Average Rating: 3.5 (105 Ratings)

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 Type: Rx Drug

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on IMIPRAMINE HYDROCHLORIDE: Reviews Summary  |  Drug Safety Information

 1  Insomnia and adhd Difficulty recalling names , places, tremors, pain while ejaculation. Post ejaculation. I think you are better off it then on it. I am going to taper it by 50 mg for 10 days (2 divided doses) 25 mg for 15 days and then off it. M 22 2 months
 5  I was 15 yrs old 9th and 10th grade I was sleepy alot, but that was my norm, i love sleeping. Never really ate, I dont remeber dry mouth, great mood, mostly happy. I went from a F DC student to A B student. I took myself off becuase My Sifu said if I want it, then I will achieve it. So I achieved an extra belt in nun chunks in 1 months. I was proud. But then hello I started not paying attention, not reading and failing. I was not interested in the material. I just daydreaming . Now I need it for work. I cant even do my routine 2 days the same. Im inconsistent and I really try. I loved it. It does wonders if you truly can not concentrate and that is real dx you cant. F 38 18 months
 5  Anxiety in response to panic Side effects only in first few weeks. ( IBS symptoms on and off in first year or so. Back in 1969 I was given LSD and had panicked on the drug. It left shocked up and had depersonalization / derealization for several months. I was subject to return bouts every so many years and felt like I could not be free of the fear of the panic and depersonalization. Then in 1986 science finally caught up with me. Started Impramine in fall of 1986 and within 3 months was a different person. I had to work up to high dose of 300 mg. Changed my life... fear of return of anxiety disappeared. On it now for 32 years and doing great.. Gave me my life back. M 67 32 years
 5  Depression Dry mouth. I have to take Biotene to stop it Absolutely wonderful drug. I have been depressed all my life. Started on imipramine at 27. Always gave me big orgasms and all anxiety, social phobia went away. Weaned myself off and tried the new Ssri's. None of them worked. They stopped the depression but ALL caused insomnia and loss of libido, not to mention not being able to orgasm. SSRI's will kill you sleep and your sex life. I hate them. Doctors push for you to go on them but that's only because of the kickbacks they get. I will never take them again you may be less depressed but your relationship and sleep will suffer. Not worth it in my book. I went back onI imprimine at 55 and there was no weight gain, depression, and anxiety. I slept as soon as I hit the pillow. My sex life is wonderful and orgasms have returned normally with the added bonus of them being big. Lucky me😀 Take what works for you. F 58 30 years
150 1X D
 1  Depression Used to take tofrinal- with imipramine it causes insomnia- tofrinal let me great great sleep. Ask pharmacy how much brand tofrinal would be and they told me $500- what a scam. F 60 2 days
 3  depression sweating alot, body weakness F 40 1 days
 5  depression and anxiety Had brain fog, loss of motivation, anxiety, mild constipation, loss of memory but all these went away within the first week.dnt have any noticeable side effects now Had been on lexapro and sertraline before this. Lexapro did well but stops working every 2weeks. Since on imipramine i feel more positive emotions. I socialize more with friends. The drug has gradually improved my mood. Although I'm still hoping for more improvements since i ve taken it for just two weeks. I will recommend it for anyone. M 24 2 weeks
 2  Depression, anxiety I recently went off prozac because my depression came back stronger after about 3 months on. I went from Cymbalta to several others but after 2 weeks on this I feel like there's just no hope for me at all. I want to feel myself again but all this switching meds and the horrible side effects it's not worth it. Just 2 weeks on this medicine I don't experience and change. With menopause,hypothyroidism, depression,anxiety,and panic attacks. I'm just a guinea pig. Hope this helps someone F 47 2 weeks
 2  Depression/agitation Horrible constipation and extreme rage. Ended up threatening and screaming at my family. Wanted to die and spent hours crying and coming up with creative ways to kill myself. I've never experienced such extreme mood swings in my life. My family was actually afraid of me. Don't just take different meds because your doctor suggests it. Do your research first. I feel like a guinea pig. 37 2 months
100 MG
 5  Depression and anxiety Bit of constipation, postural hypotention, dry nose. Don't bother me By far the best AD I have been on. I went on everything in the late 80's through to the 90's. All the SSRIs, MAOIs and some anti psychotics. SSRIs take away anxiety but did nothing for mood and depression. Made me feel hostile sometimes and numb most of the time. I had far more side effects on the SSRIs The literature says that it is as effective for panic disorder as the SSRIs and slightly better for depression. New DRs tend to use newer drugs which is a mistake and maybe because of the marketing of the newer drugs. If you are getting a partial response, you might need to increase but persevere because I find that it is a subtle drug and might take a bit longer. Only one problem, I live in South Africa and in the last few years they only make the 10mg tablet. It is a hassle taking 15 pills at night :( M 48 20 years
150mg 1X D
 5  Depression/Social phobia/Pain/ADD Constipation, dry mouth, euphoria, weight loss (10 lbs), elation, drowsiness, dizziness, brain zaps, feeling stone (1 hour after taking it) I started imipramine 3 weeks ago and it's by far the best antidepressant. My mood lifted almost instantly and the anxiety and social anxiety are completely gone. It allows me to sleep and it increased my sleep quality. I wake up happy and have the motivation to do what I have to do. It helps with concentration and ADHD. I take in combination with Vyvanse 40 mg, Lamictal 100 mg and Wellbutrin 100 mg twice daily. My quality of life is much higher than with other antidepressants I tried in the past: prozac, zoloft, Effexor XR, Celexa, Lexapro, Cymbalta, trazodone, Elavil, Abilify, etc. and nothing is comparable with Imipramine beside Anafranil which is very effective but have more side effects. The side effects are mild and will stay on imipramine for the rest of my life. M 37 3 weeks
75 mg 1X D
 5  over active bladder dry mouth,dizziness, M 33 7 days
 4  Overactive bladder I sleep around 3 hours then I'm awake. Dry mouth,head shakes mildly causing neck pain,constipation,leg twitching. I believe that if I was prescribed a lower dose these side effects might go away. F 63 3 weeks
 4  for depression F 76 10 years
10 1X D
 5  panic attacks/depression dry mouth and elevated pulse This wonder drug has made all the difference in my life. Began taking it for panic attacks and got immediate relief even though it was supposed to take time to start working. Didn't realize I had been depressed until it made me feel like a new person. About 8 years ago I tried weaning off but found that I needed 75 mg. to feel normal and have emotional buoyancy . So I quickly went back from 50 mg to 75. Over the last year I went from 75 mg down to 25 mg. Felt fine at 25 mg for two months. 25 mg is not supposed to be therapeutic but it IS for me and other people who have left comments! My doctor encouraged me to go off completely--probably because of the myth of 25 mg being nonclinical-- but the insomnia and ever decreasing energy is intolerable. My symptoms including the age of onset followed a grandfather's pattern to a T. Should have known that I needed to be on it for life. Am now looking for a new doctor. F 53 20 days
150 to 25 1X D
 5  major depression, agoraphobia Dry mouth and eyes, constipation,weight gain. I have taken it for 29 years, but site was not allowing me to indicate that from "smartphone". I was housebound before I started it. I had drowsiness at first, (at a higher dose, 125 mg), but that went away. Craving for carbs also eventually went away. Since I went on imipramine, I have held down jobs, gone to school. I would never want to go back to the life I had before taking it. F 56 10 years
50 mg
 1  Pudendal Neuralgia I just reviewed this drug a few months ago, and I decided to try it again. The entire experience was vastly different. Yes, it helped my nerve pain, and it made it so I could barely feel my physical therapist touching a huge trigger point. But I couldn't THINK or FEEL. I felt apathetic yet agitated. And the best part? Gray poop with bright red blood in it. What even. F 23 1 days
25 1X D
 3  depression Dry mouth M 26 1 days
 3  pudendal neuralgia, depression/OCD Diarrhea, difficulty urinating, and inability to orgasm They told me that Imipramine at the low dose of 25 mg would not work as an antidepressant, but wow, they were wrong! It was a lovely, lovely feeling. I felt warm, secure, clear-headed, and serene. No obsessions/compulsions. It was almost like MDMA. And the sleep was heavenly. It did dull the nerve pain, too. If it weren't for the side effects, I definitely would have continued the drug. I had torrential diarrhea 2 hours after taking it, my urine stream was pin-thin, and I couldn't even get close to orgasm. I'm keeping the bottle in case I ever get constipated. F 23 1 days
25 mg 1X D
 1  Overactive bladder constipation, terrible morning depression - I could hardly get out of bed I was taking IMIPRAMINE HCL for overactive bladder issues. Having had depression for a long time I figured it might help since it is also used as an antidepressant. In preparation for some surgery I stopped taking the IMIPRAMINE HCL and within a week of stopping it I noticed that I no longer was waking up really depressed and not wanting to get out of bed. I started just waking up "normally" and didn't fear the morning anymore. M 63 365 days
75 1X D

IMIPRAMINE HCL  (IMIPRAMINE HYDROCHLORIDE):  This medication is used to treat depression. It is also used with other therapies for the treatment of nighttime bed-wetting (enuresis) in children. Using this medication to treat depression may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living. Imipramine can help your child control nighttime bed-wetting. Imipramine belongs to a class of medications called tricyclic antidepressants. It works by restoring the balance of certain natural substances (neurotransmitters such as norepinephrine) in the brain. For bed-wetting, this medication may work by blocking the effect of a certain natural substance (acetylcholine) on the bladder.   (Sources: U.S. Centers for Medicare Services, FDA)