MIRAPEX Reviews (PRAMIPEXOLE DIHYDROCHLORIDE)

Average Rating: 2.8 (431 Ratings)

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 EXTRAPYRAMIDAL MOVEMENT DISORDERS

 Type: Rx Drug

  

MIRAPEX  (PRAMIPEXOLE DIHYDROCHLORIDE):  Pramipexole is used alone or with other medications to treat Parkinson's disease. It can improve your ability to move and decrease shakiness (tremor), stiffness, slowed movement, and unsteadiness. It may also decrease the number of episodes of not being able to move ("on-off syndrome"). This medication is also used to treat a certain medical condition (restless legs syndrome - RLS) that causes an unusual urge to move the legs. Symptoms usually occur at night along with uncomfortable/unpleasant feelings in the legs. This medication can decrease these symptoms and thereby improve sleep. Pramipexole is a dopamine agonist that works by helping to restore the balance of a certain natural substance (dopamine) in the brain.   FDA Approval Date: 1997-07-01 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Date added.

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR MIRAPEXCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  rls extreme fatigue, dizzyness, vivid nightmares, headache, spaced out,hallucinations THIS DRUG SHOULD BE BANNED. THE WORST DRUG I HAVE EVER USED. I COULD ONLY ENDURE IT FOR 10 DAYS AND WOULDNT WISH IT UPON MY WORST ENEMY M 38 10 days
10/5/2007
 1  RLS Trouble falling asleep, or staying asleep for more than 2-3 hours. Lots of headaches that don't respond to ibuprofen or Tylenol. Leg jerking while in bed became worse than ever. Dr. thinks it's withdrawal from clonazepam, but I was on a very low dose of that (.25 mg) and it's been over a week. I never experienced the typical RLS symptoms -- creepy crawly sensation or aching in legs. Sleep study revealed mild leg jerking in sleep. I think I was getting better sleep without it. F 38 11 days
9/24/2007
 1  /restkess leg I became incontinent, was drowsy in day time, than finally became itching over parts of my body On quiting it I was no longer incontinent. But it was hell coming off the drug. Laying down would cause my legs to twitch constantly and feel very irriated. I was unable to sleep more than 1 hour a night. It is now almost 2 months and the side effects of quitting are easing off. That is the most horrible drug. F 80 5 months
9/10/2007
 3  Parkinson excessive weight gain, bloating, swelling of ankles and feet, bottom of feet hurt, leg cramps. constipation I felt pretty good on mirapex even though I have put on 25 pounds in two years and am having a hard time getting it off..did get 10 pounds off...but now the swelling is bothering me and my feet and legs are cramping and I am going to ask my doctor to try something else, maybe the new drug which is a patch. F 72 22 months
8/28/2007
 5  RLS and PLMD Moderate nasal congestion. This drug is aptly named--it has been a MIRAcle medicine for me. (No I don't work for the drug company; I don't even know who makes it). If I don't take it for two nights in a row, the awful restless legs comes back and it about drives me crazy. So this is one medicine I never let myself get low on! M 47 7 years
8/27/2007
 3  Restless Leg Syndrome (RLS) Five weeks no problem, then all of a sudden became EXTREMELY nauseated and having profuse vomiting from the next morning throughout the day. Same day, problem with feeling totally fatigued and could barely force myself to stay away while driving to a (ironically) doctor's appt for my MS psych eval. I am taking Amantadine for my MS, Synthroid for hypothyroidism, Zebeta for high blood pressure, Lipitor for cholesterol, and none ever had a negative effect on me, and I've been on all of them for at least a year, some many years. The only medication that could have caused this was the Mirapex, which seems very possible as my Requip for the RLS did the exact same thing, minus the fatique and trouble staying awake. I think with both RLS medications, they work without incident for 4-6 weeks then they must be building up in some negative way in some people's systems and once they get to that tolerance point, the vomiting and such happens. F 53 5 weeks
8/21/2007
 1  RLS completely devastated, financially, physically, emotionally. family of four broken up. all money gone, no savings, no ira, still $20,000 in debt and no job. past four years i would have been better off in prison or institutionalized. M 47 5 years
8/21/2007
 1  RLS Uncontrollable gambling causing loss of thousands upon thousands of our savings, excessive weight gain, increased restlessness and uncontrollable muscle movements all over my body. Waking up in strange areas of my home. No memory of the night or going to bed. Increased forgetfulness. Have developed a "I could care less attitude" in all areas of my life (including family, pets, taking cre of myself and my home, not paying bills on time, lethargic and sleepy, cannot concentrate on anything, easily aggitated). My life has been turned around from 100% good except my problems with restles leg syndrome to me ruining not only my life, but my wife and everything around me. DON'T START IT! THE GAMBLING SATEMENTS ARE REAL! I HAVE LOST NEARLY 50 YEARS OF SAVINGS AND POSSIBLY MY WIFE M 46 1 days
8/18/2007
 3  Fibromyalgia 25 pound weight gain, anxiety, depression and irritability, drowsiness, extreme edema in feet and ankles. Mirapex helped my energy level dramatically; may have helped pain level somewhat, but the increased energy was wonderful after 8 years of feeling like my legs wouldn't support me and my coffee cup was too heavy to lift. Also I was able to get up in the mornings and felt like I had rested the night before for the first time since 1998. I didn't realize that the adverse changes I was seeing in my body were due to the drug until I saw this internet site. I have gained so much weight, fall asleep with almost no warning, and have become so anxious, depressed and irritable. My feet and ankles are extremely swollen. I will try to wean myself off this drug as soon as possible even though I really hate to give up the improved energy. F 55 2 years
8/17/2007
 1  Fibrolyalgia Perhaps the deal-breaker is severe emotional hypersensitivity and crying spells daily. I am normally a very upbeat, happy person, despite my daily physical pain. However, within 2 weeks of starting Mirapex, I began crying at the drop of a pin, even in public when just talking to someone. Other side effects I had were nausea, sleeplessness, extreme muscle twitching, and itching (no rash). I just put the crying spells together with the fact they started since Mirapex, so I have decided to start tapering off to get off this stuff!! It isn't worth it. F 44 5 weeks
8/15/2007
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 4  RLS 30 lb weight gain over 6 months, hot hands, ankle edema. works great when I take it at the right time. Weight gain is depressing and I may have to back to Requip which did not work as well. M 45 6 months
7/28/2007
 4  RLS Hallucinations, augmentation, some trouble with compulsive shopping Great for RLS but worry about augmentation and now hallucinations after having increased the dose to 2 mg. Adverse interaction with muscle relaxer in that I would fall asleep and not know it until I woke up. Fell asleep in the middle of a sentence once. Also, feelings of paranoia and anxiety. F 37 3 years
7/27/2007
 5  RLS Massive increase in appetite, moderate increase in libido, extremely vivid, horrifically violent and brutal nightmares. The drug worked somewhat well for me on the very first night and for that I give it a 5 -- first time in my life I was "kick free" at bedtime since starting it in 2003. I started at .125 but found .25 worked better. Because of the increased appetite, my doc tried Ropinerole, but that was not as effective. So I am back on the Mirapex. The nightmares are so powerful and violent and so awful that I might start taking the med every other night but want to check with my doc first. M 35 4 years
7/24/2007
 4  Parkinson's Disease Constipation, exhaustion, insomnia, mildly obsessive behaviour Very effective in alleviating most of the symptoms of PD. Very pleased overall. M 42 180 days
7/24/2007
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 5  RLS I'm on two other medications so it's hard to tell which one causes a given side effect, but the only change in meds in the last year was doubling my Mirapex dose (to .25 mg/day) - dreams are more intense, and strong increase in sexual desire despite being on antidepressants. I've traded the aggravation and sleeplessness of RLS for a happier, healthier sex life with my husband. Happy camper here! F 43 2 years
7/23/2007
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 3  rls compulsive behavior-gambling, eating, spending. Never had such behavior in the past. It was real. Also felt wideawake and not rested when I got up in the am. worked like a miracle for about 7 months. Was taking vicodin prior and was able to cut down. Now I am cutting down on mirapex and will have to take more vicodin(1000mg/day). Mirapex still helps takes the full force of rls away. Had rls for 45 years, never knew what it was until the "internet". Docs always looked at me like I was nuts. W/O meds I am up all night and until collapse. Last time w/o meds I could stay in bed for more than a minute. M 62 6 years
7/16/2007
 2  restless leg syndrome & plmd Headached, fatigue, woozy the next morning, very fuzy headed in the morning. clumsy. Fuziness stayed with me through the day. Was prescribed for periodic limb movement disorder and restless leg syndrome. It DID help the restless leg disorder but I don't care for the side effects F 51 1 weeks
7/15/2007
 4  RLS Drowsiness, nausea I'm not sure if Mirapex has helped my RLS symptoms. I still move my legs, but I think it is due to habit and not the uncontrollable urge to move them. The way Mirapex has been helpful is that I have insomnia that has been difficult to treat, and Mirapex makes me sleepy. I tend to build up tolerances to hypnotics very quickly (when they even make me drowsy at all). I've been taking Mirapex for a few days, and the effect has not worn off yet. F 26 5 days
7/14/2007
 2  RLS A little nausea I didn't have bad side effects, but it didn't help the RLS one tiny little bit. F 26 2 weeks
7/10/2007
 5  RLS Possibly addicted to carbs & sweets, but don't know if it is due to this drug. I have experienced tremendous relief from my RLS symptoms since taking Mirapex. I must remember to take it on time, usually around 9:30 PM or I will have problems with my legs for a few hours before I get to sleep. I went off the Mirapex for 2 weeks to participate in a research program and went 4 days straight without a wink of sleep... a horrible experience. I was ready to take drastic measures because of the sleep deprivation, but when I finally crashed, I was able to function again. I could have stayed off Mirapex, but as soon as the research was over, I got right back on it. I saw no need to suffer with this disorder when the relief is there. I'd recommend to anyone with primary RLS, ask your doctor or neurologist what they think about it for you. F 55 4 years
6/27/2007
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