MIRAPEX Reviews (PRAMIPEXOLE DIHYDROCHLORIDE)

Average Rating: 2.8 (431 Ratings)

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 EXTRAPYRAMIDAL MOVEMENT DISORDERS

 Type: Rx Drug

  

MIRAPEX  (PRAMIPEXOLE DIHYDROCHLORIDE):  Pramipexole is used alone or with other medications to treat Parkinson's disease. It can improve your ability to move and decrease shakiness (tremor), stiffness, slowed movement, and unsteadiness. It may also decrease the number of episodes of not being able to move ("on-off syndrome"). This medication is also used to treat a certain medical condition (restless legs syndrome - RLS) that causes an unusual urge to move the legs. Symptoms usually occur at night along with uncomfortable/unpleasant feelings in the legs. This medication can decrease these symptoms and thereby improve sleep. Pramipexole is a dopamine agonist that works by helping to restore the balance of a certain natural substance (dopamine) in the brain.   FDA Approval Date: 1997-07-01 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR MIRAPEXCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  PD severe weight gain F 71 2 years
2/3/2008
 2  Parkinsons Caused nausea and edema at the beginning, however, was effective for my Parkinsons. I then developed shortness of breath and finally wheezing in the six months that I was on it. Couldn't walk more than 20 steps without wheezing. Started back into atrial fibrillation from Mirapex?? I called my Dr. feeling like I was slowly being poisened. He thought respiratory problems. I asked to be taken off of Mirapex, which I did gradually. After one week all of my symptoms have disappeared and I feel like a new person! F 67 6 days
1/27/2008
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 1  fibromyalgia compulsive spending, strange smells, vivid dreams - often upsetting, hearing music, paranoia all of these things happened gradually and in such a way that I did not associate them to any one thing until a friend asked if I had started gambling because of mirapex. I said no but I have spent a load of unnecessary money. That's when I talked to my doctor and all of these things began to tie together. I came off mirapex gradually but it was rough. My emotions paid a price. F 55 1.5 years
1/26/2008
 2  for nerve endings instantly bloated, constipated, can't sleep, if i take more than 1 pill I become hot, dizzy, nauseous. Can't keep my eyes open during the day (even tried taking it early in the day thinking by bedtime i could sleep, didn't work) I took this for a few days felt horrid (nauseous, hot and dizzy) and stopped. Told my Dr. I would try again and now I can't sleep for more than an hour at a time at night, I immediately felt bloated and swollen (clothes are tighter) and have an increase in appetite, and constipation. I think I will stop after reading everyone's similar problems. F 28 3 days
1/24/2008
 2  Parkinson's Sleepiness in the evening, increased shaking, some increase in gambling desire. I'm in the early stages of Parkinson's with shaking primarily in right arm. Taking Mirapex 1 mg 3 times a day. Now my shaking has worsened but the constant tremor has reduced. Had better results with .5 mg 3 times a day. M 44 3 months
1/24/2008
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 5  RLS None that I can tell. Dosage is .25 per night. I take it as needed. Usually about 3 times a week. I heard about the compusive behavior before I took this from my Doctor. So far no side effects or addictive behavior. In fact kinda the opposite. Now that I get a good nights sleep I am actually more productive M 43 2 months
1/22/2008
 4  RLS Chest pain, memory loss, shortness of breath, erratic behavior My RLS has never felt better, but I am worried about these side effects. I sleep well through the night like never before. Has anyone with these side effects switched to another med with success? F 47 3 months
1/22/2008
 4  restless legs I seem to be hungry all the time and a little clumsy. I also have fibromyalgia so a lot of side effects I have are attributed to that so I'm not sure exactly what side effects are from what drug I take. Without Mirapex, I might as well not even go to bed at night. I Can't sleep without it. Yes, the dreams are pretty bad but at least I feel rested in the morning and I'm not up all night. M 56 1 years
1/7/2008
 1  Parkinson's Hallucinations, loss of appetite, confusion, couldn't walk, talk or eat without assistance. My grandfather was on this for over a week. He went from being a fun, joking around kind of grandpa, to not knowing what was going on around him, hallucinations, horrible nightmares, could not feed himself, no control over his feet or hands, constantly reaching for things that were not there, confused, terrible diahrea, tired all of the time, etc etc. We thought my grandfather would eventually not even know who we were...it was such a dramatic change in him. He could barely walk and needed 24-hour care. Couldn't follow directions from the PT or the OT, very, very confused. After my mother told the doctor to take him off of the drug (he was in the hospital at the time), he had a DRAMATIC change and was back to "normal" in two days. It was amazing....we will NEVER, NEVER allow the doctor to put him on this again. BEWARE!!! We actually admitted my grandfather into a nursing home (because the hospital was discharging him and the doctor said he needed 24-hour medical care). M 2 weeks
12/25/2007
 3  RLS - severe Recently switched to this drug from pergolide (it was pulled from market). My RLS is under control (especially the nightly pains in my legs) but I don't feel myself. I feel tired, weepy, achy. I've gained weight (quickly) and my breasts are swollen and tender - like constant pms!!!!!!! My joints hurt and I'm clumsy and groggy....what to do??? It looks like requip has more or so the same side effects. I've had RLS for 9 yrs, I was pregnant went first diagnosed and it was very severe. Are all my symptoms related to the drug? I thought I had breast cancer - in fact - I'm still wondering if there is something else causing the pains. Anyone have any thoughts? Experiences to share? F 38 3 weeks
12/11/2007
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 3  RLS Has anyone developed twitching of the eyelids with this drug? I have it on both eyes! Lots of daytime sleepiness- especially while driving! I have to be very careful with this. Some augmentation but it mostly works well for me. I'm surprised how many comments about weight gain- I'm really trying to lose those 30 lbs I've put on since starting the drug, working out vigorously at the gym for 1 and 1/2 hours 3-4 times a week and watching what i eat has done little! F 48 2 years
12/2/2007
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 1  RLS - Light To Moderate Headaches. I like, NEVER get Headaches (once a year MAX)... so having a headache was quite surprising. 0-Zero improvement in RLS. 0-Zero improvement in RLS. Trials of Mirapex as well as Requip both led to Ansomnia for me... so it could be me. However, Requip did not lead to Headaches and after seeing numerious other comments mentioning headaches - as well as a life history (of 33 years for me) basically headache free: I think it's fair to say that Mirapex is the source of my headache at this moment. It's 5:52AM, I've been up all night with a headache from Mirapex. M 33 5 days
12/2/2007
 5  RLS symdrome lethargic, fall asleep, but the side effects you do not notice until they become more dramatic are compulsive buying, overeating, and sexual behavior (pornograpy) I have been taking Mirapex almost since it was released and have gone from a .5mg dosage to 1.0mg to 1.5mg dosage. I have had a real hard time not spending money, up to $300,000 right now, addition to pornography and overweight. These addictions took a long time to get to this point and it was not noticable until it is almost to late. M 64 5 years
11/28/2007
 1  rls legs felt heavy, hard to walk,I developed twitching, jerking movement all over my body that has continued even after I quit the med. I had gross vision distortions and fell in my home tearing my knee bad enough to require surgery. F 52 14 days
11/6/2007
 2  Primary RLS Have been on Mirapex for 5 weeks, having stopped Gabapentin to try the Mirapex. At first, it worked well - even better than the Gabapentin - no breakthrough symptoms. Sleep disturbances did not improve, however - have great difficulty falling and staying asleep in spite of either medication... even though my legs are more relaxed. Recently, symptoms much worse! Terrible muscle cramps and spasms, nausea, pounding heart, headaches, tiredness and fatigue, and in the last two weeks, I have developed extreme stiffness in all my joints and muscles. I don't seem to be able to "walk it off", either. I have also been having a lot of mid-back pain which has been increasing over the past three weeks. My side effects are now bad enough that I must consider stopping the medication. What started out as a "miracle" is now a "nightmare". So far, I have tried three different meds for my RLS, and the net negative impact was the "least" with gabapentin - even though I did not experience complete relief. I have severe to moderate primary RLS which I have had since I was too young to even remember. It started out as only an feeling of "ants and crawliness in the legs".. now I get throbbing pain as well as extreme jitteriness/ ants in the legs. Worse... it is no longer confined to my legs, or even my arms and legs. The worse experience I have is when it actually affects my entire body - perhaps the progressive nature of the disorder. I am glad that there are finally treatments and a name for this disorder... for years, doctors and friends thought I was "really weird"! I just hope they come up with things that really work,and that my insurance will cover (Requip is not covered, so I haven't been able to try that one yet.) F 51 5 weeks
11/1/2007
 5  RLS a little neasea on .50 but overall great results tried a higher dosage because rls symptoms worsen before my menstrual cycle and had difficulty! .75 dosasge to high for me after about three weeks at this dose a started having shooting pains in my chest and numbness in my hand and arms that comes and goes. I thought i was having a heart attack! F 39 9 months
10/25/2007
 2  Restless Legs Everything was great on Mirapex until I started having weird buzzing feeling in heart and heart rate sent me to the ER. Twitching now is far worse than before I was taking Mirapex. I tried to wean myself off of it and the RLS was so bad.. it felt like I was having epileptic seizures in my lower calves. I have had to see a Cardiologist and they did CT of heart, EKG, Stress Test, Holter Monitor and now wish to perform a cardiac catheterization because they cannot figure out what causes my heart rate to go from 88 to 133... Last night.. I purposely did not take Mirpex and then the twitching got so bad that I had to find it... and take it..(I split the pill in half) and BAMB!!! I could feel my heart pounding and the weird buzzing sensation in my chest. I am going to pay dearly tonight.. going cold turkey.. but I do NOT take any other pills or prescriptions. Mirapex... I think it caused some heart problems for me. F 43 8 months
10/14/2007
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 1  Dystonia and Restless Legs I go nuts. I get very impulsive and compulsive...but since without Mirapex I would be in a wheelchair and I have cancer, quality of life is everything....I am trying to get used to the throwing up, etc. If you don't ABSOLUTELY have to take it....DON'T...I now have to see a shrink to get a pill to counteract the side effects....I feel like I am going NUTS F 57 6 days
10/10/2007
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 5  RLS Initially nausea and light headed due to bp drop. Increasing dose to deal with RLS to 3X 0.088mg has caused early morning waking (5am};perpetually feeling wired ending in exhaustion; big increase in weight tho not appetite. Alcohol,caffeine seem to negate effect of Mirapex. Also have to take before food even tho makes me feel nauseous. If take with or after food I get no effect from drug. It certainly has made my RLS and associated pain etc better however the feeling wired sensation is exhausting..I just can't sit down and have to be doing physical stuff. Am taking low dose Fluoxetene alongside. I find the whole senario very frustrating. 61 12 months
10/6/2007
 4  RLS I noticed decrease in appetite immediately, lost weight. Sometimes the thought of food makes me sick to my stomach. Occasionally still have RLS at night, but it has decreased. No other side effects, feel the same, except more well rested. I like Mirapex. It seems to work fine for me without all the side effects everyone else talked about. I have had RLS for many years. Its a relief to be able to sleep finally. F 34 2 months
10/6/2007

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