DEPO-PROVERA Reviews (MEDROXYPROGESTERONE ACETATE)

Average Rating: 2.1 (2474 Ratings)

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 ESTROGENS PROGESTINS ANTINEOPLASTICS

 Type: Rx Drug

  

DEPO-PROVERA  (MEDROXYPROGESTERONE ACETATE):  For use by females of reproductive potential to prevent pregnancy. Medroxyprogesterone is like a natural hormone called progesterone made by the body. It is also used with or after other treatments (such as radiation, surgery).   (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on DEPO-PROVERA: Reviews Summary  |  FDA Adverse Event Summary

RATING  REASONSIDE EFFECTS FOR DEPO-PROVERACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Birth Control This drug is dangerous and has made my life literally, a living hell for the past couple months! I have severe anxiety attacks that occur almost daily. I have shortness of breath, massive headaches, fatiqued, hot sweats.. etc. I had a severe panic attack the other day and had to go to the emergency room. I cannot leave my home because I get dizzy and feel like I am going to pass out. I know feel this way in my own home. I am a prisoner in my own home because of this aweful drug! Two more months and hopefully this drug will be out of my system so I can go back to living a normal life again! F 25
1X AN
12/25/2010
 1  Contraceptive Severe acne, moodiness, nervousness, bloating, food cravings, weight gain, hair loss, joint pain, depression. I started taking this shot around Oct 2009. The first 2 shots were heaven. I noticed some hot flashes, but they went away as my body got used to the hormones. Then, during the last 6 months, I developed severe acne and hair loss. The whole time I've been on the shot, I've been nervous, depressed and have crazy food cravings (which has caused me to gain weight. I can't seem to lose it either...and I run marathons.) I am also very tired and experience joint pain. I've also noticed a lot of hair in the drain. Also, after I would get the shot, I would feel super sick. Like I had the flu and my period at the same time. I would cramp AND have body aches, I would be hot and cold at the same time, have pain at the injection site, have headaches, crave food, be bloated...My next injection is supposed to be in a week, but I am not going back. DO NOT RECOMMENDED F 19 1 years
1 shot 1X O
12/24/2010
 1  Endometriosis Weight gain 30 lbs. Hyper tension. Severe acne. Mood swings. Fatigue. Sweating alot. Bloating. I am 18 years old and was 130 lbs since I was 13 years old. I always had a very balanced diet and when I went on this medication I experienced extreme hunger. I exercised as much as I could until I noticed that my chest began to hurt. I remember it was May and I had prom in June and I was freaking out because I had acne all over my back and face. I never had acne before this medication. I called my doctor and I was told that it was a dermatologists problem. So now it's August and I went to my doctor to get another shot. I got weighed and gained 30 lbs in under a year even with exercise. I spoke to my doctor and asked her why did I gain weight and why was I covered in acne? At this point in time the acne was down to my wrists, on my thighs, chest, back, lower back, neck, scalp, and it was going onto my stomach. Now I am off the shot and dealing with acne, stretch marks (even though I lost weight), and depression. If you notice acne or any side effect if that, please get off this medication. I can't wear t-shirts or shorts even though I lost weight because of the severe acne. People ask me if I have hives or singles. To be perfectly honest I rather not take any pills at all and live with the consequences of my disease. At least I was still me and not some ugly monster that I am now just because that doctor didn't want to operate or refer me to a more experienced surgeon who could've gotten rid of the disease for good. F 18 1 years
1X O
12/21/2010
 5  endometriosis I am a little moody and have had a little vaginal dryness, The 1st couple of days after the shot, I have mild headaches, but they go away. It has been a blessing so far. No periods since I started, so no cramps! It affects everyone differently. I feel bad for the women who have had such a terrible time on it. For me it is wonderful. My doc told me when I started that it is an appetite stimulant so I needed to be careful and monitor what I ate. I did this and found that I was able to control cravings and I have lost 8 pounds, so weight gain is not a definite side effect. Don't be scared off! After reading some of the negative experiences, I almost was. Individual people have individual side effects. F 36 4 months
1X AN
12/19/2010
 3  To be safe, fewer periods. Loss of sex drive, pain, anger and temper issues. I hadn't had any problem on the beginning, or none that i had noticed. I started taking the drug when i was 16 and now i'm almost 18. I have completely lost my sex drive. I didn't think Depo would of been the problem until i looked it up. Also started to not even feel good at all if i try to do this with my long term boyfriend. And i know this isn't him at all because i cant get even myself in any mood. I also have had bad mood swings from the first dose. I am almost done with this 3 months and i am never taking this again. and I really hope i will have my period and everything back on track and i don't lose it... Wish me luck.. i didn't gain much weight maybe 5-10 pounds but im back to bout 123 because i try to work out a decent amount. I do NOT recommend this drug. It's been messing up my relationship,personal imagine, and now i'm terrified i may lose my period. F 17 1 years
- 1X O
12/19/2010
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Patient History
 1  Doctor in St Charles MO I became somewhat within myself, meaning I knew it was me but I felt crazy! I felt like I became a tiny little mind in my own. I had no control as far as mood swings, zero sex drive, angry, hateful etc... I was never like this before the shot. I also after the 2nd shot realized something was terribly wrong at age 35. I took this shot thinking because I smoked and could no longer be on birth control it was the only answer the doctor gave me. It was new on the market I believe looking back. I went through just enough of a period to piss you off for weeks, then nothing and then the grand finale which was from hell. Then early menapause at age 39. Horrible. I was always a healthy woman/mother. After the Depo-Provera shots, 1st and then three months later the 2nd shot before I notice any horrible side effects. These shots changed me mentally and physically. I question now 11 years later if it's not the cause of my cancer. I survived the horrible side effects back then only to wake up to stage 4 cancer of gastro inestinal stromal (GIST) which normally only affects very old people. I was 46 and in excellent health otherwise. Talk about being blind sided! I truly believe that these two "simple" shots for birth control have been the cause of my cancer. If you look up GIST cancer, you'll find there is no known "one" thing that causes it, Oncologist have no idea what causes it. Yet I have it. I was a very healthy woman all my life to the point I rarely if ever even caught a cold! This shot of depo provera has caused me a great loss to include major mood swings, being very mean to people I love, throwing things which I never did before, no (zero) sex drive since, loss of the love of my life due to no sex drive. Loss of hair in certain area's. I could go on and on but the worst of all is cancer! GIST is so rare it effects so few in the U.S. I recal the statistics are about 8 woman per million, per year in the U.S. and usually are much older than 46 years old when I was diagnosed at stage 4, 17cm tumor and metastised liver full of tumors. I was poisoned by this depo-provera shot, twice! It took almost i F 48 2 months
? 1X M
12/16/2010
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 1  after an unwanted pregnancy I had horrible mood swings, almost lost my long term relationship. Cramping, sore breasts, horrible head aches. I never experienced any weight gain but i did eat a lot.I also spotted for the entire 3 months. I wanted to try for a baby after the three months and found out that fertility might not happen for me. I was very upset because my doctors never explained any of these side effects. When coming off of it i read all of these horror stories about how bad it it would be. The spotting I was experiencing went away exactly three months from the day I received my first shot. Two weeks after that I began a normal period and 4 weeks after that I was pregnant. One thing I did do was detox my body with natural methods trying to rid my self of this poison. It appeared to have worked! F 20 3 months
100mg 1X O
12/14/2010
 1  prevent pregnancy headaches, weight gain, eating a lot, mood swings, unhappy about myself F 17
26mg 1X AN
12/12/2010
 3  contraception un godly amount of weight gain- 70 lbs!! but since coming off of it (nearly 9 months ago- have only had 2 cycles-- but have lost 30 lbs of the gained bit! F 22 3 years
1X O
12/8/2010
 1  BAD periods Weight gain, SEVERE mood swings, ovarian cysts, hot flashes. Sure... It prevents pregnancy. Sure it prevents periods. SUre its great. Well guess what... U R WRONG! I got put on this when I was 14 yrs. old. I am now 19 and trying to put myself back together. been off of it for a whole year.. No periods!! Guess what?? You cant have babies with no periods!!! I havent been able to lose the weight, I still have bad mood swings, and on top of everything... I might have end organ failure (uterus doesnt work) due to the depo. Dont do it!!! It might seem worth it now, but think of the long run!!! F 19 4 years
1X AN
12/8/2010
 1  birth control spotting, hot flashes, nausea, no libido, no appetite, fatigue, mood swings I have only had one shot so and am NOT going back for another in 2 weeks when I'm supposed to. First I noticed shortly after taking the shot that I have NO appetite (which is unusual for me, I'm slim with a very high metabolism and I'm hungry about every 3 hours). I would go days without wanting to eat. That feeling is beginning to subside as I'm eating again. Anther thing, I began spotting about 3 weeks after the shot, and 2 months later, guess what.. still bleeding. There's no consistency to what kind of flow (light, heavy), it's unpredictable (prior to taking the shot, I was never irregular with 3-4 day cycle). I have NO sex drive (which is also unusual, I usually have a very high libido)... I barely even think about sex anymore. & with the constant bleeding, My boyfriend and I both get really frustrated and rarely ever try to have sex anyway. Not to mention, I never had body acne, now I have acne all over my chest. I have extreme sensitivity to food, and smells as I get extremely nauseous all of a sudden. I get hot flashes & night sweats... Oh and to top all of this off, I have extreme mood swings. I get angry at the dumbest things, I cry all the time for no reason (not usually that emotional of a person). Good thing my boyfriend has the patience of a saint, because otherwise our relationship would be ruined because of this drug (lack of intimacy & extreme mood swings)! I wouldn't recommend this drug to my worst enemy! F 23 3 months
1X AN
12/8/2010
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 1   Irregular periods and mood swings. The drug hasn't gotten me pregnant but I have horrid mood swings for the entire last 2-3 weeks of every shot!!! I get overwhelmed with emotions that come from no where and cry for NO REASON AT ALL almost every other day... Not to mention that I have a period for 6 days every 5 weeks!? It flexes between heavy and light every day of the 6 days! F 20 2.5 years
1X AN
12/7/2010
 1  Birth Control headaches, joint pain, stomach upset, sharp pains in head, neck, and back, itching, rashes, muscle weakness, insomnia, chest pain, shortness of breath, weight increase, dizziness, excessive bleeding for weeks, passing out, PARALYSIS!!!!! My 17-year-old daughter took her 1st injection of Depo in early Feb 2010. Less than 6 days later, she was having "tremors" in her head/neck/arms. It started out a few here and there, lasting 30 seconds to 10 minutes. Over the course of a month, the tremors progressed to 10-12 hours a day STRAIGHT! She was unable to attend school, went to the ER multiple times, and was told to go to a psych hospital. Finally, after an ER visit, she was admitted to the medical hospital. CT scan showed nothing, so they told us it was "all in her head", that she possibly had a "conversion disorder" and needed to be admitted to a psych ward. A week later the tremors almost completely disappeared. Over the course of Feb - Dec she has complained of a multitude of side effects. The tremors returned 11/17 and she passed out very frequently. As of this past Wednesday, 12/1/10, she was unable to walk w/out assistance. As of Friday, 12/3/10, she cannot walk at all and is now in a wheel chair. CT scan with contrast, lumbar puncture, extensive blood work all came back normal. She had MRI done yesterday, EEG & more extensive blood work done Friday. I suspect it will all come back normal if the Depo Provera indeed has caused her paralysis. Today she woke up and can't swallow!!! I am probably going to have to have home health care come in to help me take care of her, as after 3 days of lifting her up from the couch, to the wheel chair, to the bathroom, has abou F 17 9 months
1X O
12/5/2010
Email
 5  Birth Control Stable Mood, Calm, Peace of Mind, No Period at all, some weight loss, more control over appetite, happier, less anxiety I have taken depo for 10 years now. Most doctors say no one should be on it for this long. I move a lot over so I have been able to get a new doctor every few years. I had a bone density test, no issues yet. I LOVE depo, I haven't had a period in 10 years now except once when I was late for my shot and had to start my period again first. It took one month to have it again. I hated every second while I was off of it. I haven’t experienced any of the bad symptoms I hear about. I actually lost weight on depo, never gained. I feel calmer and less emotional on it. I compare it to how men must go about life feeling. I feel it begin to wear off close to next shot time, I start to get emotional. I feel so calm minded and happy within a few days of getting the shot again. Feeling like a normal girl isn't fun even in small doses. I know I need to go off of it someday soon because I am getting older, and I fear not having a normal cycle for this long is not healthy. There is no medical evidence to suggest this, but most holistic means tell you it matters and your hormones go out of balance impacting other aspects of health. So I will go off of it, but I am extremely anxious about doing it. From what I hear, my experience is rare and I am so thankful for the peace of mind I have enjoyed for so long with depo. I don't look forward to life without it. F 28 10 years
1X O
12/2/2010
 1  Birth Control I took DP for 6 years and THOUGHT it was a dream come true. When I decided to stop taking it, my period did not return as expected. Then monthly I began to experience VERY SEVERE abdominal pains periodically, for about a week each time. severe enough to go to the hospital 3 months in a row, with no diagnosis. Finally on my 4th emergency room visit and after a laparoscopy, a determined OB-GYN finally diagnosed my problem as Retrograde Menstruation. I was having a period and bleeding into my abdomen every month. He attempted to open my cervix but it closed within hours. The final treatment was a complete hysterectomy. The reason for my condition was that I took Depo Provera for more than 3 years. Don't do it ladies. Find a better way. It was the most painful experience of my life, and I have given birth and had eye surgery before. Those don't even compare to the pain of the side effects of this drug. It is a very dangerous drug. F 40 6 years
1X O
12/1/2010
Email
 1  severe bleeding/cramps weight gain,hair loss,brittle bones,acne,bloating, I was originally put on depo because my monthly period was so severe in cramping and bleeding i couldnt get out of bed and was near blood transfusions. At first i loved it because i didnt get a period and the cramps were gone. I was 14 when i got on the depo and i am now 18.5 years old and just recently got off of it because of the horrid side effects and because my obgyn insists that i switch. now that i am off it(last shot was in august 2010) i now have worse cramps then i ever have before, it can take up to 9mnths to get my period and clean out, i am having vaginal pains, my bones are so thin and frail is unbelieveable and my body is just messed up. I DO NOT RECOMMEND DEPO AT ALL. F 18 4.5 years
1X day
11/29/2010
 1  stop period Weight gain, irregular bleeding, hot flashes, depression, bone loss The first few weeks of me taking it, i didnt have any period...however, i began to see it after a while and had it for 3 weeks, then none for two weeks, then saw it again for 3 months straight...i finally went to the doctor and she said that my hormones are not in order so now i am going to gain weight and etc...so she put me on the pill for a month and i didnt see my period...but after a week or so i saw it again, and it was continuous for another 2 weeks then after that i didnt see it for a month and now its back on...I am depressed by the weight gain and moodswings...i get hot flashes like i am going the menopause...and my neck is already weak and it is tiresome F 19 6 months
1X AN
11/29/2010
 5  Severe Cramps Weight Gain of about 10 pounds, loss of period. Is a god send. I know a lot of people have issues with depo, but for me it is amazing. I've tried every type of birth control, to help with my severe cramps. Depo provera has stopped my period completely, which is amazing. I am no longer confined to a bed every month! F 19 1 years
1X AN
11/28/2010
 5  birth control / stop heavy bleeding mood swings, back ache, headache, heavy bleeding I've been on this shot twice, i love it. The first time was when i was 16, and i was on it for a year. the first two months i was bleeding nonstop but i figured out if i took vitamin c tablets every day it went away in two or three days. The i started having mood swings and snapping at my ex (but to be fair this could be because he was an asshole). I stopped after a year when we broke up because i wasnt having sex and thus, no need for it. Now im 18, and i just got my first shot a month ago and the only side effect ive gotten is some backaches or headaches and cramps. They arent that bad and over all im very happy with this shot. I reccommend people trying it, it works well for some, and not for others. Everybodies body reacts differently and like me, you might find a way to stop some of them. (again vitamin c stopped a lot of side effects try it). F 18 2 years
1 shot 1X O
11/26/2010
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 1  Birth Control Complete loss of libido (which I suppose is ironic, as it is a birth control drug). Bad bumpy face skin. Weight gain. Extreme cramps when coming off it. Very very hot at night when on it - which didn't bother me but boyfriend couldn't touch me!! I liked the idea of not having to remember taking a daily pill, I liked the idea of not having a period. In the end I hated both. I hated not having the control when I realised the side effects of it. The worse side effect was loss of libido. :-( I came off after only two shots (2 months) due to the wierd side effects. Still haven't got my period back after a further two months, but debilitating cramps since coming off it. NOT RECOMMENDED F 33 2 months
1X day
11/22/2010
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