EXCEDRIN (MIGRAINE) Reviews (ACETAMINOPHEN; ASPIRIN; CAFFEINE)

Average Rating: 2.9 (500 Ratings)

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 ANALGESICS-NON-NARCOTIC

 Type: Over-the-counter Drug

  

Results are sorted by length of time drug was taken from shortest to longest duration (reviews with no time reported listed first).

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on EXCEDRIN (MIGRAINE): Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR EXCEDRIN (MIGRACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  migraine headache I was nervous and anxious, due to the 150 mg. of caffeine for 2 tablets. It did not help my headache, advil does a better job. The anxiety was worse than the headache. F 39 1 days
8/16/2004
 2  Full on Migraine No side effects. This was my first time taking this drug. A friend of mine had said it was awesome for migraines so I thought I'd try it. My full on migraine dimished slightly, but I had to use cold packs on my head the whole time just to get relief. Less than 5 hours later, the migraine was back with a vengence. The pharmacist recommended the combination of Extra-strength Tylenol and regular strength Motrin. One of each (or two if migraine is full on) taken together works great for me. I take with milk to avoid stomach upset. F 37 1 days
4/15/2007
 2  Migraine Had taken a Max-Alt, bug the headache came back 5 hours later, and didn't have any more on me. Took EM on a full stomach. Horrid stomach pain. Started with gas, so took some Gas-x (okayed this with pharmacist), but my stomach still feels like death. F 30 1 days
5/28/2013
 2  for a headache The worst stomach pain ever. The pain started about 3 hours after taking Excedrin, and writing 7 hours after, the pain is getting worse, not better. What do people take for excedrin- caused stomach pains???? I will never take this again. I don't care how bad my headache is. Being doubled up for hour after hour is not worth it. If this lasts much longer I am going to the emergency room. F 46 1 days
6/7/2008
 2  Chronic migraines I have been taking this occasionally for years as an alternative to my prescription imitrex which usually works great but after a week of migraines I have rebound headaches just from the imitrex so I have to use something else. Normally I am just a bit jittery but this time I had upset stomach and diarrhea. Definitely not worth it since it barely helps the pain. Would rather take a legit painkiller like Vicodin or something that doesn't cause this reaction. F 28 1 days
2 caps
7/3/2013
 2  headache nausea, dizziness, sleepy but wired, abdominal cramping, weakness, shortness of breath i feel like im coming down with the stomach flu. ive been researching remedies to ease flu symptoms all morning and i remembered i took 2 excedrin migraines this morning because id had a headache all night that seemed to be only getting worse. I DO have a slight sensitivity to caffeine sometimes so i was ready for any slight on set of being jittery. but, this is rediculous. now not only is my headache just dull and annoying but i feel like im going to throw up and i am extremely weak. just like the flu. i dont think ill turn to this medicine anymore, just as i havent for this exact precaution ;( F 22 1 days
2 pills 1X AN
11/12/2010
 2  to treat a minor headache i will take excedrin every now and then when i have a headache. The last 2 times have resulted in panic attacks. One was on an airplane, and was one of the worst experiences of my life. The second one, last night was what led me to tie the panic attacks to using Excedrin. Both times it was taken at night, side effects include nausea, high blood pressure, rapid heart rate, sweating, loss of pigmentation in my face, tingling & numbness in my hands and arms, dizziness. Both times i felt that i was on the edge of vomiting and passing out. The first time, i thought i was dying, and i was on a red-eye across the country, with 3 hours left. Not a great place to have one. It killed my headache in both cases. Now knowing this, i will no longer use Excedrin. They might want to put a warning for the panic attack on the label and recommend that you don't take it again if that occurs. I really had no idea it was caused by Excedrin until my doctor told me about all the caffeine in the drug. M 28 1 days
200MG 1X day
3/30/2010
Email
 2  migraine I started with heart palpations, shakey feeling and then the worst cramping and diahrea ever.... F 37 1 days
2 tabs 1X day
5/26/2010
 2  Migraine I've taken this drug a lot to help me with migraines. Sometimes when I take it I feel extreme anxiety and i get panic attacks. My stomach gets queasy and I usually get diarrhea. If you have to take this pill as a last resort I recommend only taking 1 and NEVER take it before you go to sleep. I did that once and I woke up with the worst nausea and stomach pains i've ever had. F 16 1 days
9/5/2014
 2  Headache I think my husband had an allergic reaction to excedrin migraine. Last night, he took one for the first time to combat a headache. About an hour passed and he started getting extremely lightheaded and confused. Blood pressure was fine but breathing slowed and lightheadedness worsened. He sat down saying his body felt weird and he felt like he was anxious. Thinking that it was a possibility he may be allergic, I gave him one benadryl capsule. After benadryl began to work, he started getting back to his old self again. My experiences have been fine with excedrin; however, I can only take one instead of two or else I get very jittery. M 36 1 days
1X day
12/22/2014
Email
 2  migraine The same thing is happening to me as described by the gentlemen of 56 yrs. I am lying in bed feeling horrible but very anxious. My bp is 160/90. How did it get so high after taking those pills? Is it the caffeine? The product took away pain and migraine but after the side effects are increased bp shortness of breath heaving nausea anxiety nervousness racing thoughts. Weird feeling. Don't think I can take it anymore. F 36 1 days
2 pills
3/23/2015
Email
 2  severe migraines It took about an hour to start relieving my migraine. Then I became very dizzy and light headed. Then came the chest and neck pains, which spread to my left arm. I kept waking up during the night and was extremely hyper. In the morning I had stomach and kidney pain that was so severe I could not walk. Then I had trouble breathing. I would not recommend this drug..EVER! F 29 1 days
2 tablets
6/11/2014
Email
 2  migraine I took 2 pills of excedrin and my migraine went away slightly. My head still hurts every time I go in a room with light or when look down. M 1 days
9/12/2014
 2  Had a headache for 3 days I knew that the pills had 65 mg of caffeine in them so I wasn't worried about getting hyper anything like that. I was prepared. I took one and 2 hours later I started getting chills, blacking out, my legs were weak, I got a fever of 102.5 and I was really tired. I thought I had food poisoning. The worst part was it felt like my nervous system was attacking me. It felt like I had severe sharp pains all over my body, I could barely walk. today is the next day and my headache is incredibly worse than yesterday. And my fever is 101. I'm supposed to work all day today and now I can't. I would not recommend anybody taking thiS. I gave it A 2 rating because it did take away my headache. But not worth it with all the other side effects. F 30 1 days
1 pill
1/16/2014
 2  Headache Not long after I took the prescribed amount, my stomach starting cramping, my chest started hurting, and I started to feel nauseous. I actually threw up not long after taking it. I started having diarrhea and it was liquidly green. I would not advise taking this. F 38 1 days
2 tablets 1X day
7/10/2017
Email
 2  Had a headache or a mild migraine Nausea (in waves), bloating, stomach churning, hot feeling in stomach, laxative effect, diuretic effect, anxiety Had a moderate headache and took an Excedrin so I could enjoy my night off. I am glad I did not take 2 pills as directed! Apparently I cannot tolerate it. I took this 3 hours ago and my stomach and bowels still feel like a rolling, stormy sea. My headache is not completely gone but at least it's bearable now. I probably won't take this medication again. Believe it or not but Vicks rubbed into my forehead actually does more for my headaches than OTCs. Without the nausea. F 31 1 days
1 pill
8/4/2019
 2  Headaches After taking it for minor headache. 3hrs later I started having slow heartbeat, chest pain, discomfort, stomach pain. I couldn't sleep. I will not be taking it again. Does not work for my body. M 31 1 days
2
1/20/2020
Email
 2  Migraine Excedrin normally helps take the edge off my migraines on the rare occasion that I get one (couple times a year), but doesn't entirely remove the pain. Came down with a migraine tonight and took 2 caplets with food and glass of water. As usual it helped somewhat with the head pain, but a couple of hours later I started getting severe gas/bloating and diarrhea. The pressure has been constantly building for 3-4 hours now, only being released by bouts of diarrhea. Took some GasX, hoping it'll help me get to sleep. Don't know if I'll ever risk taking Excedrin again. M 26 1 days
2 caplets 1X day
12/26/2020
 2  Strong headache progressing to migraine Nausea / unsettled stomach, fatigue / weakness, cramping 14+ hours so far, malaise all day My body is beat. I typically have not had this bad of side effects from this medication, typically used for hormonal triggered headaches. Woke up this morning with bad headache, couldn't sleep off, so took pills at 6:30am before going to get groceries. Took on empty stomach. Had to make bathroom stop in store, cramping throughout, felt out of it and like I had to really summon my inner strength to make it through getting groceries. The past couple times I have had slight upset stomach, but nothing like today. Wanted to always be in bathroom even when nothing left. No diarrhea but the cramping was terrible. Stomach growling but had to eat bland all day and stomach still moving tonight, 14+ hrs after first dose. By the time I started searching to figure out what could be causing my symptoms, I had taken a second dose since first didn't kill headache. I'm hoping in two hours I don't have to choose to sleep on the couch. Sounds like it has significant variation in how it affects people, so if you want to try, would suggest talking to your doctor that knows your health history and medications first, and start with lowest dose to see how your body reacts. I think mine has gotten progressively and intermittently worse...super bummed because it has historically completely resolved severe headaches / migraines. F 38 1 days
2X day
1/16/2021
 2  Head ache Head ache went away after about 30 minutes, felt great, than about 2 hours later I believe, just felt so fuzzy and was unable to concentrate, then the anxiety started to rise up and I had a panic attack, felt so jittery and had to pace around and was breathing shallow. Massive feelings of worry, and feeling like was gonna die. This did not happen when I take medication with acetaminophen WITHOUT caffeine. Would be very cautious if prone to anxiety M 20 1 days
2 capsules 1X day
2/1/2022

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