Average Rating: 2.8 (16 Ratings)

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 Type: Rx Drug

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on NORPRAMIN: Reviews Summary  |  Drug Safety Information

 2  Atypical Depression Dry Mouth, Dizziness, LIght headedness, decreased libido, Pressure changes in my ears, difficulty exercising without almost passing out, fatigue I took as an augmentation to Paxil (20mg). I've only been on it for 2 weeks, but I'm ready to quit from the side effects. M 40 2 weeks
50mg 1X D
 3  Tension Headache Early waking ... sedation ... increased libido ... mind numbing This medication saved my life back in the 90s. I had a severe chronic headache that was diagnosed as psychosis and until I went to a neurologist and explained him my head pain, it went untreated. Even a 10mg my pain in my head decreased by half! I was really suicidal at the time and Desipramine saved my life. The ONLY negative thing about it was that it made me rise early and made me a little tired during the day which acted to depress me. But it does work for nasty head pain and for that I'm thankful. I found out a few years later that a dose of Zyprexa along with Despramine keeps you asleep longer. That's what I take to this day for my neuro/psyche problems. I have never had to increase my dose all these years. It works like a tryciclic "aspirin" of sorts. M 46 10 years
25mg 1X D
 5  bipolar II/SAD depression dizziness, dry mouth, weight gain have taken desipramine since 1987. An older drug, docs will tell you it has more side effects than SSRIs or that it will switch bipolar depression to hypomania. Not true for me! was transferred to SSRI for 2 years, and had such a horrible experience I refuse any anti-depressant now except desipramine. After a few months on desipramine, all side effects will dissipate. Always lost weight or had no weight effect on this drug until last year when it changed manufacturers. I think they reformulated it, because now I have a desire for sweets that I never had before on this drug. But it's still worth it. Completely stops SAD inability to get out of bed in morning. If SSRI side effects are bad for you, try desipramine (if you're bipolar, make sure to take a mood stabilizer at the same time). M 42 25 years
100 mg 1X D
 1  major depression Had extreme agitation, mood swings, crying fits, difficult getting out of bed every day...and all this 4 weeks before my wedding. The doctor had me take this after a round of ECT to try and maintain the benefits of the treatments-BAD IDEA. I'm surprised my fiance didn't postpone our wedding because of how bad off I was from the side effects. The dr. had me taper the dosage back down and gave me xanax to help calm me down to come off of it. F 28 1 months
 1  Decrease peripheral neuropathy pain difficulty breathing, increasing shortness of breath, difficulty urinating, increased heart rate, excessive sweating, heat stroke. Do not take this drug under any circumstances. F 66 6 months
 2  depression anxiety sleeplessness dry mouth increased body temp took 25mg in morning 50mg at night could not sleep made me speedy felt more anxious only take 25mg now and i sleep fine but still feel sad F 33 6 weeks
 3  Depression, snappiness,inattention Urination 3 times a night; increased pulse; reduced tolerance for physical activity; gas; non-existent sex drive. Norpramin 10mg (the smallest pill) once a day for the past 11 days. Started at the lowest dosage and am working upwards. It has bad side effects listed on the left, so I've set limits for this medication: (1) I take it in the morning; taking it in the afternoon means that I'd have trouble staying asleep; (2) I take Toprol XL 25 mg. 2 hours prior to Norpramin to counteract the increased pulse resulting from Norpramin; (3) If I exercise, I delay Norpramin; and (4) I've taken a one-day drug holiday after 10 days because I felt it was getting too much for me. On the plus side: much better thinking, less distraction, less anxiety, friedliness to family. With Norpramin, I've become a normal person and people now want to deal with me. When you're taking toxic pills like Norpramin, forget about the dosages recommended by the manufacturer and your doctor. You're the only judge. Start with the lowest dosage and work upwards. M 44 11 days
 5  depression & anxiety dry mouth, increased cravings for sweets; some agitation--but not always This is not commonly prescribed anymore, bc it is one of the 'older' antidepressants. But I think the side effects are actually must less than the newer drugs like Prozac. This drug helped me a great deal, I fell asleep at night, slept more deeply and woke up refreshed- for the first time in 5 years since having depression. It gave more energy during the day and less anxiety. The problem was that these positive effects began wearing off and when the dose increased, I got some nasty agitation. I would not rule out taking it again however. Also a good thing: I had no sexual side effects with this med at all. F 38 1 years
 4  depression Do not drink alcohol at all on this medication. They tell you to limit alcohol but I did not take this seriously, with disasterous consequences! F 24 4 months
 4  depression very dry mouth, difficulty urinatin, bad skin? F 24 3 months
 2  Major Depression urinary tract, libido, light-headedness Seemed good at first. Felt like my head was in a cooler - an almost high sensation. But I couldn't think straight to save my life. Doesn't really help with depression but might have marginal recreational value. M 35 2 months
 3  Depression dificulity urinating, pounding heart This medication needs to be increased in strength periodically M 59 7 years
 3  for depression experienced excessive sweating,easily increased body temperature,decreased sex drive M 33 3 years

NORPRAMIN  (DESIPRAMINE HYDROCHLORIDE):  Desipramine is used to treat depression. This medication may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living. This medication belongs to a class of medications called tricyclic antidepressants. It works by restoring the balance of a certain natural substance (norepinephrine) in the brain.   (Sources: U.S. Centers for Medicare Services, FDA)