PLAQUENIL Reviews (HYDROXYCHLOROQUINE SULFATE)

Average Rating: 3.2 (667 Ratings)

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 Type: Rx Drug

  

PLAQUENIL  (HYDROXYCHLOROQUINE SULFATE):  Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. It does not work against certain types of malaria (chloroquine-resistant). The United States Center for Disease Control provides updated guidelines and travel recommendations for the prevention and treatment of malaria in different parts of the world. Discuss the most recent information with your doctor before traveling to areas where malaria occurs. This medication is also used, usually with other medications, to treat certain auto-immune diseases (lupus, rheumatoid arthritis) when other medications have not worked or cannot be used. It belongs to a class of medications known as disease-modifying antirheumatic drugs (DMARDs). It can reduce skin problems in lupus and prevent swelling/pain in arthritis, though it is not known exactly how the drug works.    (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on PLAQUENIL: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR PLAQUENILCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  RA Itching skin, like a rash but with no obvious marks or redness. Mostly on the legs,feet and arms M 43 7 years
2/5/2009
 3  Lupus? I have been taking plaquenil for almost 2 months. I had to stop 3 times on my way to work, and get out of the car to wake up. I am restless at night but cannot focus during the day. I haven't the energy to go for a walk with my 4 year olds or the focus to help my 6 year old with his homework. I'm afraid they won't remember their mommy as somebody fun, but as someone who wasn't there. I constantly feel like there is drainage in my throat even though I'm not sick. Have you heard from anyone else that feels this way? I also had blurry vision and lots of goo in my eyes. The swelling in my hands and feet is still there, though not as bad. The pain of arthritis is still there, though not as bad. If the fatigue is indeed from plaquenil, then I'll stop taking it and take the pain. F 34 2 months
2/3/2009
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 1  MCTD Flu like symptoms first week, full body rash that doesn't seem to be going away even with the help of prednisone, zyrtec, clobex lotion. The rash gets worse every day and my face gets more swollen every day. This is going on for a week now. I'm totally disgusted. PURE UNADULTERATED POISON!!!!!!!!!!!! F 54 18 days
1/31/2009
 4  RA GASSY, FOGGY MEMORY, BRUSING, NIGHTMARES. I'M A LITTLE NERVOUS ABOUT TAKING THIS DRUG. MAYBE IT SHOULD BE ALOT NERVOUS. THE MEMORY INTERFERENCE IS WHAT SCARES ME MOST. I FIND MYSELF FORGETTING HOW TO USE MY FINGERS ON MY KEYBOARD. F 54 4 days
1/27/2009
 2  SLE Intense itching and rash onn back and upper chest. Chronic yeast infection. Hallucinatory nightmares. Red, rashy, and itchy palms. I was started on this drug 3 weeks ago. My SLE went undiganosed for at least 5 years. The joint pain was so intense I was practically carried into the doctor's office. I was put on 200mg of this drug, and some prednisone. The relief from joint pain was almost immediate. Two weeks into this treatment I developed a yeast infection, that usually when treated, would go away with just one treatment. I've had 3 treatments and the itching will not go away. I have been suffering from chronic itching on my upper back and chest. I have developed welts and rashes and I can't find relieve. The doctor gave me a shot of benadryl and more cortisone, but no relieve. I've used all types of creams and homeopathic itch relieve creams, but the itching would not go away. I'm strongly considering not taking this medication unless I have a flare up. My frustation level is so high, I break down and cry at least two to three times a day. F 53 3 weeks
1/27/2009
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 2  SLE Gas, bloating, starting hair loss & severe itching. Gas & bloating started by 2 days. Hair loss, 1 week. Itching started 2 nights ago. Can't see a red rash everwhere that itches but, do feel tinys bumps. Some places are red but, that may be from scratching. I can't take Benadryl (major interaction with Amitriptyline; I take that for severe insomnia). I stopped taking it yesterday (200mg twice a day). Still have itching; maybe not quite so bad today. F 2 weeks
1/27/2009
 1  Mixed connective tissue disease After 2 1/2 weeks on Plaquenil I developed flu-like symptoms, fever, could'nt get out of bed for days and a rash over my entire body. Doctor confirmed an allergy to Plaquenil and put me on a two week course of prednisone. I am so itchy I'm ready to jump out my skin. They said the rash will go away in two weeks. Don't know what I'm going to do next medication wise. 3 weeks
1/26/2009
 2  Generalized Granuloma Annulare Severe insomnia/irritability - had thyroid level checked to rule out hyperthyroid problems; ringing/echo effect in right ear, bloating/diarrhea, strange itching of fingers. My Generalized Granuloma Annulare is a chronic (mine for 7 yrs.), rare, autoimmune skin disease that causes itchy, sensitive leisons, over the entire body. Dr.'s don't know why; no drug co. has done research. Plaquenil is prescibed off-label, but must be taken for a long period, & could "possibly" help. Insomnia intolerable. Took 200 mg.-once daily & stopped after 17 days. I still have hearing problems. Considered re-trying again, but Univ. Head Dermatologist recommended Dapsone another off-label drug. Wonder if anyone else has used Plaquenil for GA? F 60 17 days
1/20/2009
 2  uctd Severe diarrhea on a weekly basis for the last 3 months. Also, no change to hair loss hair loss. Now have brain fog, increased occurance of stomach pain, abdominal pain and leg pain ("growing" pains & needle-like pains). Does not help during a flare-up, but has minimised frequency. Helps with Raynuds. My GP said the diarrhea is due to the drug, but I have to wait a couple of months to see my rheumy, so have halved my drug intake. F 22 3.5 months
1/19/2009
 5  Sjogrens flatulence; I am more aware of the neuropathy in my hands and feet I am a physician. I thought it would take weeks to have any benefit. Within hrs my fatigue was gone and the fogginess in my head had cleared. I thought it was a placebo effect but after reading the other comments, I guess it is real. So far it has given me my life back M 56 2 days
1/15/2009
 5  RA F 50 3 years
1/14/2009
 4  Early stage SLE - Connective Tissue For the first 1-2 wks, horrible gas/GI upset. Still some stomach issues occasionally. Although doc said 3 months to see improvement, I felt better after only 4 days. Joint pain is 80% improved, fatigue and malaise are 75% improved, hair loss 90% better, and no more sores on scalp or in nose. F 30 30 days
1/14/2009
 3  Lupus Slight nausea alleviated by eating a full breakfast with the medication. After that, none whatsoever. I haven't seen the benefits yet, but expect once the drug builds up in a few weeks that hair loss will decrease, energy level will rise and weight will stabilize. F 29 11 days
1/14/2009
 5  sjogren's syndrome none After just three days, my fatigue has lessened and I no longer feel mentally sad...it actually has improved my mood and I will start exercising again...beside sjogren's i have hasimoto's thyroiditis so any relief of symptoms are fantastic...so far, so good, I love this medication. F 56 3 days
1/9/2009
 4  unknown collagen vascular disease When starting I had some stomach cramping and loose stools. I also get weird dreams in which I am very anxious and have night sweats. I have stopped taking it twice (had the stomach flu for a week) and the other time when switching to sulfasalazine(currently take both). Both times when restarting the GI upset was minimal but the dreams last about the first 4-6 weeks. Never have the dreams otherwise! It has greatly decreased my joint pain, fatigue, mouth ulcers, and dizziness. The last time I did the trial stop after 2 weeks I noticed a huge difference in how I felt and started taking it again. It takes a few weeks to build up so be patient! The couple weeks of side effects are worth the response. F 26 2.5 years
12/18/2008
 1  Lupus like symptoms After taking Plaquenil for 30 days, I developed a severe rash on chest, arms, legs, back. Dr. advised to stop taking Plaquenil, and to clear up rash, take 20mg Prednisone twice daily for 4 days and to also take 4mg Cyproheptadine three times daily for five days. It worked! 30 days
12/8/2008
 1  arthritis severe skin rash I was on plaquenil for 9 days..Woke up with hives under breasts & armpit,down sides & back..Was ready to jump out of my skin.phoned pharmacist & was told to dicontinue the plaquenil. Went to emerg.and they intravenously gave me benadryl & zantac & prednisone.5 days now & still red & itchy..very irritable & my nerves are shot..I hope it goes away soon or i'll end up on the psyche ward!!! baking soda in warm bath helps & good old vicks helps the itch..Also taking xanax to help the nerves..NEVER again will I try this stuff... F 64 9 days
12/7/2008
 5  SLE It's been too long to remember. Similar side effects to what everyone describes, hair loss etc. Can't live without it. Felt so much better after many years and tried going down from 400 to 200mg. What a huge mistake. I though I was going to die. Had severe dizziness, numbness and tingeling, dull headache, ringing in ears, fatique,arthritus and joint pain like never before.Why did'nt my Dr. say this might happen. Was I a guenapig??? Relieved to hear this has happened to other. Also I took this through both pregnencies fine. I WILL NEVER GO OFF, unless my vision gets effected. F 42 15 years
11/23/2008
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 1  joint pain Nausea and vomiting a couple hours after breakfast. Loss of appetite, which I like, but I will talk to my rheum doc Tues. to get off the med. I don't like it! I'll take Aleve and live with the pain............. F 66 2 weeks
11/23/2008
 1  ra sle severe nausea hair loss ring in ears and hearing loss no sleep for 36 hours so much nausea i could not even get a sip of water down. falling hair was everywhere-bed,clothes, all over bathroom floor. the ear ringing was so loud could not concentrate on anything as well as significant loss in one ear. the day this all started (only day 6)! i went 36 hours with no sleep. this drug is poison. i will take my pain and manage it any day before doing this again. F 65 6 days
11/20/2008

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