SPIRONOLACTONE Reviews (SPIRONOLACTONE)

Average Rating: 2.4 (268 Ratings)

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 DIURETICS ALDOSTERONE RECEPTOR ANTAGONISTS

 Type: Rx Drug

  

SPIRONOLACTONE  (SPIRONOLACTONE):  Spironolactone is used to treat high blood pressure and heart failure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. It is also used to treat swelling (edema) caused by certain conditions (such as heart failure, liver disease) by removing excess fluid and improving symptoms such as breathing problems. This medication is also used to treat low potassium levels and conditions in which the body is making too much of a natural chemical (aldosterone). Spironolactone is known as a "water pill" (potassium-sparing diuretic).   FDA Approval Date: 1999-07-29 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on SPIRONOLACTONE: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR SPIRONOLACTONECOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Acne PCOS ANXIETY, panic attacks, insomnia, intrusive thoughts. NO SEX DRIVE SEVERE FATIGUE WORST MEDICATION I HAVE EVER BEEN ON!! when I first started this drug I was so hopeful because it was the only thing to clear my hormonal acne! After being on this drug for 6 weeks they up my dose from 25mg to 50mg. I was working as a nurse when I had my first panic attack. I had no idea what was going on because I had never experienced one before. I was taken to the ER because I thought I was having a heart attack. After this I noticed I would get heart palpitations, dizziness, loss of feeling in my extremities. I have always been a happy girl. Things would scare me that never have before! I would freak out in a crowded restaurant Or not be able to go to BIG family gatherings. I was having intrusive thoughts like I was choking on my food or couldn't breathe. All the doctors told me this was not a side effect of the spironolactone. Psych doctors put me on anti-anxiety medication and told me I was just stressed from planning my wedding. I was scared to go to work because it would happen then I would have to leave my work embarrassed. I tried getting off the medication 6 months into it and felt like I was literally dying. I didn't want my skin to go back because I had just gotten rid of all the scarring and was going to be a bride. So I just ate Xanax pills and roughed it. On our flight to our honeymoon I had such a bad panic attack I almost made them land the plane! I've been flying since I was four years old never have F 28 1 years
50 1X day
1/25/2023
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 1  Acne Spironolactone was supposed to treat my acne, it did, but it also caused severe anxiety and depression, the kind where I was rushed to the hospital several times for hyperventilating from panic attacks. Note that prior to that I never had anxiety or depression. I spent months bedridden, scared of leaving my apartment, severely depressed. Several dermatologists recommended I take Spironolactone to fix my acne issue. I took it twice, for 3 and 6 month intervals each and after starting it each time, went into severe depression. I didn’t make the link the first time and glad I did now. Look forward to trying to get off the anti depressants I have been taking for years as a result of Spiranolactone. If recommended to treat your acne, stay away from it. F 24 6 months
50 1X day
1/16/2023
Email
 1  Acne Panic attacks, anxiety, intrusive thoughts. & depression This is the absolute worst medication I have ever been on. Yes, it cleared up my acne but I would rather have just dealt with it to avoid the mental heath issues I have now. When I started this medication, I was going through a rough patch in my life which is why I felt that all of these problems started happening. However after finding this page and looking at all the comments I know for a fact that it's from this medication. The first bad experience that happened while on this medication was right after I took an edible. I smoke marijuana weekly so I assumed I'd be fine. After taking it, I started thinking about every bad thing I had ever done and my heart started racing. Someone else in the comments said their bf almost had to take them to the hospital and I swear that's what happened to me. I thought I honestly was going to have a heart attack. After that I stopped smoking Bc I figured that's what caused me to feel like that. But for the next couple of months I started experiencing severe anxiety before work. My heart would beat so fast and I felt uneasy. I also started getting intrusive thoughts which caused me to have to go therapy because I didn't know who I was anymore. I felt crazy and not like myself. I've been off this medication for three months now and finally in the last few weeks I feel I have been doing better but I'm still no F 19 4 months
50 3X day
1/9/2023
 1  Acne I started using spironolactone back in the summer time and after just a few weeks of using it i was uncontrollably sobbing at my job which then resulted in me putting in my 2 weeks and getting terminated early. I honestly thought it was just the stress of moving somewhere new and losing my friend so I didn't think too much into it. I slowly started to feel irritable towards everything i was making many improvements in my life but nothing ever made me happy. During November is when it all really started to go down hill I started failing almost all of my college classes and not caring because why should i? I was snapping at my roommates over the dumbest things and would hole myself up in my room for days and would talk to nobody. I had no idea what was wrong with me I didn't enjoy anything anymore and this was so unlike me. I have never been one to need therapy but in that time I knew I needed to go because something was seriously wrong. I was a pretty heavy smoker when it came to marijuana and had taken an edible one night and FREAKED out my heart rate had bumped from 75 to 150 in about 5 minutes and i almost had to ask my boyfriend to take me to the ER because I felt i was about to die. Looking back on this I knew it was the medication because I have never reacted like this to marijuana before. After that moment it just seemed to make it much worse I was thinking insane thoughts about death and every other possible thing that could spike my anxiety and I could feel anxiety attacks coming on frequently. I would randomly get shaking and dizzy and feel like i needed to throw up nothing was making me feel better. Yesterday is when i decided to look up side effects of Spironolactone and nothing I read said anything of the sort until I stumbled upon this website. I am so grateful that other women have shared their experiences because I knew I wasn't crazy. Please don't take this medicine if you can help it. it has cleared up my acne but the mental health issues it brings is simply not worth it. I will continue to warn as many people as i can about this. F 20 6 days
100 mg 1X day
1/6/2023
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 1  Acne Sever anxiety and panic attacks, fear of things I have never been scared of. Increased Heart rate I started taking this medication 5-6 months ago and I have never had any issues with it until a month ago I stopped taking it for 8 days and I started getting very bad panic attacks and anxiety attacks my heart rate would shoot up to 180 every time I have had a panic attack so I started taking it again to see if the medication was the reason I was having these panic attacks and 3-4 weeks later my panic attacks went from sever to mild. My doctor put me on 100mg to start with which I feel was high to start off with. I cannot drive, go into stores or gas stations with out thinking something bad is going to happen to me. I have never had a panic attack until I started taking these meds. Made an appointment so I can get off of them hopefully this works for me I just want my normal life back where I did not have any of these issues F 22 5 months
100mg 1X day
1/5/2023
 1  Hormonal acne Spironolactone cleared my hormonal cystic acne wonderfully.. and thats about all the good it did. After around 2 months of taking it I noticed that every other day I was feeling dizzy and having diarrhea. Every single day I was exhausted, keeping myself from falling asleep at work. I drink a lot of water throughout the day, always, and I was limited potassium rich foods. I read about taking the spiro at night to try to limit these side effects, but that didn't help. After 3.5 months I went on a camping trip and forgot my spiro at home. After 2 days of no spiro the side effects were gone. However, on the third day when I got back home I decided to continue taking the spiro. It all went down hill after that. I started getting severe anxiety and heart palpitations. A few short days later I'm laying around watching TV and my heart rate was super high and I was just sitting around thinking it will go away. I try to go lay down and go to bed and the palpitations will not go away and just feel like impending doom. So at 2am, after like 3 hours of no relief, I make my husband take me to the ER because I feel like I'm going to have a heart attack. Luckily I got a bed quickly and they gave me an ekg, heart monitor, blood work. Everything was normal, my heart rate was back to normal, and I was sent home at 5am. They told me to keep taking the spiro and consult my doctor at a follow up appointment. I kept taking it for a few more days until my appointment - extreme anxiety, palpitations (not as severe as the ER visit night) and horrible insomnia every day. My doctor told me to stop the spiro cold turkey. She also had me take further diagnostic tests - hormones, white blood cell count, diabetes, and others. All came back normal. So here I am today, almost 3 months of being off the spironolactone. Still getting increased hart rate and palpitations. Still having heightened anxiety. Still unable to easily fall asleep. F 34 4 months
100 mg 1X day
12/20/2022
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 1  Acne I was prescribed 100mg daily pills for acne. My acne is mild and I felt that this was a high dosage to start right off the bat. I went from having no anxiety at all to severe, debilitating anxiety from the second I started this medication. I couldn't sleep for 10 days, felt I was suffocating and on the brink of a panic attack all day/night long. I stopped taking the pill and it instantly subsided. I cannot believe there was NO warning of these side effects when starting the pill. If you can handle a lower dosage maybe that would be okay, but unfortunately I couldn't stand being on this medication long enough to even see if it helped clear my skin. I do NOT recommend this medication based off my experience. If you previously suffer from anxiety or similar symptoms, I would be extremely cautious. I did not have anxiety before this medication and was instantly affected by the first pill I took. F 27 10 days
100 mg 1X day
12/13/2022
Email
 1  Acne After a while taking such a high dose caused me to have severe anxiety, panic attacks, intrusive thoughts and double periods. I stopped this medication and my symptoms went away. I'd rather have acne than have such severe symptoms. Never again! Beware! F 33 1 years
225 1X day
12/9/2022
 1  Kidney, liver Having health issues, agitation,rage, insomnia,delusions , poor judgement of living decisions (money etc) Going to wean off and see it spironolactone is why this has caused major turmoil drama . M 69 4 months
50 mg 1X day
11/18/2022
 1  Kidney, liver Having health issues, agitation,rage, insomnia,delusions , poor judgement of living decisions (money etc) Going to wean off and see it spironolactone is why this has caused major turmoil drama . M 69 4 months
50 mg 1X day
11/18/2022
 2  Acne Anxiety, panic attacks, breast tenderness, increased urination, irregular periods and spotting, tiredness, decreased libido I started out with 50mg for the first 5 years and then it was upped it to 100mg. I had mild physical and mental health symptoms on 50mg but acne was not completely gone. Then they upped me to 100mg and my acne improved significantly, however at the huge expense of my mental health. I never experienced a panic attack until this medication and being upped to 100mg. I couldn't sleep, eat, travel or be a normal human being on this medication. I was so foggy, tired, and depressed. I didn't connect the mental health issues with the medication for a year and thought it was trauma related. However as soon as I stopped taking it, I have had no anxiety or panic attacks since now 10 months later. I am bummed that my dermatologist never talked through the possible mental issues that could occur when you take medications that adjust your hormones especially at higher doses. I finally feel like me again, like my personality has returned and this cloud fogging my brain has been removed. F 27 6 years
100 MG 1X day
10/19/2022
Email
 1  Acne So i have been prescribed spironolactone for about 8 months now, when I first started it I had been taking it for about 2 weeks, after the second week I noticed very bad panic attacks and anxiety so I stopped it immediately. I went to my dermatologist about a month later and he asked me how it was going. I told him I stopped taking it because i was having really bad panic attacks and anxiety. He basically told me I was wrong and the spironolactone would never cause or has any history of panic attacks or anxiety. So just recently I figured I'd try to take it again. I've been on it for about 2 weeks now and the insane anxiety and panic attacks are back and way worse. It's has caused me to feel like I'm going insane and not myself at all to the point where I feel like I need a therapist and counseling. I am not taking any other medications so my conclusion is that this is the reason for my terrible side effects. After reading these other reviews I feel so much better knowing my dermatologists made me feel stupid and that I was right all along. F 19 15 days
20 mg 1X day
10/19/2022
Email
 1  for acne ive been taking spironalactone for about two weeks and in week two noticed i was feeling very depressed and down and all i wanted to do was sleep. i had no desire to do anything even eat. i would constantly cry for no reason and at first i thought i was feeling this way because my skin was not improving but before taking it i would not cry for no reason and feel constantly down. on top of this i noticed my anxiety was a lot worse that i would even wake up at night because i was so anxious. my derm said i can stop taking it because of these symptoms or they can lower the dose. i dont want to feel this anymore so i dont think i will continue taking it F 21 14 days
50mg 1X day
10/18/2022
 1  Acne -pee often; mood swings; anxiety; depression; exhaustion; little to no sex drive (made sex painful); dry all over I began with 25mg once a day, increased it to 25mg twice a day, to 50 twice a day. When I was taking 100mg I experienced my worst side effects and lowered to 75mg a day. Even on Spiro my acne was inconsistent and I eventually realized it wasn't worth trying to have clear skin. F 24 4 years
75 1X day
10/10/2022
 1  Hirsutism At first I only noticed frequent urination (like pregnancy pee habits), nausea, gassiness, and headaches. I just recently realized, thanks to these other patient reviews, that it has been making my PTSD WAY WORSE. Like turned up to 11 (scale 1-10), ALL THE TIME. Daily unexplainable crying fits, severely depressed, uncomfortable in your own skin anxiety, intense random panic attacks. I would rather deal with the abnormal hair growth than EVER feel like this again. I don't think the mental health side effects hit me until about 5-6 months on it. 25mg was not effective. FDA and docs need to be made aware of these mental health side effects, and warn patients about them just as frequently as the physical ones. Thank you so much to the others who have commented! You have saved me! Please PLEASE share your experience in other places including reporting to the FDA! F 32 8 months
50mg 1X day
10/10/2022
 1  Acne Insomnia, Anxiety, Tremors/Shaking at night, irritability, depression, mood swings, crying, overall not feeling good. The spiro did get rid of my acne about 2 weeks after starting. After about 6 weeks on it I started to notice more anxiety and insomnia. It's been two weeks now and I can't sleep at all, even with melatonin, CBD+CBN, I feel irritable, sad, fatigued and overall not like myself. Talking with my derm today so I can figure out a way to ween off of it. I would rather have acne than all of this sh*t. F 28 2 months
100 mg 1X day
9/19/2022
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 4  High blood pressure This pill helped control my blood pressure after 10 years of trying other meds without much success. Side effects at 50 mg. included extreme tiredness and dizziness, with some confusion and increases depression, so I dropped down to 37.5 mg (one 25 mg pill plus another one cut in half). The lower dose works well enough for me. F 63 1 years
37.5 mg 1X day
9/11/2022
 1  Hormonal Acne This medication slightly helped my acne but made me incredibly irritable, pee often, constantly exhausted even after tons of sleep, an emotional wreck and gain weight. I am so upset because I've heard great things from so many people who started this and thought I had done my research through google. Which lists NONE of these symptoms. F 30 2 months
50mg 1X day
9/11/2022
 1  Low potassium and high blood pressu Mood swings, no sex drive, no drive for anything really, I was so tired all of the time. I can literally just lay there all day long and still feel tired. It made me very angry I would have Angry outbursts, I was constantly Snappy and everything irritated me and sometimes it would get bad and I would just go off! He wasn't until I looked up some of my symptoms and medications that I found all the information here. Seems like I'm not the only one feels this medication is bad news! Find something else! It can ruin your life if you don't M 49 9 months
25mg 1X day
9/2/2022
 1  Acne My mental health has always been pretty stable until taking this drug for 2 weeks. I cry over nothing every single day now. I am extremely depressed and anxious. The other day I had a panic attack that made me feel as if I were dying. My throat felt like it was closing, uncontrollable crying, heart rate spiked, weight on chest, feeling of hopelessness. This has never happened until taking this drug. Immediately stopping this. I'd rather have acne all over my face than feel this way again. F 21 15 days
50 MG 1X day
8/23/2022

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