COMBIPATCH Reviews (ESTRADIOL; NORETHINDRONE ACETATE)

Average Rating: 3.4 (163 Ratings)

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 ESTROGENS PROGESTINS

 Type: Rx Drug

  

COMBIPATCH  (ESTRADIOL; NORETHINDRONE ACETATE):  This medication contains 2 female hormones: an estrogen (estradiol) and a progestin (norethindrone). It is used by women to help reduce symptoms of menopause (such as hot flashes, vaginal dryness). These symptoms are caused by the body making less estrogen. The progestin in this medication helps to reduce the risk of cancer of the uterus which can be caused by using estrogen. Women who have had their uterus removed do not need the progestin and therefore should not use this combination medication. This medication may also be used by women who are not able to produce enough estrogen (for example, due to hypogonadism, primary ovarian failure). If you are using this medication to treat symptoms only in and around the vagina, products applied directly inside the vagina should be considered before medications that are taken by mouth, absorbed through the skin, or injected.   FDA Approval Date: 1998-08-07 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on COMBIPATCH: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR COMBIPATCHCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Hot flashes Hair loss, terrible hair loss, terrible headaches, neck and joint pain. Weight gain. When i first started taking the patch, it worked almost immediately on my hot flashes, I couldn’t have been happier. Everything was going fine until I hit 3 months in. My Hair starting falling out in piles, every time I comb it I get a hand full of hair about 5 times a day. Plus I started getting terrible headaches that would last for 3 days or more. What a shame, I just stopped the patch 2 days ago so it will be awhile before it exits my system and hopefully I will notice less shedding soon. They say it takes 3 months to exit the system lets hope I’m not bald by then. F 57 3 months
0.14 mg 2X W
4/16/2021
 5  Sleeplessness, nightsweats No side effects. I cut the patch down to 1/4 twice a week. Recently went off and back to night sweats and hot flashes. Back on for now until I run out. Dr. won't give me anymore. Not looking forward to nightsweats and sleeplessness. I used 1/2 patch twice a week until about 1 yr. ago. It's very hard to get off. F 67 13 years
1X day
4/11/2021
 5  Sleeplessness, nightsweats No side effects. I cut the patch down to 1/4 twice a week. Recently went off and back to night sweats and hot flashes. Back on for now until I run out. Dr. won't give me anymore. Not looking forward to nightsweats and sleeplessness. I used 1/2 patch twice a week until about 1 yr. ago. It's very hard to get off. F 67 13 years
1X day
4/11/2021
 2  OT
1X day
4/3/2021
 1  Hot flashes and to prevent osteoporisis I was on this patch for 8 years I felt that it was helping me with bone loss and other symptoms of menopause unfortunately I developed lobular invasive breast cancer and am very upset I was not asked to stop this sooner I do not recommend this medication F 66 8 years
50/250 2X W
3/25/2021
 4  Menopause Burning, itchy skin that's dry and now has dark spots where patch applied. Patch comes off in shower F 51 0 months
0.5/0.14 2X W
2/24/2021
Email
 4  Menapause; hot flashes Immediately helped with hot flashes and vaginsl dryness. Feel much better. However have moderate to heavy bleeding after first two weeks. Hoping it dissipates after a few more months as the heavy bleeding has its own side affects. I have not experienced the redness or itching. However adhesive is hard to remove even with scrubbing. F 58 90 days
.25 MG 2X W
2/12/2021
Email
 4  Menopause symptoms I cannot take the burning and itching this patch gives my skin. It is seriously so painful. No matter where I place this patch, I feel a severe itching and burning pain. I do not know what kind of adhesive the company is using with this patch, but it is absolutely horrible and painful. Please go back to the old adhesive. This burning and itching feeling as just as bad as hot flashes. Please, please fix this problem ASAP!! F 48 1 years
2X W
1/26/2021
 2  Menopause/Dryness/Mood Was 100% satisfied before Noven changed the transdermal material. Now 99% dissatisfied due to blistering, burning, itch & feel of new material. Used to be soft, adhere to body, move with body & not burn & itch. I now have circular permanent scarring each area of application sites which I have always used same basic areas before cheap plastic material change. Unfortunately this is not a med that we can abruptly stop or change to a different mfgr. Please go back to the original transdermal material/adhesive. We pay ALOT OOP for this patch so using cheap generic materials should not be happening. I have been on Combipatch over 2 years with zero isdue. I knew immediately that this batch was different due to color of box & hard plastic feel of the patch itself Again, please change back to the original soft transdermal material. I cannot continue to have blisters, burning itch & permanent scarring F 52 2 years
.005 2X W
1/24/2021
Email
 4  Hot flashes, anxiety The patch leaves a red mark and it is sooo itchy, it is the only bad thing about it. I do not know if it is the glue they use to make sure it sticks to your belly or the hormones itself. This really needs to be addressed by the company ASAP!! F 48 1 years
2X W
1/1/2021
 3  Severe night sweats, mind fog Vaginal discharge I started taking this due to vaginal dryness and multiple UTIs and night sweats. I like the product but I am always wet. I have to wear a pad every day day and take baby wipes with me. I may have to weigh if this is worth continuing. Will talk to my Doctor soon. F 46 2 weeks
2X W
11/8/2020
 1  Peri /menopause transition HAIR LOSS , constant period cramps with amenorrhea , flu/ cold symptoms, headaches , sexual disfunction , excessive hunger , mood swings OMG crazy mood swings !!! I have to be honest I don't think I took this for more than a complete month straight. I have used it off and on because of side effects and have not been able to see a doctor because of COVID . This has been the most miserable year, I have tried low dose birth control with norethindrone and levonorgestrel then the combipatch. I bleed for months on the birth control and it was so awful the side effects were worse than the combipatch but very similar just more depression , headache brain fog all the things I needed help with to start the only thing it helped was the crippling anxiety and crippling joint pain and urinary Incontinence . I would gladly give birth to 4 more children to escape the affects of menopause!!! I really wish some one could find a way to stop all these crazy symptoms I'm so done 😭 I really believe it's the norethindrone that is causing such awful symptoms the levonorgestrel was better but I have to believe that there is something that works with less side effects . F 47 6 months
50/140 2X W
10/22/2020
 4  Ovary removal Breakthrough bleeding and some abdominal discomfort. So far feeling like myself. Happy that I don't have vaginal dryness and no weight gain or unusual cravings. Was put in patch after ovary removal. Has kept the telltale signs of menopause at bay. The bleeding is a bit annoying but sticking with it as says after a year should subside. F 45 4 months
2X W
10/9/2020
Email
 4  Hot flashes Loved being on this, but my skin is so itchy and raw from wherever I place the patch. I have raw, itchy spots all over my lower abdomen, even weeks later, from wherever I put this patch. It is making me crazy! F 48 10 months
1X day
10/3/2020
 1  Hot flashes, insomnia, headaches I wanted to go on HRT because I was experiencing 12-14 severe hot flashes per day. I wasn't sleeping and couldn't focus. I was miserable and desperate. Days 1-5 - severe anxiety - I cut the patch in 1/2 as others had, and that helped. I was experiencing over a dozen hot flashes per day, and while this helped reduce them, they never disappeared. Days 1-14 After about 2 weeks, I noticed I was losing a ball of hair every time I took a shower. I also realized I was eating everything in sight, and felt I was gaining weight. Day 14 - 18 The patch triggered a severe migraine which lasted 5 days. When I took the patch off, the migraine subsided within an hour. I decided to go back to the natural route. I now take : Morning: * 1 GNC soy isoflavone concentrate * 2 tablespoons of flax seed in my coffee. Evening: * 2 evening primrose oil capsules to help me sleep It's not only working better than this patch, but it's controlling my appetite as well. Not only is this too expensive (even with my great insurance, it was $30 per month), but it also caused more problems than it solved. I would never recommend this to a friend. F 50 18 days
.05/14 mg 2X W
8/21/2020
 3  severe hot flushes This worked great in the beginning. I had the side effects, bleeding, breast tenderness, weight gain. All of that went away after 5 months. Then the headaches started. Some hot flushes returned as well but not horrible. Tried changing the patches every couple days instead of 3 1/2. Helped a little then the headaches came back. Talked to my Dr. Upped my dose to the larger patch. Helped for about a week then headaches are back. Wish I could figure this out cause I like using the patch over pills. Trying different things to figure out how to stop the headaches. If I can't I'll have to stop using this. Maybe the summer heat/sweating has an effect? Anyone with experience/thoughts on this would be greatly appreciated! Thanks... F 56 7 months
.05/.14 2X W
8/18/2020
Email
 4  Hot flashes My main complaint is that I am tired all day. I sleep just fine now and my hot flashes are gone I noticed that nobody commented that they feel tired during the day. I'm wondering if anybody gets tired since they have been taking it. The Prescription was one patch every three days but now I am doing one patch per week to see if that helps with the sleepiness. I am still sleepy F 49 2 months
62mg 1X W
7/26/2020
Email
 5  Vaginal dryness After reading these side effects of others, I have terrible itching, spotting, and vaginal discharge. I see my doctor in a few weeks, will discuss these side effects, and may discontinue. It totally helped with vaginal dryness. F 64 1 years
50/140 2X W
7/16/2020
 3  Menopause sleep problems Red inflammation and unending skin itching . Increased sinus drainage and unrelenting cough from this treatment?. Didn't help my sleep. Using one half patch, but once it started itching my skin, that had to be the end of my using it. F 64 4 months
.05/.14 2X W
4/1/2020
 5  Severe hot flashes, anxiety Breakthrough bleeding, weight gain, full breasts. This patch has helped me tremendously. I no longer have hot flashes or night sweats. I was getting anxiety, brain fog, and feeling overwhelmed over small things. I feel like I finally got my life back. The weight gain was worth having my sanity back. F 47 3 months
3/5/2020

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