MIRAPEX Reviews (PRAMIPEXOLE DIHYDROCHLORIDE)

Average Rating: 2.8 (431 Ratings)

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 EXTRAPYRAMIDAL MOVEMENT DISORDERS

 Type: Rx Drug

  

MIRAPEX  (PRAMIPEXOLE DIHYDROCHLORIDE):  Pramipexole is used alone or with other medications to treat Parkinson's disease. It can improve your ability to move and decrease shakiness (tremor), stiffness, slowed movement, and unsteadiness. It may also decrease the number of episodes of not being able to move ("on-off syndrome"). This medication is also used to treat a certain medical condition (restless legs syndrome - RLS) that causes an unusual urge to move the legs. Symptoms usually occur at night along with uncomfortable/unpleasant feelings in the legs. This medication can decrease these symptoms and thereby improve sleep. Pramipexole is a dopamine agonist that works by helping to restore the balance of a certain natural substance (dopamine) in the brain.   FDA Approval Date: 1997-07-01 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR MIRAPEXCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  RLS I am shocked to learn that so many of my problem behaviors have been linked to Mirapex: compulsive shopping, gambling, drinking, porn. 50 pounds weight gain. However, I am hesitant to duck personal responsibility for these behaviors. I was diagnosed with Chronic Fatigue Syndrome by Dr. Jay Goldstein in 1987, fibromyalgia in early 90s. After Dr. Goldstein's early retirement, I have tried to find a doc with his expertise. So far, no joy. My neurologist has been very helpful with sleep disorders, RLS and peripheral neuropathy (possibly related to diabetes). However, my current downward spiral has included not following up with appointments and referrals. Ideas? M 60 2 years
6/22/2007
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 2  RLS-Brain Injury Inability to ejaculate, extreme increase in sexual desire, very unsteady, nightmares so bad I cannot even bear to speak of them I took Mirapex for 1 week. I haven't taken it for 2 weeks now and I still am unable to ejaculate, and to make matters worse, my libido has multiplied by at least 1000%!?! On top of that, the nightmares are terrifying. They leave me feeling scared, anxious, depressed, and I don't know how to deal with it. My wife says she may sue the manufacturer if this doesn't stop soon, it's gotten so bad! M 35 7 days
6/22/2007
 1  Severe R:S Compulsive shopping that has devastated me finacially; inability to sleep more than 2 hours at night for 3 years, uncontrollable cravings for sweets and carbohydrates in the evening with 35 pound weight gain; severe arthritis and muscle cramps in legs; nausea; rash on lower legs; apathy about any thing other than complulsive behaviors I started Mirapex 3 years ago and it was like a wonder drug to me for my RLS. Within 6 months, I was spending uncontrollably, and gaining weight despite eating less than 1200 calories per day, plus experiencing RLS all day as well as night and needing increased dosaging of Mirapex. For the past 6 months, I have developed nausea and vomiting in the morning, rash on lower legs and difficulty walking due to muscle pains and spasms in lower legs. Also, the arthritis in my knee has advanced dramatically making it difficult to move my leg. My doctor said he didn't believe that these symptoms could be related to Mirapex. He tried me on Requip but that didn't work for me at all. I am trying to get off Mirapex and have reduced dose from 2 to 3 mg per day to 1 mg; but I'm having a terrible time reducing the dosage again due to increased RLS, anxiety, and crying spells. Does anyone know how to get off this medicine without excruciating pain and debilitating anxiety? F 57 3 years
6/7/2007
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 1  RLS and FMS Rash on legs, it did not seem to work. My doctor insisted I keep taking it. I stopped due to arthritis. See additional comments. I saw an orthopedic surgeon due to shoulder and arm pain. X-rays showed arthritis. He said in the distant future I would need surgery to remove it as it was impinging on those nerves. I saw him again a month ago and he said the arthritis had grown the equivalent of YEARS. He is recommending neurosugery to remove the arthritis. My family doctor said he has never heard of such a thing and said I should take steroid shots in my shoulders. I quit taking the mirapex and the RLS was much worse for about a week and then went away. It seems there was no difference in my FMS. If you have any hint of arthritis, be very careful with Mirapex. M 53 3 years
5/30/2007
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 3  Parkinson ? I have been taking Mirapex since 2001 for Parkinson's but I think I was diagnosed wrong. I think I'm addicted to Mirapex now . My PD has not progressed, but can't seem to go off of it.I have a tremor in left hand only and toes were moving .Wish I had gotten other opinions. Fall asleep watching TV suddenly. I am taking 1mg of Mirapexs and 100 mg of Stalevo. Mirapex's made me sleepy so instesd of increasing dosage I take Stalevo (a wearing off drug) F 66 2001 years
5/24/2007
 2  RLS For the first couple of weeks, I felt fine. My RLS had died down a bit, and I was beginning to sleep better at night. However, in the couple of weeks, I have began to experience intensely weird dreams, lack of energy, paranoia, depression, fatigue, and a return of my RLS, although not as bad as before. My stress level feels like it's risen about a thousand times for absolutly NO reason what so ever, and nausea has also become a problem, mostly in the mornings. Upon waking, I feel rather hung over which makes it extremely hard to start the day. Hunger/cravings are limited until about three hours before I go to bed, at which point I feel like I've been starving all day, even though I haven't felt hungry at all before then. RLS is still HIGHLY prominent during the day. F 17 4 weeks
5/21/2007
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 4  RLS VERY vivid dreams,scary but not really nightmares,waking several times during night,feeling hot, seems I am having trouble thinking/focus during day, maybe weight gain/compulsive eating. Waking in the morning I feel drugged up, but then much better. a bit of a headache first 2 nights, but seemed to pass. First time in 30 years I've gone days without even a stir in my legs. I hope I can continue with this, the relief from RLS feels like a miracle to me. Neurontin seemd to help for many years but in the last year or so, it seems my RLS has gotten worse. Still taking the Neurontin, and Cataflam for fibromyalsia. Have Lunesta to take when needed, I think I may need it now, but am concerned because I don't want to take so many pills. At first I had asked my Dr about requip, she said she prefers Meripex...I really hope I can continue this. F 44 8 days
5/1/2007
 4  Parkinsons Huge boost in energy and therefore improved speech and balance, etc on 2 tabs, 3 times a day (with Azilect)but badly disturbed sleep on 3 tabs, 3 times a day which obviously brought on fatigue. Neurologist and PD nurse suggested going back to 2 tabs and I feel pretty good generally and although there is very little improvement in my speed of movement in my weak arm, the energy levels more than compensate. Mood also much better. M 40 60 days
4/30/2007
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 4  RLS First year had terrible bouts of sudden sleepiness (like "crashing") and terrible nausea and sometimes vomiting-all during the first year, though, for my RLS it was miraculous and still continues to help me tremedously. I do have extremely vivid nightmares and also somewhat addicitive types of behaviors which I did not know until I started researching the medication, could even be caused by it. Overall-I do not think I could function without it as I have a very severe case of RLS M 42 4 years
4/29/2007
 4  Restless Leg None It has aided sleep problems, but not done away with. However other sleep problems could be related to apnea. M 38 9 months
4/27/2007
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 3  Restless Leg Syndrome Compulsive behaviors including: over-eating (craving snacks and sweets in evenings), viewing pornography; itching and mild rash on lower legs; augmentation. Mirapex is very effective at treating my RLS at low dose (.25 mg daily in evening), but concerns over side effects have led me to attempt to discontinue drug. Although side effects are tolerable at this point, I'm afraid that augmentation will lead to higher dosages, which will lead to worsening of side effects. Upon discontinuing, symptoms were more frequent and pronounced than when initially started taking Mirapex. Have had to go back on Mirapex until I can find something else that is effective without side effects. Can't afford to lose 2-3 hrs sleep every night! M 54 2 years
4/27/2007
 1  parkinson's disease weight gain, unable to stay asleep for more than 2-3 hrs, compulsive behavior (eating, gambling), legs and feet swollen every day, falling asleep in the middle of a sentence! I started Mirapex in July 2000 and I stopped Mirapex 6 wks ago. Since then, I have lost 23 lbs, all compulsive behavior has stopped, no swelling at all in feet, ankles or legs, sleeping 8-9 hours a night. F 63 7 years
4/10/2007
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 3  RLS Vivid Nightmares both visual and auditory. Weight Gain about 35 pounds. I strarted with .25mg and my RLS stopped being a problem. When I stop useing it I can no longer sleep at all. After taking about 2 years I started Gambleing uncontrollably which I have never done before and also I have started have unexplained compolsive behaviors ie. smokeing again after 8 years. I don't know if this has been the cause but I suspect that it is. M 53 6 years
3/31/2007
 4  PLMD/RLS If I take too high a dose it tends to keep me awake at night. Has greatly reduced my involuntary leg movements at night. I no longer have to get up out of bed to make my legs stop jerking (well hardly ever). I started on 1/2 of a .125 mg tab. I've gradually had to increase that to 1.5 tabs over the course of about 2 years. The trick is finding the minimum effective dose. If I take too much I will lie in bed awake all night feeling wired even though my legs are not jerking. M 55 2 years
3/13/2007
 4  PARKINSON'S SEVERE GAS,BLOATING. I AM TAKING ALONG WITH PARCOPA FOR PARKINSONS. I WAKE UP AT 3:00 AM WITH SEVERE GAS, BLOATING ALMOST EVERY NITE. I SUSPECT IT IS THE MIRAPEX AS I WAS TAKING THE PARCOPA WITH REQUIP AND DID NOT HAVE THAT PROBLEM. IT HELPED MY TREMOR TREMENDOUSLY THO. DID ANYONE ELSE HAVE THIS PROBLEM? F 66 3 months
3/10/2007
 1  RLS GAMBLING... LOST ENTIRE SAVINGS this occured after taking .75 mg per night for 2-3 years. Still can't believe I'm broke... Thousands of dollars were lost. Never gambled before. This side effect WAS NOT LISTED, when I first started taking it. Switched to Re-Quip, although, I have to say it is NOT as effective, and Gambling is still a concern, Mirapex had the highest rating for the Compulsive behavior side effect, for these types of drugs. MY RLS is under control, it just seems that it wears off more quickly than the mirapex did. I truly thought I had NO side effects, I never got sick, never had nausea, then I find out, that my all of a sudden, gambling addiction, can be directly related to my use of Mirapex. Makes Me ill to think about it. I am considering joining a class action suit. SO be careful. If you notice any compulsive behavior, Don't be surprised, get off the mirapex. DEW F 54 3 years
3/7/2007
 4  Resistant bipolar disorder Weight gain (around 20 pounds), forgetfulness, apathy I don't know how to rate this drug... It was miraculous in that it solved my agitation and anxiety like a dream. It started working in a matter of days. Honestly the apathy and forgetfulness was a small price to pay for this relief which I have never had before. Sadly I put on alot of weight on it and that was not from binge or compulsive eating. It was sudden weight gain and didn't seem to level off after a point. I was on it for 8 months at 2mgs and I was very unhappy to give it up. I restarted it later at a lower dose of 0.5mg and again it worked well but the weight started climbing up again. Apparently this is a very rare reaction and almost the opposite to what the drug usually does. I am very unhappy that I cant take this medication because I haven't found anything like this before. I also suffer from very severe tremors and this drug really helped with that too. I'm hoping to find a way to curb the weight gain and hope to be back on it soon. I would love to hear from any F 33 8 months
2/15/2007
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 3  RLS After a few weeks, I couldn't focus at work...felt like I had ADD...always surfing the net, often shopping, and then I found ebay and bought thousands of dollars of stuff I don't need and never wanted before. The link with COMPULSIVE BEHAVIOR is real, not for everyone but for some. That was the only side effect I had, and the first doctor I went to told me it wasn't related to the drug. I finally did some internet research, heard about the link to gambling, shopping, sex, etc., and got another doctor who had heard about this. Brain chemistry is a tricky thing to mess with, so if your behavior starts changing, it may be the drugs you're taking. I can take it on vacation as long as there's no computer around me, for work or for shopping! In terms of the RLS, it was like a miracle for me. I could sleep straight through the night, no wake-ups, on just .5 mg at night, for two years until the really crazy shopping behavior started. (Minor shopping binges and the ADD had been going on for longer but it wasn't as extreme and I didn't realize it was from the drug.) I could even nap during the day with no RLS symptoms. I tried Requip and it made me nauseous and gave me daytime RLS symptoms, which I never had before. I tried Sinemet and it just doesn't get me through the night -- I'd wake up 1-3 times with that creepy-crawly feeling and need to take more. Now I'm trying Klonapin, which so far helps with the RLS, but it makes me feel kinda stoned and unmotivated and a bit headachy. Ugh! F 46 2 years
2/13/2007
 3  Fibromyalgia /rls major crippling pain severe fibromyalgia. without meds am unable to move or function. some nausea was very happy with my 2nd try on it.. first time i ended up with edema so was taken off for awhile then started it up again. no problems yet except the sleep. hmm come to think of it i end up having problems once the dosage is higher than than 1 pill well just upped the dose by 1/2 now can't sleep for 2 nights. was happier with 1 pill big difference noticed still am disabled but pain is more tolerable. Was very close to my wits end had given up hope Mirapex is giving me hope. F 43 3 weeks
2/9/2007
 1  Parkinson's disease I hated it. I think I was on it for about 6 days and hadn't noticed any positive results. One evening at work, I felt so uncoordinated that I kept bumping into my desk at the library and finally fell down right in front of a patron. The next day, I asked my doctor to take me off it and the extreme clumsiness disappeared when it was out of my system. I found out it definitely does not work for me but I don't know if it might help others. F 52 6 days
2/7/2007

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