PROLIA Reviews (DENOSUMAB)

Average Rating: 1.4 (290 Ratings)

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 Type: Biological Drug

  

PROLIA  (DENOSUMAB):  Denosumab is used to treat bone loss (osteoporosis) in women who are at high risk for bone fracture after menopause. It is also used to treat bone loss in men who are at high risk for bone fracture. Osteoporosis causes bones to become thinner and break more easily. Your chance of developing osteoporosis increases after menopause (in women), as you age, if someone in your family has osteoporosis, or if you take corticosteroid medications (such as prednisone) for long periods. Denosumab is also used to treat bone loss in women who are at high risk for bone fracture while receiving certain treatments for breast cancer. Denosumab is also used to treat bone loss in men who are at high risk of bone fracture while receiving certain treatments for prostate cancer that has not spread to other parts of the body. This medication works by slowing bone loss to help maintain strong bones and reduce the risk of broken bones (fractures). Denosumab belongs to a class of drugs called monoclonal antibodies. It prevents certain cells in the body (osteoclasts) from breaking down bone.   (Sources: U.S. Centers for Medicare Services, FDA) FDA Approval Date: 2010-06-01

  

Results are sorted by Date added.

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15


RATING  REASONSIDE EFFECTS FOR PROLIACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  Osteoporosis went to ER with 103 fever and UTI 3 days after injection Also felt achy. Now 3 weeks out and terrible pain in joints. Esp hip and knees F 60 3 weeks
1/6 mont 1X O
9/19/2026
 1  Osteoporosis I got the prolia shot about 2 weeks ago and 2 days. In I go t EXTREME pain in my right upper back and my upper right arm which is shooting down my arm into my hand. I lost usage of both hands. . I also have EXTREME pain in both knees. I can only walk a few feet then I. Have to sit. I'm EXHAUSTED AND Dizzy. This medication has made it so I can not function. I should file a law suit. IT IS POISON!!!! F 69 13 days
30mh 1X day
8/24/2025
Email
 1  osteoporosis swelling of mouth lining, eczema on the sides of my mouth, and eye lids, my immune system hyperactive and I developed reactions to ingredients in Dawn detergent, fragrances, shampoos, body and face creams, all makeup, etc. I think it is a crime that this is given to patients without some type of patch testing to see what my reaction will be. When I called my doctors to say I had developed these reactions, they dismissed until they looked at the side effects and I had almost EVERY SINGLE one F 73
1X day
6/27/2025
Email
 1  Osteoporosis Severe fatigue and increased depression Would not recommend as far more issues if stopped. F 74 3 years
60mh 2X AN
8/26/2024
 3  Osteoporosis My only complaint is fatigue and depression. Cannot blame depression on it but it certainly hasn't helped. Can stay in bed all day am so tired from lack of sleep Wish I never started it as have trouble taking biphosphanates due to Gerd. 74 3 years
60 4X day
8/21/2024
 1  Breast cancer and osteoporosis I'm no longer taking this medication. F 60
Shot 1X O
3/24/2024
Email

Patient History
 1  Osteoporosis I'm no longer taking this medication. I feel much better six months out from my injection and don't plan on taking another shot. If it turns out after a pet scan that I do have metastasis, I will probably do it because it's better than nothing. I still think that Proia kickstarted the return of two tumors in my breast which I had removed yesterday. Just glad the biggest part of it is over. F 71 180 days
1 shot 1X day
3/12/2024
Email

Patient History
 1  Osteoporosis I'm no longer taking this medication. Symptoms took 6 months to go away. F 74
60 mg 1X O
3/12/2024
Email

Patient History
 1  Osteopenia My immune system was compromised and caused my breast cancer to return within three months. Proof? Had a clear mammogram in April and now in November it had returned at the excision site. Large mass, almost 2 cm in three months. I am so angry. I am considering a lawsuit. If you are disease free from breast cancer, do not take this drug! It will compromise your immune system and cause your breast cancer to return in a matter of months. F 71 3 months
60mg 1X day
12/7/2023
Email
 1  Osteoporosis Left sciatic pain..let knee pain ..went to my orthopedic as thought my knee replacement of 9 years was loosening ..put on prednisone taper . Helped the knee and then just this past few days started with calves aching ..feel heavy...hard to bend ..squat ...very painful and feel more at risk to fall on this and break a bone ..won't be continuing...had anyone had any relief after a time ?? How long ?? Awful medication M 62 12 months
60mg 1X O
11/4/2023
 1  osteoperosis Extreme loss of faith in the US medical profession I actually was shocked to read the side effects of this poison. Go look at the Safety Information for it. Number 1 "side effect"? DEATH! Here's the link, read it for yourself. https://www.askapatient.com/adverse-events.asp?drug=PROLIA I am disgusted that any physician would offer this up to their patient! F 75 0 days
1X O
10/30/2023
Email
 1  Osteoporosis Bone and muscle pain. Ear ringing. Constipation. Neuro symptoms too numerous to mention. Rashes Should be a class action suit but Amgen took care Of that. Black box warning. It's poison. F 71 3 years
25 3X O
9/20/2023
 1  Osteoporosis Constipation and diarrhea, loss of taste and appetite, Gerd and IBS increased, muscle weakness, and itching. I agree that this drug is not good especially if you have other ailments. It also creates new ailments. F 65
Injection 1X O
8/30/2023
Patient History
 1  Osteoporosis I received my fourth polio shot 18 days ago. This time the symptoms are extreme. Muscle weakness, joint pain and fatigue. I went to the emergency room but they didn't find anything. I even went to a rheumatologist. He said my blood tests were normal and most likely my symptoms are from prolea and a drug for my breast cancer Exemestane . I am miserable. I pray that the symptoms will go away I can barely function. I am normally a tough patient but this drug has knocked me out of the ring. F 67 2 years
2X O
6/18/2023
 1  Bone density Upper thighs pain when walking . Need to sit. Tired. Unsteady Hate it F 68 1 years
1 jab 6 mt 2X O
4/29/2023
 1  osteoporosis first injection. hot flashes started within 8 hours, brutal! three days after injection, calcium dropped so low, I had tingling in my face, knew it was bad. Started taking massive doses of Calcium and tums trying to get it under control, reached out to the rheumatologist. 2 days later, Dr. told me to go to the ER, thought I was having a stroke which I clearly was not. she was no help at all. These symptoms continued for 2 weeks so I reached out to my Endo-oncologist at Moffitt and he ordered blood work. After that came back with calcium low(surprise!) he put me on Calcitriol for better vit D and calcium absorption, which seems to have done the trick, I repeat labs in a week. no thanks...not getting any more injections. Looking into other options. F 63 1 days
1X O
3/15/2023
 1  Very low bone density Pain in every joint. Rejection of Ear Implant due to bone not healing. Avascular Necrosis in both hips. Both hips replaced. Can't have dental work done. I am now 2months over due for my next injection have decided not to have anymore will take my chances. F 76 4 years
Every 6 mo 1X M
3/8/2023
 1  Have osteoporosis-3.2 T score About 4 days after first prolia shot had extreme tiredness. EXTREME. Then back and leg pain. Tiredness and back pain are better but leg pain is painful . It's been 6 weeks-when will I feel better? Can I stop after only one shot?? Please advise!! Doctor tries to say it's probably something else besides the prolia but what?? F 54 0 weeks
1X O
3/5/2023
Email
 5  Bone loss injection received 6 months ago on july 19th 2022. NO ISSUES Received 2nd injection January 23rd of 2023. NEVER EVER AGAIN!! muscle aches and pain,loss of strengh,ringing in ears,right knee popping,breathing worse than ever,stirred up arthritis,I totally reget getting this injection. It says to be brief just too much to mention about this poison!! Use to be active not anymore. F 69 6 months
2X AN
2/22/2023
Email
 1  bone loss Awfull pain and weekness in arms and legs with loss of strength,difficulty walking,can no longer ride my horse.I regret taking this drug,will never trust a doctor again. It should be taken of the market. F 69 2 years
60mg 4X AN
2/18/2023
  

PROLIA  (DENOSUMAB):  Denosumab is used to treat bone loss (osteoporosis) in women who are at high risk for bone fracture after menopause. It is also used to treat bone loss in men who are at high risk for bone fracture. Osteoporosis causes bones to become thinner and break more easily. Your chance of developing osteoporosis increases after menopause (in women), as you age, if someone in your family has osteoporosis, or if you take corticosteroid medications (such as prednisone) for long periods. Denosumab is also used to treat bone loss in women who are at high risk for bone fracture while receiving certain treatments for breast cancer. Denosumab is also used to treat bone loss in men who are at high risk of bone fracture while receiving certain treatments for prostate cancer that has not spread to other parts of the body. This medication works by slowing bone loss to help maintain strong bones and reduce the risk of broken bones (fractures). Denosumab belongs to a class of drugs called monoclonal antibodies. It prevents certain cells in the body (osteoclasts) from breaking down bone.   (Sources: U.S. Centers for Medicare Services, FDA) FDA Approval Date: 2010-06-01

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