LUPRON DEPOT-3 Reviews (LEUPROLIDE ACETATE)

Average Rating: 2.6 (110 Ratings)

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 ANTERIOR PITUITARY HYPOTHALMIC FUNCTION ANTINEOPLASTICS

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LUPRON DEPOT-3  (LEUPROLIDE ACETATE):  Leuprolide is used to stop early puberty (precocious puberty) in children. It helps to delay sexual development (such as growth of the breasts/testicles) and the start of menstrual periods. It also helps slow down early bone growth to increase the likelihood of reaching normal adult height. Leuprolide works by decreasing the amount of sex hormones that a child's body makes (estrogen in girls, testosterone in boys).   FDA Approval Date: 1997-03-07 (Sources: U.S. Centers for Medicare Services, FDA)

  

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More on LUPRON DEPOT-3: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR LUPRON DEPOT-3COMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  Endometriosis Hot Flashes, depression, severe mood swings, weight gain, insomnia, anxiety, vaginitis I have taken 3 shots so far and I do feel a relief from the pelvic pain I was experiencing, but the side effects are very difficult to deal with. I just keep telling myself that is only temporary...I can not wait until I am done with the other 3 shots. My boyfriend deserves a medal for putting up with me. I feel so out of control from this medicine sometimes that I don't even realize how I am acting. Just recently, I have had vaginitis problems, which I originally thought was yeast. My doctor actually had to give me an estrogen cream to use which has some wonderful side effects of its own. Not fun to say the least. I have also recently been experiencing depression and weight gain. It's no wonder my clothes don't fit! I am vegetarian, exercise, eat mostly organic foods and yet I still keep gaining weight. It will be worth it in the long run, though. Hopefully, I will not have any trouble conceiving and if I do, I will really be angry. If you are thinking of taking it for endome F 25 3 months
10/7/2007
 4  Ovarian cysts Mu stomach always felt a little "off". I did have hot flashes but not until my second month...then I got them all day long.I did suffer joint pain in my knees and hands...so I took aleve and that helped. I had the insomnia too. The worst side affect was the moodiness!!! My husband deserves a medal for putting up with me! But after two months my cysts were gone!! We really want a baby and this will hopefully do the trick! You have to decide if it will be worth it for you! I had a short term therapy goal w/ Lupron. Those of you who are thinking about taking this long term need to think long and hard about these side effects...they can affect your lives more than the original problem you have! I don't have painful endometriosis though and I can't give any advice for that, F 30 2 months
9/25/2007
 4  to shrink very large fibroid I have experinced mood swings the first month and hot flashes and insomnia have been ongoing. I have not had any awful side affects from this drug. reading comments from sites made me nervous to try it, but my doctor said this was the only way to shrink my very large fibroid (17cm) If I do not take this drug to shrink this I will probably lose my uterus and cervix because of where the fibroid is. I have been taking lupron for three months and the worst side effects have been hot flashes and insomnia. I did have terrible mood swings for the first month though. However I have not experienced awful things. I would love to have a child someday and am trusting this drug to shrink this based on my doctors recomendation that this is our only hope. F 35 3 days
7/31/2007
 3  severe and extensive bleeding from night swests, mood swings -- depression, joint pain I have taken three of the three-month shots and am scheduled for a fourth at the end of August. I WILL NOT be taking any more of this medication due to the increase of side effects. It seems that with every new injection, a new side effect rears its ugly head. At first, I as grateful since my periods stopped -- I had had severe and extended (sometimes six weeks) periods which were beginning to debilitate my life. The OB-GYN had tried every possible medication to help me, and she finally suggested Lupron Depot-3. At first. I was grateful for the cessation of my periods despite the night sweats and insomnia I experienced. With second shotcame the joint pain -- primarily in my fingers. With the third shot came the knee pain -- so painful that I have a problem getting up off the floor. My fingers are now so swollen in the morning that it is painful to bend them. While the medication didwhat it was supposed to do, the side effects render it difficult to continue. F 52 8 months
7/6/2007
 1  Endometriosis hot flashes, fatigue, mood swings, stomach pains, diharria, My expereince of the Shots were horriable. My doc put me on them for 6 months for "Endometriosis". During those 6 months I have never felt soo horriable in my life. I was basically on bed rest the whole entire time. I barley got to work during the week couldnt do anything at all during the weekends. I was gettind depressed. My stomach pains and diharria and mood swings were effecting me extremely bad. After the horriable 6 months i got my period 2 months later and my cramps have been WORSE after the treatment then they were before. Since the shots my periods have been heavier and the pain is soo severe that i have ended up in the ER due to the pain. ITs horriable and i would never do it again it was a waste of $6000.00 F 20 6 months
6/17/2007
 5  Endometriosis Hot Flashes and fatigue. I was very scared to take this drug. I am sure it affects everyone differently. I am on the add-back therapy also. I had severe hot flahes in my first 2 months but now in my fourth they have gotten much better. I also feel tired a lot of the time. I made sure to start taking a multivitamin and calcium, which I think helps. Although the two side-effects I described are bothersome...it is definitely worth it. I now realize that I didn't even know how much pain I was in until it was gone(after starting treatment.) I just always had pain and cramping so I thought it was normal. I feel good after only 4 months. I can deal with the side-effects for 6 months..if the result is less pain all of the time. F 27 4 months
6/14/2007
 4  endometriosis Headaches, nausea (end of second month), fatigue, crazy hot flashes, low sex drive I am just finishing my second month of two, and am wondering when I should get my first period. F 29 2 months
5/22/2007
 5  Endometriosis Positive Side Effects - no more migraines! Weight Loss - 40 pounds! Increased sex drive! Negative Side Effects - hot flashes, waking at night, but definitely worth it due to feeling SO much better! I took it for 7 months (no period for a year), then a year later took it again for 9 months (no period for a year again). I felt fantastic! No periods, no pain, could go to the gym and exercise, lost weight, wanted to have sex, migraines went away (did have regular headaches). I felt better those months than I had in a long, long time. However, when I stopped and my estrogen levels came back up, I had severe nausea for months - as if I were pregnant. F 43 16 months
5/20/2007
 3  fibroids/endo I took the first Lupron shot 11/06.When the first shot was given I felt a sense of calmness during the fist month. Afterwards I experienced endless cramping,skin crawls on forehead and face,headaches,mood-swings,loss of sex drive.Just before the second shot I was told that the fibroids had gotten smaller. They were 3 cen. and had shrunken to about 1 cen. After the second shot (2/07) I experienced the same calmness after the shot.Afterwards periods of mild depression,I gained 15 pounds , vaginitis from extremely dry vagina,I'm totally exhaulsted on a daily basis,now I'm starting to experience pain in my knees.I would not recommend this treatment for anyone for any reason. Although the fibroids are shrinking, the the side-effects are unhealthy. F 40
5/4/2007
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 1  Endomitriosis andOvarian Cysts and When I received the 1st shot my pelvic pain went away I had hot flashes but did not realize that I was having so mucm body pain by the end of the second shot I can barely move from the pain I lost 30 pounds feel like a truck ran over me and had to take so many meds for Insomnia depression anxiety voice change and joint muscleuar pain and a feeling of complete mood swings and missery. I feel apathy and can not concentrate also the shot gave me memmory loss. I will not get another injection ever in my life again. Sure it took the pelvic pain away but I am afraid that I will suffer for a long time from the body pain. I will never take it again. The reason I took it is that the doctor needed to see how I would do with the shot to prove that I have endometriosis. She was afraid to operate on me because I was on pain killers from the cyst and fibroids. The doctors that I saw 5 in total all said that cysts do not cause pain the only doctor who said that that cysts cause pain was the Emergency room Doctor I had to go there several times and he said that many women have severe pain due to Cysts, that I know for sure. I have spoken to many women and they all said that they knew someone or they themselves had one and they had severe pain. Now what? I wonder if anyone knows when will my body stop hurting? I hope to spread awarenwss that ovarian cysts are very painfull and that you should have them removed because the shot is not worth it. This is the worst I have ever felt in my entire life. Does anyone know what I can do to get this out of my system? And how long will my body hurt? F 47 60 days
5/2/2007
 4  ENDOMETRIOSIS HOT FLASHES MINIMAL MEMORY LOSS UPON FIRST SHOT-SLEEPLESS NIGHTS BUT WENT AWAY I STILL HAVE PAIN BUT NOTHING LIKE BEFORE I STARTED THE MEDICATION I HAVE COMPLETED MY SIX MONTHS WILLING TO TAKE SHOT AGAIN MY DEPENDENCE ON GOD (PRAYING) FOR SUPPORT HAS HELPED ME THROUGH THE MOOD SWINGS.I WAS AT A POINT WHERE I WANTED TO STOP TAKING THE SHOT BECAUSE OF THE TERRIBLE HOT FLASHES IN THE FIRST TWO MONTHS THAT EASED I THINK AFTER THE THIRD SHOT. I HAVE READ OTHER COMMENTS, IT APPEARS THAT NOT EVERYONE HAVE THE SAME EFFECTS NO TWO PEOPLE ARE EXACTLY THE SAME OR HAVE THE SAME CHEMISTRY. F 39 6 months
4/9/2007
 3  Precocious Puberty-daughter My daughter has been taking Lupron for about 6 months. She has always had weight issues because of the other medication that she is on for precocious puberty also. However in the last 6 months has gained 30 pounds. Has anyone else experienced severe weight gain? The medication has stopped her periods at age 9 and hopefully will be able to give her full adult height. F 36 6 days
3/26/2007
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 1  endometriosis hot flashes, significant mood swings, weight gain, skin crawl I took one full 6 month cycle of Lupron Depot. A year later I began another cycle after my hysterectomy. I quit taking the shots after the 2nd month.. I will NEVER take this medication again. The side effects were too severe! My personality completely changed while taking this drug. My doctor wants me to take the drug again because I am still in so much pain. I told her that I would rather endure the pain twice a month than take the medication. That is how bad I think the side effects are. I would really consider the side effects before taking this medication. Also, if you choose to take the medication, ask for the one month shot so you can quit if it is too hard on you. F 38 1 years
2/10/2007
 1  severe pelvic pain i was given this injection 6 times. i would not reccomend this drug to anyone out there. At first when my obgyn gave me the injection i noticed hot flashes right away... my moods were so bad and my family was really fed up with my irribility, and constant rages. i felt like i had morning sickness all the time. my doctor told me that in time with this drug the side effects would go away. yeah right!!!!! my bones started to hurt after the 3rd injection..my doctor told me that this would go away too. well i have had my 6th injection last month and thank God i am done with this....my bones still ache so bad... i need painkillers, but since the injections my doctor does not believe me that i amin pain with this because he said this drug shrinks the uterus and my pain should be almost gone. thats a crock of crap. im miserable and wish i had some support.... PLEASE RETHINK ABOUT THIS BEFORE TAKING THIS DRUG!!!!!!!!!1 M 33 6 days
1/30/2007
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 1  severe pelvic pain I was given this injection 6 times. i would not reccomend this drug to anyone out there. At first when my obgyn gave me the injection i noticed hot flashes right away... my moods were so bad and my family was really fed up with my irribility, and constant rages. i felt like i had morning sickness all the time. my doctor told me that in time with this drug the side effects would go away. yeah right!!!!! my bones started to hurt after the 3rd injection..my doctor told me that this would go away too. well i have had my 6th injection last month and thank God i am done with this....my bones still ache so bad... i need painkillers, but since the injections my doctor does not believe me that i amin pain with this because he said this drug shrinks the uterus and my pain should be almost gone. thats a crock of crap. im miserable and wish i had some support.... PLEASE RETHINK ABOUT THIS BEFORE TAKING THIS DRUG!!!!!!!!!1 M 33 6 months
1/30/2007
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 4  endo/pelvic congestion weight gain, headaches, severe hot flashes, mood swings,scaterbrained.. hard to stay focused Although the side effects are less than pleasant it really has done wonders for me, I HAVE NOT HAD ANY cramping,heavy bleeding or pain I was dealing with on a daily basis. I was in constant pain before my injection. I do HIGHLY RECOMMEND THIS SHOT. I do already have kids but I would like to have one more I am not sure if I can get pregnant after the shot? Anyone have kids after the shot with out invetro or fertility drugs? F 29 3 days
1/28/2007
 1  Endometriosis Severe joint pain, hot flashes, insomnia, fatigue, low-grade fever, low sex drive, weight gain (from 112 to about 122), stabbing headaches, muscle weakness, vision changes. I started the Lupron injections six months after a failed laparoscopy to remove my endometriosis. For the first two injections I had the typical side effects of hot flashes, insomnia, fatigue, low-grade fever, and low sex drive. My third and final injection caused horrible joint pain that migrated around all of my joints aside for my spine and took a full year to ultimately dissipate. While taking the drug, I also had intermediate stabbing headaches that would come on in the back of my head, throbbing deeply and painfully with my heartbeat for a few minutes before disappearing. I have not had a recurrence of those headaches or the above symptoms per se. However, three years later, I now suffer easy tendon injury and flareups of joint pain as well as having multiple abnormally low hormone levels. I did ultimately decide on having a second laparoscopy where it was discovered that the majority of my pelvic pain was from a large ovarian cyst as well as multiple adhesions from my first surg F 30 9 months
12/30/2006
 1  Endometriosis Severe joint pain, hot flashes, insomnia, fatigue, low-grade fever, low sex drive, weight gain (from 112 to about 122), stabbing headaches, muscle weakness, vision changes. I started the Lupron injections six months after a failed laparoscopy to remove my endometriosis. Other than the more common side effects during the first two shots, the third and final injection caused horrible joint pain that migrated around all of my joints aside for my spine and took a full year to ultimately dissipate. While taking the drug, I also had stabbing headaches that would come on in the back of my head, throbbing deeply and painfully with my heartbeat for a few minutes before disappearing. My endometriosis pain did come back after the Lupron stopped working. Now, three years later, I suffer easy tendon injuries and flareups of joint pain as well as having multiple abnormally low hormone levels. A second laparoscopy discovered that the majority of my pelvic pain was from a large ovarian cyst as well as multiple pelvic organ adhesions from my first surgery, with only a small amount of endometriosis visible. In the end, Lupron didn't help me at all. I strongly suggest tryi F 30 9 months
12/30/2006
 1  Edometrosis Horrible leg pain, hot flashes, weight gain (47 lbs) It has been 10 years; I am still suffering!!! It destroyed my health; my body!!! DONT DO LUPRON!!!!! F 33 6 months
12/11/2006
 4  Endometriosis Hot Flashes, joint pain,severe mood swings, blurry vision, breakthrough bleeding, some crampng with the breakthrough bleedng I took this in 2004 for 6 months and soon after I got pregnant with my daughter. I'm taking it again cause we want to get pregnant again but this time the side effects are worse. I'm not sure I can take them till march 07. Its a hard drug to be on and you have to expect major side effects. F 25 3 months
12/5/2006

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