Average Rating: 3.9 (38 Ratings)

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 Type: Rx Drug

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on NALTREXONE HCL: Reviews Summary  |  Drug Safety Information

 5  Alcoholism Exhaustion, nausea first few days. This drug changed my life. I began it in early sobriety and haven't stopped it. Once I began to take it my cravings went away. I do skip it sometimes now and I have no cravings. I believe this medicine saved my life! M 36 2 years
50mg 1X D
 1  Polycystic Ovarian Syndrome Candida overgrowth Severe candida overgrowth. I had no idea what was happening to me until I put two and two together and realized that this drug made my candida out of control. For people who say it gave them IBS--it may be candida. I finally researched enough to see that this can indeed assist in candida overgrowth. DO NOT RECOMMEND F 22 2 weeks
4mg 1X D
 4  Weight loss First tried it had sleep problems. Now 2 years later, and I love it! I sleep great, no sugar cravings, motivated to eat better, muscles not as achy, better attitude. F 67 2 weeks
25 mg 1X D
 5  Fibromyalgia Tiredness at 1st, but went away in a few weeks This is my miracle drug. I was taking tramadol before which helped, but I still had mild pain. Before I took anything my pain was so bad. Before I knew I had fibro I toughed out the pain for 3 years. I couldnt lift my arms past my waist and in order to roll over in bed I had to lift my arms slowly to roll over. I would leave 2 hours before work and stop every few minutes to rest. Note I live 10 to less than 15 min from work. Lifting a pencil was so painful. I decided enough is enough and saw many many doctors before I found 2 that helped me diagnose my fibro. And maybe frozen shoulder they said. I see a pain mgmt doctor now who prescribed me the low dose naltrexone. It's my miracle drug. It gave me my life back. I work as a pharmacy tech and other patients also agree that it's working for them. One said she was just starting it and didnt like the side effects. I told her to give it a a few more days and now she said she was glad she did. They milded down. I see patients who are on continuous use opioids and often wonder if this would work for them.. I hope the FDA is looking into this drug as possible approving it. At least making doctors more aware of it to try for their patients. Getting them off opiods.. I read it can also help with crohns, which I also have. I'm not sure on how it can help with that. My crohns is under control as of today. It would be neat if it helped with that. F 40 3 years
4.5mg 1X D
 5  Fibromyalgia Energy, spaciness, tired after meals I tried naltrexone at a low dose of 4.5 mg dose years ago, and it had no effect on my pain levels. But at a higher dose (I started with 24.5 mg and now take 50 mg) it is extraordinarily effective. I'm thrilled with this result, but I worry about the long-term effects, so I do not plan to take it indefinitely. The side effects - energy, a spacey feeling - I find pleasant. But this also makes me worry that perhaps this is just another painkiller, and that I'll build up a tolerance and be worse off when I try to wean myself off it. It's promoted as safer and non-addictive, but not enough is known about it yet for those claims to be trusted. It perplexes me that naltrexone is an opioid antagonist, but it feels slightly like an opioid to me. So I'm trilled to have relief from the pain, but I proceed with caution. F 58 3 months
24.5 mg 1X D
 1  Fibromyalgia I got so sick after taking it. Nausea, shaking, anxiety, sweating. It was awful. And it always happened exactly ten hours after taking it. My doctor told me to stop it right away. No other doctors can prescribe it here in the county of 3.5 million people where I live. My rheumatologist wanted me to take it but could not write the prescription for some reason. Why not? It's all very suspicious, especially since proponents of it blame Big Pharma for it not being available to everyone for financial reasons. They also say that patient testimonials are all we need to prove it works. No, you need large double blind tests to prove it, not small groups of 12 people. That's how science works. Be wary. Research this drug. You'll probably stumble upon the people who have been barred from writing this prescription and non-physicans who write it hiding between the enthusiasm for the drug. I do hate to call it a cult. But if it was a safe drug with so many benefits, "Big Pharma" would be all over a new formulation. F 35 7 days
1mg 1X D
 4  Alcohol Not really many, maybe drowsiness but definitely gives me the stretches really bad. M 37 30 days
50 mg 1X D
 3  Irritable bowel syndrome It helped with my IBS and sleep. But it made me lazy and unmotivated during the day. When I stopped taking it I found I slept very poorly. Prior to starting on it I slept fine. I went off it for 2 months but my sleep never returned to normal so I went back on it. M 55 5 months
5 mg 1X D
 4  Mast Cell Activation Syndrome, CFS Nausea, diarrhea I have struggled with pain inflammation, sinus issues and general malaise due to chronic fatigue, and a host of other problems. Doctor felt my sinuses and trouble breathing was due to Mast Cell Activation Syndrome and put me on this. It has definitely helped my breathing but every morning I have had to deal with low grade nausea that lasts until the late afternoon. It gets worse if I increase the dose to 4.5mg. I've reduced the dose back down to 3mg but I might reduce it even further to 1.5 or stop all together if I can't get rid of the nausea as it's hard to go about my business feeling this way. F 39 60 days
 5  Alcohol dependence Early side effects of dizziness and nausea, but that passes in 2 weeks. I was a heavy drinker from the time I was 20 or so until I was 29. got Naltrexone 50mg. If I wasn't at work or asleep I was drinking. As hard as it was, I stayed sober for 6 whole days before I started the medicine. From the moment I took the first pill, it. was. gone. I was no longer an alcoholic. They say that once a drunk always a drunk, I'm living proof that is false. I took Naltrexone for 6 months and never looked back. Naltrexone changed and saved my life. M 40 6 months
50 1X D
 5  Binge drinking alcoholic 30 years Nausea in the morning with coffee, by noon super sonic energy! I usually take it late afternoon a few hours later tired..amazing, I finally feel like I am alive with a positive reasin to be aluve. Have tried suicide muliple times..believe everyone who says it is a miracle pill! A beer or 3 is all I can handle now👍 F 53 22 days
50 mg
 5  Alcohol First couple days I had nausea but went away. Then couldn't stretch enough but that passed also. A little sleepy for the first 5 days. I was drinking 8 to 10 beers everyday, for 2 days I had no cravings at all. I averaged out my drinking for 14 days and it is 3.9 drinks. 3 of those 14 I forgot to take it one hour before drinking which is the recommendation from the Sinclair Method. Works much better when I take it a hour before. I also watched a video from Ted Talks with Claudia Christian and it was awesome! Also, there is a book about the Sinclair Method called The Cure. F 62 14 days
50mg 1X D
 4  osteoporosis, DDD, fibromyalgia None Had been experiencing increasing pain from osteoporosis, degenerative disc disease and fibromyalgia. A car wreck aggravated everything. This drug did help me a lot. Not to say I didn't have some aches and pains but not nearly as bad as before. Only problem is that occasionally I felt good enough to do heavy cleaning in my house and the next day had increased pain. I have learned to pace myself. F 65 30 days
3mg 1X D
 4  Ulcerative Colitis Taking from 3-4.5 mg per night before bed. This is called low dose naltrexone and is used for things like ulcerative colitis, cancer, and a lot of other stuff at this low dose. It helps your overall health but I came on here to warn people that is does have similar side effect to steroids in that it can make you enraged to a psycotic level where you want to beat the living ____ out of someone. Be aware of this and leave the room if you get in an argument with someone otherwise you literally will not care and will say a whole lot of _____ you would normally not say or care to say. I use a 50mg tablet and dissolve it in 50ml of distilled water in a tincture then drip 3-4.5ml of that after shaking it so it may not be exact all the time but I am too cheap and lazy to order more exact ways to measure it. You have to get it illegally if you want to use it for ulcerative colitis or find some expensive alternative doctor to prescribe it (safest idea), since my bastard GI refused to prescribe it to me for UC, all he would prescribe is steroid prednisone. I use the naltima brand or the nodict brand, don't sense any difference between them, both are naltrexone. M 46 3 years
4 1X D
 5  alcohol None in particular. Having vivid, active dreams but not sure that is the medication because I've always had vivid dreams. Seems to subdue alcohol cravings. Will continue as long as need be to help break the alcohol addiction. F 63 6 weeks
 5  Binge drinking Nausea, nightmares Miracle pill. I haven't binge drank (which was a daily event) since I started it. I don't understand how it works, but I just don't want to drink. I've tried to drink but don't get past the first shot. I just immediately lose interest. *shrug* Only downside is random nausea. F 39 3 weeks
50 MG 1X D
 5  fibromyalgia, chronic fatigue Wake up briefly during the night, but fall right back to sleep. After the first dose of LDN I had increased energy & I still have a more normal energy level; fatigue is 95% gone. Pain relief came after about 6 wks. and has been reduced about 75%. This med has given me back my life. No thyroid issues while taking Armour Thyroid. F 65 5 months
3 mg 1X D
 2  fibromyalgia Heart palp and racing while taking with armour thyroid. Also, nightmares when I take it after 9 Or 9:30 At night. I stopped taking lastnight till my thyroid calms down i think this drug has potential and want to try it again. F 35 2 months
 4  Fibromyalgia, PTSD, Chronic Fatigue The first day I had so much energy and mental focus. I got more done than I have in years. Unfortunately, that did not continue; but I still have substantially more energy and mental focus than before. No negative side effects - hard to believe; but true. I experience more pain free days, increased energy, and lovely dreams. My sleep is better and longer. I used to sleep fitfully, in pain, with tense muscles and would awaken too early feeling like I had been in a battle all night. Now I sleep longer and deeper. I take less Advil. I think the hypervigilence (jumpiness) and disocciation that accompany my PTSD are much improved. I began taking this in the morning and moved to night time dosing. I took the first one on a Saturday morning and reorganized cabinets, shelves and closets all day without pain or fatigue. IF that had continued I would say that it was wonderful but not totally practical for my body. Put the first dose to good use in case that happens for you! Clean closets for the fist time in several years. Ahhhhhh....:-) F 44 2 months
3 1X D
 2  arthritis None. My doctor and the low-dose naltrexone website implied that LDN might help arthritis as it is an auto-immune disease. I tried 3.0 mg for five months and then 4.5 mg for five months but saw no change in symptoms. I saw no change after quitting either. M 60 5 months
3.0 mg 1X D

NALTREXONE HCL  (NALTREXONE HYDROCHLORIDE):  This medication is used to prevent people who have been addicted to certain drugs (opiates) from taking them again. It is used as part of a complete treatment program for drug abuse (e.g., compliance monitoring, counseling, behavioral contract, lifestyle changes). This medication must not be used in people currently taking opiates, including methadone. Doing so can cause sudden withdrawal symptoms. Naltrexone belongs to a class of drugs known as opiate antagonists. It works in the brain to prevent opiate effects (e.g., feelings of well-being, pain relief). It also decreases the desire to take opiates. This medication is also used to treat alcohol abuse. It can help people drink less alcohol or stop drinking altogether. It also decreases the desire to drink alcohol when used with a treatment program that includes counseling, support, and lifestyle changes.   (Sources: U.S. Centers for Medicare Services, FDA)