PREMPRO Reviews (ESTROGENS, CONJUGATED; MEDROXYPROGESTERONE ACETATE)

Average Rating: 2.9 (47 Ratings)

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 Type: Rx Drug

  

PREMPRO  (ESTROGENS, CONJUGATED; MEDROXYPROGESTERONE ACETATE):  This medication contains 2 female hormones: an estrogen (such as conjugated estrogen, estradiol) and a progestin (such as medroxyprogesterone, norethindrone, norgestimate). It is used by women to help reduce symptoms of menopause (such as hot flashes, vaginal dryness). These symptoms are caused by the body making less estrogen. The progestin in this medication helps to reduce the risk of cancer of the uterus which can be caused by using estrogen. Women who have had their uterus removed do not need the progestin and therefore should not use this combination medication. If you are using this medication to treat symptoms only in and around the vagina, products applied directly inside the vagina should be considered before medications that are taken by mouth, absorbed through the skin, or injected. This medication may also be used by women after menopause to prevent bone loss (osteoporosis). However, there are other medications (such as raloxifene, bisphosphonates including alendronate) that are also effective in preventing bone loss and may be safer. These medications should be considered for use before estrogen/progestin treatment.   FDA Approval Date: 1998-01-09 (Sources: U.S. Centers for Medicare Services, FDA)

  

Results are sorted by Date added.

Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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RATING  REASONSIDE EFFECTS FOR PREMPROCOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  to reduce hot flashes.night swaets F 4 months
9/8/2013
 1  Hot flashes and joint pain Severe joint pain and headaches. Stopped taking after 5 days. F 51 1 days
3mg
2/14/2013
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 4  Severe hot flashes Extreme breast tenderness, acne, weight gain, fatigue On the plus side it completely stopped my hot flashes. They were so bad I was unable to sleep at night. Now both of my breasts are extremely tender, I have acne, I am always tired, and have gained 5 lbs in 3 months. I have decided to cut back to taking it every third day to see if that helps. I cannot stop taking it because the hot flashes were intolerable. F 52 3 months
.625 / 2.5 1X day
5/23/2012
Email
 3  pre menopause No major side effects yet, but always hungry, and tired. I had thermal ablation due to heavy periods, which forced my body into menopause. Then my hormones went crazy! Severe night sweats, breast tenderness, extreme anxiety. Blood work showed my body was very low on estrogen, have been taking this for 3 months, night sweats are gone, anxiety is better. Still have some breast tenderness, but tolerable. I am always extremely hungry, and cannot get full. Fatigue also. I am going to see my doctor in a few weeks, and hope she can help with how I'm feeling. F 39 3 months
.625 1X day
3/31/2011
Email
 4  perimenopause Severe edema in my legs and feet - vascular malfunction. I actually love the effects of this, other than the edema - which is why I have to stop. I have a history of severe PCOS, PMDD, and Major Depression that led to years of disability and for the first time in a long time I feel great - other than the severe edema which is very painful and difficult to manage ( I feel like I am weighed down by wet cement ) F 42 1 months
1X day
3/13/2011
 4  Menopause In six months, no bad side effects. Good ones include losing the terrible night sweats, less unexplained hunger (lost 8 lbs), better sleep patterns. I think when analyzing ratings one has to see what the patient suffered from before. If she already suffered from depression, it isn't fair to say depression was a side effect of Prempro...if she had depression and just had surgery, who is to say it was the Prempro and not preexisting condition and/or life? Working very well. F 48 6 months
.625 1X day
1/14/2011
 1  Post oopharectomy HRT The main side effect is severe depression. I began taking this after BRCA+ related removal of both ovaries. While this is managing the beginning menopausal symptoms of hot flash the depression is horrific; despite already taking an antidepressant. I strongly recommend not taking this medication after my personal experience and reading about many others' experience. F 37 8 days
0.625/2.5 1X day
11/17/2010
 1  menopause/ mood swings I have gained 41/2 lbs in 3 months. I have acne like I'm a teenager. Did not fight acne as a teenager but do now. I get heart burn. Can not sleep less then 9 hours a night, groggy all day. Have no energy. Have had periods that last up to 10 days, every two-three weeks. (Heavy periods).I also have back problems prempro make it worse, can't hardly get around some days because of joint pain. I think I would rather go thru menopause bitchy!!! F 51 3 months
0.3mg 1X day
5/10/2010
 4  Complete Hysterectomy No side effects F 34 15 months
1X day
4/2/2010
 2  Depression Got my period for over 2 1/2 weeks and decided to come off it. I feel like I've been hemorraging since stopping about five days ago. It did nothing for my depression as far as I can tell so I wouldn't advise it to help with this! My doctor didn't think a blood test would be helpful before whipping out her Rx pad. When I returned and asked her about side effects, she mentioned cancer, stroke and heart attack. I told her I was already at risk for stroke and heart attack and she said "so you may as well take it." Needless to say, I'm starting with a new MD ASAP! F 52 35 days
11/28/2009
 1  menopause Breast cancer - this is an extremely dangerous drug and it's a crime that it was approved by the FDA. Do not take this drug. It's better to go through menopause naturally or use herbal medicine. After cancer I had surgery, chemo and radiation. Now I am in chemo induced menopause which is far worse than natural menopause. It only bought me a few years of benefit for a lifetime of greif. F 49 6 days
2/15/2009
 3  hotflashes every 15-20 minutes in my second month of the Rx. Good results at first. Now have begun menstrating again after a year and a half absense.(Absence of menses was the only good thing I find about menopause.) Am 53 years old. Menses is now in 7th day. hot flashes continue at night even with medication so now take Ambien (generic). Don't know if I will stay on it or try a natural compounding. am not crazy about having a period for the rest of my life. F 53 70 days
8/15/2008
 1  Perimenopause Severe breast swelling and tenderness - bra, no bra, didn't matter - way too sensitive. Even sleeping on them hurt. Didn't help my PMS, and after a year and a half, trying different combinations of "prem" and "pro", and not really feeling right at all, I read about the dangers of HRT and decided I needed to find another way. My mother was on HRT for about 20 years, and developed breast cancer and had her gallbladder removed. And all that estrogen over all those years didn't keep her from shrinking in height. Don't believe all the baloney from the ads on TV - and don't expect your doc to be too up on this stuff either, since all they know is what the pharmaceutical sales rep tells them. At 43, I had a period that lasted 18 days and severe sudden depression - my doc did an estrogen blood test, and finding it low, put me on Prempro. I have since learned a lot - like women that are still having periods should not be put on estrogen! And, blood tests are worthless when measuring estrogen! Ladies, do your homework - read Dr. John Lee's book, "What Your Doctor May Not Tell You About Menopause", and make those simple changes. I found a copy in my local library, and found it so compelling I bought it for myself and my mother. I now use over the counter bioidentical progesterone cream, walk and lift weights, take a good supplement with calcium, Vit. D and magnesium and feel much better even though I'm three years older. You don't have to be a slave to the pharmaceutical companies! F 46 1.5 years
7/7/2008
 1  Perimenopause Severe breast swelling and tenderness - bra, no bra, didn't matter - way too sensitive. Even sleeping on them hurt. Didn't help my PMS, and after a year and a half, trying different combinations of "prem" and "pro", and not really feeling right at all, I read about the dangers of HRT and decided I needed to find another way. My mother was on HRT for about 20 years, and developed breast cancer and had her gallbladder removed. And all that estrogen over all those years didn't keep her from shrinking in height. Don't believe all the baloney from the ads on TV - and don't expect your doc to be too up on this stuff either, since all they know is what the pharmaceutical sales rep tells them. At 43, I had a period that lasted 18 days and severe depression - my doc did an estrogen blood test, and finding it low, put me on Prempro. I have since learned a lot - like women that are still having periods should not be put on estrogen! And, blood tests are worthless when measuring estrogen! Ladies, do your homework - read Dr. John Lee's book, "What Your Doctor May Not Tell You About Menopause", and make those simple changes. I found a copy in my local library, and found it so compelling I bought it for myself and my mother. I now use over the counter bioidentical progesterone cream, walk and lift weights, take a good supplement with calcium, Vit. D and magnesium and feel much better even though I'm three years older. You don't have to be a slave to the pharmaceutical companies! F 46 1.5 years
7/7/2008
 4  to counteract the Depo Lupron shot So far I have not recived any side affects. Although I was very worried about take a hormaone replacer. It has helped tremendously with the annoying side effects of the Depo Lupron that I have been taking. Hot flashes, night sweats, cold flashes and the annoying headaches. F 31 1 months
6/5/2008
 1  HRT following early complete hyster Weight gain (about 25# first year!), bloating, breast tenderness, fatigue, depression, acne, indigestion - I hate this drug! Had complete hysterectomy/both ovaries removed at age 42 for endometriosis. Need progestins to counteract estrogen which causes endo to regrow. Am prone to depression - but this is the worst! I weight more than ever in my life and have no energy at all. Am about to start a different progestin formula because this is the pits. F 43 14 months
4/13/2008
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 5   very few side effects, worked well for me. F 49 5 years
4/7/2008
 5  Menopause symptoms No side effects Was having terrible sweats both day and night. it was really affecting my daily routine and making me crazy. I take a pill every other day and i am normal again. F 59 5 years
2/25/2008
 1  Bled for 4 months Drug info says not to take if bleed too long, but Prempro is exactly what I got! Having my tubes tied threw me into early menopause at 39, with severe cramps & longer periods.Leg Pain, varicose veins. Yes, I am now concerned that I may have gallbladder disease because of attacks I have. Quit taking Prempro. Also period free now. F 53 5 years
8/16/2007
 2  HRT after PCOS and Ovaries removed Gall bladder disease!!! Counteracts Synthroid prescribed for hypothyroidism!!!! In 2000 I was diagnosed with PCOS. Took prempro to reduce cysts and re-establish cycle after many years of two or less per year. After 3 months had to have both ovaries removed due to benign tumors. After a few months started having Gall bladder attacks. After about a year ended up in the hospiital with infection and "Thousands of Stones". Received IV antibiotics for 5 days and had Gall bladder removed. Continued on Prempro for a few years following that. Developed Hypothyroidism and began taking Synthroid for that. The estrogens in Prempro counteract the thyroid meds so I asked Gyn to reduce dosage. Seemed to be working ( have begun to lose weight FINALLY) but on last sonogram had thickening of uterine lining so was taken off of Prempro(with the thyroid meds working my body started making its own Estrogen and that's why I needed more progesterone than was in the lowest dose of Prempro that I took) will begin progesterone only and see how i do. F 38 5 years
6/13/2007

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