MIRAPEX Reviews (PRAMIPEXOLE DIHYDROCHLORIDE)

Average Rating: 2.8 (431 Ratings)

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 EXTRAPYRAMIDAL MOVEMENT DISORDERS

 Type: Rx Drug

  

MIRAPEX  (PRAMIPEXOLE DIHYDROCHLORIDE):  Pramipexole is used alone or with other medications to treat Parkinson's disease. It can improve your ability to move and decrease shakiness (tremor), stiffness, slowed movement, and unsteadiness. It may also decrease the number of episodes of not being able to move ("on-off syndrome"). This medication is also used to treat a certain medical condition (restless legs syndrome - RLS) that causes an unusual urge to move the legs. Symptoms usually occur at night along with uncomfortable/unpleasant feelings in the legs. This medication can decrease these symptoms and thereby improve sleep. Pramipexole is a dopamine agonist that works by helping to restore the balance of a certain natural substance (dopamine) in the brain.   FDA Approval Date: 1997-07-01 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR MIRAPEXCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  rls I've been having ankle and feet swelling beyond belief. My heels and ankles hurt on and off to the point that somtimes I can't even walk. I've gained about 14 pounds in about 5 months of using the drug. My face and wrists are very swollen as well. Not sure what to do but I know I'm waaaaay too young for these side effects. I've been having suicidal thoughts a lot lately as well. I know I would never act on these, but it's very disturbing. Starting taking 6 months ago for rls. It was a life saver helping instantly once I was able to overcome the nausea. It works very well, however,the side effects are now affecting my quality of life and I'm finding I have to take the drug now early in the evening for it to take effect by the time I go to bed. This causes me to be very tired in the evening and has caused a lot of problems for me and my husband concerning intamacy. Like I said, I'm waaaay too young to have these issues. Don't know what to do. My rls is so severe that I have to take something. F 36 6 days
5/24/2009
 1  RLS, PLMD I took Mirapex for several years and during that time my weight went up to over 270 pounds. I went off Mirapex for a year because I could not afford it and lost all the excess weight. Went back on it 2 months ago and have gained 15+ pounds. I didn't realize the Mirapex was the cause of my prior severe weight gain. The doctor never discussed it as a cause. After going back on and the sudden weight gain I did my own research and have since discovered this problem. I have a Dr appointment next week. I am discontinuing. Would rather use Vicodin! F 47 4 years
5/19/2009
 3  RLS Worked on my RLS, which was a great releif after more than 30 years suffering and nothing else helping. Found had to take it 3-4 hrs before bed to take effect. Was not told of any side effects until started to wonder what was going on. Started out on .125 and had to increase to .375. Side effects kicked in at .25mg. Side effects include legs hurting upon awakening, muscle cramps that effect my walking, feet hurting all the time and MAJOR mood swings, OVER HEIGHTENED SEX DRIVE, desire for kinky/overt acts with wife, but find myself thinking about other woman all the time (never cheat and wouldn't), desire to pickup drinking and tabacco use that I have been 15 years without. Anger issues that I have alway controlled, depression/manic episodes, OCD type activities, suicidal thoughts. Found this site and working on getting off Mirapex now!!!! Was wondering why my life was unraveling (I am a professional in the fire service and stable person) and getting worse the past 6 months (increased the dose to .375 6 months ago). Wife does not understand what is going on, even though I have asked her to read this site. Marriage may be on the rocks and not savable after 33 years, even if I get off because of my uncontrolled sex drive towards her and way I have treated her. This is NOT WHO I AM! Very frusterated right now. But hope is on the way now that I know what is causing it. M 49 3 years
5/6/2009
 2  RLS I started this medication (mirapex) 2 days ago at night as told by my doctor to do. I have slept for 48 hours! I can sleep during the day any time I want. I have not had the RLS pains in my legs for some time but a sleep study showed that I was suffering from restless limb movement. Therefore I am tired throughout the day. Because I am on a lot of meds including heavy pain meds I no longer felt the pains and suffering from my legs at night. I had no idea it would knock me out so much. My husband is very upset over this side effect. I have decided not to take anymore until I talk with the DR. which will be another 48 hours. F 57 2 days
4/25/2009
 1  Severe RLS Chronic headache, diarrhoea, nausea and unable to get out of bed for over a week until I stopped the tablet Within two days of taking the smallest dose of Mirapexin, I was confined to bed feeling more ill than ever in my life. I thought my head was going to burst, one sip of water gave me chronic diarrhoea and the nausea was unbearable. Never again. F 56 10 days
4/13/2009
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 1  fibromyalgia weight gain, sleeploss, memory loss,obsessive/compulsive behavior,falling asleep during the day When I first started taking mirapex I was happy with the increased energy. My dose was gradualy increased to 6mg at night. Over time my behavior became worse and I realised I had to stop taking the medication. I quit gradually with my Drs. orders. I have since had several bouts of severe depression and am still in the last one with strong suicidal thoughts/intents to the extent that mental mealth professionals are trying to get me hospitalised. M 64 7 years
3/30/2009
 4  rls none M 73 3 years
3/29/2009
 1  PD My husband (73) has had PD for 15 years. The neurologist prescribed Mirapex. It was the worse thing the doctor could have prescribed. He became a sexual monster. The longer my husband was on Mirapex the worse the symtons became. He became very sexual aggressive and I feared for my life as he started raping me several times during the night. I could tell that he did not know what he was doing as his eyes were blank. It also made him confused and forgetfull. He could not remember what he did to me. After the medication stopped he was like a new person. When he took the medication he would have freezing spells and had many falls. He no longer shakes and walks much better no more freezing spells and he is much happier and alert. He also sleeps much better during the night. M 73 3 years
3/29/2009
 5  rls slight fatigue during the day take 0,25 mg at bedtime, additional 0,25 on long flights, and when I have to sit for hours. my life is almost manageable now compared to hopeless fatigue before. It works better for me than ropinirole (requip). I wonder about all the compulsive disorder comments byother users, if these were latent and the drug acts like a release. M 52 6 months
3/27/2009
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 1  Bipolar Illness Extreme Nausea and weakness. Started by second dose. Stopped it was so bad. Mild OCD-like symptoms which have stayed. Certainly not worth the bother as it removed all quality of life that might be gained had it worked. M 45 3 days
3/24/2009
 1  RLS 3 lbs/month weight gain, shifted but not relieved pain in my legs, very vivid dreams. The .25 mg dosage is no longer effective. But I'm 9 lbs heavier and feel deceived by the doctor at the sleep clinic who should have clearly explained this common side effect. I am so angry with Dr. Wright at the Minnesota Sleep Clinic who didn't warn me of the weight gain side effect. My RLS symptoms were so mild. Now I have to deal with this massive weight gain and the self esteem problems that go with it. F 47 4 months
3/23/2009
 4  RLS NONE VERY EXPENSIVE!!! F 61 1 years
3/18/2009
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 5  RLS None whatsoever has been completely effective from virtually the first day M 73 10 years
2/25/2009
 3  RLS, PLMD Nausea, Weight Gain, Compulsive Behaviors, Exaggerated Movements, Sleep Attacks Helped legs for a while. At higher dose, side effects worsened. Developed wild flailing movements that happened when not all the way asleep. Reducing dose helped all side effects except sick feeling in pit of stomach and daytime sleepiness. Do not stop abruptly! I did and it caused neurological problems. Wean off like it says. F 58 4 years
2/23/2009
 2  Severe RLS Constantly hungry, most severe reaction after 2 years on drug is severe muscle cramps, feel like muscles in legs and feet are caught in vice for hours. Diagnosed with polyneuropathy. Stopped the RLS syndrome, was a miracle, but now I am in so much pain from the polyneuropathy and muscle pain. I am not diabetic, no other cause for these symptoms can be found. I don't know how I will live with the RLS pain without this drug. Double edged sword. F 60 2 years
2/17/2009
 3  Parkinson's I was diagnosed with Parkinson's disease in 2003. Started on Mirapex after one year. I became a compulsive gambler and gained about forty pounds. I have trouble sleeping all night and tend to eat while awake. I fall asleep during the day and have fallen asleep while driving resulting in several minor accidents. I've also had many close calls. The medication helps with my symptons but not sure its worth it. I will ask neurologist about other medications. M 56 6 years
2/16/2009
 3  Severe RLS Weight gain of 20+ pounds in less than 1 year, bizarre sexual desires, very graphic dreams all night (i.e. animal mutilations, dreams that I am having sex with dogs, bloody horror movie type nightmares) - if taken too late (not given time to take effect) it actually caused me to be in a dream, wake up, and go right back to the dream - so that means my REM pretty much lasts all night. Obsessive buying - spent over $800 on sewing patterns and fabric I have never sewn, and scrapbooking supplies never used either. eBay mania. Muscle aches and pains, eye twitching, bad short-term memory problems (not good when you are a 911 dispatcher - I fear for my career I began having RLS during my first pregnanacy in 1985, by 1988 I could not sleep at all and by that time had a second child who (now it is clear) also had RLS. I was diagnosed after a sleep study in 1995 after I had woken up cooking my bicycle helment on the stove, and constant suicidal thinking because of severe sleep deprivation. I was put on Sinemet which stopped working by 1997, I found out about Permax on the internet and asked to be put on that which worked, but was taken off the market in 2007. I drove sometimes up to an hour away to deplete pharmacies of their remaining supplies until I could no longer get it. I tried Requip and it didn't work for me. I started with one .25mg Mirapex (the Veterans Affairs pharmacies don't carry it because of the nightmares) now, 8 months later, I take six tablets. I have no choice. For me the relief from RLS outweighs all the hell of the drug -- that's how bad my RLS is to me. F 45 8 months
2/4/2009
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 1  RLS OCD type behaviors, selfishness,Money mangement and overall personal worth diminished,Approx 40 lbs weoight gain in 4 mos,Massive appetite for sugar products,over all personality change, suicidal at times, depression, anxiety and loss of energy Since on the drug wife has become very self absorbed and irrational,started compulsive shopping for items of no use,Began online chatting with strangers,Drove our company into bankrupcy,suicidal at times,very bizarre behavior which is unlike her since taking mirapex,Doesnt seem to have priorities in line like childrens welfare, house cleaning etc.Sometimes goes 2 days without showering,She also takes MS contin (morphine) for back pain in conjunction with this drug, F 36 4 months
1/29/2009
 2  Parkinson's Disease Anxiety, slight OCD I am in the early stages of PD and was prescribed Mirapexin 3 months ago(0.36 Mg 3 times daily) because the PD was affecting my ability to work. I am a bass player and my right hand was not functioning properly. When I first started taking Mirapexin I thought it was a wonderful drug, my ability to play my instrument was improved 100%, however this only lasted a couple of weeks and I now have co-ordination problems again. I have never been a particularly anxious person, but for the last couple of months wake up in the morning feeling extremly anxious, not about anything in particular, just a general feeling of dread. I am considering asking the Doc if there is anything else he could prescribe for the PD because 1) Mirapexin does not seem to relieve my symptoms and 2) I cannot carry on with this awful anxiety. M 59 3 months
1/22/2009
 1  RLS Nausea, diarrhea, lightheadness/fainting spells, headache, sweat and chills. I've suffered from RLS for about 10 years. My doctor gave me a prescription of Vicodin to take--1 or 1/2 tablet before sleep to help with the symptoms--and a prescription of Mirapex. The vicodin has been working for, but I'm not too thrilled about taking codeine every night. So I tried Mirapex one time and believe me, I will never take it again. I felt as if I had been poisoned, and had all the symptoms of poisoning. I had alternate sweating and chills, diarrhea. I fainted twice when I got up to use the bathroom, and I threw up continuously for about 10 hours. Aside from the physical, I was very agitated and nervous. I did not have food poisoning because nothing I ate was different from what my family ate. I have never been so sick in my entire life. It was a horrible, horrible experience. If you have had side effects like mine, you are not alone. F 29 1 days
1/18/2009

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