BENADRYL Reviews (DIPHENHYDRAMINE HYDROCHLORIDE)

Average Rating: 2.9 (608 Ratings)

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More on BENADRYL: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR BENADRYLCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Hay fever, allergies Urinary retention. M 51 3 days
25mg 1X day
11/26/2022
 1  Sleep aide If I would have known the side effects and difficulty I’m having getting off 12.5 mg of Benydryl I would never have taken it to sleep 15 years ago, I’ve always taken as directed and never more then the OTC drug suggested. I bought the baby liquid so I could titrate off this medication and it’s been 8 months now and I finally stopped last week. During this time horrendous side affects: altered mood and sleep schedule, anxiety and agitation, extreme fatigue and inability to sleep. Abnormal head ache, severe sinus inflammation, hallucinations in light sleep, easily startled, racing heart, sweating and chills, nausea, constipation, feelings of inertia and that I want to die. Leg, back, neck soreness and pain, tinnitus and apathy. I have fought with these feelings for months now and always end up going back to the 25 mg to feel better. Not this time because the liquid child titration has taken some of the edge off quitting this drug. I will never take this drug again unles I never abused this drug and my doctors knew I was taking it. 15 years ago the OTC dosage was 37.5 mg of Diphenhydramine per pill. Directions take 2 pills as needed. I only took 2 pills at night to sleep. It worked. Sometimes it wouldn’t be as affective so I would skip a night or two with restless sleep and then start over on a full dose. When the drug companies lowered the mg to 25 mg per pill I didn’t have any adverse affects and continued to use as directed for sleep. 4 years ago the literature on dementia and Alzheimer’s and the use of diphenhydramine were published and I stopped taking Benydryl. Unfortunately 3 days later the withdrawal symptoms were so awful I steered back up again and decided, with assistance from my doctor to titrate down. It’s been 4 years to titrate from 50 mg to 12.5 and finally stopping last week. I have no idea how long this weird fugue like state is going to last or this strange heart palpitations or paranoia or achy all over malaise will last. I know if I took one 25 mg tablet all those symptoms would go away and I’d get a great night sleep. But I’m not going there and I’m determined after 4 years to get the hell off this drug! I have realized some positives - my thinking is clearer and I’m remembering more and I’m urinating more and not feeling so dry. Also when I do sleep sans the Benydryl it’s a deeper and more restorative sleep. I’ve been getting exercise and meditating and n F 65 15 years
25 1X day
10/30/2022
 1  Suggested at emergency care Made breathing worse. Went back to emergency care center was told I am allergic to the dye in the Pink Benadryl to stay far away from Benadryl I will never use this again..not even the dye free one I have been given a breathing treatment via Nebulizer and it's not working - have to return to emergency care today Stay far away from it :( F 48 7 days
2 per nigh 1X day
6/2/2022
 1  Allergic reaction Horrible restless legs type symptoms that made me have suicidal ideations. I was so tired and half asleep, felt drunk, but couldn't sleep because of the "twitching," as I call it. All antihistamines and muscle relaxers have the same effect on me. F 29 1 times
50 mg 1X O
1/1/2022
Email
 1  Runny Nose/Congestion from cold Jitteriness, restlessness/fidgety, numbness on skin, insomnia, increased heart rate, chest tightness, anxiety, panic attacks Advised to take Benadryl for post nasal drip from a bad cold. Immediately I felt my mood change and became jittery, restless, anxious, panicky, and could not sleep. I felt jacked up - like I had taken a stimulant. I could not feel anything on my skin. Awful experience for me. Everyone's reaction is different. F 57 2 days
50 mg 4X day
8/21/2021
 1  allergies pounding heart, racing heart, insomnia ***PLEASE READ IF YOU ARE EXPERIENCING HEART PALPITATIONS ATER TAKING BENADRYL*** If you have had heart palpitations for more than a week you need to see a doctor and talk to them about the possibility that it gave you Atrial Fibrillation. People who have these reactions often had unknown heart problems already and the diphenhydramine exacerbated those to become something worse. Atrial Fibrillation is not in itself deadly but it is serious. You are 5 times more likely to have a blood clot form due to blood pooling in your heart, and twice as likely to have a stroke than the average person. PLEASE go talk to a doctor about this if you are able! M 30 7 days
25 1X day
4/6/2021
 1  seasonal allergies Panic, cold chills, pounding heart, inability to sleep. My heart has been pounding since a week ago when I stopped taking this, its making it so difficult to sleep. I'm exhausted. I would really like to hear peoples experiences with how long it took to return to normal, I can't find any extensive information online about this. M 31 6 days
25mg 1X day
3/19/2021
Email
 1  Hay fever Heart pounding, cold chills, anxiety, panic I've taken benadryl in the past once or twice with no problems, but this was the first week I took it consistently each night. TERRIBLE mistake on my part. I had between 25mg and 50mg each night, spaced out between use in the case of 50mg. (25mg once, then another 25mg four hours after) 24 hours after taking it I am still experiencing pounding heart that is causing me to be unable to sleep. I would recommend it for emergency use, or occasional use, but be very careful taking it multiple days in a row. I spent days wondering if I should see a doctor for my heart problem, only now realizing the benadryl was the culprit. I'm really hoping its out of my system soon! M 30 5 days
25mg 1X day
3/14/2021
 1  Sinus pressure I used to be able to take this and have no problem . The past 2 days I have had bad sinus pressure and the first night I took benadryl I just felt a little sleep the next day . Day 2 completely different. I feel very weak, fast heart rate, feels like the room is spinning . I feel like I am not in my own body . Well I won't be taking this anymore . I will find something different . F 38 2 days
25 1X day
2/4/2021
 1  Allergy I took this before bed and had nightmares, woke up sweating, very tired, very angry, irritated, it amped my ocd and anxiety... I since threw it out! This has happened before and I should've known not to take it... I can usually be okay after one night and then if I take it longer I get irritated, but this time really bad today! F 34 1 days
25 mg 1X day
12/5/2020
 1  Had an allergic reaction to an anti I take 2 anti depressants and valium together and they knew this and decided to still give me 3 rounds of benadryl and send me home. And my nose is now currently so numb and my face is becoming numb from the interaction with my meds. Don't care what the doctors say you damn well knew my psych doctor was in the f*ing hospital and the least bit you could have done is called and asked their opinion so now im stuck with this. Ive been sick for 15 damn days and i just want someone to actually pay attention to me and realize i have bacterial strep and quit acting stupid. You sent me home after a deadly concoction of meds. I could have died. My heart raced. I lost all functions. I couldn't walk, talk, or anything... I was a damn noodle. Be weary of things like this.. F 25 1 times
10 mg 1X O
10/8/2020
Email
 1  Hives Extreme drowsiness, weakness, severe body tingling I don't want to take this drug anymore. I couldn't sleep for nights because of the tingling pain, especially from my lower back to my lower extremeties. F 22 2 days
50mg 3X O
9/26/2020
 1  To sleep I've had anxiety and was desperate to sleep and took 2 Benadryl the first night, one the next. I was in and out of sleep all night. If I dosed off, I'd startle awake with my heart pounding, not racing, pounding. I also had these weird shaky movements, thought if I went to sleep I'd die. My last dose was earlier, today, because I didn't realize it was the Benadryl causing all of the symptoms. So, now I get to have crazy tremors and anxiety and a racing heart until it wears off. F 49 2 days
25 to 50 3X day
8/4/2020
 1  Allergies, sleep Had the scariest results from taking it. Took it when I was younger no problem. Took it now, it made me super drowsy, Paranoid, severe anxiety, irritable, aggressive and depressed. I had muscle spasms at night, insomnia and every time I slept it felt like i was falling. Then I would wake right back up. It was so scary. Its day 4 after taking it and still having some anxiety and mild drowsiness. Would not recommend, try other meds for allergies and melatonin for sleep. F 27 1 days
25mg
5/8/2020
 1  Allergic reaction to mosquito bites About an hour after I took it I felt like I had just smoked pot (without the munchies). It was awful. It was like I was dreaming while awake. This has happened to me the last 2 times that I took it. I hadn't taken it in years so not sure how it made me feel in the past. The 1st time this happened I had one vodka and soda before taking 2 Benadryl (50 mg total). So I thought that the reaction was due to an alcohol-drug interaction. The second time I only took 25 mg and no alcohol and drank a lot of water and I had the same reaction but I actually think it was worse the second time. I will never take Benadryl again. F 57 1 days
25 MG 1X day
7/30/2018
Email
 1  Seasonal allergies Insomnia,groggy, aniexty,mood swings and dizzy Lightheaded It worked for my allergies,but this morning felt all type of bad side effects... M 35 1 times
25mg
2/24/2017
 1  Counteract effect of headache drug Side effect - loss of taste - 49 days and counting: I was given this one-time injection to counteract the side effect of another medication. I was told that a bitter or metallic taste might be felt. That effect occurred immediately. To date, it has never subsided. Everything tastes bitter and strange! I had no idea that this taste side-effect might be permanent! I'm wondering if anyone else has experienced this and if it has ever abated for them. M 62 1 times
1X O
11/7/2016
Email
 1  insomnia made me nervous, and gave me the jitters I tried this to help with insomnia, but it made it worse. F 53 1 days
1X day
10/30/2016
 1  to sleep. I am 77, and took Benadryl for sleep. It has made my short term memory much worse, I have an essential tremor, and it has become worse also. I am amazed that there are no warnings on the bottle about memory loss in elderly! You can find the info on the internet, F 77 2 days
5 mg 1X day
7/23/2016
 1  Sleep aid Holy hell I cannot sleep. Loaded up after a 16 hour shift at work to pass out. Slept for about 30 minutes now I have an urge to move all over constantly. Can't sit still for more than 3 minutes. Itchy randomly. M 20 1 days
150
6/23/2016

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