SAVELLA Reviews (MILNACIPRAN HYDROCHLORIDE)

Average Rating: 3.0 (158 Ratings)

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 NOREPINEPHRINE REUPTAKE INHIBITORS

 Type: Rx Drug

  

SAVELLA  (MILNACIPRAN HYDROCHLORIDE):  Milnacipran is used to treat pain caused by a condition called fibromyalgia that affects the muscles, tendons, ligaments, and supporting tissues. This medication is a serotonin-norepinephrine reuptake inhibitor (SNRI) that works by helping to restore the balance of certain natural substances in the brain (neurotransmitters).   FDA Approval Date: 2009-01-14 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Satisfaction lowest to highest.

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR SAVELLACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Fibromyalgia After titration period no side effects. Seemed to help with energy a few days then it no longer helped. Dr put me on 100 mg tablets twice a day instead of 50. Still hasn't helped and no pain relief the whole time. Now to come off of it! Had fibro for 30 years. No drug approved for fibro has helped. Only tramadol for pain was great. They no longer want to be humane and give pain meds when needed. F 55 0 years
100 mg 2X day
8/1/2023
 1  Fibromyalgia After titration period no side effects. Seemed to help with energy a few days then it no longer helped. Dr put me on 100 mg tablets twice a day instead of 50. Still hasn't helped and no pain relief the whole time. Now to come off of it! Had fibro for 30 years. No drug approved for fibro has helped. Only tramadol for pain was great. They no longer want to be humane and give pain meds when needed. F 55 1 years
100 mg 2X day
8/1/2023
 1  fibromyalgia tachacardia severe, chronic diarrhea, . headache every day with flushing and hot flashes,breathlessness constantly during slightest exertion..scalp itching and loss and thining of hair by handfuls. paired with brilinta (60 mg. twice a day) the breathlessness was unbearable..not worth the side effects for me...not one drug I have taken has helped with 30 years of fibromyalgia F 80 21 days
50 mg 2X day
6/16/2021
 1  Fibromyalgia Tachycardia, pounding heart, high blood pressure, several trips to ER due to racing heart. Went to cardiologist, decided to taper off medication, getting Echocardiogram in 2 weeks to see if I have permanent heart damage, caused high calcium levels and high d-dimer level. Never again..I want to live.. F 48 8 months
50mg
6/17/2020
 1  Fibro Profound and incapacitating memory loss that occurred gradually over time. Got so bad I could not remember how to run my coffee maker. MD thought I had Lewy bodies but mercifully the MRI was fine. Dangerous medication with memory issues during the drug trials but somehow still got through the FDA. F 61 2 years
6/4/2020
 1  Fibromyalgia Vivid dreams, confusion, and suicide thoughts F 47 2 days
12.5
2/19/2020
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 1  Chronic Pain Hot flashes, sweating, terrible urinary problems (felt like I had a constant kidney infection at 100 mg) lessened when dose decreased but still caused irritation and frequent urination. Horrific withdrawal I thought I had found the answer the first couple months and had my life back. My pain was 90% gone. I could deal with the sweating and hot flashes but the urinary problems were too much, I was in the bathroom at work every five minutes. Stopping this drug was the worst nightmare I've ever had, and I've tried lots of meds. Took six months to get off and still don't feel normal and have strange brain zaps sometimes. F 34 1 years
100
2/28/2017
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 1  Fibromyalgia management Blurry vision, dilated eyes, headaches, dizziness, nausea I was taking 50mg twice a day but reduced to just once a day in hopes side effects would reduce. They have not. I have no reduced to 25mg once a day and I am having withdrawal episodes from lowering my dose. F 21 7 weeks
50
11/25/2016
 1   Help with stiffness.but the pain got worse and I started to get shortness of breath weakness my left arm and the left side of my back hurts me so much had to stop it but the weakness and shortness of breath is still bothering me!!!!! M 38 1 days
200mg
8/12/2016
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 1  fibromyalgia Extreme headaches, blurry vision, excessive sweating to the point I was soaked during night in bed and during day. Memory gets fuzzy and all I have wanted to do is cry, which is not like me. I also feel like my insides are quivering all the time and when I go to bed I cannot get my body to relax.. I hope that some people did not have these reactions and maybe it will help them, but I cannot keep taking it and feeling this way. F 60 2 months
50mg 2X day
7/14/2016
 1  pain non fibromyalgia Panic attacks, memory loss, red blood count low requiring transfusions, anger, no desire to do anything, inability to think or comprehend at an advanced level He is post doc educated and could not read or converse at a high school level. He was scared all the time and would lash out irrationally. He didn't remember what he said or saw hours even minutes sometimes later. M 55 6 years
50 MG
5/11/2016
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 1  Fibromyalgia Great at first, other than severe sweating. The third month, ER visit with racing heart and really high blood pressure. Another ER visit for the same thing. Now, at month six, off Savella, my blood pressure still high and taking blood pressure meds. Still have racing heart and sweats. Before Savella, blood pressure was below normal to normal. I'm worried this is a permanent injury to my system, now. It works for the pain, but dying from a stroke or heart attack isn't worth it. F 49 6 months
50 MG 1X day
12/14/2015
 1  Fibromyalgia Nausea, vomiting, severe stomach pain, diarrhea, gas, bloating, headaches, anger, irritable, no appetite, weight loss This medication is awful. I started on the sample pack from the doctor's office. My symptoms began the day I took the 50 mg dose. Severe vomiting and diarrhea. My doctor told me to wean off the drug. I took my last dose of 12.5 mg yesterday. I will NEVER take this medicine again. I would rather suffer daily flares then swallow a Savella pill. Dangerous drug! F 43 2 months
25 mg 1X day
4/16/2014
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 1  Fibro & CFS Severe memory loss, 3 times I was driving down the road and had no clue where I was, who I was or where I was going. And I had my 6 kids in the van with me. Very Scary! I still have memory problems today. Other problem, tingly scalp, nausea, cramping, hot flashes, increased heart rate and blood pressure. I had really bad mood swings, went off on my children for no reason. I felt jittery, had my 1 and only ever panic attack on this medicine. Helped with my pain a bunch. Normal pain level a 12 on a 1-10 scale. While on meds I would say a 3-4. I felt like I had energy again, but. The side effects were WAY too BAD! F 34 2 months
50 mg 2X day
7/27/2013
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 1  Fibromyalgia I had the worst case of constant sweating & at night soaking my Bed. The only reason I took Savella was because it is an approved Fibromyalgia Drug. - I am already taking Lyrica, which took a while to find the right dose, so that I no longer wake up in the morning and my hands and feet do not work (As though I have severe Arthritis in my extremities). I started feeling well on the 1st dosage of 50mg 2xday, but kept going higher until I was at 200mg 2xday, which gave me no more relief and caused weird side effects, so I stopped taking it, only to find out that I really needed it. I now take 100 mg 2 x day and it works great with no side effects. - 3rd drug is Cymbalta, of which I am in need of to stop Depression and some pain. - Summary; Savella may work for some, but the side effects outweighed the Pro's for me taking this drug (of which I feel more than likely works for many others). I however, take Lyrica & Cymbalta to function & continue working. I have found through my very rare Family Doctor who specializes in Fibromyalgia (Dr Janet Ciarkowski) the exact comination of medication that works for me. M 46 2 weeks
20? 2X day
3/24/2013
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 1  Fibromyalgia Panic, personality change, forgetfulness, burst of anger, literally craziness, racing heart I was put on this to help with my numbness and tingling. It was a horrible mistake. I have been on medicines throughout my life and never felt the way I did. I forgot where I was driving (with kids in the car), blew up on my son who did nothing wrong, cried and was sick. It was horrible. My heart was racing, I was clammy and just couldn't function. I almost went to the er. It is most likely my inability to handle too much serotonin, or whichever it is, but yikes! F 28 6 days
30 1X day
11/19/2012
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 1  Chronic migraines Sweat like a stuck pig, head felt like it was on fire. Dreams were awesome though. Had to quit after 7 days. M 50 7 days
5 2X day
8/23/2012
 1  Back Pain Heart Pounding,High Blood Pressure,Extreme Nausea,Vomiting,Stomache Pain, Irritable, Hot Flashes, Sweating Worst Medicine Ive Ever Taken!!!!! F 18 1 days
50MG 2X day
7/12/2012
 1  Bipolar/chronic pain Wow so taking this medicine was one of the weirdest experiences I've ever had. At first I was incredibly nauseous and felt like I had to burp or I'd throw up. Then I got incredibly irritated. I just wanted to bitch to everyone about how I felt cause honest I felt sick at first. Not to mention my body was so hot. Then I felt so wide awake and couldn't stop laughing uncontrollably. Literally, I couldn't stop laughing and nothing was funny. I had to actually try not to laugh. During this time I had so much energy I was debating doing a workout video. lol Finally the laughing wore off but was still wide awake. I dont know what the hell my doctor was thinking putting me on this medicine. Its stupid. I was supposed to take this medicine twice a day. Basically if I did I'd be a nutcase that couldn't function. This was terrible for me and did not react will to my mental disease. Made me incredibly manic so I couldn't sleep. Finally I surrendered and had to take my saphris. Seriously what a weird night. F 23 1 days
50 2X day
5/17/2012
Email
 1  Fibromyalgia I became extremely agitated, irritable,and suffered with a severe headache with my blood pressure up on the second day of taking to 170/130 with my heart rate at 120's. I felt like my head was going to explode. I went to the ER immediately and was diagnosed with Seritonin Syndrome, which is life threatening. I was told by the ER doctor to never take this drug again and that she has seen this syndrome with serval other patients recently. This drug is new and not widely researched. When combined with other types of SSRIs it can cause serious, sometime irreversable effects. There needs to be more studies on this drug. MD's need to have more information regarding interactions of this drug with other drugs one may be taking. IF ANYONE is on this drug, please monitor your blood pressure and heart rate especially with any dose changes. F 40 2 days
12.5mg 1X day
2/4/2012
  

SAVELLA  (MILNACIPRAN HYDROCHLORIDE):  Milnacipran is used to treat pain caused by a condition called fibromyalgia that affects the muscles, tendons, ligaments, and supporting tissues. This medication is a serotonin-norepinephrine reuptake inhibitor (SNRI) that works by helping to restore the balance of certain natural substances in the brain (neurotransmitters).   FDA Approval Date: 2009-01-14 (Sources: U.S. Centers for Medicare Services, FDA)

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