ACCUTANE Reviews (ISOTRETINOIN)

Average Rating: 3.3 (746 Ratings)

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 DERMATOLOGICS

 Type: Brand name discontinued; available as generic

  

ACCUTANE  (ISOTRETINOIN):  This medication is used to treat severe cystic acne (also known as nodular acne) that has not responded to other treatment (e.g., benzoyl peroxide or clindamycin applied to the skin or tetracycline or minocycline taken by mouth). It belongs to a class of drugs known as retinoids. It works by decreasing facial oil (sebum) production. High amounts of sebum can lead to severe acne. If left untreated, severe acne may cause permanent scarring.   FDA Approval Date: 1982-05-07 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Gender with females listed first (reviews with no gender reported listed before females).

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on ACCUTANE: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR ACCUTANECOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  severe cystic acne reddness all over...my lips peeled off by the layers...night blindness it was misery!!!several people i knew including my brother that needed help refused to take it after they saw what it did to me.. the 1st time i took acutane i was 14 years old an it was still experimental and i took it a second time about 3 years later when i was about 17...im now 37..and have had no relief...i continue to suffer F 37 2 times
8/4/2006
 1  Acne It caused anger problems. I got more violent and moody than ever. I never had a mood problem before taking acutane. It has been over a year and that problem has still not worn off. I would rather have felt with the acne than have anger problems for the rest of my life F 17 6 months
30
6/10/2012
Email
 1  Mild Acne Severe hair loss, Severe tight dry crepey skin, recurrance of acne after 12 months, severe depression from physical side effects, muscle wasting in face & upper body, MADE ME UGLY. Premature aging of skin, DO NOT TAKE THIS DRUG!!!!Roaccutane has runied my life. 3 mnths after stopping 10 mnth tx, hair began shedding like crazy and continues 18 mnths later I have about 25% of my hair left ( was long thick and healthy before accutane), my skin has become like a kabuki mask - tight and severley dry and Ive aged about 20 years in 18 months. SUICIDAL does not even begin to describe how depressed I feel. severe dry mouth, yellowing of askin on face, eye brow & lash loss - VERY patchy and not looking like they will grow back either. ROCHE, I hope you all burn n hell for eternity. My life has been robbed from me and I had a great one before this medication F 31 10 months
60mg/40 1X day
9/12/2012
Email
 1  Light acne I had some acne, not lots, but acne that wouldn't go away. I was prescribed this drug by doctors (outside the US) who are incented to prescribe it because there is probably a majority rate of success, and in their perspective the benefits outweighed the risk. I started getting depressed but not realizing it was from the accutane which is not as highly monitored overseas. I started trying to figure out ways to committ suicide as everything irritated me. I began to hallucinate that there was a man inside my apartment and needed to stay with friends. I began having severe memory loss where it disrupted my daily activities. For instance, I'd leave the house, forget where I was going and have to go back home but I'd realize I'd forgotten my keys and locked myself out and couldn't remember phone numbers etc. I'd forget whether I'd already taken my accutane that day so I'd have to write it on post it notes ie date and dosage. I'm sure I'd taken multiple doses on days I'd forgotten to write it down. My brain felt like Swiss cheese. I couldn't remember names of people. I eventually did commit suicide and woke up in the hospital. This is in addition to severe weight loss ie my shoe size went from an 8.5 to a 6 and I had dry chapped lips and still do to this day. I lost years of my life from this drug since even after stopping it, my memory didn't immediately return. There are still times I wonder what happened when I went out with friends or on a date- I imagine it must be like getting F 22 1 years
30 mg
1/20/2012
Email
 1  acne dry everything!! it worked alright but now a few yrs later (16-20yrs old) i have constant intestinal pain and fluctuating constipation and diarhea. i was and am a very healthy girl...i jus have VERY painful insides!! i understand the desire for beauty but....try something else!!!! not worth the pain im in now!!!! wish i could save everyone from this!! :'( F 20 6 months
30 ? 2X day
4/2/2011
 1  bad acne cleared up skin,but bad side effects that started 6 years after taking it. I took this 14 years ago, it worked.But 6 to 7 years after taking it I have had bad side effects from it and are still having them.Including, hair loss,back pain,arthritis in hands,bad blurred vision,finger nail problems and very tired all the time.This is not worth taking.You get the side effects much later.Doctor says my problems are from this drug. F 45 5 months
2X day
1/18/2011
 1  Acne Permanent side effects that I still have 10 years after the drug: total loss of sexual sensation, vaginal numbness, painful intercourse, loss of libido, low mood, anxiety, joint pain, food intolerance, cognitive problems, lack of energy, lethargy, tender spleen off and on, floaters, horrible night vision. I would give, LITERALLY, an arm and a leg to get my health back to where it was before I took Accutane. It sure cleared up my acne permanently. So if you want to risk it, you'd be insane. F 36 6 months
20 md 1X day
10/24/2011
 1  Acne treatment I had a baby 1 week ago born with Sirenomelia an extremely rare congenital disease occurring only 1 in 100 000 births. After researching the condition in some detail the only possible cause and common factor that recurs in my research is Roaccutane usage. I used Roaccutane 20 years ago. My pharmaceutical knowledge tells me that It is physically impossible for drug traces to remain inside the body for such a lengthy And extended period of time as all traces are considered expelled within 6 months. The area too coincidental is Roaccutane. This is implicated with birth defects in Sirenomelia as well as the anotia which does not present in any of the other sirenomelia cases I have read. I had an approximate 6 month treatment of roaccutane approximately 20 years ago. This might seem a total improbability I know and I might be clutching at straws. I am a pharmacist who has studied further in the area of natural health during the last few years. During my natural health stud F 38 6 months
3X day
2/8/2010
Email
 1  Moderate Acne Life long dry lips (Extreme during treatment, never back to normal over 10 years later), Dry skin (face and hands), joint pain (over the years it gets worse and worse.. Knees click and have pain, wrists and elbows are easily fatigued (Can't handle doing a gentle yoga class). Thinning hair (might be genetic, many of the women in my family suffer from this condition) Over all, my acne never went away completely.. just during treatment. But, I am left with a life-long pain of the joints. I feel like a woman in her 70's or 80's sometimes..not normal. I used to be active and athletic. I have an abundance of energy and am a slender woman, weighing 130 lbs at a height of 5'9. I should be completely healthy. I have now been diagnosed with chondromalaycia patella, a degenerative condition of the lubrication tissue just under the knee joint. This tissue is regulated by oils. Accutane shuts off your oil glands. Correlation: absolutely no coincidence! I am so upset to be reading these posts. There is obviously a link. I took this medicine at the ages of 19 and later again at 21, because it didn't work the first round. They up'd my dose the second time around, and my acne was still never cured. I still suffer from acne at the age of 31. F 31 6 months
10 MG 1X day
3/13/2010
Email
 1  Adult-onset acne IRREVERSIBLE, SEVERE JOINT/BACK PAIN, THIN HAIR, VISUAL CHANGES I am absolutely amazed at the people on here who are basically calling the ones with permanent side-effects from Accutane liars!! You have no idea! I was a 5'8", 135 pound, healthy, non-smoking, active person when I took this HORRIBLE drug. Just because everyone doesn't experience the debilitating side effects doesn't make them untrue for others. I am a nurse, and there's NO doubt in my mind Accutane caused every one of my symptoms. A study has been done that confirms this drug causes cell death all over the body. It's the same drug as chemotherapy! That's why the body ages so quickly, thin hair, vision deficits, aging joints,etc. http://www.topix.com/forum/drug/accutane/T9QJ8DO1TLI41VBPN It's hard to go from doing EVERYTHING to near disability! How can you sit in judgement of us when you have no idea the pain we suffer. We can't all be crazy; just read how many of us have the same symptoms, and they all started after taking Accutane. F 39 2 months
? 1X day
3/26/2010
Email
 1  ADULT ACNE WHEN TAKING ACCUTANE I ALMOST IMMEDIATELY EXPERIENCED HIGH BLOOD PRESSURE AND JOINT PAIN. NEVER HAD THESE PROBLEMS BEFORE. YEARS LATER THE DR WAS UNABLE TO GET AN ACCURATE EYE EXAM ON ME. MY EYE SIGHT HAD CHANGED SO MUCH AND ALSO DIASGNOSED WITH THINNING OF THE CORNEA WHICH LED TO EYE SURGERY. I STILL CANNOT BE IN THE SUNLIGHT OR EVEN DRIVE WITHOUT SUNGLASSES. MY EYES ARE VERY SENSITIVE TO LIGHT. I NOW, WHICH IS THE MOST SERIOUS HAS BEEN DIAGNOSED WITH A KIDNEY DISEASE. I FEEL THAT ACCUTANE ELEVATES AND PRODUCES DISEASES. MY SKIN WAS LEFT VERY THIN, LARGE PORES AND LOOSE SKIN. STILL HAVE ACNE FLARE UPS. I WORK IN THE MEDICAL FIELD AND JUST HATE SO BAD WHEN I SEE A TEEN OR ANYONE COME IN BECAUSE THE ARE GETTING READY TO START TAKING ACCUTANE..... I ALSO HAD PROBLEMS WITH HAIR THINNING. PATIENT IN SOUTH CAROLINA F 52 9 months
50MG 1X day
6/21/2010
 1  Acne I suffered dry skins and lips and hair loss. My skin aged rapidly which my dermatologist denied could happen. I then began to experience disabling fatigue, memory loss and loss of train of thought which have now been present nearly 2 years after stopping the drug. I want my life back. My skin still has break outs but not as bad, was it worth - NO. This drug should be BANNED. F 35 3 months
1X day
6/24/2010
 1  Persistant mild acne Back and joint pains, muscle pains, persistent eye infections, cracks in corner of mouth, very dry skin, hair thinning, rash on arms and face, bloody sore nose. Please think twice before taking this horrendous drug. The only side effects I was told about was dry skin and 4 months later I have daily joint and back pain. After 2 months after coming off of this drug I started to notice my hair shedding and it has since continued. I was a very healthy and active before taking accutane and now I'm very worried for my future. The constant worry and stress has started to make me very depressed. The doctors prescribing this awful drug just don't seem to know enough about it. I should never have been prescribed it for mild acne and certainly not on 40mg a day. Taking this drug was the worst decision of my life. F 31 2.5 months
40MG 1X day
8/12/2010
 1  acne cystic PERMANENT BACK/JOINT PAIN! DEBILITATING MED! I took Accutane in 2001, and I haven't been the same since. I was a healthy nurse working full-time, taking care of 2 small children, and kept an immaculate house. THEN, ACCUTANE RUINED MY LIFE! I haven't been able to nurse full-time or work full-time for that matter. I can no longer walk long distances b/c the back and joint pain is so SEVERE. I've been taking arthritis and pain meds for years now. Every time I try to come off, the pain is absolutely unbearable. I manage if I take my meds and be as active as the pain will allow. I also have a bladder disease, poor eyesight and thinning hair. This med is like chemo; it ages your entire body. My skin looks 10 years older than I am, and I still have acne! If you've taken it and have the same permanent symptoms, I feel so bad for you. You may email me, if you'd like. BEWARE,IT'S NOT WORTH IT! F 39
? 1X day
8/12/2010
Email
 1  acne DRY SKIN AND LIPS I FELT THIS MEDICINE WAS DESTROYING ME INSIDE AND OUT IM THIRSTY 24-7 and I GET HEADACHES IN SECONDS MY SKIN IS DRY HORRIBLE TERRIBLE DEATHLY DRUG WOULD NOT SUGGEST THIS DISGUSTING DRUG TO ANYONE!!!!!!!!!!! COMMON ON NOW its MANDATORY to be on birth control and look at all THE LEGAL PAPER WORK YOU HAVE TO SIGN TO EVEN BE ON THE DRUG! look how hard it is to even PICK UP YOUR PRESCIPTION!!! F 22 7 months
30 1X day
7/13/2010
 1  severe acne/cystic acne I stopped taking accutane about a year ago. I haven't grown since I've taken it. I have stomach aches every day. I've had a colonosopy, an MRI, and an endoscopy. The doctors still don't know what's happened to my digestive system. When I go to the bathroom, my stools are loose and basically resemble half-digested food in weird shades of nasty yellow and green. I feel tired even if I sleep for hours and hours straight. It hurts to work out. It's hard to see when I try to drive at night. I have problems focusing on school. I went from making A's to making D's. I have scars from minor injuries and bug bites that wouldn't heal while I was on accutane. My speech slurs. My head hurts. My hair still falls out and it's thin and dry. I have joint and muscle pains. I exercise, sleep, and have a well-rounded diet, I take probiotics, but I still have stomach problems. Don't compromise your health for a clear face. It's not worth it. F 16 6 months
40 1X day
12/12/2010
 1  acne Accutane has more long term side effects that go along with the depression and anger. My brother was on accutane when he was between 16 and 19. He became a very angry person. He was irritable and had thoughts of suicide. He is now 40 years old and his depression, irritability and anger have not gone away. I would love to have my brother back, but the drug has ruined him forever. who in their right mind would want that for their child? A few years of bad acne or lifetime of anger, depression and irritability? F 35 3 years
30mg 1X day
11/14/2010
 1  adult acne 18 years on, early menopause, depression, osteo arthritis including huge spurs growing and snapping off having operations so I can bend my knees. I have had hair loss continually, but now i have balding thining patches at the side of my hair which causes anxoiusness, chronic gastric problems, I am a non smoker, non drinker, extrem fit ....my liver has NEVER recovered, and so bad that drs are amazed and think I'm an alcoholic! Yes its annoying all the drying skin blood tests, blah blah blah but that aint NOTHIN compared with the annoyance and stuff you are going to be dealing with for the rest of your life after using this drug.....believe me, pimples will be and would be welcomed in my life now in place of what i HAVE now ! F 50 6 months
cant rembr 1X day
10/5/2010
Email
 1  Severe Acne on face, back and chest Ulcerative Colitis resulting in the removal of my small intestine after years of suffering from pain and incontinence. High Blood Pressure, hair thinning, on meds for irritability, liver problems, eczema... Most of these symptoms occurred 4+ years after taking Accutane. I noticed that most of the people who rated this drug as a 5 have just finished it or are still taking it and those who have rated it as a 1 took it years ago. Seems to me that the worst side effects take some time to develop. All those who gave Accutane a high rating should be asked again 5 years from now. DO NOT TAKE THIS DRUG! It is not a coincidence that so many people are suffering the same health issues after taking Accutane, it's not worth the risk. I was very healthy and active before taking Accutane. I feel like I lost 7 years of my life and I will never be completely healthy again. F 44 6 months
? 1X day
11/2/2010
 1  Persistent Cystic Acne Fatigue, mood swings, back ache, joint pain, headache, stomach cramps, naseau, depression, permanent hair loss NO ONE SHOULD EVER TAKE ACCUTANE!!! THE CONS OUTWAY THE PROS BY FAR! MY ACNE IS NOW RETURNING AFTER ONE YEAR. MY ONCE BEAUTIFUL THICK BROWN HAIR HAS NOW TURNED INTO THIN FRIZZY WISPS OF HAIR. THIS DRUG KILLS HEALTHY CELLS AND CAUSES LONG TERM PERMANENT DAMAGE. STAY AWAY!!! F 17 6 days
3/13/2007

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