PLAQUENIL Reviews (HYDROXYCHLOROQUINE SULFATE)

Average Rating: 3.2 (667 Ratings)

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 Type: Rx Drug

  

PLAQUENIL  (HYDROXYCHLOROQUINE SULFATE):  Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. It does not work against certain types of malaria (chloroquine-resistant). The United States Center for Disease Control provides updated guidelines and travel recommendations for the prevention and treatment of malaria in different parts of the world. Discuss the most recent information with your doctor before traveling to areas where malaria occurs. This medication is also used, usually with other medications, to treat certain auto-immune diseases (lupus, rheumatoid arthritis) when other medications have not worked or cannot be used. It belongs to a class of medications known as disease-modifying antirheumatic drugs (DMARDs). It can reduce skin problems in lupus and prevent swelling/pain in arthritis, though it is not known exactly how the drug works.    (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on PLAQUENIL: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR PLAQUENILCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  Rheumatoid arthritis I stopped this drug after being on it successfully for 7 years. I had the onset of terrible menopausal symptoms, especially anxiety followed by hot flashes many times a day. I don't know if the Hormone replacement therapy interacted with the Plaquenil, but both drugs list depression/anxiety as possible side effects. The anxiety and weird dreams were worse than the pain of the RA ever was. So...I went off both the HRT and the Plaquenil...and feel much better mentally after 7 days. I was on the combination of HRT and Plaquenil for 9 months. It did help the pain and seemed to prevent the worsening of the joint damage... I don't want to go on anything else as I seem to react badly to many drugs but only after I am on them for a while so it is hard to tell that the drug or drugs is the cause. F 56 7 years
8/17/2008
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 4  Reactive Arthritis Mild diarrhea with some cramping. I've been a massage therapist for 11 years and suddenly one day I developed horrible stiffness and joint pain. After seeing many dr.s my Rheumatologist diagnosed me with RA. First I tried Prednisone, but did not like the side effects. He switched me to Plaquenil. I have to say that I have been able to work, deep tissue therapy, since taking Plaquenil for the past 3 months. I do at times feel achy, but nothing compared to before. I never want to be without this med. again. F 42 3 months
8/16/2008
 5  RA Maybe diarrhea In the very short time I have been on it, I have improved about 95%. I want to comment about itchiness: I've noticed others attributing this to plaquenil. Well, two months ago, before I started on the plaquenil, I had one night where both my underarms and the palms of both hands were unbelieveably itchy. But there was no rash and the skin was unbroken, and the next day the itch was gone. Maybe it's not the plaquenil, but, for some people maybe it is. M 74 3 weeks
8/7/2008
 2  MCTD/Lupus Rash on my sides and back that I could not tolerate - extremely itchy. The doctors thought maybe I was allergic to Plaquenil. I stopped this medication and was started on Imuran. The rash or itch did not leave for quite a while after I stopped the taking Plaquenil. I then learned that medications to control Malaria (Plaquenil)can sometimes cause the development of Large Plaque Parapsoriasis. It took weeks for the rash and itch to go away. The Large Plaque Parapsoriasis has not come back. F 66 90 days
8/2/2008
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 5  Subacute cutaneous lupus No side effects, infact my hot flashes diminished??? Have been taking it x 2 months, my rash within 3 days started fading. I had breast cancer 2 years ago, Stage III, triple negative and had a terrible time with radiation, burned me up. I now know I probably had the beginnings of lupus....wish we had hindsight! F 59 2 months
7/16/2008
 5  RA occasional bouts of diarrhea and gas It has really worked for me. I took myself off the medicine once, thinking I might not really have RA since it was totally in remission. And then I had an unbelievable flare. I hurt so much I became depressed, I could barely work. I have not done that again. I'm a believer. M 64 6 years
6/23/2008
 3  Idopathic Chronic Angioedema Stomache pain, cramps, gas, diarreha, constipation(it would rotate for day to day). But after the second week my tongue became sore, and it progressively became worse. I then went to the dentist's and she asked when I developed these funny red bumps in my mouth. I called the doctor and he told me to stop the Plaquenil immediately. I did and the bummps and sore tongue went away in around two days. It was working. I can put up with the upset stomache because I get worse upset stomaches from the angioedema than the medication. It gave me back my energy, stop the swelling in and around my lips, and stop the twitch I get in my neck when I am very tried. But it seems I have a rare reation and so I had to stop. F 37 14 days
6/22/2008
 1  RA Plaquenil 200 mg once a day: Red, raised, rash with terrible itching appeared after 3 weeks. It covered my whole body with the exception of the palms of my hands and the bottom of my feet. Two weeks later after stopping the medication, I am still suffering from this reaction. Does anyone know how long this will last? Didn't seem to help my RA while taking it. The steroids (prednisone and methylprednisolone) for the rash helped more. Will not attempt this drug again. F 50 3 weeks
6/20/2008
 4  RA I seem to sweat more than usual. A change in dream patterns. Irritable at times, as well as nervous and anxious. The RA symtoms have greatly dimished at this point and doctor says I may reduce from 400mg to 200mg soon. P.S. he also says the (irritable at times, as well as nervous and anxious)should not be a typical side effect. Maybe some of us are not typical as I read where several of you had the same side effects. M 50 1.5 years
6/19/2008
 5  Palindrome RA Very sensitive skin and hearing loss Fantastic drug, no more pain, no more swelling, no more piles of pain killer drugs!! F 44 1.5 years
6/15/2008
 5  SLE Diarrhea for about a week I've been taking Plaquenil for 3 months now. From the beginning, it stopped my muscle and joint aches. Thank God. It helped me to function more like I use to before I had my first flare up and was diagnosed with SLE 8 months ago. I really thought at one point I would have to stop working and go on disability or something, the aches were too much. My hair has stopped falling out, but it does not grow as it use to. Plaquenil has not yet help me with the butterfly rash I have on my face. I can live with it. It is still early with my usage of it. I hope Plaquenil continues to be a blessing for me. F 40 3 months
6/15/2008
 5  Lupus In the beginning, I did have stomach problems and also seemed to have more flare ups, however at the advise of my doctor, I stuck it out for the full 6 months trial and I'm so glad I did! I have not had any, zero,zip - symptoms of lupus at all since then... this is wonderful! I still take 2 tablets a day and for the first time since I was 17, I feel like I'm living a normal life... on occastion, depending on what I've eaten, I may still have some stomach issues but nothing worth complaining about... Plaquenil has been a miracle for me!! F 45 9 months
6/13/2008
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 2  arthritis There were no discernible side effects. This drug did not do anything for my arthritis. I ran out and had to wait a couple of days to get more. During that time without it, I didn't feel any different than when I was taking it. Have stopped now to try Arava. F 36 7 weeks
6/5/2008
 1  inflammatory arthritis increased/worsening anxiety and depression. felt like I was going crazy. Worsening fatigue. some increased stomach acid, but that died down after the first couple or three months. Did help with the joint pain - but with the side effects I have felt - is not worth it for me. I have stopped taking the medication for a few days and already am feeling slightly better. Probably will get the pain back - but I am going to look into natural remedies now. No more prescription drugs with their side effects for me! F 28 5 months
5/31/2008
 1  RA 3 1/2 weeks after being on medication. Severe rash over body except for palm of hands, bottom of feet and face. Rash became welts, welts formed into one big blotch with dark center, skin started peeling like a sun burn. Hospitalized for 6 days. Severe itching...... I will never have it in my house! Concerned about future health problems caused by this medication F 52 3 weeks
5/29/2008
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 4  Systemic lupus none After taking plaquenil about 4 months I felt much improved. I had more energy, reduced pain which lasted a few months. I now take other, stronger meds, but if I run out of plaquenil I quickly become fatigued. F 50 2 years
5/23/2008
 4  lupus dry burning eyes and blurred vision. Terrible acne on face and neck. Has helped with joint pain, especially in my feet. F 55 5 months
5/21/2008
 2  SLE First 24 hours had diarrhea then it went to rashes, swelling, joint pains, off and on one day joint pains the next day a rash.. 600 mgs a day + 10 mg Prednisone I have only been taking Plaquenil for 3 weeks and I feel I have more flare ups now than I did when I wasn't taking any medication. I was told by my doctor that it would take a month to notice a difference but I have read that it could take much longer. I'm not sure if I can hang on much longer. Some flare ups keep me from going to work & functioning properly. I guess I don't really have a choice. F 35 3 weeks
5/21/2008
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 5  Scleroderma Stomach cramps Due to the stomach cramps, my Dr. had me start with 1/4 of a tablet and work up from there. I am still in the first week but so far, I am feeling SO MUCH BETTER. My joint pain and fatigue are going away and I am still on 1/4 of a 200 mg tablet. Good luck to everyone and thank you for this site. It was very helpful. F 53
4/29/2008
 2  RA Absolutely none. Didn't seem to have any effects at all, 'side' or otherwise. Might as well have been a sugar pill. Looks like it's on to methotrexate. M 52 4 months
4/29/2008

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