MIRAPEX Reviews (PRAMIPEXOLE DIHYDROCHLORIDE)

Average Rating: 2.8 (431 Ratings)

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 EXTRAPYRAMIDAL MOVEMENT DISORDERS

 Type: Rx Drug

  

MIRAPEX  (PRAMIPEXOLE DIHYDROCHLORIDE):  Pramipexole is used alone or with other medications to treat Parkinson's disease. It can improve your ability to move and decrease shakiness (tremor), stiffness, slowed movement, and unsteadiness. It may also decrease the number of episodes of not being able to move ("on-off syndrome"). This medication is also used to treat a certain medical condition (restless legs syndrome - RLS) that causes an unusual urge to move the legs. Symptoms usually occur at night along with uncomfortable/unpleasant feelings in the legs. This medication can decrease these symptoms and thereby improve sleep. Pramipexole is a dopamine agonist that works by helping to restore the balance of a certain natural substance (dopamine) in the brain.   FDA Approval Date: 1997-07-01 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR MIRAPEXCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  RLS aka Willis Ekbom Disease Started on .5mg to 1mg over first few years. During last year went up to 2mg, which my neurologist told me was my max. During last two years have experienced weight gain, migraines, chronic fatigue, memory issues, vivid nightmares on higher dose. I've had RLS (now referred to as Willis Ekbom Disease: see RLS.ORG (connect with others/discussion board... you don't have to create an account to read boards like it says) since I was in high school and was able to control with exercise and OTC pain meds for years. Finally got so bad I started Requip. Augmented on that after taking it for several years and started taking Mirapex after discovering no natural ways to control symptoms. The nausea and fatigue have been constant since day one. Since upping my dose, due to symptoms returning, I have been experiencing weight gain and increased symptoms previously described... I am trying amino acids and Jigsaw Magnesium as an alternative to upping my dose. My neuro doc says I have to go on Neupro (patch) if the Mirapex isn't working any more. Having had bad results with Epilepsy drugs, and running out of options with PD drugs, my only resort is opioids. My current career goal involves working for the government. I cannot get a job there while taking that class of drug. I am convinced that this condition is brain chemical and or neuro transmitter producer/reciever related, and am seeing positive results from taking amino's (see: http://bb.rls.org/viewtopic.php?f=1&t=7977). I am also taking .5 Clonazepam 1x day with Mirapex before bed. I believe these drugs are doing more harm than good in the long run, may increase symptoms, and am not looking forward to the withdrawals when I get up the nerve to give them the boot. M 44 4 years
1.5 1X day
7/30/2012
 1  Parkinson's Disease Sleepiness, irritability, personality changes, gambling, lying This drug has turned someone I love very much into a raging gambling addict who goes to any means necessary to gamble slots. I don't even know who this person is anymore. It got so bad I had to separate myself from them. They would lie about anything and everything no matter how big or small. M 58 9 months
1.5 1X day
6/30/2012
 1  parkinsons fatigue, hyper sexuality, erectile dysfunction, slowed reflexes, drop foot, IT band, fine motor skills particularly on right side, I was poisoned by car exhaust with lead and possibly manganese 40 yrs ago. I probably have hereditary hypothyroid. I got over chronic fatigue for the most part. I have been stressed out of my mind for over 50 yrs. I did chelation for the lead for years and had a reverse osmosis system without proper remineralization for 6 yrs. I like my beer. Stress, diet, alcohol, diarrhea sweating and of course chelation and reverse osmosis water will deplete minerals out of your body and Magnesium in particular. I told the dr that I couldn't continue the chelation because of cramping all over my body. He didn't say a word. I am getting divorced! Once your Mg levels drop, your potassium will drop and you might get the runs. Get the runs and your Mg drops and you start a downward cycle. If you run out of Mg, you die. Simple RBC Mg tests don't work. Two weeks ago two of us did a preliminary search of Mg and Potassium deficiencies and screened every one of my symptoms we could think of. Hit after hit after hit including MG def cns vasculitis. Ma Barker's herbal tea site doesn't mention that one. Mg def comes up for RLS, tremors, chronic fatigue (cfs), anxiety, agoraphobia etc. Hypothyroid comes up for fatigue, cholesterol, suicidal thoughts, cfs, fibromyalgia, agoraphobia etc. I used to focus on thyroid but mg and other mineral deficiencies are more relevant to me. They are both important but I have ADHD - mag related! It is time consuming. Then there are the idiot doctors M 64 2 years
1mg 3X day
6/15/2012
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 1  Restless Leg Syndrome Highly addictive!!! Would sometimes bring on the RLS; but mostly just didn't really do much after the first couple of years. Mirapex worked great for the first year. Then it slowly lost its effectiveness. My doctor tried increasing the dosage and changing the frequency and times of day I was taking it. We tried drug holidays which worked for the first couple of times then stopped. We added other drugs and I even tried many, many non medical treatments. But the real problem is that it just really didn't work any more and when I tried to stop using it, my RLS became unbearable. I used to believe this drug was a miracle. Now I would not recommend any one starting it. Just go on the web and you will find hundreds of stories of people who can't find a way to get off it. M 64 10 years
.5 Mg 2X day
6/10/2012
Email
 5  RLS Possible memory impairment. I don't care. Mirapex is a miracle for me. No obsessive/compulsive behaviors, narcolepsy, nausea, etc. I can SLEEP! My RLS is so awful that my legs jump by themselves if I don't move them proactively. It's unbearable torture. I'd rather be in pain. Thank you Mirapex! F 51 1 years
0.25 mg x2 1X day
4/29/2012
Email
 1  rls My Husband was diagnosed around 1999 with Rls.This diagnosis was just a verbal diagnosis from Doctor Frank Chiampi with my husband explaining his symptoms to the doctor.The symptoms being the irratating feeling as his legs and feet had worms and bugs crawling through them so bad that he would be trying everything to relieve them banging them against the wall etc.My husband was immediadley perscribed Mirapex.Not long after my husband developed a compulsive gambling addiction.He has decribed this as urges so strong and would be thinking about gambling all the time .He also describes this as just gambling to gamble not for gain but to fulfill really bad urges. He has got really high amounts of money online and just gambled that away.I had once found sheets of paper with numbers written down as like as to find a pattern or something.I had to keep our bank accounts in my name after many times of online gambling .He eventually did the unthinkable and stole from his job.This record has been e M 11 years
5 mg 3X day
4/3/2012
Email
 1  Orig Clinical Study in 1997Park Dis SEVERE Sleep Attacks, SEVERE Impulse Control Disorders, Cellulitis from swollen ankles, SEVERE Dopamine Agonist Withdrawal Syndrome-Included suicide attempt. Restless Leg Syndrome, Inability to Sleep. Interesting to find another person who has also fallen down a flight of stairs during a sleep attack. I was not so 'lucky' After two spinal surgeries I have rods and pins in my back. I had my first car accident , plus over ten more. In the one I totaled I was told the pressure on my knees was the car engine. I've been on anti-seizure meds a year since I started DAWS Studies have shown the longer you ingest this drug the less your chances for full recovery. The Dr. who titrated me off this Hell-go-Round saved my life, what's left of it. INGESTER BEWARE! There s/b a zero rating. F 60 14 years
1.5 3X day
3/7/2012
Email
 1  Multiple Sclerosis induced RLS Within 6 months I have gained almost 20 pounds, and I work out 5 days a week! I am very athletic. My hair is thinning and I have been out of control with Home Shopping Network. I wake up in the middle of the night. Every night and eat about 600 calories before 6am. I have to stop because I cannot afford a new wardro be and I am going into debt from all my compulsive shopping. PS I alos experience incontinence. Please don't take this unless there is no other option. I do want to say it was effective with my RLS but with very, very high price. F 44 6 months
.75 ER 1X day
2/3/2012
Email
 1  rls I writing in for my father. About 18 months ago he started gambling... stealing everything he could find to gamble, distancing himself from family and suicdal thoughts. After given an ultimatum he decide to check himself into a hospital to help him with severe depression. The hospital looked at his meds and advised us that a mirapex is under a law suit for not advertising these side effects!! Being off the meds for 2 days it seemed as if a fog lifted and my family had their old dad back. Now 2 weeks later we are in the hospital with what appears to be seizures... what's next?? Any advice please email me. pcesshill@AOL M 54 2 years
2x day
1/28/2012
Email
 1  RLS My husband takes Mirapex for RLS. Excessive Gambling, Cocaine use, compulsive behavior, memory loss, Poor sleep habits My husband started taking Mirapex for RLS and at first it was a miracle drug for him. He could finally have a restful night's sleep. I strongly believe this drug is changing him in a bad way and destroying our marriage. He always enjoyed gambling, but now he spends so much money its scary. He started using cocaine over the past few years while we'd be away on vacation then started using it at home over the past year. He only admitted to the cocaine use after me questioning it for a year and finding evidence of use and threatening to leave our marriage. He says he isn't doing it anymore. I strongly believe this drug is changing him into someone else. He goes from one compulsive thing to the next. Gambling, drug use, smoking too much, drinking too much, distancing himself from family, lying. Help! I want him to go to the DR to get a full physical and to see if this drug has anything to do with the compulsive strange behavior. He doesn't even have to go to the Dr for regular physicals each year to check this med and what it's doing to him. The Dr just continues to prescribe it when prescriptions run out without any medical evaluation. I'm positive its the Mirapex that's changing him. He started on .25mg and just recently had taken 4mg to find relief and then had an episode of such a terrible headache he was in bed for 24 hours. F 40 10 years
1mg + 1X day
1/12/2012
Email
 1  Myoclonus sudden narcolepsy. Nothing I could do we keep me awake. Happened at work, while driving, while talking to people and any other situation Was prescribed Mirapex about 8 years ago for myoclonic epilepsy. Worked wonderfull at first. Than the effects started to wear off. So they increased the dose by .05 mg. Over the course of time I was eventually up to 5 mg per day which is above and beyond the reccomended dosage. The Narcolepsy was really bad and I was still twitching at night. I finally stopped taking Mirapex and substituted another non-prescription drug which has been working wonders. I would be very careful with the use of Mirapex. Do not drive and do not do anything requiring one to be alert. M 46 8 years
5 mg 1X day
12/31/2011
Email
 1   swollen ankles, painfull joints, weight gain am always hungry I want to get off mirapex. Iam having some luck with smaller, earlier evening meals, no caffiene or alcohol,chocolates. also easy to digest foods help.I am convinced my rls is food related M 81 2 years
1X day
12/11/2011
Email
 1  RLS I was prescribed Mirapex for RLS. I have had it for about 12 years and have never taken anything. I was going through a really bad time with it and just could not go on any longer. My symptoms were daytime and nighttime. I was told I could add .5 mg until the RLS subsided so the first night I took 3 doses approx 4 hrs apart. Suddenly I felt like I was dying. I had major flu-like symptoms: sweating, nausea, sore throat, extreme body aches and a massive headache. It took about 24 hrs before I could get out of bed! Haven't taken it since. F 36 2 days
.5 mg prn
12/3/2011
Email
 1  PARKINSONS the worst was sleep attacks. i totaled my car due to this. memory very bad. slept an average of maybe 4 hrs per night. on occasion wouldn' t sleep for days. constantly on the move, always cleaning, rearranging, but things got worse not better. gained at leasst 40# telling people it may cause drowsiness just doesn't get it with this drug. they neglect to mention you may not get drowsy at all and suddenly fall asleep at the top of the stairs like i did. yes i fell head over heels and after hitting lower back and back of head i woke up in mid air,saw and grabbed the railing in time to stop myself with only three stairs remaining. it's a miracle i wasn't killed but i didn't even get a bruise F 59 9 years
1.5 MG 3X day
12/2/2011
 1  Fibromyalgia-based muscle twitches Severe depression, suicidal thoughts After reading all the positive reviews for this med, I was hoping it was going to be my wonder drug. But I wasn't one of the lucky ones. It had no effect on my chronic muscle twitches that occur all over my body. Neither did it help with my exhaustion. But it caused acute severe depression. F 55 2 weeks
.5 1X day
11/27/2011
Email
 1  parkinsons Fell asleep without warning x2.1st time while on the phone--thought I had a seizure. Heart studies normal.2nd time,3 yrs. later fell asleep while walking--head hit cement hard.Trauma cost $30,000 to repair. I stopped taking Mirapex after last fall.I am afraid to take any meds.$30,000 of dental repair and permanent scars.Again my heart studies were normal.I have a slight tremor but I sleep better off of Mirapex. F 79 4 years
.25 mgm 3X day
9/27/2011
Email
 4  RLS Vivid dreams where I don't know if I'm awake or asleep.Nausea if I don't take with food. Memory issues. Heightened sex drive. Weight gain. This was my last resort after being in a study for rls for a drug that was AMAZING, but they decided not to market. Mirapex is a poor substitute, but better than Requip. I have had RLS since i was a baby. The side effects so far are outweighed by the effectiveness. I also take neurontin (400mg)with the mirapex with success, as prescribed by my neuro. F 47 7 years
.1875 mg 1X day
8/24/2011
Email
 5  RLS Initially some drowsiness. Some obsession with a particular relationship and increased sex drive while taking bioidentical hormones also, for first two years. Recently some fibro type stuff. But all these could have other explanations or have appeared anyway. Overall a life saver the last five years. Previously had RLS for 35 years, had gotten to be nightly two hour sessions. I started on half a min. dose: .125 mg once a day at dusk, and that worked (unless I forgot) for 4 years. Then, along with some stressful life events, RLS would break through some and I increased it to .2 mg. Now I think I better up it some more, a year later. F 61 5 years
.125 mg 1X day
8/17/2011
Email
 5  RLS None that I'm aware of - I was taking Permex previously. My Mother, Sister, and Daughter also have severe RLS and take Merapex- with no apparent side effects. It has been a "lifesaver" for us. F 68 10 years
50 mg 2X day
7/20/2011
 1  RLS Husband takes this medication. Terrible side effects that increase over time. Things experienced include withdrawal from family, lying, stealing, gambling, hallucinations, binge eating, etc.. Our marriage of almost 30 years is in SERIOUS jeopardy. He does not recognize the issues that he is experiencing. Unfortunately, this has been the ONLY drug that has worked thus far. This is a SERIOUS drug. BE EXTREMELY CAREFUL IF YOU DECIDE TO TAKE THIS DRUG! F 54 6 years
.50 1X day
7/12/2011
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