills/day (one early, one later) and the anxiety became tenfold. I slept 3 hours in two days. The only way I can describe what came next was " a whole lot of crazy". I felt like I've lost my mind, unsure of everything. Feeling completely like I can't get through the next minute, exasperated. On the last day I took this med (day 6) I took only 1 pill as I thought it might lessen the effects, and it was not any less, I was still crazy crazy crazy. I was terrified like I was trapped in a bad place and could not get out. My whole body was twitching, shaking, headache, nausea. The thoughts would not slow down, just on overdrive for everything. Today being day 7 I am not taking any more of this medication and I feel a little better today but still feel some of the effects. I feel more rational of mind like my real true self. Yesterday I felt like it was someone else in control and it was SOO bad, oh so bad. I had a lot of struggle just getting through every moment of the day yesterday. Still craved cigs whole time. Will try patch next. F 42 6 days
150-/300 2X day
8/5/2011
 1  Stop smoking Doctor prescribed to help me stop smoking. Bt 3rd day was climbing the walls, unable to sleep, docotor gave me sleeping pills and increased zyban dose. That night my husband checked me into hotel as i was scaring our children. Next day I drove to a field and calmly put hose pipe from exhaust into car. A farmer saw me and i drove away. Went home to find rope to hang myself. My husband called ambulance and I was admitted to psychiatric ward. I have four children whom I love dearly and Before I took Zyban never had suicidal thoughts, or depression,panic, aggressiveness insomnia etc. Who would unless depressed which I wasn't? I took Zyban 7 years ago and from time to time I google the name and see the next lot of unsuspecting people the pharmacy company selfishly and knowingly make money from their misery, health and their family. A recent research study listed a well known and trusted journal examined in a randomised control study the effect of zyban on suicide and psychological impac Don't risk it at your peril! F 42 5 days
75mg 2X day
4/25/2010
Email
 5  to stop smoking no side effects after many attempts to stop smoking with other methods, zyban worked for me by reducing the cravings for a cigarette M 41 3 months
6/2/2001
 5  Smoking Cessation Mild changes in behaviour. Mild increase in sweating ***** Most people here complaining about DEPRESSION-like symptoms are generally confusing the nicotine-withdrawal symptom as a Zyban side-effect, which it is NOT!!! Depression is a highly common symptom of NICOTINE WITHDRAWAL. Works well for me, cheap & effective way of ridding myself of a suicidal habit (smoking). M 41 6 months
3/24/2009
 5  Quit smoking Insomnia homicidal suicidal sex crazed weird dreams drymouth Works great M 41 5 weeks
150mg
5/8/2016
Email
 5  to stop smoking Nervousness, getting edgy, trigger happy, insomnia, restlesness, Absolutely brilliant way to stop smoking, did it once an year ago but started smoking again due to personal issues. I would definitely recommend this to anyone willing to stop despite all the side effects. M 41 10 days
12/28/2004
 5  to stop smoking Nervousness, getting edgy, trigger happy, insomnia, restlesness, Absolutely brilliant way to stop smoking, did it once an year ago but started smoking again due to personal issues. I would definitely recommend this to anyone willing to stop despite all the side effects. M 41 10 days
12/28/2004
 5  To stop smoking The first time I had insomnia and dry mouth. Four years later, after starting to smoke again, I now have tightness of the chest, irratibility, depression, no energy-very tired, but no insomnia or mouth dryness like the first time. (My husband says the above is nothing compared to what he is putting up with ;0) I first learned about zyban in the US. I was afraid to take it because I like a drink and you are not allowed to drink with it. Five years ago I moved to the UK and went to the Dr. to discuss zyban once more and was told you can have a drink with it, just not excessive drinking. So, I took it for 2 wks couldn't sleep, was a disaster, so quit taking it but I also quit smoking too! I figured if I hadnt smoked for a week why couldnt I just continue not smoking and thats what I did.......until 4 years later. Last Dec. I started smoking again, only socially. Then it became more and more until I decided to take zyban again. I started taking it quit for a wk then started smoking again. A month later I started taking it again, stopped smoking and things are going good. Do have tightness in the chest, feels like I am stressed,which I am, and want to knock someone upside the head, but it will all be over soon and I will be smoke free again! Good Luck everyone!!! PS In the UK they only suggest yo F 41 24 days
9/14/2006
 4  To stop smoking I was ok when I was only taking one table for the first 10 days but when I started taking 2 a day I suffered from lack of co-ordination, lack of concentration, constipation,an"out-of-it" feeling in my head to the extent I didn't feel it was safe to drive. I went back to taking only 1 tablet a day but by the end of 2 weeks I had "stinging nettle" feelings on the soles of my feet and the palms of my hands and the doctor told me to discontinue with the drug straight away. I wish that I had not had side effects from Zyban because it really is great as far as stopping the craving for nicotine. I still am not smoking (3 weeks later) but have a lot more cravings than on the Zyban. I would recommend this drug if you don't get the side effects! F 41 17 days
8/24/2002

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