LUPRON DEPOT Reviews (LEUPROLIDE ACETATE)

Average Rating: 3.0 (783 Ratings)

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 ANTERIOR PITUITARY HYPOTHALMIC FUNCTION ANTINEOPLASTICS

 Type: Rx Drug

  

LUPRON DEPOT  (LEUPROLIDE ACETATE):  Leuprolide is used to treat advanced prostate cancer in men. It is not a cure. Most types of prostate cancer need the male hormone testosterone to grow and spread. Leuprolide works by reducing the amount of testosterone that the body makes. This helps slow or stop the growth of cancer cells and helps relieve symptoms such as painful/difficult urination. Talk to your doctor about the risks and benefits of treatment.   FDA Approval Date: 1989-01-26 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
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More on LUPRON DEPOT: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR LUPRON DEPOTCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  uterine fibroids hot flashes, night sweats, weight gain, insomnia, joint and bone pain, osteoporosis I had two injections 3 months apart. I stopped the injections after 6 months. I gained 30 lbs and work out 6 days a week and cannot lose a pound. My body was strong before and now I have chronic joint and bone pain and my body feels so weak. I never sleep thru the night I feel as if I aged 20 years over night. I went into menopause and never came out. It has been 18 months since my last injection and my body is still a mess. I would NEVER have taken this medication. F 53 6 months
8/10/2009
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 2  Breast cancer/to stop periods I can put up with the night sweats and hot flashes, uncomfortable as they are. What I can not tolerate is the lack of motivation or apathy I am suffering from because of this drug. I didn't believe it at first. I thought it was just me, and I gave it six weeks while I investigated every other possibility. But it is true. The mood swings don't even bother me as much as this; this apathy or lack of motivation is a disaster and I could be out of a job. I can't do meaningful work, I eat chocolate because I am too lazy to cook, I drink wine instead of coffee because I don't have to prepare it. I am calling my doctor on Monday and telling him that I will not be taking a third shot. Unfortunately, I still have three weeks of the second shot "left". I hope to God I will return to my normal self. My dose is 7.5 mgs once per month. The main reason for taking it is to stop my periods because I want that separately from the breast cancer. However, after I got dx'd and had surgery for early stage breast cancer I was not allowed to go on the pill or use anything w/female hormones. Hence, the Lupron. It did work. Period is GONE. However, the side effects make the period look like less of a hassle by comparison. Not worth it for me. F 42 2 months
8/1/2009
 5  precocious puberty No side effects, except pain during injection, which has been relieved by using emla cream one hour prior to injection. 7.5 mg has suppressed my young daughter's linear growth and pubertal development nicely with no ill effects. F 7 11 months
7/31/2009
 5  prostate cancer Tiredness and bowel problems but this may be due to old age. PSA reading shot up to high twenties and an operation was considered but I chose the Lupron injection treatment every 3 months. 'Something else will probably kill you first' was one bit of advice. My latest PSA reading was under 2 so I am pleased with the results so far. M 81 2 years
7/24/2009
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 1  Fibroids This should be called the shot from "HELL"! I was a perfectly happy, bubbly person. I would brighten a room when I walked in. I have severe, extreme hot flashes that are uncontrollable. I am suffering from depression. I cry every day as if I am attending a funeral. I have only had two injections due to a hysterectomy that I had to have. I would never recommend this shot to anyone. It has changed my personality because I suffer from the side effects very bad. I am now applying estrogen patches to level the side-effects out. The hot flashes are every hour instead of every 15min. God Bless who ever has to get this shot! COMPLETE NIGHTMARE!!! F 36 2 months
7/3/2009
 3  fibroid tumors weight gain, facial hair, night sweats, day sweats, depression. Hi I had 2-3 month shots of Lupron and it was good and bad. The last shot was Jan 3rd 2009 and I have still have not had a cycle. The second shot made a very depressed to the point of suicide thoughts. I have never been a depressed person my doctor put me on lexapro for that and that has helped. I have gained 20 pounds since I started the shot and I workout six times a week ugh! I have had night sweats everyday. I am going in tomorrow to see if the tumors have shrunk. I have also had some facial hair growing around my lip GROSS... I guess the only positive thing so far is I have not had the monthly visitor..... F 33 6 months
7/1/2009
 1  Fibroids HOT FLASHES, NIGHT SWEATS AND ANXIETY ATTACKS! I took my shot in Jan. (3 months dosage) and I'm still experiencing these symptoms. My doctor said they should start tapering off in April- THEY'VE GOTTEN WORSE! F 44 1 days
6/28/2009
 3  endometriosis & ovarian cysts soreness at injection area, hotflashes, night sweats, headaches, loss of concentration, mood changes, forgetful, low sex drive, dryness, some joint pain I take monthly because I was so afraid of this Lupron. Had cysts all my adult life. Last year found out also have endo. had surgery 9/08 removed cysts on right and left ovary, untwisted right ovary and removed endo. 1 mth later back in hosp had surg again, found another cyst on right ovary and ovary twisted back up. dr removed right ovary and tube. wanted me on lupron - i was too afraid after reading about it. continued having abdom paid 6 mths so started monthly lupron in Apr 09 -get my 4th shot in 1 wk. 1st shot: injection site (butt/they call it the hip) hurt badly for 2 days, had headache and felt ill. (that went away after 2 days) breast grew atleat 1 cup size for 2 weeks (yeah!) then shrank then next 2 weeks to a small B when I was a Large B. (that sucked) I also started the night sweats and hot flashes. like once a day/night. 2nd shot: same 2 days of illness and pain at shot. breasts never grew back. now have severe night sweats all night long and severe hotflashes all day long, sometimes loose concentration or get forgetfull but now I feel my pain is subsiding and It might be worth the side effects if I can just figure out how to handle the hotflashes. 3rd shot: same 2 day issues. night sweats, hotflashes, low sex drive, now i have very low right and LEFT side pain--something in the urinary tract but doesnt feel like infection. no burning..just internal pain lowever than ovaries...the abdomin pain is gone but the lower pain is now worse..that combined F 39 3 months
6/21/2009
 3  Regrowth of ovary Maybe some lightheadedness, dizzy right after shot, some gi problems (bowel movements, tummy aches), feel bloated, night sweats first night after shot and warmer than normal but no hot flashes so far, headaches. I'm not sure if the side effects are from the lupron or something else. So far nothing really to report. I can't say my pain is gone but I am only three days into the medication so I will continue to report as the days go by F 33 3 days
6/17/2009
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 1  Endometriosis Meridian, MS I am a 32y/o black female. I had a hystorectomy in Jan 2009 because of bad cramps during my cycle. My doctor told me this was what I needed to do in order to get rid of the pain. He left my ovaries because of my age. During the surgery he saw no signs of endometriosis. After my recovery period (3 months) Every month around the time my cycle should have been coming on, I would begin having cramps as if I was having a period. Then I noticed blood in my stool. I thought maybe it was some after affects of the surgery. I told my doctor about my pains and blood. He prescribed Darvocet for the pain. And began trying to evaluate the problem. I've had 3 colonoscopies, CT scan with rectal contrast, regular CT scans and the only thing that was found was a knot underneath where my uterus would be near my colon (segmond area. (He noticed this during my surgery and called another doctor in for a second opinion, they both agreed that it was probably nothing due to know other signs of F 32 2 days
6/17/2009
 5  Endometriosis mild hot flashes (evening primrose really helped), loss of sex drive, and a lot of weight gain. Had one injection/month for six months. Purpose was to see how I would handle a hysterectomy. Completely lost the pain within the first month and side effects were almost non exsistent by the third shot. Gained 15 pounds in 3 months but doc says if you gain on the shot, it's a good indication you will continue to gain with menopause. 10 wks after last injection, I still have no period but my breasts hurt and the pain is back full force. Would continue Lupron if I could afford it. Being pain free is worth the minimal side effects. The shot was better than surgery. Too bad it's only temporary. F 30 6 months
6/14/2009
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 1  Endometriosis Hot flashes, night sweats, heart palpitations, joint pain, memory loss, difficulty concentrating, depression, breast pain, headaches, anxiety, and no relief from pain (except my period pain)! I was given the shot as a 'diagnostic tool,' instead of a laparoscopy. BIG MISTAKE. NEVER USE THIS DRUG FOR DIAGNOSIS-ONLY A LAP CAN DIAGNOS ENDO. I took ONE shot of Lupron Depot at the end of January of this year (2009). I took only one, because although I was scheduled for a second shot three months from the first, I absolutely refused to take it again. My side effects were EXTREME during the first three months, and have begun to subside, slowly. I still experience the night sweats (these are not just 'night' sweats btw...these are 'at-any-time' sweats), hot flashes (I initially clocked them at approx. every 40 min., now it is every couple hours), headaches, memory function, and breast pain. I still have not had my period since the shot, and it is now the middle of June (2009). That is the only thing that I am grateful for, since the majority of the pain comes and goes with my periods. However, the pain I experience which is not cyclical was not helped at all by this drug. It has actually gotten worse. I am again being given the option to take this drug after surgery in a couple weeks. I am again refusing. Avoid this drug as much as possible...the company that makes it pumps A LOT of money into marketing ("feel good" websites, blogs such as this one with many 'positive' experiences, paying doctors/hospitals to use the drug, etc.). Research all you can! Much love! F 27 3 months
6/12/2009
 4  Stage 3/4 Endometriosis Hot flashes/night sweats, headaches, all of which have gotten better the longer I've been on it. Annoying weight gain. Pain is better, though not gone completely. I feel I have reacted very well to this medicine. I had laparoscopic surgery in Dec '08 for my endo. Started monthly 3.75mg Lupron injections in Feb '09. I only have one shot left! Only had spotting in months 1 and 2, now no bleeding at all. :) The one thing I hate is the weight gain - 15 lbs! I'm really hoping that goes away after I am done with the treatment. I hope the pain stays manageable as well. F 25 4 months
6/8/2009
 5  Large fibroids, anemia, heavy bleed Hot flashes, low energy This drug has given me back my life! For the past 3 years I was bleeding almost everyday. Extrememly heavy periods, couldn't leave the house. I had two blood transfusions - my hemo was down to 4. I am on my 9th monthly shot without add back therapy. It took the first 4 shots to really make a difference. The hot flashes (I call them power surges) are much less annoying than they were in the beginning. My last ultrasound showed a 40% shrinkage in fibroids and uterus. I was afraid to take this drug but so far I am happy with the results. I must mention that I exercise regularly, eat mostly organic and rest when I feel like I need to. F 52 240 days
6/1/2009
 4  Endometriosis Mild hot flashes, breast shrinkage, fatigue, some moodiness, lack of sex drive, vaginal dryness I wanted to post a note on this site because the comments scared me half to death before I started taking. It hasn't been bad at all for me, and I'm 4 months into the monthly shots. Two more to go. The hot flashes are not bad at all. My main complaint is my complete lack of interest in sex anymore, so all in all not much to complain about at all. Don't be scared to take this drug if your doc recommends it. F 30 4 months
5/29/2009
 4  Prostate Cancer It's been 6 weeks since I was injected with 22.5 mg Lupron to reduce the size of my prostate. My prostate needs to become smaller so that I can have seed implants. So far I have not had any adverse effects. Insomnia was a problem I had prior to the Lupron so I can't attribute the drug to that problem. Wheter the drug is working or not will be determined in about 7 weeks when the volume check will be done. Nothing more to say except, I was expecting all the side effects, but after 5 weeks, can't say that I have experienced any.I will continue to keep my fingers crossed. One other thing. I saw how much my health insurance company was billed for the shot and understand now why the health business in this country is going to collapse soon unless something is done. $3433.00 M 35 days
5/27/2009
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 1  prostate cancer 13.7 PSA gleason 7 I refused surgery, I won't have chemo. At the time May 2, 2009 I thought brachytherapy was my only option. Then I found proton therapy. I had 2 weeks of tests done. ...>MRI Pelvis w/wo contrast NM Body scan-whole body ...>NM inflammatory prostascint test ...>Prostascint scan ...>CT ABD pelvis scan with contrast ...>will get a transrectal ultrasound in 2 weeks The cancer has not spread outside the prostate. While in testing, away from home, the radiology oncologist recommended LuPron Depot 22mg. Not aware of the side effects I consented. After returning home I have found this was one of the worst mistakes I have ever made. This drug has so many side effects, major side effects not just the head aches and weight gain. Then after doing some major research I found a drug that would help considerably if I had "NOT" taken the Lupron. Now it is to late for the alternative, "Low dose Naltrexone", I am in search of another method over radiation Lupron is a pharmaceutical get rich drug. Please do your research and the side effects and how it is affecting peoples lives. Don't consent until you know everything you can about this drug. M 53 25 days
5/26/2009
 3  Endometreosis Two hot flashes so far, mood swings this is the only one that is really getting to my husband and kids, night sweats this is still real bad, lack of sex drive, but others times seems like i can't get enough, joint aches, and last but not least and the worst so far is the insomnia, oh this has been horrible. I have been on this shot for three months now and am two weeks away from my next shot, It as not been that bad. I have lost weight, and the size of my stomache has gone done, it looks like I had a lot of swelling in my upper abdominal region. I have no idea what to expect with the next two shots but hopefully it will not be too bad. F 32 90 days
5/20/2009
 5  endometriosis hot flashes and lack of sex drive F 36 12 months
5/19/2009
 4  endo/shrink ovarian cysts First I would like to mention I would take any of the side effects I had any day over the pain I was having before on Lupron. Was on Lupron for 3 months. Bad Headaches,mild hot flashes,tiredness,some mood swings. After first shot did have some spotting for 3 weeks. It worked for shrinking my cysts and helped with all my endo pain!! and NO weight gain!! please remember everyone reacts differently to medication. F 36 3 months
5/14/2009

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