FDA Adverse Events Reports (FAERS) Summary for PERIDEX

These tables and charts are based on 1,441 total reports for PERIDEX (CHLORHEXIDINE GLUCONATE) received by the FDA Adverse Event Reporting System (FAERS) from 2004 through July 30, 2026.

This FAERS total includes 1,330 pharmaceutical company-submitted and non-U.S. FAERS reports and 111 U.S. consumer or healthcare provider-submitted MedWatch reports. Adverse events listed on this page represent serious and sometimes rare adverse events reported to pharmaceutical companies, and often do not represent typical side effects for the medication. Find common side effects in the most recent official drug label.

For a separate summary of the 111 U.S. reports filed via the FDA MedWatch voluntary reporting system, view our FDA MedWatch PERIDEX summary report. (See notes section below for explanation of FDA’s mandatory and voluntary reporting system.)

Top 20 Adverse Effects Associated with PERIDEX (reported in FAERS Database)

	Side Effect	# of FDA Reports
1	FATIGUE	156
2	PAIN	151
3	DIARRHEA	142
4	NAUSEA	137
5	SHORTNESS OF BREATH	128
6	OSTEONECROSIS OF JAW	125
7	ANXIETY	120
8	PNEUMONIA	120
9	ANEMIA	113
10	FEVER	112
11	FALL	106
12	LACK OF STRENGTH AND ENERGY (ASTHENIA)	97
13	BACK PAIN	92
14	DEATH	92
15	BONE INFECTION	88
16	JOINT PAIN	81
17	HEADACHE	81
18	CONSTIPATION	80
19	INJURY	79
20	VOMITING	77
21	OSTEOARTHRITIS	76
22	ABDOMINAL PAIN	75
23	PAIN IN JAW	74
24	DIZZINESS	73
25	URINARY TRACT INFECTION	73
26	HIGH BLOOD PRESSURE	71
27	PAIN IN EXTREMITY	71
28	SPINAL OSTEOARTHRITIS	71
29	BONE DISORDER	69
30	LOW BLOOD PRESSURE	69
31	WEIGHT DECREASED	69
32	DIFFICULTY SWALLOWING	68
33	THROMBOCYTOPENIA	67
34	INSOMNIA	65
35	NUMBNESS	64
36	NEUROPATHY PERIPHERAL	63
37	COUGH	62
38	DEPRESSION	62
39	SEPSIS	61
40	METASTASES TO BONE	60
41	CELLULITIS	59
42	CHEST PAIN	58
43	GAIT DISTURBANCE	58
44	PLEURAL EFFUSION	57
45	KIDNEY FAILURE	57
46	ATELECTASIS	56
47	DECREASED APPETITE	55
48	DEHYDRATION	55
49	INFECTION	55
50	OFF LABEL USE	55
51	GASTROOESOPHAGEAL REFLUX DISEASE	53
52	EMOTIONAL DISTRESS	52
53	SWELLING OF LIMBS	52
54	ORAL PAIN	51
55	RESPIRATORY FAILURE	51
56	LOSS OF ALL PLEASURE	50
57	OSTEOPENIA	50
58	PANCYTOPENIA	50
59	INTERVERTEBRAL DISC PROTRUSION	49
60	SINUSITIS	49
61	LOW WHITE BLOOD CELL COUNTS	48
62	ATRIAL FIBRILLATION	46
63	EXPOSED BONE IN JAW	46
64	OSTEOSCLEROSIS	46
65	PINS AND NEEDLES	46
66	BONE LESION	45
67	CONFUSIONAL STATE	45
68	FEBRILE NEUTROPENIA	44
69	SWELLING	43
70	FAINTING	43
71	BONE PAIN	42
72	HYPOKALAEMIA	42
73	INTERVERTEBRAL DISC DEGENERATION	42
74	MUSCULOSKELETAL PAIN	42
75	DEEP VEIN THROMBOSIS	41
76	RAPID HEART RATE (TACHYCARDIA)	41
77	TOOTH LOSS	41
78	ACUTE KIDNEY INJURY	40
79	CONGESTIVE HEART FAILURE	40
80	IMPAIRED HEALING	40
81	STOMATITIS	40
82	DEFORMITY	39
83	OSTEOPOROSIS	39
84	RASH	39
85	BRONCHITIS	38
86	MUSCLE SPASMS	38
87	DENTAL CARIES	37
88	GENERAL PHYSICAL HEALTH DETERIORATION	37
89	OSTEOLYSIS	37
90	RIB FRACTURE	37
91	SKIN REDNESS	36
92	PULMONARY EMBOLISM	36
93	RENAL CYST	36
94	UPPER RESPIRATORY TRACT INFECTION	36
95	CATARACT	35
96	HAEMORRHOIDS	35
97	HYPERLIPIDAEMIA	35
98	MUSCLE PAIN	35
99	OSTEONECROSIS	35
100	ITCHING	35

Latest Known Outcomes for Reactions Reported for PERIDEX

	Latest Known Outcome for Reported Reactions	Number of Cases
1	Unknown Outcome	641
2	Patient recovered	422
3	Patient has not recovered/symtoms have not resolved	345
4	Patient is recovering/symptoms resolving	180
5	Patient died	177
6	Patient has recovered but has consequent health issues	20

Yearly FDA Adverse Event Reports (Table)

Year	Number of Reports
2003	1
2004	22
2005	19
2006	42
2007	31
2008	42
2009	43
2010	45
2011	57
2012	52
2013	41
2014	43
2015	79
2016	97
2017	83
2018	97
2019	92
2020	123
2021	118
2022	98
2023	67
2024	47
2025	65
2026	37

Reports by Patient Age Group (Table)

Age Group	Number of Reports
0-10	28
11-20	49
21-30	31
31-40	56
41-50	94
51-60	192
61-70	262
71-80	185
81-90	73
91+	13

Based on 983 reports that included a patient age.

PERIDEX Total Reports

Male	Female	Unknown	Total
603	734	104	1,441

Top Countries Reporting

	Country	Number of Reports
1	United States	1081
2	Canada	49
3	South Korea	14
4	United Kingdom	2

Outcomes for Reports

Serious: 1099
Not Serious: 341
Note: A serious outcome means the adverse event resulted in death, a life threatening condition, hospitalization, disability, congenital anomaly, or other serious condition.

Top Indications

Top Companies Reporting

Safety-Related FDA Updates

FDA Approval Date: 1986-08-13

For serious adverse events, report them to the FDA by contacting the drug manufacturer or report directly through the MedWatch voluntary reporting form.

Notes

Events listed on this page represent serious and often rare adverse events reported to pharmaceutical companies, and do not represent typical side effects for the medication. Find common side effects on the most recent official drug label This report, created by AskaPatient.com, is derived from the cases for PERIDEX reported to the United States Food and Drug Administration (FDA) FDA Safety Information and Adverse Event Reporting System (FAERS) and obtained from Open FDA. Data was last updated with reports received through July 30, 2026.

This summary includes ALL reports where the drug is a "primary OR secondary OR suspected interacting" drug. Typically, reports are filed for the most serious type or "event" and do not represent incidental or minor side effects. The majority of these reports are mandatory reports submitted by pharmaceutical companies, who receive complaints from consumers. The reactions, side effects, or "adverse events," represent up to the 20 most frequently occuring events in the database for a drug related to the event. This report also features counts of latest known outcomes associated with reported side effects, but does not provide the specific outcomes for specific adverse events.

Adverse Event Reports are submitted to the FAERS database by pharmaceutical companies (mandatory reporting is required by manufacturers, distributors, or importers). Health care providers such as doctors (voluntary reporting), and patients themselves (voluntary reporting) report to the FDA directly through the MedWatch program. Those MedWatch reports are coded and included in the FAERS database. This report mainly consists of the mandatory reports, because the MedWatch reports are a small percentage (3 - 5%) of total reports. Link to the MedWatch summary report at the top of the page for a summary of the directly reported (voluntary) adverse events for this drug.The number of reports included here might differ somewhat from the number of reports in the downloadable quarterly FAERS reports and in the online FAERS dashboard, due to lags in reporting, drug name differences, duplicates, and other factors. Open FDA states that it only includes the most recent version of a case report. It also adds the disclaimer: "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated."

FDA uses the "MedDRA" classification system to describe reported adverse reactions. MedDRA is a standardized medical terminology that facilitates sharing of regulatory information internationally. In some cases, "patient friendly" terms for the layman designated by MedDRA have been substituted for medical jargon. Please contact us with questions or comments about this report.