LINZESS Reviews (LINACLOTIDE)

Average Rating: 3.4 (44 Ratings)

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 GUANYLATE CYCLASE C AGONISTS

 Type: Rx Drug

  

LINZESS  (LINACLOTIDE):  See also Warning section. Linaclotide is used to treat certain types of bowel problems (irritable bowel syndrome with constipation, chronic idiopathic constipation). It works by increasing fluid in your intestines and helping speed up movement of food through the gut. Linaclotide may improve stool texture and lessen symptoms such as bloating, abdominal pain/discomfort, straining, and feelings of incomplete bowel movements. This medication must not be used in children younger than 6 years because of the risk of serious side effects.   FDA Approval Date: 2012-08-30 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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  Charts & graphs: Drug Safety Information

RATING  REASONSIDE EFFECTS FOR LINZESSCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  IBS-C I have been taking Linzess for 9 months. As far as I am concerned, it is a miracle medication. I have been dealing with IBS-C for 18 years. I used to take Zelnorm until it was discontinued, but that only treated the horrible belly pain. To regulate my bowels I would take daily probiotics, intermittent laxatives, daily fiber supplements, a morning spinach/fruit smoothie, one meal with beans, and I would still only have 2-3 bowel movements a week. Since day one of starting Linzess, I have daily bowel movements and I have stopped taking the extra supplements and can eat well balanced meals instead of overdoing the fiber. It has changed my life. F 38 9 months
145mcg 1X day
6/12/2020
 1  Severe constipation Poor response, nausea, weight gain, and heavy watery stools. After two weeks, it didn't work, but I kept gaining weight. I have found Mag07 and my life has changed. No side effects, and it works daily. F 48 1 months
6/9/2020
 5  Ibs/ constipation This is the only medication that has worked for me since my 20’s , slow motility because of a surgery when I was 16, lately I have been experianceing more than usual sweating and chills, anyone else experience this? I am taking menopause drugs yet this hasn’t happened before? F 51 3 years
145
4/3/2020
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 5  Ibs/ constipation This is the only medication that has worked for me since my 20’s , slow motility because of a surgery when I was 16, lately I have been experianceing more than usual sweating and chills, anyone else experience this? I am taking menopause drugs yet this hasn’t happened before? F 51 3 years
145
4/3/2020
Email
 4  ibs-c explosive diarrhea, gas, unusually bad odor explosive diarrhea if you eat certain foods within an hour of taking it. does a fantastic job of flushing bowels. my only complaint is that I cannot take it every day (because of the explosion) I only take when I am positive that I will be home. some days the results require complete bleaching and clean up, plus a shower for me. F 43 4 months
145mg
11/20/2019
Email
 1  Constipation Stomach cramps, nausea, diarrhea, vomiting I’m sure this is normal the diarrhea and cramping because duh constipation. But the vomiting?? Never again, worst day of my life! F 29 1 days
290mcg
11/18/2019
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 2  IBS/with constipation explosive diarrhea for the four days I have taken it F 78 4 days
72 mcg 1X day
9/26/2019
 3  Constipation due to medications I developed constipation from taking one of the new migraine crgp meds. I took Linzess at 10:33 am, and got very sleepy at 6 pm. I had an evening telephone meeting, so I took a 40 minute nap. When I woke up, my headache had got worse. I took my regular rescue meds, plus Cambia (nsaid) and Sudafed. After my phone meeting, I went back to sleep for 11 hours. My blood pressure had increased. I have high BP, so nsaids and decongestants are not good for me because they increase BP. M 64 1 days
145
8/22/2019
 2  IBS-C Diarrhea, very gasey. This Medication works Very well, however, even the lowest dose it so powerful/enough. I think they show make a even lower dose and test on humans not animals inorder to get True results F 37 7 days
30mg
6/30/2019
 1  Constipation Uncontrollable diarrhea, chills , lightheaded . Very sick. F 71 1 days
145
5/2/2019
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 4  For Chronic Constipation From time to time, I experience intense abdominal pain and maybe even intestinal pain. It can get so bad I have to let it pass due to the level of pain I feel coming from my intestine. During the very few intense episodes, I have pretty bad abdominal pain, intestinal cramping, bubble cut, sweating and maybe even cold sweats if the pain gets bad enough, shakes and just all around out of it. F 21 1 years
4/17/2018
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 3  IBS-C This rx is not for a person who commutes to work. Taking the lowest dose and it gives me the runs along with increased intestinal pain, gas and spasms. While it does eleivate my constipation, it aggregates my other painful symptoms. F 58 8 days
72
4/1/2018
 5  constipation due to antibiotic use Diarrhea is possible if you over do it. I take one pill every other day to avoid this problem. This compound is remarkable. I take it a half-hour before breakfast and am in the bathroom within a half-hour after breakfast. Nothing else I have tried works as well. M 81 3 weeks
145 mg 1X day
1/14/2017
 3  IBS Linzess really helps the bloating and the over full feeling and the distension. I am taking another medication called byetta which makes me very constipated. And so they put me on Linzess for my IBS constipation period and what seems to happen is that I may have a normal BM for a constipated BM and then shortly after that I have to run to the bathroom and nothing comes out except for liquid. I do feel a little bit nausea and tiredness with the linzess as well M 48 3 weeks
145
12/28/2016
 5  Idiopathic Constip./Stool Retention Nothing significant. I am using this product for slow bowels. Not really overly constipated, but it's not a smooth process each day! On the Linzess for the last few days since starting, I have been able to have bowel movements which do not hurt my stomach. I do drink lots of water, though, which I know is good for me. I called the manufacturer of this product and wanted to know how long it would take to notice results, if the product worked. They said, very interestingly, it would take a week to see results BUT would take between 6 and 9 weeks to reach its full effect! This is the reason to keep on taking a medication, and give it time to work...unless, of course, you have terrible side effects. I will be taking this every day for the next few weeks and give it time to work. It already does! F 57 4 days
145MCG 1X day
5/25/2016
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 4  IBS-C Seem to have more headaches and a little tired! F 72 90 days
149 mcg 1X day
3/9/2016
 4  IBS C I think that this medication is giving me migraine headaches. I am prone to headaches but they are worse then ever. Anybody else notice that they have getting more headaches and feeling a little fatigued since starting Linzess? Other than the headaches, Linzess is doing the job quite well. I don't seem to be bloated or constipated as I was before using the Linzess. Although, sometimes I have to take Oval 180 to handle the bloating later in the day. I get the occasional diarrhea but I can live with that. I also seem to get some fatigue from the medication. Everyone else seems to love Linzess, so am I the only one that is getting the headaches and fatigue? M 62 7 months
290 1X day
1/6/2016
Email
 4  IBS-C hours long diarrhea, chills, feeling ill, taking to my bed between bouts (usually have at least two) Rated it a 4 because NOTHING else worked...can go a week or longer without pooping but have decided to take one day a week since I need hours out of the day to empty my bowels after taking one pill. When I was taking it every day, it was extremely bothersome, even it was only water being ejected after nothing else left to come out. Have had IBS-C for 30 years or more. Back then it was diagnosed as "spastic colon." F 48 1 years
290 mcg 1X W
10/26/2015
 5  Constipation None 36 1 days
145
8/6/2015
Email
 5  IBS-C/ bowel surgery Diarrhea This drug is amazing!! It works very well. I take it before I go to bed and when I wake up I go to the bathroom like normal most of the time. Occasionally will have diarrhea but not all day. Once I go in am it stops. Life changer!! F 37 1 months
290
7/16/2015

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