Average Rating: 3.6 (30 Ratings)

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 Type: Rx Drug

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on DESIPRAMINE HCL: Reviews Summary  |  Drug Safety Information

 5  Depression and anxiety Dry mouth, constipation, and weight gain. Helped relieve my anxiety and allows me to function at a higher level of happiness in my life. When I try to wean off, I get very sad and depressed. F 49 22 years
100 mg 1X D
 4  Ptsd Constipation Helps me sleep, stopped thoughts, better adhd F 50 4 months
25 1X D
 4  Ptsd None Helps me sleep feel way better!!!!! F 50 0 days
5 1X D
 3  Anxiety This med took away my anxiety quickly in the first week. It helped my IBS. My side effects are typical - headache, loss of appetite (which for is a good thing), sexual. Now after 2 months, my appetite seems to have returned, and the sexual stuff is still there. It sort of seems as if I have to keep taking more. M 51 2 months
30 1X D
 5  Ibs-d and anxiety Best for my IBS-D. Never sure when to take it though. I've tried 3 different ones, this one works for my IBS-D the best! I feel normal now, no anxiety about going all the time, I've had this probably all my life. As I've gotten older it become more troublesome. Also takes a edge off things that piss me off..which are many lately. M 60 60 days
 5  Unable to sleep nightmares anxiety Blue face and hands. I have to go off it now. Its very noticeable as it reacts to sunlight exposure rare ad it is, it has happened to me. I've tried coming off a few times but nothing else works like it does for me.. F 59 10 years
300mg qhs
 5  Migraines Dry mouth and nightmares (but not too disturbing) Started at a very low dose and gradually increased to 100mg by the end of 4 months. It has significantly reduced the frequency and severity of my daughter's migraines. She had previously tried topiramate and propranolol with horrible side effects. She tolerates the Desipramine very well and it works wonders. Much easier to tolerate than protriptyline, which she also tried. F 14 5 months
 2  nerve pain in pelvic area Slightly having issues with sleeping. Increasingly painful orgasms. The longer I am on this drug, the worse the pain gets each orgasm. M 29 30 days
25 1X D
 2  Fibromyalgia pain Only took two days. Could not sleep, dry mouth and nausea. F 75 2 days
 1  Depression Panic Disorder Practically no side effects at all, just some mild tiredness at bedtime dose This was like taking a placebo--nothing happened at all even as I increased the dose. Seems to affect norepinephrine more than serotonin. I read it may be better for people withdrawing from stimulants like cocaine. M 50 40 days
50 3X D
 5  Chronic Fatigue Syndrome M 57 21 years
97 MG 1X D
 1  Major Depression with anhedonia Dry mouth, difficulty urinating, somewhat decreased sex drive/anorgasmia, constipation, heptatoxicity. I took this medicine because of my anhedonic depression (apathy, lack of drive, inability to feel pleasure, feeling "empty," etc.). It felt like a sugar pill other than the side effects, which I guess alerted me that the medicine was at least in my body. It wasn't good on my liver so I had to stop. M 20 3 weeks
100mg 2X D
 5  Depression & anxiety Serious constipation, dry mouth, trouble sleeping, weight gain F 40 2 years
 2  dysthymia, bulimia trouble falling asleep and staying asleep, binge eating/compulsive over-eating, weight gain This medication brought back my bulimia, which was in remission for over a year. It caused me to have very strong urges to binge eat daily after being on it for a few weeks that I could not fight despite using all my therapeutic tools I could think of. Additionally, I had previously been able to cope with episodes of overeating without purging since my recovery from my eating disorder, though not while on this medication. It seemed to increase my impulsivity in that way, which is counter to almost evertying else I've read about this medication. Also, it didnt' do much for my depressive symptoms (if anything it made it worse because of how out of control I felt with the return of the bingeing and purging and fear of weight gain). F 23 60 days
100mg 2X D
 5  Depression Dry mouth, constipation, lightheadness when I stand up suddenly, itching, sleep disturbances. I was put on this medication as one of my last resorts after trying nearly every other anti-depressant on the market and having to discontinue them because I couldn't tolerate the side effects. This medication has been wonderful. I feel less depressed than I have in a decade and the most of the side effects either went away completely or were greatly reduced after a couple of weeks on the medicine. My dosage was very slowly increased from 25mg to 75mg and now I feel great. Hooray!! F 42 2 months
75mg 1X D
 2  Depression Gained 30 pounds, difficulty urinating, dry mouth, forgetfulness, stammering, constipation, craving for sweets This med gave me very little benefit and a LOT of crummy side effects. I hope everybody else has a better experience with it! F 45 6 months
 3  depression weight gain, occasional constipation It was recommended in a trial of R-EEG to find what meds should work best for me. It worked ok for a while at a high dose of 250 mg and now I'm at 350 mg and it's quit working. worked ok for about 6 months but I've been through over 10 anti-depressants and nothing's worked for long. I've gained 20 pounds since starting to take it. F 61 10 months
 2  depression acid reflux in the morning, change in sleep cycle (couldn't stay asleep as long, felt too cold or too hot, some minor nausea I started on the lowest possible dose of 10mg at night. On the second day I couldn't stay asleep more than 4 hours. After that I started taking it in the morning. My sleep pattern was still altered. Also, immediately after I woke up I would have the worst acid reflux. I gave up after 7 days. I know its not enough time to judge a drug but my tolerance for these kind of side effects is really low. M 55 7 days
 1  Panic disorder Extreme worsening of panic attacks: more frequent and more intense. Do not recommend taking this for panic attacks or anxiety. F 22 10 days
 4  depression/anxiety dry mouth, heart palpitations, increased sweating. -no weight gain Desipramine was the 1st anti-depressant that I took. It worked well for me. I went on it very slowly....probably taking about 6 months to get to my daily dose of 200mg (taking 100mg 2xday). I was so glad to be feeling "happy" that I did not care about the side effects. After going off it, however, when I became pregnant...then going back on, it seemed to lose its effectiveness. I had to switch to a new med and am still trying to find one that I can live with and that works well. F 39 7 years

DESIPRAMINE HCL  (DESIPRAMINE HYDROCHLORIDE):  Desipramine is used to treat depression. This medication may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living. This medication belongs to a class of medications called tricyclic antidepressants. It works by restoring the balance of a certain natural substance (norepinephrine) in the brain.   (Sources: U.S. Centers for Medicare Services, FDA)