MIRAPEX Reviews (PRAMIPEXOLE DIHYDROCHLORIDE)

Average Rating: 2.8 (431 Ratings)

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 EXTRAPYRAMIDAL MOVEMENT DISORDERS

 Type: Rx Drug

  

MIRAPEX  (PRAMIPEXOLE DIHYDROCHLORIDE):  Pramipexole is used alone or with other medications to treat Parkinson's disease. It can improve your ability to move and decrease shakiness (tremor), stiffness, slowed movement, and unsteadiness. It may also decrease the number of episodes of not being able to move ("on-off syndrome"). This medication is also used to treat a certain medical condition (restless legs syndrome - RLS) that causes an unusual urge to move the legs. Symptoms usually occur at night along with uncomfortable/unpleasant feelings in the legs. This medication can decrease these symptoms and thereby improve sleep. Pramipexole is a dopamine agonist that works by helping to restore the balance of a certain natural substance (dopamine) in the brain.   FDA Approval Date: 1997-07-01 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Date added.

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR MIRAPEXCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  RLS Fatigue, falling asleep during the day, morning nausea, muscle weakness. I was prescribed this drug about a year ago for RLS. at a dosage of .125 which seemed to work if taken 2 hours before bedtime. Recently it was not working as well and my doctor increased to two 0125 tablets. I guess one question I have is what problems are side effects of the drug or just the body getting older, like muscle weakness. However, lately I have felt like I wake up in a fog even after getting 8-10 hours sleep. This weekend I took my motorcycle out of the garage and after a short ride returned as my balance and general control was off. I also felt mentally impaired, just not sharp. I now can fall asleep at the computer with no effort at all, yesterday I fell asleep and didn't even realize it. As far as the RLS the drug works! I am now thinking about getting off the drug and trying to find some other source of relief from RLS. M 63 1 years
0.5 1X day
7/11/2011
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 3  RLS Weakness in legs. I can hardly walk up 2 flights of stairs without feeling like my legs won't take me any further. When I have a few alcoholic drinks and I get up to walk, on occasion, my legs require a lot of effort to get them moving. It's like I have lead in my feet. After a short time this goes away, but it's scarey when happening. I am thinking about going off this med. to see if I can't tolerate my RLS as these side effects are just not worth it. I have had RLS since a baby...my mom always told me she had to take the rollers off my crib as I would start my nap on one side of the room and end up on the other by rocking so hard! F 57 10 months
.5 1X day
7/8/2011
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 1  anhedonia helped at first then reversed all the sudden after a few weeks and made me much worse. its been a year and a since i stopped mirapex and i still feel horrible from it. horrible M 23 1 months
.5 mgs 1X day
7/5/2011
 3  RLS At first Amazing, I have been suffering RLS for 25-30 years. the first night i took it I slept all night long, I woke up well rested alert and I lost 14lbs in 10 days, Who woulnt love that? I take it the same time every day, on day12 however woke up feeling like I had the flu. horrible headache, neck stiffness, and leg weakness. I just shook it off and went about my business......the next day the joint pain was even worse I couldnt go to work.The pain was horrible! I called my neurologist and he said that there was no way this could be a side effect because I was on the lowest dose. and gave me medrol dose pack, that didnt work so I called my pharmacist and he told to stop the mirapex immedatley.....I dont know what to do I have'nt been able to sleep more than 2 hours a night ( and that was while I was taking 12.5mg of ambein and some times I was taking 2 of the ambein) WIth mirapex I sleep 8-9 hours and feel really good. But this joint pain, neck stiffness, headaches, and mus I wish my body would just allow me to take it with no side effects because it really DOES work for RLS. F 45 2 weeks
0.05 1X day
6/29/2011
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 5  RLS This drug has saved my life. I could not sleep without it. I have had no side effects from taking Mirapex. I have had no side effects at all with Mirapex. It truly has been a "Miracle" pill for me. I have been taking it for 2 years. F 64 2 years
0.5 1X day
5/28/2011
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 1  RLS I have been taking Mirapex for 3 years and recently began terrible side effects. I wasn't even aware of them except my boyfriend experienced them. I fall asleep heavily after 1/2 hour and apparently start snoring "enough to take the paint off the walls" and begin hallucinating, accusing my boyfriend of "looking like a german shephard with big teeth, a giraffe, etc." I have no recollection. He cannot sleep with me anymore and it is causing major relationship issues. I now am so depressed because I don't know what to do. I can't go without the Mirapex. I would be up all night. F 51 3 years
0.50 1X day
5/17/2011
 1  RLS abnormal dreams, diarrhea, fatigue, muscle twitching My doctor wanted me to take this medication 3 times a day. I felt uneasy about taking this medication as it is prescribed for Parkinsons, so I only took 1 at bedtime. I've missed time from work due to diarrhea. I can't imagine what shape I would be in if I took 3 a day. I have a appointment with my doctor today..I am demanding that he take me off of this crap. The side effects are far worse than the RLS. F 33 2 weeks
0.125 3X day
4/28/2011
 1  Parkinson's this medication seems to destory all emotions. There's no right/wrong. no good/bad. Nothing to cry about. M 60
1.0 1X day
3/7/2011
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Patient History
 4  Fibromyalgia Pros: Can tolerate more foods. Have more drive. Have less pain. Cons: Quicker impulses. Nausea. It works for me. The side effects are annoying but its fine. I think people need to watch themselves carefully during the first months. Also, if you dont have to take it during the day time then dont. Take it before sleep. It works best this for Fibro anyways. M 31 3 months
1.5@night 1X day
2/25/2011
 1  RLS Started med in Sept on FL vacation after a badly failed sleep study that said RLS. Extreme muscle pain and charlie horses. Started in foot, then calf, then inner thigh/groin muscle with rock hard muscle. Couldn't even get up in the morning to move. Felt robotic and extremely stiff. Felt this would go away. I started having terrible ankle pain with swelling and had an MRI in Jan that showed a torn post. tibialis tendon. Could this have been snapped from the extreme charley horses?? Never had an ankle injury or hurt it in anyway. Also low in Vit D (No winter sun here)that increases muscle weakness/pain. After reading other reports, I'm lucky I quit and am not addicted to something. F 56 10 days
.5mg? 1X day
2/18/2011
 5  Restless Leg Syndrome slight morning headache at first; none now drowsiness This drug was an excellent fit for my situation. The sleep study results indicated 'involuntary periodic limb movements' and I exhibited the symptoms of RLS over the years. My sleep was disrupted and not restful. Now, I sleep through the night and am very comfortable. I take one .5 about three hours before bed. It is possible that .75 might be needed when I go in for my 90 day follow-up with my primary care physician-I still have some symptoms during the afternoon but counter that by doing some physical labor--weed, clean the pool, vacuum. I have a lot of energy! F 56 2 months
.5 mg 1X day
2/14/2011
 4  RLS Until i read other peoples comments I thought my side effect were minimal. I am not sure if the side effects are from a combination of menopause and mirapex? I would still never go off mirapex as I would never sleep? Have run out of the drug for one night and literally did not sleep all night. As I age the RLS gets worst and is in my arms and legs. Occasional memory loss (perhaps menopause) word reterval (also could be menopause) and misplacing objects. The side effects are not nearly as frustrating as not sleeping and literally walking the floors all night. F 54 8 years
1.25 mg 1X day
2/11/2011
 1  RLS Intensified usual pain. Unusual leg and foot cramping, extreme drowsiness, racing thoughts, short term memory loss, easily distracted, inability to perform daily functions or verbalize thoughts. First & second dose allowed me to sleep through the night, experiencing odd dreams but no nightmares and foot pain was lessened to a large degree. Day after the first dose I was drowsy but could function & complete my office work. Day after the second dose I had racing thoughts and rambling conversations and txt messages, couldn't recall names or phone numbers, was easily distracted. Following the third dose, the usual pain in feet was intensified. Cramping & trobbing in my feet AND legs hit me so hard that is was intolerable. Due to extreme drowsiness I was unable to get out of bed to exercise or "walk it off" until five hours later. When finally "awake" I was unable to complete the smallest task. Couldn't remember how to make coffee. Burned food I left in the oven. Set the wrong temp for drying clothes. Misplaced things and later found them in odd places. Sense of time passing was distorted. Didn't trust myself to leave the house. Gave up on accomplishing anything and slept until late in the afernoon when the effects had worn off. The meds are now in the trash and my pain level is back to where it was before the first dose & my mind is clear. I'll return to my walking and exercising routine. Maybe will try acupucture and massage therapy. Can endure the pain better than the side effects of the meds. F 56 3 days
.0125 1X day
2/6/2011
 4  Parkinsons Weight gain, sleeping problems Works well for me so far. I also take Sinemet so don't know if Mirapex is helping or not, but with the minimal side effects, I will continue taking it. M 59 1 years
.25mg 3X day
1/26/2011
 5  RLS Minimal side effects. Nasal congestion 30 minutes after daily dose. Poor sleep habits, frequently awake at night, drowsy while driving. To be fair, have had sleep issues since onset of RLS and could never stay awake while in a car. Mirapex could be your miracle drug. I spent 10 years in pain and insomnia before RLS was diagnosed 8 years ago. Without Mirapex I would be a basket case. Based on what I read here you will want to proceed with caution. M 54 5 years
2mg 1X day
1/18/2011
 4  rls/fibro The side effects stink...weight gain, urges etc. but my life isn't worth much without this drug. I don't sleep at all. I have had rls since my 20's and I just wish I had this drug back then. F 44 10 years
.25 4X day
1/5/2011
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 1  Parkinson's Horrible reaction. All PD symptoms became dramatically worse within days of starting Mirapex. I quit the drug after 4 days. I've been off the drug now for almost 3 weeks and my symptoms have still not returned to their pre-Mirapex level. Shuffling gait, constant spasms, frequent muscle cramping, unsteadiness-all much worse than before I started Mirapex. I also take Azilect and Propranolol. Has anyone else experienced this or heard of anyone who has. I'm quite anxious about how much longer the intensified symptoms will last. My neuro says she's never seen this before. Doesn't know what to do. Any ideas/info would be greatly appreciated. I understand my reaction is not typical, but I think the drug warrants much stronger warnings re side effects, and perhaps even to be taken off the market. My reaction has been dreadful, but based on so many other postings on this cite, Mirapex has absolutely devastated many lives. I have urged my neuro to never again prescribe it for anyone. M 56 4 days
.25 3X day
1/4/2011
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 1   Took for leg cramps at night. Caused high blood pressure. The side effects listed for this drug include low blood pressure but it affected me exactly the opposite. I took this drug at night for about a week and the nightly leg cramps had stopped. Then the next few nights, when I awoke at night, I just didn't feel right. The last night, I woke in the middle of the night and thought I was having a heart attack - the pressure on my chest was very intense. I took my blood pressure and it was very high (for me). I immediately discontinued this drug and have had no further symtoms. If you are prone to high blood pressure, I would NOT recommend this drug! F 68
0.125 1X day
12/30/2010
 2  For Secondary Progressive MS F 45
1.5mg 1X day
12/21/2010
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Patient History
 1  RLS worked but led to compulsive shopping i would not recommend this drug to anyone, and feel that patients should be warned about these side effects when this is prescribed (i was not ) F 58
0.18 1X day
11/29/2010
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