IMIPRAMINE HYDROCHLORIDE Reviews (IMIPRAMINE HYDROCHLORIDE)

Average Rating: 3.5 (106 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

IMIPRAMINE HCL  (IMIPRAMINE HYDROCHLORIDE):  This medication is used to treat depression. It is also used with other therapies for the treatment of nighttime bed-wetting (enuresis) in children. Using this medication to treat depression may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living. Imipramine can help your child control nighttime bed-wetting. Imipramine belongs to a class of medications called tricyclic antidepressants. It works by restoring the balance of certain natural substances (neurotransmitters such as norepinephrine) in the brain. For bed-wetting, this medication may work by blocking the effect of a certain natural substance (acetylcholine) on the bladder.   FDA Approval Date: 1990-06-05 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on IMIPRAMINE HYDROCHLORIDE: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR IMIPRAMINE HYDRCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  Depression So so so much sweating! I sweat when it's the dead of winter and freezing outside! Crazy side effect! It's helped a lot but I wish it didn't have excessive sweating as a side effect. I hope it goes away, it's awful. I sweat like I've spent hours at the gym, just going to the store for a brief period. F 32 4 months
100 mg 1X day
2/11/2022
 5  I was 15 yrs old 9th and 10th grade I was sleepy alot, but that was my norm, i love sleeping. Never really ate, I dont remeber dry mouth, great mood, mostly happy. I went from a F DC student to A B student. I took myself off becuase My Sifu said if I want it, then I will achieve it. So I achieved an extra belt in nun chunks in 1 months. I was proud. But then hello I started not paying attention, not reading and failing. I was not interested in the material. I just daydreaming . Now I need it for work. I cant even do my routine 2 days the same. Im inconsistent and I really try. I loved it. It does wonders if you truly can not concentrate and that is real dx you cant. F 38 18 months
30mg
10/21/2019
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 5  Anxiety in response to panic Side effects only in first few weeks. ( IBS symptoms on and off in first year or so. Back in 1969 I was given LSD and had panicked on the drug. It left shocked up and had depersonalization / derealization for several months. I was subject to return bouts every so many years and felt like I could not be free of the fear of the panic and depersonalization. Then in 1986 science finally caught up with me. Started Impramine in fall of 1986 and within 3 months was a different person. I had to work up to high dose of 300 mg. Changed my life... fear of return of anxiety disappeared. On it now for 32 years and doing great.. Gave me my life back. M 67 32 years
300
7/3/2018
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 5  Depression Dry mouth. I have to take Biotene to stop it Absolutely wonderful drug. I have been depressed all my life. Started on imipramine at 27. Always gave me big orgasms and all anxiety, social phobia went away. Weaned myself off and tried the new Ssri's. None of them worked. They stopped the depression but ALL caused insomnia and loss of libido, not to mention not being able to orgasm. SSRI's will kill you sleep and your sex life. I hate them. Doctors push for you to go on them but that's only because of the kickbacks they get. I will never take them again you may be less depressed but your relationship and sleep will suffer. Not worth it in my book. I went back onI imprimine at 55 and there was no weight gain, depression, and anxiety. I slept as soon as I hit the pillow. My sex life is wonderful and orgasms have returned normally with the added bonus of them being big. Lucky me😀 Take what works for you. F 58 30 years
150 1X day
2/20/2018
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 5  depression and anxiety Had brain fog, loss of motivation, anxiety, mild constipation, loss of memory but all these went away within the first week.dnt have any noticeable side effects now Had been on lexapro and sertraline before this. Lexapro did well but stops working every 2weeks. Since on imipramine i feel more positive emotions. I socialize more with friends. The drug has gradually improved my mood. Although I'm still hoping for more improvements since i ve taken it for just two weeks. I will recommend it for anyone. M 24 2 weeks
100MG
3/31/2017
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 5  Depression and anxiety Bit of constipation, postural hypotention, dry nose. Don't bother me By far the best AD I have been on. I went on everything in the late 80's through to the 90's. All the SSRIs, MAOIs and some anti psychotics. SSRIs take away anxiety but did nothing for mood and depression. Made me feel hostile sometimes and numb most of the time. I had far more side effects on the SSRIs The literature says that it is as effective for panic disorder as the SSRIs and slightly better for depression. New DRs tend to use newer drugs which is a mistake and maybe because of the marketing of the newer drugs. If you are getting a partial response, you might need to increase but persevere because I find that it is a subtle drug and might take a bit longer. Only one problem, I live in South Africa and in the last few years they only make the 10mg tablet. It is a hassle taking 15 pills at night :( M 48 20 years
150mg 1X day
5/23/2016
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 5  Depression/Social phobia/Pain/ADD Constipation, dry mouth, euphoria, weight loss (10 lbs), elation, drowsiness, dizziness, brain zaps, feeling stone (1 hour after taking it) I started imipramine 3 weeks ago and it's by far the best antidepressant. My mood lifted almost instantly and the anxiety and social anxiety are completely gone. It allows me to sleep and it increased my sleep quality. I wake up happy and have the motivation to do what I have to do. It helps with concentration and ADHD. I take in combination with Vyvanse 40 mg, Lamictal 100 mg and Wellbutrin 100 mg twice daily. My quality of life is much higher than with other antidepressants I tried in the past: prozac, zoloft, Effexor XR, Celexa, Lexapro, Cymbalta, trazodone, Elavil, Abilify, etc. and nothing is comparable with Imipramine beside Anafranil which is very effective but have more side effects. The side effects are mild and will stay on imipramine for the rest of my life. M 37 3 weeks
75 mg 1X day
5/6/2016
 5  over active bladder dry mouth,dizziness, M 33 7 days
50mg
3/26/2016
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 5  panic attacks/depression dry mouth and elevated pulse This wonder drug has made all the difference in my life. Began taking it for panic attacks and got immediate relief even though it was supposed to take time to start working. Didn't realize I had been depressed until it made me feel like a new person. About 8 years ago I tried weaning off but found that I needed 75 mg. to feel normal and have emotional buoyancy . So I quickly went back from 50 mg to 75. Over the last year I went from 75 mg down to 25 mg. Felt fine at 25 mg for two months. 25 mg is not supposed to be therapeutic but it IS for me and other people who have left comments! My doctor encouraged me to go off completely--probably because of the myth of 25 mg being nonclinical-- but the insomnia and ever decreasing energy is intolerable. My symptoms including the age of onset followed a grandfather's pattern to a T. Should have known that I needed to be on it for life. Am now looking for a new doctor. F 53 20 days
150 to 25 1X day
10/2/2014
 5  major depression, agoraphobia Dry mouth and eyes, constipation,weight gain. I have taken it for 29 years, but site was not allowing me to indicate that from "smartphone". I was housebound before I started it. I had drowsiness at first, (at a higher dose, 125 mg), but that went away. Craving for carbs also eventually went away. Since I went on imipramine, I have held down jobs, gone to school. I would never want to go back to the life I had before taking it. F 56 10 years
50 mg
9/15/2014
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 5  Insomnia, anxiety attacks I tried weaning myself off 8 weeks ago since I felt it had run its course. Within 3 days I developed tinnitus (ringing in ears) and IBS (irritable bowel syndrome). Two weeks later I was lethargic, emotional, irritable and mildly depressed. By week 5 I had actually resolved the insomnia on my own but my stomach started getting worse and worse each day. I thought I had a urinary tract infection. I was bloated, constipated, emotional, lethargic, and mildly depressed. I continued to cut the dosage. Even consulted an herbalist and became a vegetarian. I finally got an emergency appointment with my doctor today, begging for a colonoscopy. Unfortunately, as I suspected, she told me to go back on the imipramine and that once I was back to 100 mg all of these physical symptoms would be reversed. Bottom line: as much as I hate being on something like this and I feel it may be toxic in the long term, I can't live with these side effects, or apparenly, without the imipramine. My doctor explained that I will probaby be on it for the rest of my life. I am ambivalent about this diagnosis, since I feel my anxiety and insomnia issues have been resolved, however, my quality of life over the past 8 weeks of going from 100 mg to 25 mg has been horrendous. Just my two cents... F 52 20 years
100 mg 1X day
6/27/2013
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 5  Major Depression and ADD Dry mouth, Strange taste on mouth, more willingness to smoking, episodic memory fog and muscle weakness. Great drug. It helped me with the depression and the excessive sleeping. My concentration is a little better, but I still need to take ritalin together to treat ADD. The muscle weakness, fogged episodic memory and loss of libido helps me to relax. M 21 4 months
75mg 1X day
1/29/2012
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 5  SEVERE LEG PAIN FROM NERVE IN BACK THIS MEDICINE STOPS THE PAIN CYCLE OF LEG NERVE PAIN & EVENTUALLY EASES SHARP PAIN DURING THE DAY. IT ACTUALLY SAVED MY LIFE BECAUSE THE PAIN WAS SO SEVERE. A DOCTOR IN LAS VEGAS PUT ME ON IMPARMINE I HAVE A LITTLE PAIN BUT NOT SERIOUS LIKE BEFORE I CAN FUNCTION ALL DAY WITH OUT MUCH TROUBLE THE MEDICINE LELAXES THE LEGS & STOPS THE PAIN NIGHTLY I WOULD RECOMEND ANYONE SUFFERING FROM SEVERE NERVE PAIN IN THE LEGS DUE TO A BACK INJURY BE PUT ON THIS MEDICINE IT IS VERY VAULABLE TO STOP THE PAIN CYCLE & FUNCTION THE NEXT DAY F 69 10 years
50 1X day
6/4/2011
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 5  Major Depression/Anxiety dry mouth, low-to-no libido, insane sweet tooth, excessive sweating in summer, Had terrible anxiety/panic attacks and depression for 8 months after my daughter was born. A GP had prescribed Elavil and Xanax, but that put me into a drug induced fog. I stopped the Elavil but continued the Xanax. Another GP told me to stop the Xanax, so I tried to do so but was unable to. I then got brave enough to see a psychiatrist who put me on Imipramine (25mg/day) and weened me off the Xanax. He gradually increased the dosage. It took about 10 weeks, but all of a sudden the black cloud lifted. Since then, i've been at a 250mg maintenance dose. About 13 years ago, my doctor tried switching me to Prozac. I gradually stopped he Imipramine while taking 20mg/day of Prozac. Once the Imipramine was stopped altogether, I felt like I couldn't sleep and had awful dreams that I would think about all day until I had new ones the following night. I spiraled back down very quickly. My doctor stopped the Prozac and put me back on Imipramine and ramped me up to 300mg/day. it took me about 10 months to get back to "normal". Imipramine is a miracle for me and well worth the side effects. M 54 27 years
250mg 1X day
1/20/2011
 5  Depression Taken for 20 years F 70 20 years
25mg 1X day
11/28/2010
 5  Migraines None Helps control vascular headaches. Reduced occurrences of headaches from one per week to less than three per year. I periodically try to reduce dosage to 50 mg per day, but eventually the headaches begin to return. 75 mg per day dosage controls the headaches without additional medication. M 66 24 years
25 mg 3X day
4/13/2010
 5  Major Depression/Anxiety Dry Mouth, Weight gain, Head rush when standing up quickly, Constipation. This drug has helped me to have quality of life. I first took it when I was 23 for Major depression and Anxiety. The weight gain and Dry mouth are the worst side effects, however I tried taking Zoloft and Prozac. Zoloft helped but not like this drug, and while taking Zoloft I experienced sexual dysfunction. Prozac gave me the worst headaches. I was able to be drug free for about six years and then had a relapse, so I started taking it again. Hope this helps someone who's looking for some direction. God Bless M 49 22 years
12/26/2009
 5  eurinesis initially; mood disorder dry mouth My son has been taking this for 9 years since age 7. Initially he took it for bed-wetting but when I tried to wean him off, his previous "melt-downs" returned. I had thought this was a stage he was outgrowing. He had intensive implosive melt-downs prior to going on this drug. I realized that it was the same drug that cured my father from debilitating long-term depression and put two and two together. At age 11, my son stopped taking it cold-turkey without my knowledge. He suffered two days of nighttime hallucinations--very scary stuff. After that, he toyed with going off it again in middle school but decided that the anxiety he felt without it was worse than taking the drug. He only has dry mouth as a side effect. He has a really high iq and tests in the 99th percentile so I guess it didn't hurt his brain development. He does have a small stature and is skinny. I don't know if the medicine stunted his growth in any way. I would be interested in any comments from other long-term youth users of this drug to see if they had normal growth. He is 5 ft 8 inches which is a lot smaller than my husband and my brothers. M 16 9 years
5/31/2009
 5  Panic Attacks/Agoraphobia Dry Mouth, Constipation, hand tremors, weight gain, sleepiness, irregular heartbeat. Side effects stayed with me the entire time I was on drug. After suffering with totally dibilitating and constant panic attacks and agoraphobia for several years, imipramine incredibly helped to a point I could get out of the house and work again. But, after 5 years I had a life threatening cardiac reaction and was immediately taken off of it, leaving me totally dibilitated again. Nothing since has helped like this drug did. Too bad it had the side effects it had. F 32 5 years
1/28/2009
 5  Panic Disorder Dry mouth I was having severe panic attacks and this medication saved my life. It worked very well for me. I took it for about 3 years after my divorce. Since then I only need it when in a very stressful situation. F 61 25 years
12/9/2008
  

IMIPRAMINE HCL  (IMIPRAMINE HYDROCHLORIDE):  This medication is used to treat depression. It is also used with other therapies for the treatment of nighttime bed-wetting (enuresis) in children. Using this medication to treat depression may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living. Imipramine can help your child control nighttime bed-wetting. Imipramine belongs to a class of medications called tricyclic antidepressants. It works by restoring the balance of certain natural substances (neurotransmitters such as norepinephrine) in the brain. For bed-wetting, this medication may work by blocking the effect of a certain natural substance (acetylcholine) on the bladder.   FDA Approval Date: 1990-06-05 (Sources: U.S. Centers for Medicare Services, FDA)

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