PROVIGIL Reviews (MODAFINIL)

Average Rating: 3.6 (619 Ratings)

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 CNS, MISCELLANEOUS    DEA Schedule IV   

 Type: Rx Drug

  

PROVIGIL  (MODAFINIL):  Modafinil reduces extreme sleepiness due to narcolepsy and other sleep disorders, such as periods of stopped breathing during sleep (obstructive sleep apnea). It is also used to help you stay awake during work hours if you have a work schedule that keeps you from having a normal sleep routine (shift work sleep disorder). This medication does not cure these sleep disorders and may not get rid of all your sleepiness. Modafinil does not take the place of getting enough sleep. It should not be used to treat tiredness or hold off sleep in people who do not have a sleep disorder. It is not known how modafinil works to keep you awake. It is thought to work by affecting certain substances in the brain that control the sleep/wake cycle.   FDA Approval Date: 1998-12-24 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on PROVIGIL: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR PROVIGILCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  sleep apnea/excessive daytime sleep If taken too late in the day, I experienced difficulty getting to bed at an appropriate time. I have experienced very few other side effects (using 200-300 mg/day). It's definitely improved the quality of my life. F 37 3 years
5/12/2009
 1  Have CFS, and POTS After taking the drugs for 3 days, I began hallucinating, could not sleep. Had to go to the hospital last week because I kept having visions. In the last 2 days my face is breaking out, my left eye is swollen shut and I have have violent diarhea. PLEASE, PLEASE be informed of the possible side effects. They are VERY SERIOUS and SEVERE!!! I am still afraid what may happen in the next few months from taking this 200mg for 3 days. F 18 3 days
5/9/2009
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 5  daytime sleepiness/ mild narco. Mild headaches, Tylenol took them away. Dry mouth and nose. Extremely irritable, angry. Not hungry, change in taste. I have noticed that most of the side affects reported are typical in stimulant drugs. I will undergo the side effects as long as they arent life threatening, I feel I am a danger to other people and myself driving, I fall asleep at lights, run of the road, take out mail boxes and signs, was ready to give up my license. I am not sleepy at all, I was miss diagnosed and have suffered for 20 yrs. Very happy that I can function. I wont have to quit another job or worry about killing some one. If anyone can let me know if you experienced anger and irritability and did it or does it go away? F 41 2 days
5/6/2009
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 3  OSA / SWSD / Excessive Sleepiness Mild dizziness,headache, at first. Increase in spontineity in speech and thought. 100 mg/day. To early to tell if effective or beneficial. Im experiencing the stimulant effect/ nothing outragous though. Im somewhat skeptical on the long term benefits. M 48 3 days
5/3/2009
 3  depression, sleepiness mild headache first few days, intensified depression The main reason my doctor prescribed Provigil was that I have extreme morning sleepiness and lack of energy. I've been on Cymbalta for over 2 years, but at the dose I tolerate best it doesn't completely relieve the depression. I started Provigil at 1/3 of a 200 mg tablet (approx. 67 mg) for 10 days, and then increased to 1/2 (100 mg) per doctor's instructions. The first two or three days on Provigil I did have increased energy and motivation, and although that faded somewhat after a week or so I did feel more alert. Some nights I had a lot of trouble getting to sleep, and my sleep schedule became erratic because I would stay up very late until I became sleepy. Earlier this week, after having taken Provigil for about 1 month, I became extremely depressed, anxious, and tearful. I didn't link it to Provigil until I read the comments of others who have had a similar experience. I had also noticed that I was talking a lot, which is out of character for me, but I didn't link that to the Provigil, either, until I read other patients' comments. My doctor has taken me off Provigil and increased the Cymbalta. I may try it again at a low dose because I need some relief from the sleepiness/fatigue, which has returned full force. F 54 1 months
5/2/2009
 5  Narcolepsy Decreased effectiveness if taken consistently. Occasional headaches. Panic attacks if I mix high doses with other stimulants. Insomnia if taken after noon. Anxiety with dose of 200mg or more. This medicine is a life-saver for me. Taking it keeps me from falling asleep in classes, airports, at work, or while eating, but 100 mg doesn't disrupt my sleep cycle at all. It helps me concentrate and keeps my thoughts from wandering off as often, too. Taking it has made me a much better student without negative psychological effects. F 19 3 years
5/1/2009
 1  extreme sleepiness / sleep apnea hallusinations, hearing voices, constant fear of death/being killed, anxiety, verdigo, sleepiness, depression, shaking, ringing in ears, loss of apitite, loss of weight, incohirent thoughts, inappropriate social behavior, foggy mind, could not stop talking - as if on cocaine but worse, mental addiction. I CANNOT STRESS MORE TO ANYONE PLEASE NEVER TOUCH THIS DRUG AND IF YOUR ON IT, GET OFF IT. When i first took this pill i was in love with it, i thought i found the missing link to how to live life normally. I was constantly tired, sleeping all day if i could, but then i could not sleep at night. The first few weeks i took as perscribed 200 mg a day, then i felt it was not enough and begged to get perscribed 400mg a day, which is rare for someone to take and the most a doctor legally can perscribe. From then on i was hooked, taking 5- 7 pills a day which would back fire more and more as time went on, but it was impossible for me to stop cause i couldnt get out of bed anymore without it. i eventually had to sleep two days straight to get off it . . i would consider this a legal herion when it comes to how quick a person can get hooked on it. i believe this because being constantly tired all the time no matter who you are, makes a person feel hopeless in life and depressed, we try eveything but nothing works, we eny others who can live life normally, then we find something that can actually give us the enegy we believe everyone else possesses normally - but its a lie. i would take the way i feel now over provigil anyday. i cant even eblieve who i turned into , i almost lost my child. and my home just because of my behavior, i am completely sane and i found myself on easter upstairs at my parents talking to " ghoasts" i could only see through reflextions or shadows, but F 23 1 years
4/30/2009
 4  
4/23/2009
 3  OSA treated with CPAP but still EDS itchiness after taking 50 mg of Provigil... I split a capsule in fourths. I usually bounce out of bed today I did not. Yesterday, My first day on Provigil I was not as sleepy. I was focused. But reading the side effects and experiencing the itchiness and not bouncing out of bed. I will discontinue and maybe give it another try in a few weeks. I think I would rather be sleepy.... F 53 1 days
4/23/2009
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 5  Depression - with Effexor Headaches,nausea,motion sickness(sensitivity to motion, I didn't have before)loss of appetite, sadly no weight loss yet ;) The side effects I experienced were because I had to tinker with how I took the medication in time with my other medications (effexor and suboxone). I was taking all my meds together and it made me VERY sick. Now i wait an hour between each med and it's made a world of difference. Let me be clear: PROVIGIL IS A MIRACLE FOR ME. I feel like a brand new person. I don't feel manic or high, or jittery like a stimulant, just CLEAR, FOCUSED, CALM AND HAPPY. My family notices a difference and I thank God every day that I have doctors who listen to what I need and the research I did on this drug. F 36 10 days
4/15/2009
 2  Sleep Apnea I have sleep apnea and I am still trying to get a good setup on my cpap machine so until then I am always tired. When I took the sample pack it was wonderful to finally not have to take a nap at work. I had to fight with my isurance for 6 weeks to get it and I still have to pay $50. Now I am on the 4th day of taking it again and I am a walking zombie and almost more tired then before. I would love to feel the affects I felt the 1st week, I have not changed any medication and it seems that my apnea is actually getting better (cpap is working a little better than before) M 43 10 days
4/7/2009
 1  fatigue from MS & MS medications The horrible side effect, after about four years' of use, was hypomania, which I didn't associate with the Provigil, and which became full-blown mania within the next year. Early side effects, which I'd been managing, seemed related to getting the dose correct to allow normal sleep -- after the first month or two, I ended up going for many months being awake 36 hours, sleeping 6 hours until I "mixed and matched" a lower dose of Provigil with a high dose of Celexa antidepressant at neurologist's and psychopharmacologist's suggestion I wouldn't take Provigil over a long period of time. I began taking it after enrolling in a double blind study of Tysabri, a then-new MS drug given by infusion. I thought I was getting the Tysabri, not a placebo, because the first infusion knocked me on my ass so much that I couldn't get out of bed for three days. (It did turn out to be the Tysabri.) Hence the Provigil prescription. Once the balancing of the dose seemed to be settled, I didn't see any problem with it. About four or so years into its use, I began having intrusive, running thoughts that prevented sleep. Others with MS said it sounded like mania, which can come with the MS, and which is treatable. My doctor said it was hypomania, gave me some Ambien, and it went away on its own after only two nights of Ambien -- or did it? I could sleep, but without me really being aware of it, I wasn't even thinking about sleeping, and I wasn't tired. When I did sleep, I wasn't being kept awake by racing thoughts, so all seemed well. Wrong. I ended up with full-blown mania. While manic, I stopped taking all my meds, and the mania lifted. Because I'd taken the Provigil so long with no apparent ill effects, I (illogically) assumed it was the Tysabri which caused the mania. I stopped the Tysabri, added back in the Provigil, and gradually noticed I was beginning to have "magical thinking," a symtpon which presaged the hypomania turing into mania. So, I stopped the Provigil and the magical thinking went F 50 5 years
3/24/2009
 4  for SSRI apathy Provigil does raise your body temperature a little bit so I felt hot sometimes. It also has a tolerance build up that is perceptible. So when you take it at first it is stronger and more effective than if used every day. I think this works but works better if you take a weekend or a few days off here and there. M 53 2 years
3/21/2009
 3  Mixed connective tissue dz/fatigue Alopecia, itchy scalp, dark, strong colored urine. I was prescribed a 200 mg tab to take once a day, but had only been taking 100 mg (1/2 tab). I noticed accelerated hair loss (on Plaquenil too, which had already thinned me out considerably), but felt so much more "with it" on the Provigil, that I hung in there. After about 7 months on the 100 mg daily dose, I began to notice the accelerated hair loss (especially thinning at the temples and "crown"), and then unexplained itchiness in my scalp area. The dark strong colored urine was apparent immediately after starting the med. I am afraid that I felt the need to discontinue this medication, even tho it helped (significantly) with my severe day time fatigue. Concerned that I was going to eventually lose all of my hair and the itchiness was bothersome! F 39 8 months
3/17/2009
 5  severe narcolepsy Extremely dry eyes; had dry eye syndrome for several years prior to taking Provigil, then it became much worse after taking Provigil. Still looking for the best dry eye treatment. This drug is a miracle. I began taking one 200MG pill daily three weeks ago. I went from depression and pain caused by constantly fighting extreme fatigue to feeling NORMAL again. Have eliminated celebrex and flexeril for muscle pain, eliminated pulmicort and singulair for asthma. Rarely take arthritis tylenol. Has changed my life in a very positive way. I've also lost 12 pounds, need weight loss after gaining 50 pounds since narcolepsy set-in perhaps 3 years ago (hard to assess the starting point). F 51 3 weeks
3/8/2009
 1  sleepiness/weight gain from Seroque Panic attacks, blurred vision, RASH, RASH, RASH!!!! I had taken Provigil about 1.5 years ago, and it was wonderful! No problems whatsoever. I had discontinued it because the blurred vision was getting a little intolerable, though. I started again about six months ago, got this nasty rash all over, including my face! I didn't link it to the Provigil until I googled it and read the FDA black box warning about the possibility of Stevens-Johnson syndrome and other possible fatal rashes. My last dose was a couple of days ago. I still have an intolerable rash and I can't wait for it to go away - if it does. F 45 2 years
3/6/2009
 5  side effect of tegretol I have to take tegretol for trigeminal neuralgia, it makes the excruciating pain go away, but it makes me so sleepy. I end up sleeping all the time. Provigil has totally cured that with no side effects at all. I take 100 mg in the morning with my morning tegretol. No provigil with my evening tegretol. No trouble sleeping. F 61 5 days
3/2/2009
 3  Difficulting getting up feelings of physical tension I have insomnia and sleep apnea. Even with a CPAP and doses of Trazodone, Seroquil and klonopin, I still have difficulties going to sleep. I find it hard to get up as a result oif the meds I need to get to sleep and stay asleep. I take 100 mg of Provigil to try and become awake earlier. The doctors keep playing with the dosage and the dosages of my sleep meds to try and get a balance, but haven't found one yet. M 61 2 months
2/28/2009
 3  Fibromyalgia, CFS, EDS Day 1: 100 mg, felt awesome for about 5 hours. Day 2: 200 mg (as prescribed), massive migraine. Day 3: back to 100 mg - still massive migraine that not even Imitrex could shake. Day 4: 50 mg, awaiting effects... scared about migraines but am not willing to give up yet! I've read so many great reports on this drug, I had to give it a try. I was prescribed 200mg in the am, but I think that was way too much for me. I'm going to start a bit lower (50mg) and see what happens. Maybe you have to build up to it. I hope so, because I'm not ready to give up yet! I'll rate it again after I (hopefully) find the right dosage for me. I thank the people on this site for sharing their experiences. I consult it any time I am given a new rx. Very helpful! F 39 4 days
2/27/2009
 3  Idiopathic Hypersomnia The only side effect that i've experienced is headaches, which seems to be less frequent over time. I started taking Provigil about a month ago. Originally I took 200mg in the morning. Now I take 200 mg in the morning and 100 mg (half a pill) at around 3 each day. One of my main problems was not being able to wake up in the morning, so I set my alarm for 6am and take my provigil and go back to sleep. Waking up has been less difficult. I still don't feel wonderful, and often get tired. At night I become EXTREMELY talkative. It's almost embarassing that I can't shut myself up. I'll report back after I've taken it for a few months F 19 1 months
2/24/2009
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