DEPO-MEDROL Reviews (METHYLPREDNISOLONE ACETATE)

Average Rating: 1.9 (144 Ratings)

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 ADRENAL CORTICOSTEROIDS

 Type: Rx Drug

  

DEPO-MEDROL  (METHYLPREDNISOLONE ACETATE):  Methylprednisolone is used to treat pain and swelling that occurs with arthritis and other joint disorders. This medication may also be used to treat various conditions such as blood disorders, severe allergic reactions, certain cancers, eye conditions, skin/intestinal/kidney/lung diseases, and immune system disorders. It decreases your immune system's response to these conditions and reduces symptoms such as swelling, pain, and allergic-type reactions. Talk to your doctor about the risks and benefits of methylprednisolone, especially if it is to be injected near your spine (epidural). Rare but serious side effects may occur with epidural use. Methylprednisolone is a corticosteroid hormone. Methylprednisolone may also be used with other medications in hormone disorders.    (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on DEPO-MEDROL: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR DEPO-MEDROLCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  arthritis pain in feet loss of muscle mass,sevier mood swings, sevier leg and hip pain, tendon rupture My dr. gave me this crap to releive foot pain. When I complained about leg and hip pain he up-ed my dosage and kept giving it to me. It wasnt until the tendon rupture that I started puttin 2 and 2 together. I have stopped taking the Depo 3 months ago but the hip pain is still very intense and I am having to take oxycodone several times a day to releive the pain. M 49 1 years
40mg 1X M
11/1/2010
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 1  shoulder pain I was given a shot of this in my shoulder. Within 2 days i developed severe anxiety, heart palps,cramps in both legs,both arms,extreme next and upper back pain,eye twitching,ears ringing,chin and left face twitching,burning mouth and tounge,lips,weight loss, blue toes...For eight months these symptoms went on. It is now a year and my mouth still burns and face still feels odd. Countless doctors,spinal tap yielded nothing. No doctor but my dentist will admit it was the depo medrol. Very active woman who is an endurance horse rider and runner. Life was nearly shattered because of this drug! F 48 1 days
80mg
8/26/2013
Email
 1  facet joints injected neck pain I have experienced loss of appetite,nausea,boils, increased neck pain but worst of all severe depression and severe anxiety. Began three days after injection and continues 5 weeks later. Am now on antidepressant and anti anxiety medication. Also have had several nightmares and just felt very sick both emotionally and physically. I would never let anyone give me this drug again. I am very sensitive to medication and hypothyroid which may have made it worse for me. Had 60 injected into facet joints 5 weeks ago F 48
12/30/2007
 2  Dr. assumed nerve block Made me sweating, stomachache, vision worsen, more pressure, both eyes burn. And big deep pain between my shoulder blades. I will tell Dr. Next meeting for no more injection for me, it was worsen after shot. F 47 2 weeks
20 mg 1X M
9/29/2020
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 1  psoriatic arthritis Extreme anxiety, depressed- never been depressed in my life, dizziness, short of breath with light exertion, nausea, no appetite, numbness in face, diarrhea, nervousness, left shoulder pain. Never again, it has been two weeks since my injection, two weeks i will NEVER get back and i still do not feel myself. F 47 1 days
80mg 1X day
2/21/2020
Email
 4  Rheumatoid Arthritis A single Depo-Medrol injection was prescribed by my rheumy one week ago as a "bridge" to manage pain from RA until the Methotrexate and Enbrel take affect. Took 2 days to feel any benefit from the injection, but it has helped immeasurably. At day six I experienced an anxiety attack in the middle of the night with perceived difficulty breathing. I experienced this same side effect 4 years ago while taking the pill form for several weeks due to a neck injury, so I was prepared for it. If not for the anxiety attacks, I would be very satisfied with this medication. Depending on any returning pain levels as this injection wears off, I may submit to another one to continue to hold me over until the other meds kick in. Also, found the injection to have much more efficacy over the pill form. Good luck to you who are reading this and I hope this review helps you. As a footnote, I want to also mention that I am not normally prone to anxiety attacks and have only experienced them while taking Prednisone. F 46 1 days
80 mg
7/4/2012
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 2  dermatomyositis Numbness, moody, metal taste in mouth, can't sleep. ringing in ear first treatment doctor give, yet the side effects are not worth it. It doesn't cure anything just gives the insurance more time to not approve better treatments. At the end of day I am still sick. F 46 1 days
80 1X day
4/30/2010
 1  Epidural injection in lower back 1 WEEK AFTER INJECTION AND ALL WITHIN 2 MONTHS: anxiety, depression, neuropathy in hands and feet, sensitive skin, dry eyes and mouth, irregual periods, 50% hair loss with thinning, follicutitis, inflammation of eye lids, chronic fatigue, muscle/tendon pain, numbness in hands and arms when sleeping (already had the carpal surgery prior to injection and was fine), burning in feet and hands, skin changes, insomnia DO NOT TAKE THIS DRUG THE SIDE EFFECTS ARE PERMANENT. I was completely healthy before this injection except for a bulging disc. 1 week later they symptoms started and were full blown within 2 months. F 46 1 days
8/27/2008
 1  thoracic disc herniation Extremely high blood pressure. Racing heart. Faint. Made me insane. Loss of appetite. Motion sickness. Depression. Could not sleep. Skin crawly. Numb limbs. Extreme endocrine illness symptoms. Ear pressure. Eye pressure. Could not form sentences. could not think right. many many more awful symptoms for 4 months then alleviated a little at a time. I thought i was going to die. Never ever again for any reason! !!!!! F 46 1 days
160 mg
4/1/2017
 1  Rheumatoid Arthritis It made me feel strange, confused, crazy. One shot made my head and stomach hurt for three days and made it feel like every bone and joint in my body ache enough to the point...I almost went to the ER. I've been going to my Rheumatologist for over a year now and I hurt so bad and feel so bad from this shot, I will NEVER go back to her again. The site of injection had lumps and was so painful, my arm felt like it weighed 50 lbs for 3 or 4 straight days. I'm trying to figure out if this was some sort of allergic reaction?? Horrible experience! Would not recommend this drug! F 46 1 days
30
8/25/2016
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 1  RA, shoulder pain Joint pain, shoulders felt amazing however left me to feel like I am going through severe PMS, caffeine overload, heart racing and menopause all at once. I am only 9 days in so I am unsure how long this will last for. I will never do this again. F 44 1 days
6/1/2018
 1  Allergy-Poison OAK I got the shot in my hip. The next day my back started hurting. It's been three days now, I still have my Allergy and my back feels as though its being crushed. I am in so much pain! Almost constant muscle spasms in the mid section by spine and rib area. F 44 1 days
40 MG 1X day
12/10/2012
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 1  supposed trigger point in back Update from 7.5.12, 7.10.12, 7.18.12 postings: side effects of pain in extremities persist as well as extreme fatigue and muscle weakness. Also, the injection had no therapeutic effect whatsoever. It seems there is a common, scenario - what I experienced along with many others - that makes me wonder about the competence of doctors who administer these injections: doctors not informing patients in advance about possible long-term, serious side effects; doctors being far too cavalier in administering these injections; doctors denying side effects patients experience (some patients are told that they have "anxiety issues" or it's all in their heads! - read reviews elsewhere, the level of medical incompetence is truly amazing); and doctors being completely uneducated about side effects. PLEASE, everyone who has experienced serious adverse reactions to corticosteroid injections, file a report with the FDA: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053074.htm or call the FDA at 1-800-FDA-1088 to report by telephone. I had trouble filing online and sent a hardcopy to the FDA (which was acknowledged by letter from the FDA). Lawsuits are very difficult to bring, and the only way to force responsible administration of these potent drugs is for EVERYONE who has suffered serious side effects to report to the FDA. Corticosteroid use (abuse) is now booming business for doctors and drug companies, and it seems that the administration of these drugs has become unbelievably irresponsible. MANY people are suffering from the cavalier administration of corticosteroid injections and you can help put an end to the irresponsible administration of these medications by reporting your experience to the FDA. F 44 1 days
20 mg 1X day
9/29/2012
 1  supposed trigger point in back menstrual irregularities; red face and chest; extreme insomnia; pain/tingling/numbness/weakness in extremities - arms, hands, legs, feet. Just one trigger point injection of 20 mg. depo-medrol 3 1/2 months ago resulted in numerous side effects. The menstrual irregularities, red face and chest and extreme insomnia have subsided, but the pain in arms, hands, legs and feet persists and isn't letting up at all. I was told by my doctor that this was merely a "pediatric" dose and harmless. Well, not for me and it may well not be a small dose for the purposes of one trigger point injection. Corticosteroids are very potent drugs and in my experience with both depo-medrol and kenalog (also horrible side effects) doctors tend to be incredibly cavalier in administering these meds and have a collective blind spot when it comes to side effects. F 44 1 days
20 mg 1X day
7/5/2012
 1  osteoarthritis in hip Increased muscle pain at injection, uncontrollable sweating, anxiety, depression and dizziness. I will never take this again - did not help much with pain and side effects are worse than before I had injection. F 44 1 times
80mg 1X O
9/28/2012
Email
 1  supposed trigger point Update from 7.5.12: all side effects persist. Found out proper dosage for depo-medrol. In addition to being in the package insert material it's posted in the July 15, 2002 issue of the American Family Physician Journal (article title "Joint and Soft Tissue Injection"): 2 to 10 mg for soft tissue and small joints. So, the 20 mg I received for one trigger point (soft tissue injection) is excessive. I was told by the doctor who injected this that I was receiving a "tiny amount" of depo-medrol, and when I later complained about side effects, I was told that the dose was a "pediatric" amount. Btw, I'm under 100 lbs. and along with horrible nerve related side-effects, lost weight because of this injection. F 44 1 days
20 mg 1X day
7/10/2012
 2  shouler pain torn labrum Had injections twice within a 4 month peroid. Servere cramping of all muscles. orthapedic doctor who did injections NEVER informed me of SIDE EFFECTS or AFTER CARE let alone what he was injecting! I think these injections are used very recklessly and are doing far more damage than good. After second injection ring finger has gone totally numb. Also pain in kidneys. M 43 1 days
injection
2/12/2014
 1  Allergic reaction to Benadryl When I got the injection in my arm my whole body went numb then fever,rash,hot,turned red, folliculitis,stomach aches, horrible dreams, depression,thought I was gonna die... That was eight months ago and I’m still not right been to six other doctors.. my potassium and testosterone very low and my immune system is very weak now!! Still having dizzy spells& muscle aches. I can’t believe there given people this mess. I was very strong and healthy before this shot now I’m going down.... this not right at all! M 43 1 days
80mg
7/27/2018
 1  Low back pain Leg cramps leg muscle weakness can’t bear weight on leg. I think it’s a horrible drug for anyone to take. F 43 1 days
11/18/2019
Email
 4  Severe asthma I have severe asthma and take 2 inhalers, 2 pills and a nebulizer on a daily basis to breathe. I get an 80mg shot of Depomedrol once every 30 days without the shot I end up in the ER because I can't breathe. Yes I have gained weight and get itchy at the injection site but I will take that any day over not being able to breathe. My Asthma is so severe, without the shot I feel like I have an elephant on my chest and then a panic attack because I feel I will die The shot relieves all of that for about 30 days. They need to work on the weight gain issues because breathing and fat don't go well together F 42 3 years
80mg month
1/21/2015

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