Average Rating: 3.0 (20 Ratings)

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 Type: Rx Drug

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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 1  Dry mouth Severe abdominal pain. Some diahrea previous to that. No sweating at all F 66 11 days
10 mg 2X D
 3  Sjorgrens First dose in morning causes nausea and hypersalivation with feeling that I will vomit. Overtearing of dry eye as well. As day goes on nausea is reduced but hypersalivation continues. Will give it time. F 64 12 days
5mg 3X D
 1  Sjogrens - dry eyes and mouth no noticeable side effects - Plaquenil kept my Sjogrens symptoms under manageable control - when Salagen was prescribed in addition to Plaquenil, there was no improvement in reducing the symptoms - did not work F 47 14 months
5 3X D
 1  Chemo treatment no saliva Sweaty, chills ,runny nose Very disappointed, was my last hope. F 69 4 months
20mg 3X D
 1  Sjogren Sweating M 66 3 months
60 mg
 4  Dry eye dry mouth disease Thrusting and headaches. This is my 2nd try with this drug. I already lost all my upper teeth from dry mouth so I need to be patient and make this work. F 61 2 months
5mg4x perd
 5  Sjogren's Syndrome/Burning Mouth Occasionally I have experienced excessive sweating and/or cold chills within 20 minutes of ingestion. I noticed if I spaced the doses out further apart, the side effects decreased greatly. Salagen has improved my quality of life with Sjogren's Syndrome and Burning Mouth Syndrome. My pain has been greatly reduced as I actually have saliva! Occasionally I have more saliva than I really want, but I'll take that! F 48 11 months
7.5 MG 3X D
 4  Sjogrens Severe sweating/hot flashes for at least the last 6 months. Been taking Salagen for at least 4-5 years or longer.No side effects other than a runny nose for the first few years. Not positive the hot flashes are from the Salagen. ?? F 63 1 days
 3  Dry mouth due to radiation Mainly profuse sweating as well as chills and runny nose. It definitely helps produce salvia and dry mouth. But the side effects are getting harder to deal with. However I'll continue taking it as I'd prefer the side effects over a dry mouth. F 50 5 months
5 mg 3x/da
 4  Sjogrens For the first week I was warm but never really experienced the flushing. I do have more frequent urination. Mouth would be so dry. Now I have saliva. I could sleep through the night if I did not have to urinate. This has been a great improvement. F 53 2 months
5 mg 5X D
 1  Dry mouth due to SSRI Makes my throat feel restricted hard to sleep M 44 2 weeks
 5  sjogrens syndrome feel flush about 20 minutes after taking this medication. makes you sweat and help with saliva and tear production. I've also lost 15lbs since starting this medication. It's a good idea to drink plenty of water while on this medication because it will cause you to sweat. Before I started taking Salagen I had hardly any tears or saliva. This drug is well worth the flush feeling. F 31 1 years
5mg 3X D
 4  SJOGREN'S SYNDROME/Dry Mouth I haven't had any side effects which amazes me because I'm very ultra sensitive to medications. I'm taking one {4 times a day.} It helps to relieve my super dry mouth especially when I'm trying to have a conversation. I've had a dry mouth for so long it's a relief to have a normal amount of saliva. I've gone so long without having any saliva that it took me awhile to get use to having any. I had a huge grin on my face the other day while I was concentrating on my computer work because I actually drooled. Thankfully I was at home and not in public! There's nothing like a woman walking around town drooling with a big smile on her face. It's a blessing to have any sort of saliva. I feel badly for the people who have experienced side effects with this particular medication. I realize that no two bodies react the same, but Salagen is working great for me. I would recommend this medication to others if they are able to tolerate it :-) I'm happy that Salagen works great for me! F 60 1 months
5mg 4X D
 2  Sjogrens and SLE Lupus Profuse sweating - I had to change my clothes 3 times in one night. Chills, head ache, and hot flashes. Also, one night I had so much saliva in my mouth that I woke up in the middle of the night choking on my own saliva. A very scary experience! Just note that I am generally sensitive to medications that I take, but I did not expect these side effects. F 32 3 weeks
5 MG 2X D
 2  Sjogren's Strong pain in ducts on roof of mouth. Right submandibular pain. Difficulty swallowing. I won't be taking it again. Not sure what I'll do. F 48 1 days
5 mg 3X D
 5  cancer-post treatment effects Initial dosage (while I was in radiation treatment)was 1 pill 3X per day. For the first few months I had flashes of sweating but adjusted. I am now (for several years)taking 1 pill 4 times per day. I have no adverse side effects. I had Stage IV throat cancer requiring surgical removal of the submandibular salivary gland (rt. side) and 7 weeks of radiation, which greatly reduced the salivary function. I am quite dependent on Salagen at this point. My system has adjusted to "expecting" the boost to salivary function every 6 hours--for talking (I teach), eating, living. My quality of life would not be good without Salagen. It has helped me a great deal. F 67 12 years
5 mg 4X D
 4  Dry mouth due to Sjogren's Syndrome flushing and sweating briefly 20 minutes after taking it. Works great for me. I only wish that the effects were longer lasting. Had to add a fourth dose to make things more comfortable. M 37 2 years
 4  dry mouth I take 10 mg when I wake up, 5 mg in the afternoon, and 5 mg at night. I do experience (periodically) sweating in the morning about 20 minutes after I take them. It only lasts about 10 minutes and then, I'm fine. There are no other side effects for me. My life prior to being prescribed this medication was a ZERO on a 1 to 10 scale. Talking was uncomfortable. Kissing my husband, out of the question, life was miserable. At first I was less than thrilled by the medication but I kept taking it. After about 2 months, it was miraculous. Life was a 4 or 5 out of 10, which anyone with a dry mouth will tell you is AWESOME. Now, I have been on it for 4 months and now it's a 6. If it doesnt get any better than this, that's fine. I am happy, able to talk, sing, kiss.....I will never again be without this medication. I highly recommend it to EVERYONE. F 47 121 days
 3  dry mouth, no diganosis Repeated hot flashes and sweating. It is a sanity-saver when I can't stand the dry mouth any more or have to take part in a conversation. However, the duration of the improved salivation is so short and the side effects are so unpleasant that I prefer not to take it regularly as prescribed (3 times per day). F 58 6 months
 3  Sjogrens Syndrome Hot flashes and profuse sweating, starting about 20-30 minutes after taking the drug. This is followed by chills since I'm so damp from the sweats! The amount of saliva in my mouth does increase for awhile, but initially the sensation is uncomfortably reminiscent of what one experiences with nausea prior to throwing up. Not pleasant. After about an hour of these sensations, my body returns to I take one 5mg Salagen tablet 3 times a day after meals. My Dr. would like me to add a 4th dose before bedtime, but I doubt I can tolerate that since I would be taking it without having eaten a meal. I really don't care for the side effects, especially since I'm experiencing additional hot flashes the rest of the day due to menopause. F 51 6 months

SALAGEN  (PILOCARPINE HYDROCHLORIDE):  This medication is used to treat symptoms of dry mouth due to a certain immune disease (Sjogren's syndrome) or from saliva gland damage due to radiation treatments of the head/neck for cancer. Pilocarpine belongs to a class of drugs known as cholinergic agonists. It works by stimulating certain nerves to increase the amount of saliva you produce, making it easier and more comfortable to speak and swallow.   (Sources: U.S. Centers for Medicare Services, FDA)