METHOTREXATE Reviews (METHOTREXATE SODIUM)

Average Rating: 2.7 (33 Ratings)

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 ANTIMETABOLITES

 Type: Rx Drug

  

METHOTREXATE  (METHOTREXATE SODIUM):  Methotrexate is used to treat certain types of cancer or to control severe psoriasis or rheumatoid arthritis that has not responded to other treatments. It may also be used to control juvenile rheumatoid arthritis. Methotrexate belongs to a class of drugs known as antimetabolites. It works by slowing or stopping the growth of cancer cells and suppressing the immune system. Early treatment of rheumatoid arthritis with more aggressive therapy such as methotrexate helps to reduce further joint damage and to preserve joint function.   FDA Approval Date: 1999-02-26 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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  Charts & graphs: Drug Safety Information

RATING  REASONSIDE EFFECTS FOR METHOTREXATECOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  psoriatic arthritis some abdominal discomfort but not pronounced helped reduce inflammation and pain in knuckle joints in hand M 76 2 years
10 mg 1X W
10/30/2021
 3  Rheumatoid Arthritis Dizziness (quite strong after injection), nausea, fatigue, acne (was told by doc that this wasn't related but I know it is). Stomach cramps, brain fog. Symptoms changed over the weeks. During the second week, I had a headache on the day of injection. Thankfully, it went away after that. Haven't experienced headaches since. The biggest challenge is dealing with nausea, fatigue, and dizziness. It tends to be much worse a day or two after the shot and then slowly dissipates throughout the week. I personally don't love the way it makes me feel, but wouldn't stop it given that I had really severe joint pain before taking it. I still sporadically get pain in my hands and other joints - but not as frequent and intense. F 33 7 weeks
15 MG 1X W
5/13/2021
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 3  Lupus I have a burning sensation when it's being injected I inject a nighttime the next day I have to stay home have stomach ache , weird headache , diarrhea, nausea, body aches pretty much lose my day or two, I have noticed hair thinning I bruise easily and I'm really sensitive to pain and cold .. on my good days I do feel more like myself and am able to do more , too soon to know if it's working no blood tests yet F 36 1 months
12.5 1X W
1/13/2021
 1  Rheumatoid Arthritis Constant stomach ache, nausea, depression and anxiety. Wanted to die. F 57 2 weeks
10/10/2020
 2  Sarcoidosis I loose 2 to 3 days every week after taking, so tired and heavy head, feeling sick constantly, I'm thinking of stopping and just deal with the consequences F 43 11 months
25 1X W
9/23/2020
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 1  Autoimmune Weight gain after a period of time , flu like symptoms large lipoma appeared on my back think I had a bad reaction to my system wasn't to bad when I first took It but symptoms got progressively worse . 55 3 days
25 mg inje 1X W
9/15/2020
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 3  Psoriatic Arthritis Initially nausea, I have been on it for 10 months and no more nausea. Chronic fatigue every time I take the shot of Methotrexate. Vertigo , tinnitus. The medicine helped in the7 months of taking it, now I have started with pain in different parts of my Body and it's not helping the pain anymore. F 63 10 days
25 mg 1X W
9/1/2020
 4  Rheumatoid arthritis Loose bowels , hair loss, and ,after 9months, acne. It was very helpful with RA. I had limited pain though at times I had aching pain and I used Tylenol. I also had reduced ability to tolerate any type of work and o felt exhausted every day. 76 7 months
25 mg 1X W
8/27/2020
 4  Psoriatic arthritis bloating, weight gain, brain fog, gradually worsening stuffy ear and tinnitis, post nasal drip, 80% hearing loss on one side and vertigo - all came of gradually over several years Stopped taking mtx 2 weeks ago...all symptoms which very gradually appeared over 5 years (so gradual you kind of do not notice until they become bad enough) are already starting to disappear:) Rather have pain and skin lesions than that lot of side effects. M 52 5 years
7.5mg 1X W
8/4/2020
 5  PA Had nausea, dizziness, and migraine headaches on 15mg. Reduced dosage to 10mg and switched to injection form Rasuvo. No side effects now and joint pain is tolerable. Feet especially feel 100x better. F 46 1 years
10mg
2/25/2020
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 1  RA With first dose I experienced a burning sensation on roof of my mouth. And I had a brief period of losing my voice and welts on my face. Both symptoms disappeared with an antihistamine. Rheumatologist advised to try again. I took two more doses and each time angioedema in my throat which caused me to lose my voice occurred and I got large welts on my face. severe allergic reaction. angioedema causing voice loss. F 74
10mg 1X W
2/17/2020
 1  Sjogren’s Diarrhea the day that I take the medication. I have now developed neuropathy in my feet and can barely walk. I see no benefits from this medication I only continue to get worse . I believe it is poison and I am not going to take it anymore . F 61 1 years
20
1/23/2019
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 1  psoriatic arthritis Nausea and funny taste in my mouth after injection lasting up to three days and general fatigue The drug does nothing but make me ill. I literally start feeling Nausea the second I start filling my needle because I associate the mere act of filling it with the sickness I'm about to endure. Also it hasn't seemed to reduce the inflammation and the pain caused by it at all. I am dicontinuing use againt my doctor's advice. I'm sick of being sick! F 38 8 months
5mg
12/22/2016
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 5  Ra Works really well for me except one thing heavy menstrual bleeding but thanjs to mtx I am now back in work and feeling a lot better. F 46 1 days
10
9/26/2015
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 5  Ra Works really well for me except one thing heavy menstrual bleeding but thanjs to mtx I am now back in work and feeling a lot better. F 46 1 days
10
9/26/2015
Email
 1  dermatomyositis CANCER is a side effect, please read side effects of methotrexate. my husband now has large b cell lymphoma M 66 2 years
100 10X W
5/27/2012
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 4  RA Thinner hair but no other side effects I was really worried about going onto mtx but it's been a positive experience and helped my RA. F 40 4 years
20 1X W
12/30/2011
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 3  Psoriatic Arthritis When I was taking the pills I had really horrid stomach aches and bleeding. When I switched to the shot it really cleared up, still sick for the day of the shot, but not nearly as bad helped some wtih arthritis pain, and not at all with the psoriasis F 31 3 years
25 1X W
7/24/2011
Email
 4  psoriatic arthritis hair loss, vomiting I take this in pill form w/Humira. My concerns are the side effects more than anything. I am taking calcium pills for the hair loss, which is not helping. I do feel so much better though. F 37 1 years
1X W
7/23/2011
 1  RA Just the severe coughing from December to October which was down to mtx causing inflamm. to lungs Still watching this space?.....eventually put on sulphasalazine which never really made any difference ....it took months to get rid of the cough, had lung x-rays& breathing tests all ok. now been prescribed plaquenil 200mg /day and the pain in hands has gone,-Heaven be praised !! M 74 12 weeks
20mg 1X W
2/1/2011
  

METHOTREXATE  (METHOTREXATE SODIUM):  Methotrexate is used to treat certain types of cancer or to control severe psoriasis or rheumatoid arthritis that has not responded to other treatments. It may also be used to control juvenile rheumatoid arthritis. Methotrexate belongs to a class of drugs known as antimetabolites. It works by slowing or stopping the growth of cancer cells and suppressing the immune system. Early treatment of rheumatoid arthritis with more aggressive therapy such as methotrexate helps to reduce further joint damage and to preserve joint function.   FDA Approval Date: 1999-02-26 (Sources: U.S. Centers for Medicare Services, FDA)

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