SEROQUEL XR Reviews (QUETIAPINE FUMARATE)

Average Rating: 3.1 (142 Ratings)

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 ANTIPSYCHOTICS ANTIMANICS

 Type: Rx Drug

  

SEROQUEL XR  (QUETIAPINE FUMARATE):  This medication is used to treat certain mental/mood conditions (such as schizophrenia, bipolar disorder, sudden episodes of mania or depression associated with bipolar disorder). It is also used with other medications to treat depression. Quetiapine is known as an anti-psychotic drug (atypical type). It works by helping to restore the balance of certain natural substances (neurotransmitters) in the brain. This medication can decrease hallucinations and improve your concentration. It helps you to think more clearly and positively about yourself, feel less nervous, and take a more active part in everyday life. It may also improve your mood, sleep, appetite, and energy level. Quetiapine can help prevent severe mood swings or decrease how often mood swings occur.   FDA Approval Date: 2007-05-17 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on SEROQUEL XR: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR SEROQUEL XRCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  Bipolar Disorder 1 The only side effect is a slight increase in apetite when taking my meds and sleepiness 3-4 hours after intake. I take them at night so the sleepiness is a welcomed effect. Nothing short of a miracle. I've been switched from Risperdal and Depakote to this and it's been uphill from there. I lost close to 25lbs and was able to go back to work and live my life again like it's meant to be lived. M 43 1 years
600mg 1X day
5/13/2010
 2  To regulate sleep cycles I have gained 20+ pounds and my weight continues to inch up. I was prescribed XR as it seemed that the regualr Seroquel (which I had been taking for 7 years) was no longer effective. Initially XR didn't seem as effective, but then it started working. I don't feel as well rested as I did with regular Seroquel and the weight gain is bothering my joints and arthritis. I am going to discontinue use and see what happens. I plan on contacting my doctor about other options to help my sleep issues. F 49 6 months
50mg 1X day
4/28/2010
 1  Bipolar II Lethargy, weight gain I was initially treated for depression and took prozac, cymbalta, and zoloft (at different times). Each one made me suicidal. I was then diagnosed at bipolar II. I started at 75mg and felt great for a week. It helped me stop the cymbalta cold turkey. Then it stopped working for me, so my doc upped the dose to 150mg. I was useless. I couldn't get out of bed or mentally wake up until 6pm then had to take another pill 3 hours later. I was extremely hungry and I gained 10 lbs. I quit cold turkey and feel better with no meds even though I can feel my mood swings at least I'm awake and can concentrate. I found they actually prescribe some people this drug for sleep and there is no problem stopping cold turkey. I guess your mood is stable if you are always asleep. F 34 2 months
150mg 1X day
4/22/2010
 3  insomnia/ bi-polar weight gain 20 lbs, vivid dreams, no sex drive, drowsiness, dizziness within the 6th month. When I went off the drug I began having suicidal thoughts & slept for 14+ hrs & still felt exhausted for a period of 2-3 weeks. USE CAUTION DRIVING: I hit 2 parked cars. When I began taking Seroquel XR 50mg I not only slept better but, my anxiety was non-existant. I went off because of the side effects. F 29 9 months
50 mg 1X day
4/21/2010
 3  Bipolar I/Insomnia Since I have been on Seroquel XR, I have had some problems with Akathisia (uncontrolled muscles twitches), and for the only time in my life, my cholesterol and triglyceride levels have been terrible. It has also significantly increased my blood sugar. I have also had problems with my weight (gain of 60lbs) but I don't know if that's from the depakote or the seroquel. Although the Seroquel has helped with my depression and sleep and we are using it to help wean me off the depakote, I do not like the idea of it affecting my lipid levels and blood sugar the way it has, and am terrified that because I seem to be so sensitive to the medication that it will begin to affect my liver as well. I do not know what path my doctor plans on taking at this point, but I think that the risks and side effects have slightly outweighed the benefits. F 25 8 months
200mg 1X day
3/13/2010
 2  Bipolar II Irritable, stomach pains, sensitivity to light, solemn, zoned-out, foggy, drunk-like (morning hangover) The XR 300 was not great. Side effects were enough to discontinue after 14 days. It's quite strong. It's on to Zyprexa 2.5mg -- low doses seem to be more effective with these. M 25 14 days
300 XR 1X day
2/6/2010
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 4  insomnia, mood disorder dry mouth, constipation I have tried both regular Seroquel and the XR form. I have more even moods on the XR form and also the XR version doesn't raise my heart rate like the regular kind does. It doesn't make me as sleepy as fast as the regular kind but its better than feeling like I am free falling through my bed at night like I did on the regular version. F 30 9 months
1/31/2010
 3  bipolar desorder (type II) eating every single minute of my life, kind of fatty now, no more libido, cry a lot for nothing well, i do get up in the morning now. mood is better, though i'm very sensitive F 24 2 months
1/19/2010
 4  depr, anxiety, borderline personali sedation, slow, memory loss, cognitive distortion was in a mental hospital for 3 months, was severely anxious and depressed, not getting any better, finally i was put on this medication along with lithium, Gabapentin, and hydroxyzine as needed. i feel better than i felt in 6 years after stressful event in my life. not happy with the fact that i have a hard time reading I hope the side effect will go away though i don't know if it's possible after 2 months, because i need to go to school, but at the same time this medication is mainly the main reason why i'm home not at the hospital F 24 2 months
1/17/2010
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 2  Bipolar Extreme lethargy, emotional numbness While I'm trying to "stay positive" I feel that this drug may very well be a waste of my time. I started on 150mg but was a complete zombie...I was sleeping 14 hours a day and barely functioning at work, but the doc was thrilled that I wasn't manic anymore. I complained long enough and finally got the dosage dropped to 75mg and now I'm not a zombie anymore but the anxiety has returned. Still, the doctor say, "give it a little more time." I think I was better unmedicated...lol. F 29 3 months
12/22/2009
 5  Borderline Personality, Anxiety I take 600 milligrams of Seroquel XR which is a relatively high dose, yet compared to the standard Seroquel the side-effects are much better. On the XR I don't have the hunger and weight gain nearly as bad. The sedation is only mild and is much less than the immediate-release drug. The way you take it about 3 to 4 hours before bed is perfect to get really restful sleep. I wake up energized and bright every morning. Another nice benefit I've noticed is that the XR version of Seroquel is actually a bit cheaper than regular Seroquel. The XR is awesome for anxiety because it stays with me all the time and doesn't wear off like Risperdal, Zyprexa, or Geodon. Seroquel XR also has FDA approval as an antidepressant, and I can really tell it is bringing me out of some deep, hard-to-detect depression symptoms. Overall, I think this is my favorite drug I have ever taken. I can't wait till 2011 when it goes generic (regular Seroquel, don't know about XR version). M 27 2 months
12/3/2009
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 2  GAD, panic, social phobia From the first day on very drowsy and lethargic. Locked up in my own world. Loss of libido and erectile dysfunction. Scary heart palpations and chest pain. Orthostatic hypotension. I was only on 50 mg XR and although Seroquel managed to stop my negative thoughts for the better part, it also robbed me from all the positive emotions. I felt completely drugged the whole day and I couldn't care less about the world outside. At day 5 I got this chest pain and a very irregular heart beat and since I have a history of heart disease I had to quit immediately. Also without the irregular heart beat I don't think that I would have continued Seroquel. If the price that you have to pay to get rid of your anxiety is a complete loss of emotions, sexual dysfunction and a complete loss of initiative, I'd rather prefer to stay with a low dose of Xanax to help me through those difficult moments. This is a very serious medicine and I really wonder if it should be FDA approved for GAD/anxiety. M 55 5 days
11/14/2009
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 1  bipolar I hate Seroquel and doctors who prescribe it. Chance of diabetes. Increases by 60% terrible side effects, weight gain, hunger. Just try to prescribe this it to me without warning me of side effects. It costs $550 for 30 pills. Lorazepam only cost $27 for 50 pills. M 29 3 years
10/9/2009
 4  depression, anxiety, insomnia Sleep too long (avg. 12 hours), sometimes groggy, swollen throat (can barely inhale while coughing) I've only been on it a month but so far it's working. I've gone from not being able to work to seriously multi-tasking. The real test is how I'll be while employed. I'm having to take Cogentin b/c I'm allergic to the Seroquel XR. I'm able to drink caffeine without becoming anxious. But my anxiety is usually work related. We shall see how this goes. F 27 1 months
10/2/2009
 1  mood stabilization/bipolar/sleep 25 weight gain, sugar craving, daytime sleepiness/zombie effect, no sex drive. I had also commented on regular Seroquel and what it had done to me - jacked up my blood sugar and also had me eating three ice cream bars in one sitting. Doc also had me on 200mg of XR during the day. I've given up both and put myself both on the Wellbutrin SR I had laying around in my medicine cabinet. I tried to call in refills for it and bastard doctor will not refill it. He instead sent me this "special rate" card from the Seroquel mfg with a script for 600 mgs of the sh*t a day because he insists I'm "agitated." OF COURSE I'M AGITATED! We're in a recession and I'm in a sh*t job where management froze salaries, is threatening layoffs, plays favorites with an employee who doesn't do her job and makes the rest of the staff do her job for her. The Seroquel XR only made me depressed the first time around to where I never wanted to do anything after work or leave the house on weekends. Now I'm on the Wellbutrin I've taken up roller skating and doing it 3-4 times a week. I'm also beginning to let the employee favoritism slide. The receptionist can screw herself and so can the psychiatrist with his so-called expert opinion because this prescription is not getting filled and the next time I see him I am going to insist on my Wellbutrin because I know if I gave it up, any motivation to skate or do anything else would go down the drain. Took off/on 3 months. F 46 2 days
9/20/2009
 1  borderline personality disorder The extended release properties make the side effects worse then the regular seroquel. The weight gain is horrible. The sedation is even worse. This drug is way more powerful then regular seroquel. XR is nothing but a patent extender. The side effects are horrible. Would not ever take again. M 29 6 months
9/13/2009
 5  Bipolar 1, OCD The only side effect is sedation but only at night. I take it at about 6.30pm and get sleepy at about 10.30pm. It is important to note that I feel fully awake during the day. Seroquel XR is by far the most effective drug I've taken since being diagnosed with BD and OCD.I have no "highs" and the OCD symptoms have been irradicated. M 43 4 months
9/10/2009
 5  Bipolar 1, anxiety I get a little tired, but I take it so it makes me tired at bedtime. Other than that, no side effects noticed. I love Seroquel XR. It has obliterated my anxiety and ocd. Im more stable along with my Lithium than Ive ever been. I feel great. F 31 3 months
9/4/2009
 4  ADHD with manic episodes, insomnia Upset stomach and unusual fatigue. Noticed a very slight case of "feeling blue" as well (from a scale of -10 being the epitome of depression to +10 being off-the-walls manic and cannot control it, i would rate it a -3), Increased muscle tone but decreased strength and aggrivated issues speaking (I'll have problems speaking too slow then way too fast) on 50 MG: I've noticed that though the passing 7 days, it's been taking longer for the medication to "kick in" to help me fall asleep. it takes up to 4+ hours now for it to really kick in. Overall I tend to be more even-tempered than I used to be, and I can fall asleep (usually) quicker. Overall, I would say the medication is doing what it was intended without much problems in nasty side effects, and it's helping me get into a place where I can deal with my impulsiveness as a result of the ADHD. M 24 7 days
8/16/2009
 4  Not taking Seroquel Rep Here Many companies choose to do xr later in order to extend patent. There r though benefits. Regualar ser. causes your plasma concentration to peak rapidly after taking and then drops rapidly causing the sedation. XR is slowly released over a 24 hr pd and peaks 3-4 hrs after taking. If you go to sleep @ 11 take at about 7. It does not peak until about this time so any sedation will occur while you are already in bed. It then reaches steady state instead of the plasma level dropping thus a little more manageability of sedation/orthostatic hypotension (dizziness). Any slow release is a little cleaner regarding side effects. Weight gain is an avg of4-6 pds. Occassionally you may gain more. It is due to histamine blockade. Also if your dr. is not getting you to 300mg for dep. and 6-800 for mania it will not do anything but make you sleepy. It works on neurepinephrine, dopamine and serotonin at 3-400mg. Anything less is just causing sedation thur histamine blkade. Invega only works on dopamine and and a receptor that is pt. of the serotonin family. Ser xr wks (at correct dose) on dopamine, serotonin and neurepinephrine. The neurep.blkade allows it to treat depressive bipolar symptoms as well as manic and schizophrenia. Others in the class do not wk on neuepinephrine a major contributor to the dep. episodes. Ser and xr also bind much less tightly to dopamine so you won't see the akathisia, restless leg (inner restlessness, movement disorders) etc seen with others that bind more tightly to dopamine. M 42
8/4/2009

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