Average Rating: 2.0 (32 Ratings)

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 Type: Over-the-counter Drug

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on PRILOSEC OTC: Reviews Summary  |  Drug Safety Information

 1  Acid Reflux This medicine caused some loss of feeling in my arms and legs for about an hour. I stopped taking it. Because of the loss of some feeling in my arms and legs for about an hour, I stopped taking the drug. I had similar problems with Nexium. M 49 1 days
20 MG. 1X D
 5  GERD tingling of feet after eating not attributed to any other reason When researching the tingling and Prilosec otc I found that it depletes B12 so started taking 1000 mcg per day and no tingling and my tummy is 90% better. I also use Apple cider vinegar and eat an apple between meals...awesome results and life back to normal finally F 60 2.5 weeks
20 1X D
 3  irritation, duodenum Worked well for me, but pain came back when I stopped taking it. Prilosec has a rebound effect. When I stopped taking it, the stomach acid came back in full force. So I most recently started cutting the pills in half, making it 10mg. They dont sell these otc, you have to get a doctors prescription. For me, cutting the pills works well. I then start alternating the Prilosec OTC 10mg one night, with Zantac 75 the next night. I continue reducing the dosage of Prilosec and increasing the Zantac until off. I now use the Prilosec on an as-needed basis, and depend more on the Zantac. Too bad they don't provide more info on the rebound and other side effects of Prilosec. F 68
20 mg 1X D
 3  heartburn muscle cramps F 79 5 years
20 mg 1X D
 1  gerd this is just a note to those trying to come off this drug without rebounding. ASK YOUR DR FOR THE 10MG version... they DO make it! you can't cut the 20 pill in half! so alternate a 20mg with a 10mg for like 2 weeks, then cut down to the 10 version. start taking the 10 every other day then ween down to zantac 150.. then zantac 75 to avoid any rebound. this should work! F 26 1 years
20 1X D
 2  Dyspepsia (indigestion), GERD Rebound reflux after stopping Prilosec helped with my symptoms of burping/indigestion that the doctors diagnosed as GERD. After an upper GI endoscopy and other tests revealed no illness and no esophogeal damage, I decided to stop taking Prilosec. I'd read that it's best to taper the dose slowly. But when I cut the dose to 20mg I experienced terrible heartburn for about 2 weeks - and I'd never really had any heartburn before. My GI doc and internist both said I should go back on the 40 mg does and stay on it basically forever. Instead, I took one 20 mg tablet for two weeks, then cut back to every other day for two weeks, then stopped (and took a lot of Tums instead). Now, after nearly 8 weeks, I'm starting to feel nearly back to normal. So,if you find you have terrible heartburn after quitting, and you want to get off the meds, I recommend that you taper and stick with it for at least 2-3 months. Otherwise, you'll be taking the stuff forever. F 48 4 months
40 MG 1X D
 4  acid reflux I star to take prilosec in the end of 2004 because i have acid reflux almost every day,and the medicine work very well in controling the acid refux,but after 2 year i star to feel pain in my legs and loosing hair,6 month later i star gain weight.I was 197lb and now i weight 237lb.3 years after star this madication i star to get blurry vision and my pain goin all over my body especialy on my back and neck.I have normal blood pressure and now i am 150/102.I get tire all the times and i quik many time the jobs in the last 4 years because all this side efects of this drug.The drug work very well in the acid reflux but is allmost kill me and destroyed my life.I belive the medical asociation have to study all this side efects before put this medications on the marked.We prilosec is more what we loose than what we gain.Astra Zeneca have to be more respomsable with the products they put on the market. M 46 6 years
20mg 1X D
 3  Acid Reflux Aura without migraine? It does get rid of my reflux but if I stop taking it, within 24hrs the heartburn is back. Also, I think my auras without migraine have been a result of taking this due to the timing when I take the pills for awhile and when I get the auras. Not sure though. Its the only think I can afford right now. Generic. F 25 1.5 years
1 pill 1X D
 5  GERD None. I have been taking prilosec first and then the last few years as OTC. I have GERD if I forget to take it even one day, by 4 or 5 in the afternoon my heartburn is back. When I first started it years ago I had tons of nausea too, it totally got rid of that, I had bouts of diarrhea and it seemed to clear that up too. This has been a life saver for me. F 48 20 years
20 1X D
 1  heartburn/reflux ANXIETY!!!! FATIGUE! You can see my post on the 16th for my history... Okay. I've been off Prilosec for 10 days. The anxiety is affecting me a lot less now. I actually had a pretty good day yesterday. I have also changed my eating habits (eating smaller portions more often and chewing my food thoroughly) if I do start getting heartburn I control it with TUMS. I am still having some muscle pain and my pulse rate goes up from time to time for no apparent reason. Still feeling fatigued. The best part is that I don't feel like I'm going out of my mind or that I'm going to die at any moment. I can't say for sure that the drug was causing these symptoms, but since stopping it, I sure feel a lot better. I'll update again in a few days. M 42 2 months
20 1X D
 1  GERD Insomnia, external head pain, bloating This certainly helps with acid reflux, but I felt like a zombie after two weeks of poor sleep. I did not make the connection at first. Once I stopped the Prilosec OTC, I began to sleep better. The pain on my head went away too (not a headache; it was external). The bloating stopped too, which was nice! F 37 14 days
20 mg. 1X D
 4  Acid reflex severe joint pain M 52 4 months
20 MG 1X D