LUPRON DEPOT-3 Reviews (LEUPROLIDE ACETATE)

Average Rating: 2.6 (110 Ratings)

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 ANTERIOR PITUITARY HYPOTHALMIC FUNCTION ANTINEOPLASTICS

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LUPRON DEPOT-3  (LEUPROLIDE ACETATE):  Leuprolide is used to stop early puberty (precocious puberty) in children. It helps to delay sexual development (such as growth of the breasts/testicles) and the start of menstrual periods. It also helps slow down early bone growth to increase the likelihood of reaching normal adult height. Leuprolide works by decreasing the amount of sex hormones that a child's body makes (estrogen in girls, testosterone in boys).   FDA Approval Date: 1997-03-07 (Sources: U.S. Centers for Medicare Services, FDA)

  

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More on LUPRON DEPOT-3: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR LUPRON DEPOT-3COMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Ovarian Fibroid and Heavy Bleeding Severe weight gain, horrific hot flashes, mood swings which effected my everyday life, severe depression, joint pain and frequent, long lasting headaches. I was happy with this medication on my first go around, I used it for a little over a year and it did what it was suppose to do, decreased pain, stopped my bleeding. After losing insurance coverage I had to go off this medication for about 2 years during which the pain and bleeding returned worse than before. I was able to get back on the shot for about 1 1/2 years during which the side effects were awful. I continued the shot because of the fear of the pain in my pelvic region returning and the uncontrollable bleeding. I have been off the shot since Feb and all my old symptoms are returning. This time I do believe I will seek a surgical treatment versus Lupron Depot! F 30 1.5 years
1X M
6/6/2010
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 5  prostate cancer physical & mental exhaustion, loss of stamina, loss of concentration, hot sweats, raised liver functions & mild nausea,high blood pressure, high glucose level, raised cholestrol; increased appetite early on and periodically, bone thinning (first posted below on 4/2/08) - now finished Tx: this drug is like being on mild chemo, especially after the first 12 mos. BUT it seems to have worked for me. each man experiences it differently, but i do think it is harder the younger the patient, based on my support group experience.exercise is a great mitigator - i missed very few days - and resistance ex. is v. important - google RoAnne Segal's JCO article, 12/8/08 ascopubs.org/cgi/content/abstract/JCO.2007.15.4963v1. feel free to e-mail me for info and support. M 59 27 months
22.5 1X O
6/5/2010
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 1  Endometriosis hot flashes & sweating bad at night, decrease in sex drive, mood swings I would never take this shot again. I took my last shot in February and have yet to have a period. My pain was not bad at all and this treatment was not worth it. My endimetrosis was discovered when i had a cyst removed. He said it was a light case but went ahead and put me on a 4 month shot. One one month and then three the next month. If i had to do it all over i would not. When should i expect a period if anyone knows? F 30 4 months
4X O
5/17/2010
Email
 4  Endometriosis Horrible embarrasing hot flashes, could not sleep, serious hair loss, weight gain (20 pounds), fatigue, mood swings (angry, sad), hands, legs and hips joint pain...I finished the treatment in january, just got my period back and was not painful at all, still not losing weight and Im having acne breakouts in my face and back that I didnt have even as a teenager. I feel better now that i am finished with the treatment but I gained a lot of weight....dont know yet if it was worth it. F 33 6 months
1X M
5/12/2010
 2  Uterine Fibroids & Heavy Bleeding High blood pressure. Joint pain (Knee & finger) Could hardly walk on occassions! Migraines. Depression/weepy. Palpitations. Memory loss/Forgetful Initially agreed to to have 3 x monthly PROSTAP injections, prior to my hysterectomy. Ended up having 5 as they couldn't fit me in for the op. They did help with the bleeding, no more flooding or clots, just light bleeding. F 50 5 months
1X M
4/24/2010
Email
 2  Uterine fibroids Briefly? Leg pain, vertigo, nausea, vomiting, fever, chills, sweats, flu-like symptoms, debilitation, fatigue I have known I've had fibroids for some 15 years now, but they (one 15cm one, plus other smaller ones) have become so problematic that my uterus was the size of a six-month pregnancy, and was pressing on my leg veins (I've had a clot), and central veins (feeling dizzy if I lay on my back for too long). I am of course a prime candidate for hysterectomy, but do not want to have one for various reasons, so was keen to try Prostap (UK name). Was given the treatment (1-month depot injection) by the nurse who said that most women are fine, without being told of the possible adverse side effects. It was only after reading the leaflet later, that I became concerned. Felt OK in the first 2 weeks of treatment, and it was like a miracle in terms of the notable uterine shrinkage. My stomach became flat again, and my legs stopped swelling up. Great! However, I then developed the excrutiating leg pain (bone pain), that kept me awak at night. Next was the vertigo attacks. Usually on rising in the morning, but so bad that I had to take time off work. Next was the worse nausea and vomiting I have experienced in my life, to the point I had to go to A&E with dehydration from it. Then came the flu-like symptoms and the hot flushes, plus the affects on sleep. As a business woman and fitness enthusiast, the treatment has totally pollaxed me. I am due for my third shot next week. The week I had the N&V, I swore I would not have any further treatment, but no have the dilema of f F 48 2 months
1X M
3/5/2010
 4  Prostate cancer I was prescribed this, which they call Prostap in the UK, as a preliminary treatment before having radiotherapy. After a few days I started to experience obsessions with certain things, and this developed into a mania over about 3 weeks. Then I had what felt like an emotional crisis, with insomnia, anxiety, extreme swings of mood (elation, weeping) and over-reaction to any emotional event. I felt I was deeply in love with one of my best friends! (Never told her) Also physical symptoms like palpitations and sweaty episodes, but these were insignificant in comparison to the mind-bending effects. After 3 months the effects are wearing off, thank god, And I am much calmer. Now I just have the effects of the radiation to suffer. It had the desired effect on my prostate cancer, but I hope I never have to have this drug on a long-term basis. M 65 3 months
11.25 mg 1X O
2/13/2010
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 3  Endometriosis Hot flashes, hair loss, depression, irritability, lack of energy, joint pain especially in knees, less frequent but more intense migraines, loss of sex drive. The pain and bleeding went away within the first week. I am anxious to see what the long term effects will be and how long it will take to be eliminated from my system. F 36 6 months
12/10/2009
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 1  Endometriosis, Heavy periods Tingling under skin, severe migrane, spots in vision, emotional meltdowns, anxiety, hot flashes, memory loss, confusion, anger, mood swings, weight gain, joint pain, strange shooting pains, loss of period, extreme fatuige, heart palpatations, rashes and skin problem, darkening of skin on face like above upper lip and under eyes, insomnia On January 25th I had a lap for endo. On February 12th I had a lupron depot shot(3month).I was told the only way to keep endo from coming back for 5 years is taking the lupron. The third week was hell.............I started to have panic/anxiety attachs. I scaring my family. Then came the hot flashes, ever 15 to 30 minutes!!!horrible. I still have not started my period and I am coming up on 6 months. I WILL TELL YOU FROM MY EXPERIENCE THIS DRUG IS EVIL AND SHOULD NOT BE USED! THE SIDE EFFECTS ARE FAR WORSE THAN WHAT YOU COULD EVER IMAGINE. MY HUSBAND AND I ARE GETTING A DIVORCE AND I BLAME IT ON THE SHOT!!! IF YOU HAVE A FAMILY DO NOT TAKE THIS MEDICINE. MY 11 YEAR OLD SON AND I ARE VERY CLOSE AND IT IS HARD FOR HIM TO UNDERSTAND THE SHOT AND WHY I AM STILL HAVING PROBLEMS. NEVER EVER TAKE THIS SHOT!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! SOME DAYS I WONDER IF I WILL EVER BE MYSELF AGAIN OR HAS IT ALTERED MY CHEMISTRY FOR GOOD???? THERE IS NOTHING THE DRS OR ANYTHING I HAVE READ ON THE INTERNET ABOUT HOW LONG IT STAYS IN YOUR SYSTEM OR HOW LONG IT WILL BE BEFORE I FEEL LIKE MY SELF AGAIN..............BE CAUTIOUS ABOUT WHAT YOU LET BE PUT IN YOUR BODY. GOOD LUCK TO ALL AND BELIEVE WHAT IS WRITTEN IN THESE COMMENTS I DID NOT AND AM PAYING THE PRICE, MY LIFE HAS BEEN STRIPPED FROM ME AND I DONT WANT THAT TO HAPPEN TO ANYONE ELSE F 30 6 months
8/3/2009
 2  15 cm fibroid & cycts SEVER MOOD SWINGS! VERY ANGRY MOST OF THE TIME , YELLING OUT OF MY NORMAL CHARACTER, EASILY PISSED OFF AND ANNOYED. HOT FLASHES EVERY DAY, HEADACHES,STILL HAVE PAIN IN OVARIES WHILE ON MEDICINE, EASILY BRUISE ALL OVER BODY, CHANGES IN SKIN COLOR I HAVE NOW SUFFERING FROM DARK BROWN SPOTS ON SKIN FACE, HANDS, ALSO THE MUSCLE PAIN THAT I AM CURRENTLY EXPERIENING ON MY ARMS AND LEGS IS TREMENDOUS I FEEL AS THOUGH I GOT HIT BY A CAR .. THIS IS REALLY BULLSHIT.. I STARTED TAKING THIS MEDICINE IN MARCH 2009 AND I JUST RECENTLY TOLD MY DOCTOR THAT I AM STOPPING TREATMENT. I HAVE TWO MORE MONTHS TO GO BUT I REFUSE TO CONTINUE. I HAVE PUT MYSELF AND MY FAMILY THROUGH HELL SO FAR. ESPECIALLY MY CHILDREN I AM 34 YEARS OLD AND I AM A MOTHER OF TWO BOYS, ONE IS 10 YEARS OLD AND THE OTHER IS 1 1/2 YEAR OLD. PLEASE THINK TWICE BEFORE STARTING TREATMENT... I DID DO MY RESEARCH ON THIS MEDICINE BUT I NEVER IN A MILLION YEARS WOULD'VE THOUGHT THAT I WOULD SUFFER FROM SO MANY OF THESE SIDE EFFECTS AND F 34 4 months
7/18/2009
Email
 4  Endometriosis fatigue, weight loss, unexplained crying spells, night sweats/chills I have had two months of shots, the normal side effects, and it is well worth it. The pain from the endometriosis had taken over my life and I was hospitalized twice. I had constant pain. Please know this is a personal decision and can change your life for the better ! I also do add back therapy and would highly recommend it. F 42 60 days
7/3/2009
 1  To Shrink Fibroid EXTREME HOT FLASHES, Mood Swings, Chills, Restless Sleeps, Crying, depression, and Hungry all the time. I was an outgoing, friendly, bubbly person. I would walk into a room and brighten it. I barely want to leave the house because of the HOT FLASHES! I carry a fan everywhere I go and its so embarrassing when the flashes just come out of no where. If I am emotional, which is all the time because of the shot, the FLASHES ARE WORST!! I am going through a horrible crying spell that I have no control over. I feel so sad and depressed and I have no reason to feel that way. IT SHOULD BE CALLED THE SHOT FROM HELL!!! I wish that I had listened to a friend of mine that had to go through the same thing, when she told me, "whatever you do, don't take the Lupron Shot". I am now suffering more than I was before. I had to have a Hysterectomy and my Dr. was great. I just wish I hadn't ever agreed to shrink the fibroid before surgery.I am now applying estrogen patches to level the side effects. The hot flashes are every hour instead of every 15 min. I would never recommend taking this medication to anyone, not even my worst enemy! God Bless the women and their marriages that have no option, but to take the "SHOT FROM HELL"! F 36 2 months
7/3/2009
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 5  premenopausal breast cancer After 2 yrs in combination with tamoxifen: thin eyebrows, cramping in calves, no periods (great!), but finally some severe cramping in calves and pain/swelling in am in knuckles and soles of feet. But I would do this combo again - not bad at all. Effects may be just menopausal. Used Lupron with Tamoxifen for 2 years for hormonal treatment of breast cancer. I believe Tamoxifen does stimulate the endometrium because I got my period back after chemo, 1 month after starting tamoxifen. Therefore I used Lupron for ovarian suppression to hopefully keep my estrogen down and prevent reoccurance of my breast cancer. I think it was a good decision - no cancer return so far, and quality of life was OK. F 47 21 months
4/17/2009
 3  endometriosis Freaky dreams, edgyness, acne, weight gain, headaches Laproscopy for endo 4-2008. 9 months later, started lupron. I am always wary about medicines, so I do a lot of research and consideration before starting something new. This one had me a little nervous especially b/c of the bone loss, but after discussing all my ?'s with the dr. I decided to try it. She suggested the 1 month shot to give it a try. I said that if all went well, I would continue to have them given one month at a time b/c I like to have the option of getting a medicine out of my body asap if needed. Anyway, the very first night after getting the shot, I had a very disturbing dream! These types of disturbing dreams continued for 2 solid weeks, all night, every night! After 2 weeks they began to get less disturbing, but I was still dreaming all night--feeling like I had a restless sleep. My husband said I was very edgy that whole first month and the first couple days after the shot I felt kind of crazed like a wild energy and ambition. So, I decided to not pursue any m F 37 1 months
3/13/2009
 1  guinnea pig PAIN PAIN PAIN PAIN PAIN PAIN PAIN and depression. I can barely function and live on a day by day moment by moment basis. Come to find out my dr. gave me this drug without telling me it wasn't approved by the FDA for my condition F 31 8 months
2/24/2009
 4  Endometriosis I took Lupron for 4 years off and on. I am 29 years old and was very concerned about infertility after having 2 lap's to remove adhesions and still experiencing pain. I happened to have a very good experience with Lupron but I do urge one to do tons of homework on this med and it's side effects prior to taking it. After 3 months on Lupron, I had lost 10lbs, was not experiencing as much pain, felt much less moody and unpredictable, and did not have a period through the whole course of my treatement. However, I also experienced hot flashes that were out of this world, occasional fatigue, as well as osteopenia (or bone loss) in my hips and knees (Osteopenia has since improved with regular weight bearing exercise and calcium supplements) I stopped taking Lupron about 3 months ago and luckily all my symptoms went with it. My cycle is beginning to return but is in no way "a regular monthly cycle." I am very sorry to hear about the awful effects this med has had on so many women. I have not read many positive ratings on this med and do feel very fortunate after reading all of yours. I, like most of you, did not do my homework and jumped on the Lupron wagon with my eyes wide shut. My 2 concerns were; 1. no more pain and unbearable periods but most importantly 2. Fertility protection. From what I have read these have been the concerns of most women contemplating Lupron therapy. We all must weigh out the risks and benefits of starting any new medication and it is always best to get more than one opinion especially if you do not fully trust your physician. Also, there are many holistic therapies that have been effective in treating the pain associated with endo, fibroids, as well as other repoductive disorders. My recommendation to anyone considering Lupron therapy would be to seek out alternative therapies before putting this drug (or any drug) into your body. F 29 4 years
11/10/2008
 1  wife with endometriosis hot flashes, constant bleeding, head aches, pain, mood swings, depression. my wife has endometriosis. this was the second time she had this treatment. She got a new doctor, she gave her a 3 months dose, in one shot! She has been worst, and she is constantly bleeding off and on. Right now she is in the hospital because of the bleeding and the pain. This treatment should be your last option. F 37 7 days
11/4/2008
 1  prostae cancer Hot flashes, extreme sensitivity to sun. Mania (without depression) Loss of libido. Difficulty with erections. Orgasm without ejaculation. Took 2 one-months shots. No problem. Then one three-month shot: after two months 24-hour hot flashes and recurrent bouts of mania. I don't mind about the loss of libido. I expected that. Shot was supposed to have worn off one month ago, but the effects are worse than ever, while my psa slowly climbs. I'll never have any kind of treatment for prostate cancer again. I'm not afraid to die if I have to live like this. M 64 5 months
10/28/2008
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 3  endometriosis Hot flashes, cold flashes, memory loss, sex drive better, "tired" due to hot flashes at night, emotionaly up and down, but i do feel more level headed then before...kinda weird! After 2 pelviscopy surgeries for my endometriosis, and finding out that i have another disease called endomytosis, the doctor recommended this procedure for 6 months... i wish i did a little more research on it BEFORE i decided to go through hell for 6 months. I would have to say the only major problems were my hot flashes and memory loss. I noticed that after my 2nd shot i lost alot of weight almost too much if there is such a thing. But by the 4th shot and no really change in my work out pattern i notice the weight came back on but only in my mid section, i know this might not make sense but my pain started to come back again as well. I did notice the depression was a on going battle, up and down...etc. Listen people ask me all the time would i recommend it...and the answer would be ....i don't know, it is such a complicating shot, some people have the results THEY hoped for and others don't. All i know is that physically i feel as if i am poisoning my body, i look at photos of me a M 6 months
10/25/2008
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 1  Endometriosis Insane hot flashes, mood swings (aka crying for no reason every day) I took Lupron as a last resort after, even after surgery did not provide relief, for severe endometriosis pain. I took it for 6mo. six years ago without the progesterone supplements. Although my back pain subsided during the 6 mo. my other side effects were just as bad and the pain returned as soon as I stopped the Lupron. One important thing to note is that the use of Lupron has been tied to the development of other autoimmune diseases such as rheumatoid arthritis. My cousin and I used Lupron for endo ~6 years ago and now we have both been diagnosed with RA. We are only in our early 20's and have debilitating joint pain and she has had more health complications. I would not recomend Lupron to anyone. Natural hormone replacement has been the most effective for my endo., and 2 laporoscopies. F 24 6 months
6/17/2008

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